Gene info: ID 2260

Gene: FGFR1

GENE ID: 2260

Synonyms: BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1

Description: fibroblast growth factor receptor 1

Gene type: protein-coding

Location: 8p11.23

dbXrefs: Ensembl:ENSG00000077782 MIM:136350 Vega:OTTHUMG00000147366 UniprotKB:P11362

RefSeq: NG_007729.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 29

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.181e-1 (AD) 6.579e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SEC61A1	0.839
TM9SF1	0.837
EHD1	0.811
CCNK	0.811
CALR	0.81
POLDIP3	0.807
WBP1L	0.806
MAPK7	0.802
ST5	0.799
SLC35A4	0.796

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.618
OR4F29	-0.567
OR6C74	-0.266
CETP	-0.214
C10orf67	-0.195
EDN3	-0.185
RNASE8	-0.178
HAPLN1	-0.167
RPL10L	-0.159
SPRR2B	-0.157

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00039	Palifermin	BiotechDrug	162394-19-6	Approved	Target
DB00398	Sorafenib	Small Molecule	284461-73-0	Approved\|Investigational	Target
DB01109	Heparin	Small Molecule	9005-49-6	Approved\|Investigational	Target
DB02058	SU4984	Small Molecule		Experimental	Target
DB05014	XL999	Small Molecule	921206-68-0	Investigational	Target
DB07525	3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine	Small Molecule		Experimental	Target
DB07840	(E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol	Small Molecule		Experimental	Target
DB08577	3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE	Small Molecule		Experimental	Target
DB08896	Regorafenib	Small Molecule	755037-03-7	Approved	Target
DB08901	Ponatinib	Small Molecule	943319-70-8	Approved\|Investigational	Target
DB09078	Lenvatinib	Small Molecule	417716-92-8	Approved\|Investigational	Target
DB09079	Nintedanib	Small Molecule	656247-17-5	Approved	Target

