Gene: ALDOA

226
ALDA|GSD12|HEL-S-87p
aldolase, fructose-bisphosphate A
protein-coding
16p11.2
Ensembl:ENSG00000285043 MIM:103850 Vega:OTTHUMG00000132107 UniprotKB:P04075
NG_008010.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.506e-1 (AD)  1.534e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08683263chr16:30078162ALDOA2.340e-8Maternal smoking in pregnancy27040690
cg00583733chr16:30075102ALDOA1.500e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GDI10.974
PKM0.972
MTCH10.972
PPP2R1A0.964
MLF20.963
TPI10.962
ARPC1A0.962
ARF10.961
WBP20.961
VPS4A0.96

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.818
OR4F29-0.789
KLRB1-0.296
TFPI2-0.275
CXCR2-0.273
SH2D1A-0.273
VNN3-0.272
IL18RAP-0.268
KLF17-0.266
KLRF1-0.263

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB025121,6-Fructose Diphosphate (Linear Form)Small MoleculeExperimentalTarget
DB04326Dihydroxyacetone phosphateSmall Molecule57-04-5InvestigationalTarget
DB047331,6-DI-O-PHOSPHONO-D-MANNITOLSmall MoleculeExperimentalTarget
DB08240N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDESmall MoleculeExperimentalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of ALDOA mRNA"19502547
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ALDOA mRNA25596134
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of ALDOA mRNA"22101062
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ALDOA mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDOA mRNA"15215175
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ALDOA mRNA"21346803
C0275764-hydroxy-2-nonenalALDOA protein binds to 4-hydroxy-2-nonenal20043646
C0275764-hydroxy-2-nonenalHydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein]20889679
D000082AcetaminophenAcetaminophen affects the expression of ALDOA mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of ALDOA protein15800402
D020106AcrylamideAcrylamide results in increased expression of ALDOA mRNA28959563
C560978aegeline[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA28843594
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ALDOA gene27153756
D000452AldrinAldrin results in decreased expression of ALDOA mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALDOA mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of ALDOA mRNA28713220
D001151ArsenicArsenic results in increased methylation of ALDOA promoter21291286
C006632arsenic trioxidearsenic trioxide results in decreased expression of ALDOA protein15894607
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of ALDOA mRNA15894607
D001241AspirinAspirin results in decreased expression of ALDOA mRNA15928584
D001280AtrazineAtrazine results in increased expression of ALDOA mRNA22378314
C004456beauvericinbeauvericin results in decreased expression of ALDOA mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDOA protein17292933
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ALDOA mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALDOA mRNA20440473
D004958EstradiolEstradiol results in decreased expression of ALDOA mRNA19484750
D004958EstradiolEstradiol results in increased expression of ALDOA mRNA15289156
D004958EstradiolEstradiol results in increased expression of ALDOA mRNA17522070
C095105bexarotenebexarotene results in increased expression of ALDOA mRNA16648578
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALDOA mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of ALDOA promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ALDOA mRNA18180321
C006780bisphenol Abisphenol A results in increased expression of ALDOA mRNA25181051
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of ALDOA mRNA11841787
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of ALDOA protein11841787|2373607
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ALDOA mRNA15003993
D002104CadmiumCadmium inhibits the reaction [Oxygen deficiency results in increased expression of ALDOA mRNA]10866824
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALDOA mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALDOA mRNA24794047
D002110Caffeine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA28843594
D002220CarbamazepineCarbamazepine affects the expression of ALDOA mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALDOA mRNA17522070
C099555CD 437CD 437 results in decreased expression of ALDOA mRNA12958071
D002509CephaloridineCephaloridine affects the expression of ALDOA mRNA18172885
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of ALDOA mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ALDOA mRNA23650126
D002725ChloroformChloroform results in increased expression of ALDOA mRNA17522070
C100187chloropicrinchloropicrin results in decreased expression of ALDOA mRNA28476498
C100187chloropicrinchloropicrin results in increased expression of ALDOA mRNA26352163
D002746ChlorpromazineChlorpromazine results in increased expression of ALDOA mRNA25596134
C059262cidofovircidofovir results in increased expression of ALDOA mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of ALDOA mRNA25596134
D002994ClofibrateClofibrate results in increased expression of ALDOA mRNA21318169
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALDOA mRNA17602206
D003024ClozapineClozapine results in increased expression of ALDOA mRNA15860345
C018021cobaltous chloridecobaltous chloride results in increased expression of ALDOA mRNA17553155|1932097
C018021cobaltous chlorideL-4F peptide inhibits the reaction [cobaltous chloride results in increased expression of ALDOA mRNA]22537771
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ALDOA mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of ALDOA mRNA24386269
C018021cobaltous chloridecobaltous chloride results in increased expression of ALDOA protein24386269
C026305cobalt sulfatecobalt sulfate results in increased expression of ALDOA mRNA19502547
C004690coclaurine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA28843594
D003300CopperCopper results in increased expression of ALDOA mRNA18522721
C029892cupric chloridecupric chloride results in increased expression of ALDOA mRNA17211630
C030973cupric oxidecupric oxide results in decreased expression of ALDOA protein25470785
D003474CurcuminCurcumin results in decreased expression of ALDOA mRNA16880289
D016572CyclosporineCyclosporine results in decreased expression of ALDOA mRNA21163907|2163298
D016572CyclosporineCyclosporine results in increased expression of ALDOA mRNA25596134
D013759DronabinolDronabinol results in increased expression of ALDOA mRNA18163980
D013759DronabinolDronabinol results in decreased expression of ALDOA mRNA11015613
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALDOA mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of ALDOA mRNA17522070
D003976DiazinonDiazinon results in increased methylation of ALDOA gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDOA mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDOA mRNA17379624|2126653
D002945CisplatinCisplatin results in increased expression of ALDOA mRNA25596134
D002945CisplatinCisplatin affects the expression of ALDOA mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ALDOA mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of ALDOA mRNA19030233
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ALDOA mRNA21318169
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALDOA mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ALDOA mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ALDOA mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ALDOA mRNA15289156
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ALDOA protein"22248470
C067311docetaxel[docetaxel co-treated with Doxorubicin] results in decreased expression of ALDOA protein20457137
D004298DopamineDopamine results in increased expression of ALDOA protein24675778
D004317Doxorubicin[docetaxel co-treated with Doxorubicin] results in decreased expression of ALDOA protein20457137
D004726EndosulfanEndosulfan results in decreased expression of ALDOA mRNA26615145
C013525ENNG[ENNG co-treated with Isoflavones] results in increased expression of ALDOA protein22248470
C013525ENNGENNG results in increased expression of ALDOA protein22248470
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ALDOA protein23301498
D000431EthanolEthanol results in increased expression of ALDOA mRNA15513904
D000431EthanolEthanol results in increased expression of ALDOA mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ALDOA mRNA16954407
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ALDOA mRNA19400957
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDOA mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ALDOA mRNA17557909|1940095
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ALDOA mRNA23649840
D011345FenofibrateFenofibrate results in increased expression of ALDOA mRNA25596134
D005485FlutamideFlutamide results in increased expression of ALDOA mRNA17702527
D005485FlutamideFlutamide results in increased expression of ALDOA mRNA24136188
C056933fumonisin B1fumonisin B1 results in increased expression of ALDOA mRNA16221962
C039281furanfuran results in increased expression of ALDOA mRNA25539665
D019833GenisteinGenistein results in increased expression of ALDOA mRNA15289156
D005897GlafenineGlafenine results in increased expression of ALDOA mRNA24136188
C010974glyphosateglyphosate results in increased expression of ALDOA mRNA25636363
D006220HaloperidolHaloperidol results in increased expression of ALDOA mRNA15860345
C012348higenamine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA28843594
D047348Hydrolyzable Tannins[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA28843594
D002112CalcifediolCalcifediol deficiency results in decreased expression of ALDOA mRNA17293106
D006918HydroxyureaHydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein]20889679
D007052IbuprofenIbuprofen results in increased expression of ALDOA mRNA25596134
D007069IfosfamideIfosfamide results in increased expression of ALDOA mRNA25596134
C020758indium trichlorideindium trichloride results in decreased expression of ALDOA protein19539025
