Gene: FGF10

2255
-
fibroblast growth factor 10
protein-coding
5p12
Ensembl:ENSG00000070193 MIM:602115 Vega:OTTHUMG00000131153 UniprotKB:O15520
NG_011446.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.142e-1 (AD)  2.757e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNPO20.759
KLHL380.704
GNPNAT10.69
MREG0.689
ARNTL20.671
PLCXD20.661
ARHGEF280.659
FILIP10.655
SLIT30.654
GPR630.654

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.497
TLCD1-0.475
RLBP1-0.475
PIPOX-0.459
ENDOU-0.455
GPR143-0.455
STON2-0.452
RBP1-0.44
CYP11A1-0.437
ABHD1-0.426

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FGF10 mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]15618436
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of FGF10 mRNA"18648102
C496492abrineabrine results in increased expression of FGF10 mRNA22595364
D000171AcroleinAcrolein results in decreased expression of FGF10 mRNA18515264
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF10 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of FGF10 mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in increased expression of FGF10 mRNA]12205029
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FGF10 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of FGF10 mRNA18585445
D001151ArsenicArsenic affects the methylation of FGF10 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of FGF10 mRNA26705709
D001194AsbestosAsbestos results in decreased expression of FGF10 mRNA22076105
D001194Asbestos2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]15618436
D001194AsbestosFGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]15618436
D001194AsbestosU 0126 inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]15618436
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of FGF10 mRNA18585445
D004958EstradiolEstradiol results in decreased expression of FGF10 mRNA15680359
D004958EstradiolEstradiol results in decreased expression of FGF10 protein15680359
C006780bisphenol Abisphenol A results in increased expression of FGF10 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of FGF10 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FGF10 mRNA20147733
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FGF10 mRNA16644059
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FGF10 mRNA17805973
C084597chlorcyclizinechlorcyclizine results in increased expression of FGF10 mRNA21058326
D002713ChlorineChlorine results in decreased expression of FGF10 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA18636392
D002809Chondroitin SulfatesChondroitin Sulfates analog binds to FGF10 protein12221095
D002809Chondroitin Sulfates[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein15385557
D002809Chondroitin Sulfates[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein14699094
D005576ColforsinColforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]12533312|1497593
D005576ColforsinColforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]12533312|1497593
C009160cyclonitecyclonite results in decreased expression of FGF10 mRNA25559034
D003871Dermatan Sulfate[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein15385557
D003871Dermatan Sulfate[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein14699094
D003907DexamethasoneDexamethasone results in decreased expression of FGF10 mRNA28453788
D003907DexamethasoneDexamethasone results in increased expression of FGF10 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FGF10 mRNA19464577|2521318
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FGF10 protein26514922|2891949
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FGF10 mRNA15829613
D004041Dietary FatsDietary Fats results in increased expression of FGF10 mRNA25016146
C058705diethyl malatediethyl malate affects the expression of FGF10 mRNA24814887
D004391DustDust results in increased secretion of FGF10 protein29319804
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate affects the expression of FGF10 mRNA15059950
D005419FlavonoidsFlavonoids results in increased expression of FGF10 mRNA18035473
C096856FTI 277FTI 277 inhibits the reaction [FGF10 protein results in increased expression of and results in increased activity of ATP1A1 protein]12804770
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans affects the activity of FGF10 protein16221725
D006493HeparinHeparin promotes the reaction [FGF10 protein binds to FGFR2 protein]15632068
D006497Heparitin SulfateHeparitin Sulfate affects the activity of FGF10 protein12781692|1281888
D006497Heparitin SulfateHeparitin Sulfate analog binds to FGF10 protein14707131
D017313FenretinideFenretinide results in decreased expression of FGF10 mRNA28973697
D007213IndomethacinFGF10 protein results in decreased susceptibility to Indomethacin11052999
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of FGF10 mRNA"19524256
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA23519560
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of FGF10 mRNA15120970
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FGF10 mRNA"22076105
C007350nitrofennitrofen results in decreased expression of FGF10 mRNA11404268
C007350nitrofennitrofen results in decreased expression of FGF10 mRNA12861530