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FGFR1 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of FGFR1 mRNA"	19095052
C568950	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	"3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea results in decreased activity of FGFR1 protein"	21936542
C117011	3-(4-dimethylamino-benzylidenyl)-2-indolinone	3-(4-dimethylamino-benzylidenyl)-2-indolinone results in decreased activity of FGFR1 protein	15728459
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNA	12419474
C561052	5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one	"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of FGFR1 protein"	21608528
C529910	5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo(2,3-b)pyridin-5-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-amine	"5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo(2,3-b)pyridin-5-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-amine results in decreased activity of FGFR1 protein"	20100840
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of FGFR1 mRNA	21420995\|2906747
D000117	Acetylglucosamine	Acetylglucosamine analog promotes the reaction [FGF2 protein binds to FGFR1 protein]	12440867
D020106	Acrylamide	Acrylamide analog promotes the reaction [FGF2 protein binds to FGFR1 protein]	12440867
D020106	Acrylamide	Acrylamide analog promotes the reaction [FGFR1 protein binds to FGFR1 protein]	14733594
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of FGFR1 mRNA	17023530
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGFR1 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of FGFR1 mRNA	12558987
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of FGFR1 mRNA	24449571
C463061	AP20187	AP20187 results in increased activity of FGFR1 protein mutant form	12654294
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [PD 173074 results in decreased expression of FGFR1 protein]	27794399
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of FGFR1 mRNA	15761015\|1912883
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of FGFR1 protein	27794399
C006632	arsenic trioxide	arsenic trioxide results in decreased phosphorylation of FGFR1 protein mutant form	17027752
C006632	arsenic trioxide	arsenic trioxide results in increased expression of FGFR1 mRNA	17258074\|2045855
C006632	arsenic trioxide	FGFR1 protein results in decreased susceptibility to arsenic trioxide	27794399
C006632	arsenic trioxide	PD 173074 promotes the reaction [arsenic trioxide results in decreased expression of FGFR1 protein]	27794399
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of FGFR1 mRNA"	23634900
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGFR1 mRNA	22316170\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of FGFR1 gene	25435355
D004958	Estradiol	Estradiol results in decreased expression of FGFR1 mRNA	19167446
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of FGFR1 mRNA	20678512
C006780	bisphenol A	bisphenol A results in increased expression of FGFR1 mRNA	26063408
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA	25607892
C006780	bisphenol A	bisphenol A results in increased expression of FGFR1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of FGFR1 gene	28505145
D001786	Blood Glucose	FGFR1 protein affects the abundance of Blood Glucose	11130726
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA	25607892
D002104	Cadmium	Cadmium results in increased expression of FGFR1 mRNA	23369406
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of FGFR1 mRNA	12760830
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of FGFR1 promoter	22457795
D002118	Calcium	[Calcium co-treated with Calcitriol] affects the expression of FGFR1 mRNA	15913539
D002211	Capsaicin	Capsaicin results in decreased expression of FGFR1 protein	14521749
D002220	Carbamazepine	Carbamazepine affects the expression of FGFR1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FGFR1 mRNA	17484886
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of FGFR1 mRNA	15924885
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FGFR1 gene	20938992
D003042	Cocaine	Cocaine results in increased expression of FGFR1 mRNA	16076954
D005576	Colforsin	Colforsin results in increased expression of FGFR1 mRNA	10320526
D003375	Coumestrol	Coumestrol results in decreased expression of FGFR1 mRNA	19167446
C551994	crizotinib	[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]	22683780
C029892	cupric chloride	cupric chloride affects the expression of FGFR1 mRNA	17211630
D003471	Cuprizone	Cuprizone results in increased expression of FGFR1 mRNA	26577399\|2752363
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]	12805413
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGFR1 mRNA	25562108
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]	12805413
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of FGFR1 mRNA	23640034
C014347	decitabine	decitabine results in decreased expression of FGFR1 mRNA	17785578
C014347	decitabine	decitabine results in increased expression of FGFR1 mRNA	27915011
D003907	Dexamethasone	Dexamethasone results in decreased expression of FGFR1 mRNA	28453788
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA	28628672
D003976	Diazinon	Diazinon results in decreased expression of FGFR1 mRNA	17589599
D003976	Diazinon	Diazinon results in increased expression of FGFR1 mRNA	19130878
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FGFR1 mRNA	21266533
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of FGFR1 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of FGFR1 mRNA	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of FGFR1 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in increased expression of FGFR1 mRNA	21151649
D004008	Diclofenac	Diclofenac affects the expression of FGFR1 mRNA	24752500
D004026	Dieldrin	Dieldrin results in increased expression of FGFR1 mRNA	23041725
D004026	Dieldrin	Dieldrin affects the expression of FGFR1 mRNA	19130878
D004041	Dietary Fats	Dietary Fats results in decreased expression of FGFR1 mRNA	18042831
D004052	Diethylnitrosamine	FGFR1 protein results in increased susceptibility to Diethylnitrosamine	19009564
D002117	Calcitriol	Calcitriol results in decreased expression of FGFR1 mRNA	26485663
D002117	Calcitriol	[Calcium co-treated with Calcitriol] affects the expression of FGFR1 mRNA	15913539
C472511	dimethylarsinous acid	dimethylarsinous acid results in decreased expression of FGFR1 mRNA	16507463
D004147	Dioxins	Dioxins affects the expression of FGFR1 mRNA	20463971
D004237	Diuron	Diuron results in decreased expression of FGFR1 mRNA	25152437
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [FGF2 protein results in increased phosphorylation of FGFR1 protein]"	25856345
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased activity of FGFR1 protein"	25856345
D004610	Ellagic Acid	Ellagic Acid results in decreased expression of FGFR1 mRNA	12002526
C118739	entinostat	entinostat results in increased expression of FGFR1 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR1 mRNA"	27188386
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA	25607892
C024552	estrone benzoate	estrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form]	15120423
C560274	ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate	"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate analog inhibits the reaction [FGF2 protein results in increased phosphorylation of FGFR1 protein]"	21517068
C560274	ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate	"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate analog results in decreased activity of FGFR1 protein"	21517068
C560274	ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate	"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate inhibits the reaction [FGF2 protein results in increased phosphorylation of FGFR1 protein]"	21517068
C560274	ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate	"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate results in decreased activity of FGFR1 protein"	21517068
C032773	ethyl caffeate	ethyl caffeate affects the expression of FGFR1 protein	24892518
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of FGFR1 mRNA	28189721
C540355	fenamidone	fenamidone results in increased expression of FGFR1 mRNA	27029645
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FGFR1 gene	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of FGFR1 mRNA	23649840
C039281	furan	furan results in increased expression of FGFR1 mRNA	27387713
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in decreased expression of FGFR1 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of FGFR1 mRNA	17109745
D019812	Heparan Sulfate Proteoglycans	[Heparan Sulfate Proteoglycans binds to FGF2 protein binds to FGFR1 protein] which binds to ANOS1 protein	15548653
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]	15767480
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR1 protein]	10336501
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the reaction [FGF2 protein binds to FGFR1 protein]	10336501
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the activity of FGFR1 protein	15923150
D006493	Heparin	Heparin promotes the reaction [FGF2 protein binds to FGFR1 protein]	12440867
D006493	Heparin	Heparin binds to FGFR1 protein binds to FGF2 protein	15096041
D006493	Heparin	Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]	1379594
D006493	Heparin	Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]	1379594
D006493	Heparin	Heparin promotes the reaction [FGF2 protein results in increased activity of FGFR1 protein]	12799194
D006497	Heparitin Sulfate	SULF1 protein inhibits the reaction [Heparitin Sulfate results in increased activity of FGFR1 protein]	15051888
D006497	Heparitin Sulfate	FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein	12604602
D006497	Heparitin Sulfate	Heparitin Sulfate analog results in increased activity of FGFR1 protein alternative form	12460940
D017313	Fenretinide	Fenretinide results in decreased expression of FGFR1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [FGF2 protein binds to FGFR1 protein]	8849686
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of FGFR1 mRNA	12419474
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FGFR1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA	28628672
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of FGFR1 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of FGFR1 mRNA]	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of FGFR1 mRNA	25961927
D007608	Kainic Acid	Kainic Acid results in increased expression of FGFR1 mRNA	7649223
C008261	lead acetate	[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA	22839698
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FGFR1 gene	20938992
D008727	Methotrexate	FGFR1 protein affects the susceptibility to Methotrexate	16217747
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of FGFR1 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of FGFR1 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of FGFR1 mRNA	21613230
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FGFR1 mRNA"	20188158
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of and affects the localization of FGFR1 protein	15581186
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of FGFR1 mRNA	22108045
D009020	Morphine	Morphine results in increased expression of FGFR1 mRNA	15183518
D009287	Naphthyridines	Naphthyridines analog results in decreased activity of FGFR1 protein	16000000
C038541	N-benzyloxycarbonylprolylprolinal	N-benzyloxycarbonylprolylprolinal results in decreased expression of FGFR1 mRNA	21487212
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA	25607892
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]	11714710
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to FGFR1 protein alternative form]	9174673
C412603	orantinib	orantinib results in decreased phosphorylation of and results in decreased activity of FGFR1 protein	16144927
C412603	orantinib	orantinib results in decreased activity of FGFR1 protein	14760097\|1555134
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of FGFR1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of FGFR1 mRNA	25729387
D000073878	Palm Oil	Palm Oil results in decreased expression of FGFR1 mRNA	18042831
D010261	Paraoxon	Paraoxon results in decreased expression of FGFR1 mRNA	24413757
D052638	Particulate Matter	Particulate Matter results in increased expression of FGFR1 mRNA	28412507
C107527	PD 161570	PD 161570 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]	12805413
C113399	PD 166866	PD 166866 results in decreased activity of FGFR1 protein	15522930
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]	15773903
C113399	PD 166866	PD 166866 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]	12805413
C113399	PD 166866	PD 166866 results in decreased activity of FGFR1 protein	15121739\|1577390
C115711	PD 173074	arsenic trioxide promotes the reaction [PD 173074 results in decreased expression of FGFR1 protein]	27794399
C115711	PD 173074	PD 173074 promotes the reaction [arsenic trioxide results in decreased expression of FGFR1 protein]	27794399
C115711	PD 173074	PD 173074 results in decreased activity of FGFR1 protein	22683780\|2779439
C115711	PD 173074	[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]	22683780
C115711	PD 173074	PD 173074 results in decreased expression of FGFR1 protein	27794399
D030421	Peroxynitrous Acid	FGFR1 protein alternative form affects the susceptibility to Peroxynitrous Acid	12573278
D010578	Petroleum	Petroleum affects the expression of FGFR1 mRNA	25208076
D010710	Phosphates	FGFR1 protein alternative form promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
C008922	piperine	piperine binds to FGFR1 protein	28341137
C006253	pirinixic acid	pirinixic acid results in increased expression of FGFR1 mRNA	12832660
C545373	ponatinib	ponatinib analog results in decreased activity of FGFR1 protein	21561767
C545373	ponatinib	ponatinib results in decreased activity of FGFR1 protein	19878872\|2156176
C545373	ponatinib	ponatinib results in decreased activity of FGFR1 protein mutant form	19878872
C545373	ponatinib	ponatinib results in decreased phosphorylation of FGFR1 protein mutant form	21482694\|2287561
C545373	ponatinib	ponatinib affects the activity of FGFR1 protein mutant form	22301675
C545373	ponatinib	ponatinib inhibits the reaction [FGFR1 protein mutant form results in increased phosphorylation of SRC protein]	22781593
C545373	ponatinib	ponatinib results in decreased activity of FGFR1 protein	22238366
C545373	ponatinib	ponatinib results in decreased phosphorylation of and results in decreased activity of FGFR1 protein mutant form	22781593
D011374	Progesterone	estrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form]	15120423
D011374	Progesterone	Progesterone results in decreased expression of FGFR1 mRNA alternative form	15120423
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FGFR1 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of FGFR1 mRNA	27029645
C059514	resveratrol	resveratrol results in increased expression of FGFR1 mRNA	12002526
D015474	Isotretinoin	Isotretinoin results in increased expression of FGFR1 mRNA	20436886
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of FGFR1]	24136780
C010327	salinomycin	salinomycin results in decreased expression of FGFR1 mRNA	19682730
C009277	sodium arsenate	sodium arsenate results in increased expression of FGFR1 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of FGFR1 mRNA	21281968
C017947	sodium arsenite	sodium arsenite results in decreased expression of FGFR1 mRNA	16876216
C016104	sodium bichromate	sodium bichromate results in decreased expression of FGFR1 mRNA	12760830
D013311	Streptozocin	rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of FGFR1]	24136780
D013311	Streptozocin	Streptozocin results in decreased expression of FGFR1	24136780
C105686	SU 5402	SU 5402 results in decreased activity of FGFR1 protein	16091734\|1615419
C105686	SU 5402	SU 5402 results in decreased activity of FGFR1 protein mutant form	16103074
C105686	SU 5402	SU 5402 results in decreased activity of FGFR1 protein	12421715
C105686	SU 5402	SU 5402 results in increased expression of FGFR1 mRNA alternative form	12421715
C105686	SU 5402	SU 5402 results in decreased activity of FGFR1 protein	12704805\|1525595
D014284	Triiodothyronine	Triiodothyronine results in increased expression of FGFR1 mRNA	16150908
D014284	Triiodothyronine	Cycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]	12805413
D014284	Triiodothyronine	Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]	12805413
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]	12805413
D014284	Triiodothyronine	Triiodothyronine results in increased expression of FGFR1 mRNA	12805413
D014284	Triiodothyronine	Triiodothyronine results in increased expression of FGFR1 protein	12805413
C061133	tamibarotene	tamibarotene results in decreased expression of FGFR1 mRNA	15498508
D013629	Tamoxifen	FGFR1 protein results in decreased susceptibility to Tamoxifen	20179196
D013654	Taurine	Taurine results in decreased expression of FGFR1 mRNA	16579726
D013739	Testosterone	Testosterone results in increased expression of FGFR1 mRNA	7536664
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGFR1 mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of FGFR1 mRNA]	15667827
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGFR1 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGFR1 mRNA	17586704
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FGFR1 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of FGFR1 mRNA	15289447
D024505	Tocopherols	Tocopherols results in decreased expression of FGFR1 mRNA	15144885
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of FGFR1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of FGFR1 mRNA	25729387
D014204	Trenbolone Acetate	Trenbolone Acetate results in increased expression of FGFR1 mRNA	23314276
D014212	Tretinoin	Tretinoin affects the expression of FGFR1 mRNA	15498508
D014212	Tretinoin	Tretinoin results in decreased expression of FGFR1 mRNA	15498508
D014212	Tretinoin	Tretinoin results in increased expression of FGFR1 mRNA	16604517
D014212	Tretinoin	Tretinoin results in increased expression of FGFR1 protein	15389522
D014508	Urea	Urea analog results in decreased activity of FGFR1 protein	16000000
D014520	Urethane	Urethane results in increased expression of FGFR1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of FGFR1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FGFR1 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of FGFR1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of FGFR1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of FGFR1 mRNA	19136453
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of FGFR1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of FGFR1 mRNA	19165385
C025643	vinclozolin	vinclozolin results in increased expression of FGFR1 mRNA	22615374
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of FGFR1 mRNA	26682919
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR1 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of FGFR1 mRNA	26272509
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of FGFR1 mRNA"	25208076
C017803	zinc protoporphyrin	[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA	22839698