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALDOA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALDOA mRNA28628672
D007529Isoflavones[ENNG co-treated with Isoflavones] results in increased expression of ALDOA protein22248470
C410337K 7174K 7174 results in decreased expression of ALDOA mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of ALDOA mRNA15469884
C472885L-4F peptideL-4F peptide inhibits the reaction [cobaltous chloride results in increased expression of ALDOA mRNA]22537771
C472885L-4F peptideL-4F peptide inhibits the reaction [INS protein results in increased expression of ALDOA mRNA]22537771
D007854LeadLead affects the expression of ALDOA mRNA28903495
C008261lead acetatelead acetate results in increased expression of ALDOA protein20797405
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ALDOA mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ALDOA mRNA25613284
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ALDOA mRNA16415329
C025340manganese chloridemanganese chloride results in increased expression of ALDOA mRNA22281203
D008687MetforminMetformin results in increased expression of ALDOA mRNA25596134
D008701MethapyrileneMethapyrilene results in increased expression of ALDOA mRNA16393664|2893558
D008727MethotrexateMethotrexate results in decreased expression of ALDOA protein24736981
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ALDOA mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ALDOA mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ALDOA mRNA17475336
D015741MetriboloneMetribolone results in increased expression of ALDOA mRNA17010196
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ALDOA mRNA26924002
D009151Mustard GasMustard Gas affects the expression of ALDOA mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ALDOA protein"22001959
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ALDOA protein"21135415
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ALDOA mRNA17522070
C051752nefazodonenefazodone results in increased expression of ALDOA mRNA24136188
C022838nickel chlorideHIF1A affects the reaction [nickel chloride results in increased expression of ALDOA mRNA]12426141
C022838nickel chloridenickel chloride results in increased expression of ALDOA mRNA12426141|1283993
C028007nickel monoxidenickel monoxide results in increased expression of ALDOA mRNA19167457
D009582NitrofurantoinNitrofurantoin results in increased expression of ALDOA mRNA11841787
D009582NitrofurantoinNitrofurantoin results in increased expression of ALDOA protein11841787
C464660obeticholic acidobeticholic acid results in decreased expression of ALDOA mRNA27939613
D019319Okadaic AcidOkadaic Acid results in decreased expression of ALDOA protein19397276
D010100OxygenCadmium inhibits the reaction [Oxygen deficiency results in increased expression of ALDOA mRNA]10866824
D010100OxygenHIF1A protein alternative form inhibits the reaction [Oxygen deficiency results in increased expression of ALDOA mRNA]11739637
D010100OxygenOxygen deficiency results in increased expression of ALDOA mRNA10866824|1173963
D010100OxygenOxygen deficiency results in increased expression of ALDOA mRNA20880076
D010126OzoneOzone results in increased expression of ALDOA mRNA25838073
C530734p-aminophenylarsine oxidep-aminophenylarsine oxide binds to ALDOA protein22422341
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ALDOA protein19954255
D010416PentachlorophenolPentachlorophenol results in increased expression of ALDOA mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ALDOA mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ALDOA mRNA19162173|2131816
D010634PhenobarbitalPhenobarbital affects the expression of ALDOA mRNA23091169
D010665PhenylpropanolaminePhenylpropanolamine results in decreased expression of ALDOA mRNA16465460
C018637phoronephorone results in increased expression of ALDOA mRNA11841787
C018637phoronephorone results in increased expression of ALDOA protein11841787
C006253pirinixic acidpirinixic acid results in increased expression of ALDOA mRNA16221962|1830175
C006253pirinixic acidpirinixic acid results in increased expression of ALDOA mRNA19162173|2131816
D010936Plant ExtractsPlant Extracts results in decreased expression of ALDOA mRNA28533734
C045950propiconazolepropiconazole results in increased expression of ALDOA mRNA21278054
C031280pyrazolepyrazole results in increased expression of ALDOA mRNA17945193
C030984pyrenepyrene results in decreased expression of ALDOA mRNA15963578
D011794QuercetinQuercetin results in increased expression of ALDOA protein17292933
D011794QuercetinQuercetin results in decreased expression of ALDOA protein18095365
D011802QuinidineQuinidine results in increased expression of ALDOA mRNA17522070
C502851quinocetonequinocetone results in increased expression of ALDOA protein27046791
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ALDOA mRNA16415329
C059514resveratrolresveratrol results in decreased expression of ALDOA protein25505154
D012176RetinoidsRetinoids results in decreased expression of ALDOA protein28886987