D016627OxidopamineOxidopamine results in increased expression of FGF10 mRNA15303306
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA18636392
C029217phenyl-N-tert-butylnitronephenyl-N-tert-butylnitrone inhibits the reaction [Thalidomide results in decreased expression of FGF10 mRNA]12242718
D010936Plant ExtractsPlant Extracts results in decreased expression of FGF10 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of FGF10 mRNA18753603
D011441PropylthiouracilPropylthiouracil results in decreased expression of FGF10 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of FGF10 mRNA27029645
C059514resveratrolresveratrol results in decreased expression of FGF10 mRNA23525482|2533817
C032706sodium chloratesodium chlorate affects the activity of FGF10 protein12818887
C105686SU 5402SU 5402 results in increased expression of FGF10 mRNA12421715
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGF10 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased susceptibility to FGF10 protein19805408
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGF10 mRNA26139165
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA23519560
D013792Thalidomidephenyl-N-tert-butylnitrone inhibits the reaction [Thalidomide results in decreased expression of FGF10 mRNA]12242718
D013792ThalidomideThalidomide results in decreased expression of FGF10 mRNA12242718|1471333
D014118Toxins, Biological"Toxins, Biological affects the expression of FGF10 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of FGF10 mRNA21934132
D014212TretinoinTretinoin affects the expression of FGF1010862743
D014212TretinoinTretinoin results in increased expression of FGF10 mRNA15328022
D014212TretinoinTretinoin results in increased expression of FGF10 mRNA15328022
C012589trichostatin Atrichostatin A results in increased expression of FGF10 mRNA23463510
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FGF10 mRNA19042947
C113580U 0126U 0126 inhibits the reaction [FGF10 protein results in increased expression of and results in increased activity of ATP1A1 protein]12804770
C113580U 0126U 0126 inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]12574212
C113580U 0126U 0126 inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]12574212
C113580U 0126U 0126 inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]15618436
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FGF10 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FGF10 mRNA18629315

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005104fibroblast growth factor receptor binding-IDA11923311  
GO:0005111type 2 fibroblast growth factor receptor binding-IPI19224135  
GO:0005515protein binding-IPI12591959  25241761  
GO:0008083growth factor activity-IDA11923311  15690149  
GO:0008201heparin binding-IDA11923311  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0042056chemoattractant activity-IDA9740653  17449030  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000132establishment of mitotic spindle orientation-IEA-  
GO:0000165MAPK cascade-TAS-  
GO:0000187activation of MAPK activity-IDA14975937  
GO:0001525angiogenesis-IEA-  
GO:0001656metanephros development-IEP18437684  
GO:0001759organ induction-IEA-  
GO:0001823mesonephros development-IEP18437684  
GO:0001974blood vessel remodeling-IEA-  
GO:0003338metanephros morphogenesis-IEA-  
GO:0007368determination of left/right symmetry-IEA-  
GO:0007431salivary gland development-IMP17213838  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS-  
GO:0008589regulation of smoothened signaling pathway-IEA-  
GO:0009880embryonic pattern specification-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010631epithelial cell migration-IEA-  
GO:0010634positive regulation of epithelial cell migration-IDA17500053  
GO:0010838positive regulation of keratinocyte proliferation-IDA17449030  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0021983pituitary gland development-IEA-  
GO:0030538embryonic genitalia morphogenesis-IEA-  
GO:0030878thyroid gland development-IEA-  
GO:0030916otic vesicle formation-IEA-  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IEA-  
GO:0031016pancreas development-IEA-  
GO:0031069hair follicle morphogenesis-IEA-  
GO:0031076embryonic camera-type eye development-IEA-  
GO:0031532actin cytoskeleton reorganization-IDA17449030  
GO:0031659positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle-IDA17188682  
GO:0032355response to estradiol-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032781positive regulation of ATPase activity-IDA12804770  
GO:0032808lacrimal gland development-IMP17213838  
GO:0032925regulation of activin receptor signaling pathway-IEA-  
GO:0034394protein localization to cell surface-IDA17449030  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0042060wound healing-IDA11896977  19152659  
GO:0042246tissue regeneration-IEA-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0042693muscle cell fate commitment-IEA-  
GO:0043410positive regulation of MAPK cascade-IDA12804770  
GO:0043616keratinocyte proliferation-IEA-  
GO:0045596negative regulation of cell differentiation-IEA-  
GO:0045739positive regulation of DNA repair-IDA14975937  
GO:0045740positive regulation of DNA replication-IMP17471512  
