Gene: FGFR1

2260
BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1
fibroblast growth factor receptor 1
protein-coding
8p11.23
Ensembl:ENSG00000077782 MIM:136350 Vega:OTTHUMG00000147366 UniprotKB:P11362
NG_007729.1
PubMed
ND
29   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.181e-1 (AD)  6.579e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC61A10.839
TM9SF10.837
EHD10.811
CCNK0.811
CALR0.81
POLDIP30.807
WBP1L0.806
MAPK70.802
ST50.799
SLC35A40.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.618
OR4F29-0.567
OR6C74-0.266
CETP-0.214
C10orf67-0.195
EDN3-0.185
RNASE8-0.178
HAPLN1-0.167
RPL10L-0.159
SPRR2B-0.157

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00039PaliferminBiotechDrug162394-19-6ApprovedTarget
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalTarget
DB01109HeparinSmall Molecule9005-49-6Approved|InvestigationalTarget
DB02058SU4984Small MoleculeExperimentalTarget
DB05014XL999Small Molecule921206-68-0InvestigationalTarget
DB075253-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridineSmall MoleculeExperimentalTarget
DB07840(E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanolSmall MoleculeExperimentalTarget
DB085773-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONESmall MoleculeExperimentalTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
DB08901PonatinibSmall Molecule943319-70-8Approved|InvestigationalTarget
DB09078LenvatinibSmall Molecule417716-92-8Approved|InvestigationalTarget
DB09079NintedanibSmall Molecule656247-17-5ApprovedTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FGFR1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of FGFR1 mRNA"19095052
C5689503-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea"3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea results in decreased activity of FGFR1 protein"21936542
C1170113-(4-dimethylamino-benzylidenyl)-2-indolinone3-(4-dimethylamino-benzylidenyl)-2-indolinone results in decreased activity of FGFR1 protein15728459
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNA12419474
C5610525H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of FGFR1 protein"21608528
C5299105-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo(2,3-b)pyridin-5-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-amine"5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo(2,3-b)pyridin-5-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-amine results in decreased activity of FGFR1 protein"20100840
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of FGFR1 mRNA21420995|2906747
D000117AcetylglucosamineAcetylglucosamine analog promotes the reaction [FGF2 protein binds to FGFR1 protein]12440867
D020106AcrylamideAcrylamide analog promotes the reaction [FGF2 protein binds to FGFR1 protein]12440867
D020106AcrylamideAcrylamide analog promotes the reaction [FGFR1 protein binds to FGFR1 protein]14733594
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of FGFR1 mRNA17023530
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGFR1 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of FGFR1 mRNA12558987
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FGFR1 mRNA24449571
C463061AP20187AP20187 results in increased activity of FGFR1 protein mutant form12654294
C006632arsenic trioxidearsenic trioxide promotes the reaction [PD 173074 results in decreased expression of FGFR1 protein]27794399
C006632arsenic trioxidearsenic trioxide results in decreased expression of FGFR1 mRNA15761015|1912883
C006632arsenic trioxidearsenic trioxide results in decreased expression of FGFR1 protein27794399
C006632arsenic trioxidearsenic trioxide results in decreased phosphorylation of FGFR1 protein mutant form17027752
C006632arsenic trioxidearsenic trioxide results in increased expression of FGFR1 mRNA17258074|2045855
C006632arsenic trioxideFGFR1 protein results in decreased susceptibility to arsenic trioxide27794399
C006632arsenic trioxidePD 173074 promotes the reaction [arsenic trioxide results in decreased expression of FGFR1 protein]27794399
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of FGFR1 mRNA"23634900
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGFR1 mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of FGFR1 gene25435355
D004958EstradiolEstradiol results in decreased expression of FGFR1 mRNA19167446
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of FGFR1 mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of FGFR1 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA25607892
C006780bisphenol Abisphenol A results in increased expression of FGFR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FGFR1 gene28505145
D001786Blood GlucoseFGFR1 protein affects the abundance of Blood Glucose11130726
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA25607892
D002104CadmiumCadmium results in increased expression of FGFR1 mRNA23369406
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FGFR1 mRNA12760830
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of FGFR1 promoter22457795
D002118Calcium[Calcium co-treated with Calcitriol] affects the expression of FGFR1 mRNA15913539
D002211CapsaicinCapsaicin results in decreased expression of FGFR1 protein14521749
D002220CarbamazepineCarbamazepine affects the expression of FGFR1 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FGFR1 mRNA17484886
D002746ChlorpromazineChlorpromazine analog results in decreased expression of FGFR1 mRNA15924885
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FGFR1 gene20938992
D003042CocaineCocaine results in increased expression of FGFR1 mRNA16076954
D005576ColforsinColforsin results in increased expression of FGFR1 mRNA10320526
D003375CoumestrolCoumestrol results in decreased expression of FGFR1 mRNA19167446
C551994crizotinib[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]22683780
C029892cupric chloridecupric chloride affects the expression of FGFR1 mRNA17211630
D003471CuprizoneCuprizone results in increased expression of FGFR1 mRNA26577399|2752363
D003513CycloheximideCycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]12805413
D016572CyclosporineCyclosporine results in decreased expression of FGFR1 mRNA25562108
D003609DactinomycinDactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]12805413
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of FGFR1 mRNA23640034
C014347decitabinedecitabine results in decreased expression of FGFR1 mRNA17785578
C014347decitabinedecitabine results in increased expression of FGFR1 mRNA27915011
D003907DexamethasoneDexamethasone results in decreased expression of FGFR1 mRNA28453788
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA28628672
D003976DiazinonDiazinon results in decreased expression of FGFR1 mRNA17589599
