Gene: FGF13

2258
FGF-13|FGF2|FHF-2|FHF2
fibroblast growth factor 13
protein-coding
Xq26.3-q27.1
Ensembl:ENSG00000129682 MIM:300070 Vega:OTTHUMG00000022532 UniprotKB:Q92913
NC_000023.11
PubMed
0   ANCO-SNPs
CD|ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP20.96
PTPRN20.937
FGF120.936
PAK30.926
GAP430.925
NRIP30.922
HPCAL40.922
GNG30.922
C2orf800.922
MLLT110.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.525
CDA-0.52
OR4F5-0.491
CNN2-0.489
NFE2-0.487
MAGEA12-0.485
KCNJ15-0.479
RUNX3-0.478
CXCR2-0.474
S100A12-0.474

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FGF13 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF13 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF13 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FGF13 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of FGF13 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FGF13 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGF13 gene27153756
D005680gamma-Aminobutyric AcidFGF13 protein results in increased uptake of gamma-Aminobutyric Acid9751161
D001151ArsenicArsenic affects the methylation of FGF13 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGF13 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGF13 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FGF13 mRNA20127859
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FGF13 mRNA19619570
D004958EstradiolEstradiol results in increased expression of FGF13 mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of FGF13 mRNA18692832
C053541bicalutamidebicalutamide results in increased expression of FGF13 mRNA15638997
C006780bisphenol Abisphenol A results in decreased expression of FGF13 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of FGF13 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of FGF13 mRNA26079696
D002104CadmiumCadmium results in decreased expression of FGF13 mRNA21120746
D003300CopperFGF13 protein results in decreased susceptibility to Copper24113164
C029892cupric chloridecupric chloride results in increased expression of FGF13 mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of FGF13 mRNA20106945
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene affects the expression of FGF13 mRNA"26496743
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FGF13 mRNA17361019|2126653
D002945CisplatinFGF13 protein results in decreased susceptibility to Cisplatin24113164
D002945CisplatinCisplatin results in decreased expression of FGF13 mRNA22023808
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FGF13 mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FGF13 mRNA17557909
C039281furanfuran results in increased expression of FGF13 mRNA25539665
D019833GenisteinGenistein results in decreased expression of FGF13 mRNA22228119
D019833GenisteinGenistein results in increased expression of FGF13 mRNA24967385
D017313FenretinideFenretinide results in decreased expression of FGF13 mRNA28973697
C533894LG 100815LG 100815 results in increased expression of FGF13 mRNA16951191
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of FGF13 mRNA26558463
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FGF13 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FGF13 mRNA26558463
C523799MRK 003MRK 003 results in decreased expression of FGF13 mRNA21169257
D009532NickelNickel results in decreased expression of FGF13 mRNA25583101
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of FGF13 mRNA17616710
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of FGF13 mRNA"16951191
D052638Particulate MatterParticulate Matter results in increased expression of FGF13 mRNA17987463
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FGF13 mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of FGF13 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGF13 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in decreased expression of FGF13 mRNA23608068
D017035PravastatinPravastatin results in increased expression of FGF13 mRNA27225895
D017035PravastatinPravastatin affects the expression of FGF13 mRNA27225895
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of FGF13 mRNA18692832
C005556propionaldehydepropionaldehyde results in increased expression of FGF13 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of FGF13 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of FGF13 protein17337753
D012906SmokeSmoke results in decreased expression of FGF13 mRNA21095227
D012964SodiumFGF13 protein promotes the reaction [SCN8A protein affects the transport of Sodium]15282281
C075117squalestatin 1squalestatin 1 affects the expression of FGF13 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of FGF13 mRNA27225895
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FGF13 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGF13 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGF13 mRNA22808131
D019284ThapsigarginThapsigargin results in decreased expression of FGF13 mRNA19442820
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FGF13 mRNA20133372
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF13 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FGF13 mRNA24935251|2627250
C022884undecaneundecane results in decreased expression of FGF13 protein17337753
D014635Valproic AcidValproic Acid affects the expression of FGF13 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FGF13 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased expression of FGF13 mRNA17987463

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15282281  26392562  
GO:0008017microtubule binding-ISS-  
GO:0008083growth factor activity-IEA-  
GO:0017080sodium channel regulator activity-IDA15282281  
GO:0017080sodium channel regulator activity-ISS21817159  
GO:0030295protein kinase activator activity-IGI12244047  
GO:0044325ion channel binding-ISS21817159  
GO:0048487beta-tubulin binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IDA12244047  
GO:0001764neuron migration-ISS-  
GO:0006814sodium ion transport-ISS21817159  
GO:0007026negative regulation of microtubule depolymerization-ISS-  
GO:0007165signal transduction-TAS8790420  
GO:0007267cell-cell signaling-TAS8790420  
GO:0007399nervous system development-TAS8790420  
GO:0007612learning-ISS-  
GO:0007613memory-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0021766hippocampus development-ISS-  
GO:0021795cerebral cortex cell migration-ISS-  
GO:0032147activation of protein kinase activity-IEA-  
GO:0045200establishment of neuroblast polarity-ISS-  
GO:0046785microtubule polymerization-ISS-  
GO:0048671negative regulation of collateral sprouting-ISS-  
GO:0072659protein localization to plasma membrane-ISS21817159  
GO:0098909regulation of cardiac muscle cell action potential involved in regulation of contraction-ISS21817159  
GO:1990834response to odorant-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IDA8790420  
GO:0005634nucleus-ISS21817159  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IPI12244047  
GO:0005737cytoplasm-ISS21817159  
GO:0005829cytosol-IDA-  
GO:0005874microtubule-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0014704intercalated disc-ISS21817159  
GO:0016328lateral plasma membrane-ISS21817159  
GO:0030175filopodium-ISS-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0030426growth cone-ISS-  
GO:0043005neuron projection-ISS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal