Gene: FGF9

2254
FGF-9|GAF|HBFG-9|HBGF-9|SYNS3
fibroblast growth factor 9
protein-coding
13q12.11
Ensembl:ENSG00000102678 MIM:600921 Vega:OTTHUMG00000017412 UniprotKB:P31371
NG_016272.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.487e-1 (AD)  3.656e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAM230.944
ABCG40.94
ATP2B20.938
KCNQ50.934
GABRB20.931
PNMA30.931
DRP20.929
RBFOX10.929
MAGEE10.927
SLC12A50.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR1-0.621
RAI14-0.618
CNN2-0.602
YES1-0.596
REST-0.59
SGMS2-0.586
TFPI2-0.579
HEY2-0.578
RAB13-0.573
MYL3-0.572

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of FGF9 mRNA"19358281
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of FGF9 mRNA23792671
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]20464547
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]20464547
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in increased expression of FGF9 mRNA"19358281
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of FGF9 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FGF9 mRNA"19358281
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FGF9 mRNA"23196670
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]20464547
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]20464547
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGF9 gene27153756
D019386AlendronateAlendronate affects the expression of FGF9 mRNA16079270
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF9 mRNA16483693
D000735AndrostenedioneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Androstenedione]]22872763
D000735AndrostenedioneFGF9 protein inhibits the reaction [[LHB protein co-treated with IGF1 protein] results in increased abundance of Androstenedione]22872763
D000735AndrostenedioneFGF9 protein inhibits the reaction [LHB protein results in increased abundance of Androstenedione]22872763
D001151ArsenicArsenic affects the methylation of FGF9 gene25304211
C547126AZM551248AZM551248 results in decreased expression of FGF9 mRNA22323515
C487081belinostatbelinostat results in decreased expression of FGF9 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FGF9 mRNA19358281
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FGF9 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of FGF9 mRNA19358281
D001564Benzo(a)pyrene2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]20464547
D001564Benzo(a)pyrene4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]20464547
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FGF9 mRNA16002475|1935828
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FGF9 protein20464547
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FGF9 mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FGF9 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of FGF9 mRNA12072406|1460280
D004958EstradiolEstradiol results in increased expression of FGF9 protein12072406
D004958Estradiol[FGF9 protein co-treated with FSHB protein] affects the abundance of Estradiol22798350
D004958EstradiolFGF9 protein inhibits the reaction [Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D004958EstradiolFGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D004958EstradiolFGF9 protein inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased abundance of Estradiol]22798350
D004958EstradiolFGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Estradiol]22798350
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of FGF9 mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of FGF9 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of FGF9 mRNA22732146
C006780bisphenol Abisphenol A results in increased expression of FGF9 mRNA27022677
C006780bisphenol Abisphenol A results in decreased expression of FGF9 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FGF9 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FGF9 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of FGF9 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of FGF9 mRNA26191083
D002101Cacodylic AcidCacodylic Acid results in increased expression of FGF9 mRNA17720352
D002118CalciumCalcium affects the expression of FGF9 mRNA15913539
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FGF9 protein17662249
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of FGF9 mRNA26272509
D004390ChlorpyrifosChlorpyrifos results in decreased expression of FGF9 mRNA20350560
D004390ChlorpyrifosChlorpyrifos affects the expression of FGF9 mRNA18502319
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FGF9 mRNA24374135
C031180chrysenechrysene results in increased expression of FGF9 mRNA26377693
D005576ColforsinFGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D005576ColforsinFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]22798350
D000069439DasatinibDasatinib results in increased expression of FGF9 mRNA20579391
D003976DiazinonDiazinon affects the expression of FGF9 mRNA19130878|2254681
D003994BucladesineFGF9 protein inhibits the reaction [Bucladesine results in increased abundance of Progesterone]22872763
D003994BucladesineFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Androstenedione]]22872763
D003994BucladesineFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22872763
D003994BucladesineFGF9 protein inhibits the reaction [Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D003994BucladesineFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22798350
D003994BucladesineFGF9 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]22798350
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of FGF9 mRNA28962523
D002945CisplatinFGF9 protein affects the susceptibility to Cisplatin16217747
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FGF9 mRNA26924002
D004026DieldrinDieldrin affects the expression of FGF9 mRNA22546817
D004026DieldrinDieldrin results in increased expression of FGF9 mRNA19130878
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of FGF9 protein27060630
