Gene: FGF11

2256
FGF-11|FHF-3|FHF3
fibroblast growth factor 11
protein-coding
17p13.1
Ensembl:ENSG00000161958 MIM:601514 Vega:OTTHUMG00000108136 UniprotKB:Q92914
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.833e-2 (AD)  5.005e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF20.858
TMEM176A0.857
PALLD0.856
FGFRL10.856
CNN30.853
NEK60.851
LRP100.847
ADORA2B0.846
SH3BP20.841
SLC44A30.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.584
ADTRP-0.575
ZNF860-0.568
CALHM1-0.549
TYRP1-0.548
ABCC12-0.544
TRABD2A-0.539
AGMAT-0.539
SLC7A4-0.535
SAMD5-0.535

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FGF11 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FGF11 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF11 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FGF11 mRNA22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF11 mRNA16483693
D001151ArsenicArsenic affects the expression of FGF11 protein24675094
C006780bisphenol Abisphenol A results in decreased expression of FGF11 mRNA25181051
D004390ChlorpyrifosChlorpyrifos affects the expression of FGF11 mRNA17589599|1850231
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FGF11 mRNA28472532
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of FGF11 mRNA26033743
D003300CopperCopper deficiency results in increased expression of FGF11 mRNA26033743
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FGF11 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FGF11 mRNA27392435
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of FGF11 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of FGF11 mRNA26033743
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of FGF11 mRNA"27840820
C118739entinostatentinostat results in increased expression of FGF11 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF11 mRNA"27188386
C039281furanfuran results in increased methylation of FGF11 gene22079235
D017313FenretinideFenretinide results in decreased expression of FGF11 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FGF11 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FGF11 mRNA26752646
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FGF11 mRNA24810058
D009151Mustard GasMustard Gas results in decreased expression of FGF11 mRNA15674843
C022838nickel chloridenickel chloride results in increased expression of FGF11 mRNA21455298
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of FGF11 mRNA"21673326
D010100OxygenOxygen deficiency results in increased expression of FGF11 mRNA20042640|2423605
D010936Plant ExtractsPlant Extracts results in decreased expression of FGF11 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FGF11 mRNA24680724
D013849ThimerosalThimerosal results in decreased expression of FGF11 mRNA27188386
C011559tributyltintributyltin results in decreased expression of FGF11 mRNA27614199
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FGF11 mRNA19042947
D014520UrethaneUrethane results in decreased expression of FGF11 mRNA28818685
C111237vorinostatvorinostat results in decreased expression of FGF11 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8790420  
GO:0007267cell-cell signaling-TAS8790420  
GO:0007399nervous system development-TAS8790420  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21203850Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers. (2011 Nov)Lee MMol Biol Rep