GO:0045747positive regulation of Notch signaling pathway-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA17500053  
GO:0045931positive regulation of mitotic cell cycle-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046579positive regulation of Ras protein signal transduction-IDA12804770  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0046877regulation of saliva secretion-IMP19102732  
GO:0048146positive regulation of fibroblast proliferation-IEA-  
GO:0048536spleen development-IEA-  
GO:0048538thymus development-IDA17969154  
GO:0048557embryonic digestive tract morphogenesis-IEA-  
GO:0048754branching morphogenesis of an epithelial tube-IDA17959718  
GO:0048807female genitalia morphogenesis-IEA-  
GO:0048808male genitalia morphogenesis-IEA-  
GO:0050671positive regulation of lymphocyte proliferation-IDA19152659  
GO:0050673epithelial cell proliferation-IDA19224135  
GO:0050674urothelial cell proliferation-IDA11923311  
GO:0050677positive regulation of urothelial cell proliferation-IDA11923311  
GO:0050679positive regulation of epithelial cell proliferation-IDA15690149  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA17449030  
GO:0050872white fat cell differentiation-IEA-  
GO:0050918positive chemotaxis-IDA9740653  17449030  
GO:0050930induction of positive chemotaxis-IEA-  
GO:0051145smooth muscle cell differentiation-IEA-  
GO:0051549positive regulation of keratinocyte migration-IDA17449030  19152659  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060019radial glial cell differentiation-ISS-  
GO:0060054positive regulation of epithelial cell proliferation involved in wound healing-NAS19152659  
GO:0060174limb bud formation-IEA-  
GO:0060428lung epithelium development-IDA9740653  
GO:0060430lung saccule development-IMP17071719  
GO:0060436bronchiole morphogenesis-IEA-  
GO:0060447bud outgrowth involved in lung branching-IDA9740653  
GO:0060449bud elongation involved in lung branching-IEA-  
GO:0060496mesenchymal-epithelial cell signaling involved in lung development-IEA-  
GO:0060510type II pneumocyte differentiation-IEA-  
GO:0060513prostatic bud formation-IEA-  
GO:0060595fibroblast growth factor receptor signaling pathway involved in mammary gland specification-IDA11923311  
GO:0060615mammary gland bud formation-IEA-  
GO:0060661submandibular salivary gland formation-IEA-  
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesis-IEA-  
GO:0060665regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling-IEA-  
GO:0060667branch elongation involved in salivary gland morphogenesis-IEA-  
GO:0060879semicircular canal fusion-IEA-  
GO:0060915mesenchymal cell differentiation involved in lung development-IEA-  
GO:0061033secretion by lung epithelial cell involved in lung growth-IDA10541313  
GO:0061115lung proximal/distal axis specification-IEA-  
GO:0070075tear secretion-IMP19102732  
GO:0070352positive regulation of white fat cell proliferation-IEA-  
GO:0070371ERK1 and ERK2 cascade-IDA17959718  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA14975937  
GO:0070384Harderian gland development-IEA-  
GO:0071157negative regulation of cell cycle arrest-IDA17188682  
GO:0071338positive regulation of hair follicle cell proliferation-IDA16086254  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA16597614  
GO:0005634nucleus-IDA11923311  16597614  17471512  
GO:0005886plasma membrane-IDA16597614  
GO:0009986cell surface-IDA16597614  
GO:0009986cell surface-NAS11923311  
GO:0031012extracellular matrixcolocalizes_withIDA17959718  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839126FGFR2 mutant receptor activationTAS
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-190236Signaling by FGFRTAS
R-HSA-190241FGFR2 ligand binding and activationTAS
R-HSA-190242FGFR1 ligand binding and activationTAS
R-HSA-190370FGFR1b ligand binding and activationTAS
R-HSA-190377FGFR2b ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2033519Activated point mutants of FGFR2TAS
R-HSA-210747Regulation of gene expression in early pancreatic precursor cellsIEA
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-5654219Phospholipase C-mediated cascade: FGFR1TAS
R-HSA-5654221Phospholipase C-mediated cascade; FGFR2TAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654688SHC-mediated cascade:FGFR1TAS
R-HSA-5654689PI-3K cascade:FGFR1TAS
R-HSA-5654693FRS-mediated FGFR1 signalingTAS
R-HSA-5654695PI-3K cascade:FGFR2TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654699SHC-mediated cascade:FGFR2TAS
R-HSA-5654700FRS-mediated FGFR2 signalingTAS
R-HSA-5654726Negative regulation of FGFR1 signalingTAS
R-HSA-5654727Negative regulation of FGFR2 signalingTAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5658623FGFRL1 modulation of FGFR1 signalingTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22074045The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate. (2013 Jan)Wang HCleft Palate Craniofac J
29339516Human airway branch variation and chronic obstructive pulmonary disease. (2018 Jan 30)Smith BMProc Natl Acad Sci U S A
25058584The impact of maternal cigarette smoke exposure in a rodent model on renal development in the offspring. (2014)Al-Odat IPLoS One