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of FGF9 mRNA28123099
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of FGF9 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of FGF9 mRNA20146380
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of FGF9 mRNA21040762
C118739entinostatentinostat results in decreased expression of FGF9 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
D004967EstrogensFGF9 protein promotes the reaction [Estrogens results in increased expression of TBX3 protein]21098263
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FGF9 mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FGF9 mRNA16551644
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FGF9 mRNA23550701
C070081fulvestrantfulvestrant results in decreased expression of FGF9 mRNA14602803
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of FGF9 mRNA]17109745
D005944GlucosamineGlucosamine results in increased expression of FGF9 mRNA17109745
C492448ICG 001ICG 001 results in increased expression of FGF9 mRNA26191083
C051890irinotecanirinotecan analog results in decreased expression of FGF9 mRNA18927307
C004809isopentenyl pyrophosphateisopentenyl pyrophosphate results in increased expression of FGF9 mRNA14704367
C004809isopentenyl pyrophosphateisopentenyl pyrophosphate results in increased expression of FGF9 protein14704367
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of FGF9 protein"23604539
C482199lipopolysaccharide, E coli O55-B5"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGF9 protein]"23604539
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of FGF9 mRNA"19524256
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FGF9 mRNA12057914
D008070Lipopolysaccharides"[Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased expression of FGF9 protein"12639846
D008550MelatoninMelatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA]19476551
D008550MelatoninMelatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein]19476551
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FGF9 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FGF9 mRNA23179753|2718838
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA19476551
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein19476551
D0156551-Methyl-4-phenylpyridiniumMelatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA]19476551
D0156551-Methyl-4-phenylpyridiniumMelatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein]19476551
D0156551-Methyl-4-phenylpyridiniumFGF9 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium19476551
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FGF9 mRNA26924002
D009151Mustard GasIL10 protein affects the reaction [Mustard Gas affects the expression of FGF9 mRNA]16173061
C002701neocuproine"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGF9 protein]"23604539
C007350nitrofennitrofen results in decreased expression of FGF9 mRNA23897418
C007350nitrofennitrofen results in decreased expression of FGF9 protein23897418
D010126OzoneOzone results in decreased expression of FGF9 mRNA12763052
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of FGF9 mRNA26272509
D052638Particulate Matter2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]20464547
D052638Particulate Matter4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]20464547
D052638Particulate MatterParticulate Matter results in increased expression of FGF9 mRNA20464547
D052638Particulate MatterParticulate Matter results in increased expression of FGF9 protein20464547
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FGF9 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of FGF9 mRNA14741686
D010936Plant ExtractsPlant Extracts results in increased expression of FGF9 mRNA21297082
D000072317Polychlorinated DibenzodioxinsPolychlorinated Dibenzodioxins results in increased expression of FGF9 mRNA19358281
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased expression of FGF9 mRNA16002475|2046454
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased expression of FGF9 mRNA16002475
D011192Potassium DichromatePotassium Dichromate results in decreased expression of FGF9 mRNA23608068
D011284PregnenoloneFGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone]22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [Bucladesine results in increased abundance of Progesterone]22872763
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22872763
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Progesterone]22872763
D011374ProgesteroneFGF9 protein inhibits the reaction [[LHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]22872763
D011374ProgesteroneFGF9 protein inhibits the reaction [LHB protein results in increased abundance of Progesterone]22872763
D011374ProgesteroneFGF9 protein results in decreased abundance of Progesterone22872763
D011374Progesterone[FGF9 protein co-treated with FSHB protein] affects the abundance of Progesterone22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased abundance of Progesterone]22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Progesterone]22798350
D011374ProgesteroneFGF9 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]22798350
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of FGF9 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of FGF9 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of FGF9 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of FGF9 mRNA23274088
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of FGF9 mRNA16079270
D012999SomanSoman results in increased expression of FGF9 mRNA19281266
D014284TriiodothyronineTriiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]16150908
D014284TriiodothyronineTriiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein]16150908
D013629TamoxifenTamoxifen affects the expression of FGF9 mRNA24769059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGF9 mRNA19358281|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FGF9 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of FGF9 mRNA21602191