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IDA	8622701
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005007	fibroblast growth factor-activated receptor activity	-	IBA	21873635
GO:0005007	fibroblast growth factor-activated receptor activity	-	IDA	18480409 20133753
GO:0005007	fibroblast growth factor-activated receptor activity	-	TAS	2167437
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005515	protein binding	-	IPI	1656221 8321198 8753773 9660748 10464310 10490103 10830168 11030354 11401320 18412956 18441324 19665973 19696444 19966287 20932831 21765395 22035699 22751148 23063561 23597563 24157794 25241761 26267536
GO:0005524	ATP binding	-	IEA	-
GO:0008201	heparin binding	-	IDA	18480409
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0017134	fibroblast growth factor binding	-	IBA	21873635
GO:0017134	fibroblast growth factor binding	-	IDA	8663044 18480409
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0042802	identical protein binding	-	IPI	19696444 20133753
GO:0042803	protein homodimerization activity	-	IPI	20133753
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-
GO:0090722	receptor-receptor interaction	-	IDA	24157794

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0000165	MAPK cascade	-	TAS	-
GO:0001501	skeletal system development	-	TAS	7874169
GO:0001525	angiogenesis	-	IBA	21873635
GO:0001525	angiogenesis	-	IEA	-
GO:0001657	ureteric bud development	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001759	organ induction	-	IEA	-
GO:0001764	neuron migration	-	TAS	15863030
GO:0002053	positive regulation of mesenchymal cell proliferation	-	IEA	-
GO:0002062	chondrocyte differentiation	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006468	protein phosphorylation	-	NAS	1846977 2159626
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007417	central nervous system development	-	IBA	21873635
GO:0007605	sensory perception of sound	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	IDA	8663044
GO:0008284	positive regulation of cell proliferation	-	IGI	8663044
GO:0008284	positive regulation of cell proliferation	-	IMP	8622701
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IDA	8663044
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IGI	8663044
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IPI	10830168
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	22235191
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0010518	positive regulation of phospholipase activity	-	TAS	12141425
GO:0010863	positive regulation of phospholipase C activity	-	IDA	18480409
GO:0010966	regulation of phosphate transport	-	IEA	-
GO:0010976	positive regulation of neuron projection development	-	IEA	-
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	TAS	15863030
GO:0016477	cell migration	-	TAS	15863030
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	8622701 18480409
GO:0021847	ventricular zone neuroblast division	-	IEA	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030326	embryonic limb morphogenesis	-	IEA	-
GO:0030901	midbrain development	-	IEA	-
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	-	IEA	-
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0042472	inner ear morphogenesis	-	IEA	-
GO:0042473	outer ear morphogenesis	-	IEA	-
GO:0042474	middle ear morphogenesis	-	IEA	-
GO:0043009	chordate embryonic development	-	TAS	15863030
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043406	positive regulation of MAP kinase activity	-	IDA	8622701 18480409
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0043410	positive regulation of MAPK cascade	-	IMP	8622701
GO:0043536	positive regulation of blood vessel endothelial cell migration	-	IGI	23263626
GO:0045595	regulation of cell differentiation	-	TAS	12141425
GO:0045666	positive regulation of neuron differentiation	-	IMP	8622701
GO:0046777	protein autophosphorylation	-	IDA	8622701
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0048015	phosphatidylinositol-mediated signaling	-	TAS	12141425
GO:0048339	paraxial mesoderm development	-	IEA	-
GO:0048378	regulation of lateral mesodermal cell fate specification	-	IEA	-
GO:0048469	cell maturation	-	IEA	-
GO:0048705	skeletal system morphogenesis	-	TAS	15863030
GO:0048762	mesenchymal cell differentiation	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0060045	positive regulation of cardiac muscle cell proliferation	-	IEA	-
GO:0060117	auditory receptor cell development	-	IEA	-
GO:0060445	branching involved in salivary gland morphogenesis	-	IEA	-
GO:0060484	lung-associated mesenchyme development	-	IEA	-
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0070640	vitamin D3 metabolic process	-	IEA	-
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	-	IEA	-
GO:0090272	negative regulation of fibroblast growth factor production	-	IEA	-
GO:1903465	positive regulation of mitotic cell cycle DNA replication	-	IEA	-
GO:1905564	positive regulation of vascular endothelial cell proliferation	-	IGI	23263626
GO:2000546	positive regulation of endothelial cell chemotaxis to fibroblast growth factor	-	IDA	21885851
GO:2000830	positive regulation of parathyroid hormone secretion	-	IEA	-
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	1652059
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	IEA	-
GO:0005886	plasma membrane	-	IDA	18480409
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	10918587
GO:0016021	integral component of membrane	-	NAS	1652059 1846977 2159626
GO:0031410	cytoplasmic vesicle	-	IEA	-
GO:0043235	receptor complex	-	IBA	21873635
GO:0043235	receptor complex	-	IDA	23382219