C089730rosiglitazonerosiglitazone results in increased expression of ALDOA mRNA25596134
D012524SarinSarin results in decreased expression of ALDOA mRNA19522546
D012643SeleniumSelenium results in increased expression of ALDOA mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased secretion of ALDOA protein25895662
C080703SK&F 83959SK&F 83959 affects the expression of ALDOA protein25852303
C009277sodium arsenatesodium arsenate results in increased expression of ALDOA mRNA16882884
C017947sodium arsenitesodium arsenite results in increased expression of ALDOA mRNA28713220
C017947sodium arsenitesodium arsenite results in increased expression of ALDOA protein15899475
C016104sodium bichromatesodium bichromate results in increased expression of ALDOA mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of ALDOA mRNA21340527
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of ALDOA mRNA16214533
D013629TamoxifenTamoxifen results in increased expression of ALDOA mRNA19400957
D013629TamoxifenTamoxifen results in increased expression of ALDOA mRNA19400957
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of ALDOA mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDOA mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDOA mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALDOA mRNA15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDOA mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDOA mRNA16267337
D013752TetracyclineTetracycline results in increased expression of ALDOA mRNA17522070
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of ALDOA protein"25852303
D013849ThimerosalThimerosal results in decreased expression of ALDOA mRNA27188386
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ALDOA mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of ALDOA mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased metabolism of ALDOA protein23396223
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of ALDOA mRNA15894607
C012589trichostatin Atrichostatin A results in decreased expression of ALDOA mRNA27188386
C012589trichostatin Atrichostatin A results in increased expression of ALDOA mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALDOA mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of ALDOA mRNA25596134
D014635Valproic AcidValproic Acid results in decreased expression of ALDOA mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ALDOA gene29154799
D014635Valproic AcidValproic Acid affects the expression of ALDOA mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of ALDOA mRNA21318169
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ALDOA gene25560391
D014810Vitamin EVitamin E results in increased expression of ALDOA mRNA19244175
C111237vorinostatvorinostat results in decreased expression of ALDOA mRNA27188386
D015016Yohimbine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA28843594
D015032ZincALDOA protein binds to Zinc14534351
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ALDOA mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003779actin binding-TAS1008835  
GO:0004332fructose-bisphosphate aldolase activity-EXP6696436  
GO:0004332fructose-bisphosphate aldolase activity-IDA9244396  14766013  
GO:0005515protein binding-IPI20849852  23355646  
GO:0008092cytoskeletal protein binding-IDA9244396  
GO:0015631tubulin binding-TAS17329259  
GO:0042802identical protein binding-TAS14766013  
GO:0045296cadherin binding-HDA25468996  
GO:0070061fructose binding-IDA10048322  14766013  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006000fructose metabolic process-IMP14615364  
GO:0006094gluconeogenesis-TAS-  
GO:0006096glycolytic process-IMP14615364  
GO:0006754ATP biosynthetic process-IMP14615364  
GO:0006941striated muscle contraction-IMP14615364  
GO:0007015actin filament organization-TAS1008835  
GO:0007339binding of sperm to zona pellucida-IMP23355646  
GO:0008360regulation of cell shape-IDA9244396  
GO:0030388fructose 1,6-bisphosphate metabolic process-IDA9244396  14766013  
GO:0043312neutrophil degranulation-TAS-  
GO:0046716muscle cell cellular homeostasis-IMP14615364  
GO:0051289protein homotetramerization-ISS-  
GO:0061621canonical glycolysis-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA23580065  
GO:0005634nucleus-HDA21630459  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-IDA9244396  
GO:0016020membrane-HDA19946888  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0031430M band-IEA-  
GO:0031674I band-TAS1008835  
GO:0034774secretory granule lumen-TAS-  
GO:0061827sperm head-IDA23355646  
GO:0070062extracellular exosome-HDA12519789  19056867  19199708  20458337  23533145  
GO:0070062extracellular exosome-IDA17641064  
GO:1904724tertiary granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa00051Fructose and mannose metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-70171GlycolysisTAS
R-HSA-70263GluconeogenesisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26063603Alteration of sperm protein profile induced by cigarette smoking. (2015 Jul)Chen XActa Biochim Biophys Sin (Shanghai)