D013974ThyroxineThyroxine results in increased expression of FGF9 mRNA22798350
D013935Thymic Factor, Circulating"[Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased expression of FGF9 protein"12639846
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FGF9 mRNA20464547
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of FGF9 protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of FGF9 protein]24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FGF9 protein27793746
C483909torcetrapibtorcetrapib results in increased expression of FGF9 mRNA23228038
D014212TretinoinTretinoin results in increased expression of FGF9 mRNA21934132
D014212TretinoinTretinoin results in increased expression of FGF9 mRNA15621532|7656983
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FGF9 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of FGF9 mRNA24935251
C009954trilostaneFGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone]22798350
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of FGF9 mRNA23179753|2438349
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of FGF9 mRNA17459161
D014640VancomycinVancomycin results in increased expression of FGF9 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of FGF9 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF9 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of FGF9 mRNA26272509
D015032Zinc"[Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased expression of FGF9 protein"12639846
C088658zoledronic acidzoledronic acid results in decreased expression of FGF9 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005104fibroblast growth factor receptor binding-IEA-  
GO:0008083growth factor activity-IEA-  
GO:0008201heparin binding-IEA-  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000165MAPK cascade-TAS-  
GO:0001525angiogenesis-IEA-  
GO:0001649osteoblast differentiation-IEA-  
GO:0001654eye development-IEA-  
GO:0002053positive regulation of mesenchymal cell proliferation-IEA-  
GO:0002062chondrocyte differentiation-IEA-  
GO:0006606protein import into nucleus-IEA-  
GO:0007165signal transduction-TAS8575785  
GO:0007267cell-cell signaling-IEA-  
GO:0008284positive regulation of cell proliferation-IDA8321227  
GO:0008543fibroblast growth factor receptor signaling pathway-IGI8663044  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS-  
GO:0008584male gonad development-IEP17848411  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0021762substantia nigra development-HEP22926577  
GO:0030178negative regulation of Wnt signaling pathway-IEA-  
GO:0030238male sex determination-IEA-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IEA-  
GO:0032927positive regulation of activin receptor signaling pathway-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0042472inner ear morphogenesis-IEA-  
GO:0043410positive regulation of MAPK cascade-IEA-  
GO:0045880positive regulation of smoothened signaling pathway-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048505regulation of timing of cell differentiation-IEA-  
GO:0048566embryonic digestive tract development-IEA-  
GO:0048706embryonic skeletal system development-IEA-  
GO:0050679positive regulation of epithelial cell proliferation-IEA-  
GO:0051781positive regulation of cell division-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0060484lung-associated mesenchyme development-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IGI29118903  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-ISS-  
GO:1904754positive regulation of vascular associated smooth muscle cell migration-ISS-  
GO:1905931negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IEA-  
GO:0005615extracellular space-IDA8321227  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839122Signaling by activated point mutants of FGFR1TAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-1839126FGFR2 mutant receptor activationTAS
R-HSA-1839130Signaling by activated point mutants of FGFR3TAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190239FGFR3 ligand binding and activationTAS
R-HSA-190241FGFR2 ligand binding and activationTAS
R-HSA-190242FGFR1 ligand binding and activationTAS
R-HSA-190322FGFR4 ligand binding and activationTAS
R-HSA-190371FGFR3b ligand binding and activationTAS
R-HSA-190372FGFR3c ligand binding and activationTAS
R-HSA-190373FGFR1c ligand binding and activationTAS
R-HSA-190375FGFR2c ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2033514FGFR3 mutant receptor activationTAS
R-HSA-2033519Activated point mutants of FGFR2TAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-5654219Phospholipase C-mediated cascade: FGFR1TAS
R-HSA-5654221Phospholipase C-mediated cascade; FGFR2TAS
R-HSA-5654227Phospholipase C-mediated cascade; FGFR3TAS
R-HSA-5654228Phospholipase C-mediated cascade; FGFR4TAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654688SHC-mediated cascade:FGFR1TAS
R-HSA-5654689PI-3K cascade:FGFR1TAS
R-HSA-5654693FRS-mediated FGFR1 signalingTAS
R-HSA-5654695PI-3K cascade:FGFR2TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654699SHC-mediated cascade:FGFR2TAS
R-HSA-5654700FRS-mediated FGFR2 signalingTAS
R-HSA-5654704SHC-mediated cascade:FGFR3TAS
R-HSA-5654706FRS-mediated FGFR3 signalingTAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654710PI-3K cascade:FGFR3TAS
R-HSA-5654712FRS-mediated FGFR4 signalingTAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654719SHC-mediated cascade:FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654726Negative regulation of FGFR1 signalingTAS
R-HSA-5654727Negative regulation of FGFR2 signalingTAS
R-HSA-5654732Negative regulation of FGFR3 signalingTAS
R-HSA-5654733Negative regulation of FGFR4 signalingTAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22074045The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate. (2013 Jan)Wang HCleft Palate Craniofac J
24239165Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer. (2014 Jan)Ohgino KLung Cancer