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04520	Adherens junction
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05215	Prostate cancer
hsa05218	Melanoma

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1839120	Signaling by FGFR1 amplification mutants	TAS
R-HSA-1839122	Signaling by activated point mutants of FGFR1	TAS
R-HSA-1839124	FGFR1 mutant receptor activation	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-190242	FGFR1 ligand binding and activation	TAS
R-HSA-190370	FGFR1b ligand binding and activation	TAS
R-HSA-190373	FGFR1c ligand binding and activation	TAS
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-373760	L1CAM interactions	TAS
R-HSA-375165	NCAM signaling for neurite out-growth	IEA
R-HSA-422475	Axon guidance	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-445144	Signal transduction by L1	TAS
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654688	SHC-mediated cascade:FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5655302	Signaling by FGFR1 in disease	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-8853336	Signaling by plasma membrane FGFR1 fusions	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27785367	FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer. (2016 Oct)	Theelen WS	J Pathol Clin Res
25537505	Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma. (2015 Feb 10)	Kim HS	Oncotarget
25433983	FGFR1 amplification in lung squamous cell carcinoma: a systematic review with meta-analysis. (2015 Jan)	Jiang T	Lung Cancer
24736592	Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease. (2014)	Toschi L	PLoS One
29764586	[Relationship between FGFR1 Gene Regulation of Circulating Tumor Cells and Clinical Features of Non-small Cell Lung Cancer]. (2018 May 20)	Liu L	Zhongguo Fei Ai Za Zhi
23182986	Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. (2013 Feb 20)	Kim HR	J Clin Oncol
22179561	Increased FGFR1 copy number in lung squamous cell carcinomas. (2012 Mar)	Sasaki H	Mol Med Rep
19856868	Pfeiffer-like syndrome with holoprosencephaly: a newborn with maternal smoking and alcohol exposure. (2009 Oct)	Su PH	Pediatr Neonatol
25870798	Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. (2015 Apr)	Kohno T	Transl Lung Cancer Res
26164066	Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma. (2015 Sep)	Preusser M	Eur J Cancer
28483948	High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer. (2017 Aug)	Sokolowska-Wedzina A	Mol Cancer Res
26793001	The clinical pathological characteristics and prognosis of FGFR1 gene amplification in non-small-cell lung cancer: a meta-analysis. (2016)	Xie FJ	Onco Targets Ther
27901003	Fibroblast Growth Factor Receptor 1 Gene Amplification in Nonsmall Cell Lung Cancer. (2016 Dec 5)	Miao JL	Chin Med J (Engl)
23154548	FGFR1 amplification in squamous cell carcinoma of the lung. (2012 Dec)	Heist RS	J Thorac Oncol
23887299	Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer. (2014 Feb)	Schultheis AM	Mod Pathol
23434054	Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. (2013 Jun)	Young RJ	Oral Oncol
24077455	Prognostic value of fibroblast growth factor receptor 1 gene locus amplification in resected lung squamous cell carcinoma. (2013 Nov)	Craddock KJ	J Thorac Oncol
29281903	Assessment of FGFR1 Over-Expression and Over-Activity in Lung Cancer Cells: A Toolkit for Anti-FGFR1 Drug Screening. (2018 Feb)	Hu P	Hum Gene Ther Methods
26601054	Experience with targeted next generation sequencing for the care of lung cancer: insights into promises and limitations of genomic oncology in day-to-day practice. (2015)	Rangachari D	Cancer Treat Commun
28240520	Roles of Signal Transducer Pathways in Investigation of Biopsies from Patients with Bladder Tumors (2017 Jan 1)	Bayrak A	Asian Pac J Cancer Prev
26617686	Expression of fibroblast growth factor receptor 1, fibroblast growth factor 2, phosphatidyl inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma of the lung. (2015)	Usul Afsar C	Int J Clin Exp Pathol
25662388	Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. (2015 Apr)	Kim MY	Lung Cancer
21160076	A therapeutic target for smoking-associated lung cancer. (2010 Dec 15)	Turner NC	Sci Transl Med
25086725	FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer. (2014 Nov)	Seo AN	Virchows Arch
23806793	Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer. (2013 Sep)	Tran TN	Lung Cancer
24850843	FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. (2014 Aug 1)	Wang R	Clin Cancer Res
25488863	Alterations of a spectrum of driver genes in female Chinese patients with advanced or metastatic squamous cell carcinoma of the lung. (2015 Feb)	Qiong Z	Lung Cancer
24163741	Molecular biology of lung cancer. (2013 Oct)	Cooper WA	J Thorac Dis
22074045	The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate. (2013 Jan)	Wang H	Cleft Palate Craniofac J