D003976DiazinonDiazinon results in increased expression of FGFR1 mRNA19130878
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FGFR1 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of FGFR1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of FGFR1 mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of FGFR1 mRNA]27392435
D002945CisplatinCisplatin results in increased expression of FGFR1 mRNA21151649
D004008DiclofenacDiclofenac affects the expression of FGFR1 mRNA24752500
D004026DieldrinDieldrin results in increased expression of FGFR1 mRNA23041725
D004026DieldrinDieldrin affects the expression of FGFR1 mRNA19130878
D004041Dietary FatsDietary Fats results in decreased expression of FGFR1 mRNA18042831
D004052DiethylnitrosamineFGFR1 protein results in increased susceptibility to Diethylnitrosamine19009564
D002117CalcitriolCalcitriol results in decreased expression of FGFR1 mRNA26485663
D002117Calcitriol[Calcium co-treated with Calcitriol] affects the expression of FGFR1 mRNA15913539
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of FGFR1 mRNA16507463
D004147DioxinsDioxins affects the expression of FGFR1 mRNA20463971
D004237DiuronDiuron results in decreased expression of FGFR1 mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [FGF2 protein results in increased phosphorylation of FGFR1 protein]"25856345
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased activity of FGFR1 protein"25856345
D004610Ellagic AcidEllagic Acid results in decreased expression of FGFR1 mRNA12002526
C118739entinostatentinostat results in increased expression of FGFR1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR1 mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA25607892
C024552estrone benzoateestrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form]15120423
C560274ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate analog inhibits the reaction [FGF2 protein results in increased phosphorylation of FGFR1 protein]"21517068
C560274ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate analog results in decreased activity of FGFR1 protein"21517068
C560274ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate inhibits the reaction [FGF2 protein results in increased phosphorylation of FGFR1 protein]"21517068
C560274ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate results in decreased activity of FGFR1 protein"21517068
C032773ethyl caffeateethyl caffeate affects the expression of FGFR1 protein24892518
C024565ethylene dichlorideethylene dichloride results in decreased expression of FGFR1 mRNA28189721
C540355fenamidonefenamidone results in increased expression of FGFR1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FGFR1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of FGFR1 mRNA23649840
C039281furanfuran results in increased expression of FGFR1 mRNA27387713
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in decreased expression of FGFR1 mRNA]17109745
D005944GlucosamineGlucosamine results in increased expression of FGFR1 mRNA17109745
D019812Heparan Sulfate Proteoglycans[Heparan Sulfate Proteoglycans binds to FGF2 protein binds to FGFR1 protein] which binds to ANOS1 protein15548653
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]15767480
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR1 protein]10336501
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans affects the reaction [FGF2 protein binds to FGFR1 protein]10336501
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans affects the activity of FGFR1 protein15923150
D006493HeparinHeparin promotes the reaction [FGF2 protein binds to FGFR1 protein]12440867
D006493HeparinHeparin binds to FGFR1 protein binds to FGF2 protein15096041
D006493HeparinHeparin promotes the reaction [FGFR1 protein binds to FGF1 protein]1379594
D006493HeparinHeparin promotes the reaction [FGFR1 protein binds to FGF2 protein]1379594
D006493HeparinHeparin promotes the reaction [FGF2 protein results in increased activity of FGFR1 protein]12799194
D006497Heparitin SulfateSULF1 protein inhibits the reaction [Heparitin Sulfate results in increased activity of FGFR1 protein]15051888
D006497Heparitin SulfateFGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein12604602
D006497Heparitin SulfateHeparitin Sulfate analog results in increased activity of FGFR1 protein alternative form12460940
D017313FenretinideFenretinide results in decreased expression of FGFR1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [FGF2 protein binds to FGFR1 protein]8849686
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of FGFR1 mRNA12419474
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FGFR1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGFR1 mRNA28628672
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of FGFR1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of FGFR1 mRNA]27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FGFR1 mRNA25961927
D007608Kainic AcidKainic Acid results in increased expression of FGFR1 mRNA7649223
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA22839698
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FGFR1 gene20938992
D008727MethotrexateFGFR1 protein affects the susceptibility to Methotrexate16217747
D008748MethylcholanthreneMethylcholanthrene results in increased expression of FGFR1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FGFR1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of FGFR1 mRNA21613230
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FGFR1 mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of and affects the localization of FGFR1 protein15581186
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of FGFR1 mRNA22108045
D009020MorphineMorphine results in increased expression of FGFR1 mRNA15183518
D009287NaphthyridinesNaphthyridines analog results in decreased activity of FGFR1 protein16000000
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in decreased expression of FGFR1 mRNA21487212
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of FGFR1 mRNA25607892
D009844OligosaccharidesOligosaccharides promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]11714710
D009844OligosaccharidesOligosaccharides promotes the reaction [FGF1 protein binds to FGFR1 protein alternative form]9174673
C412603orantiniborantinib results in decreased phosphorylation of and results in decreased activity of FGFR1 protein16144927
C412603orantiniborantinib results in decreased activity of FGFR1 protein14760097|1555134
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FGFR1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of FGFR1 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of FGFR1 mRNA18042831
D010261ParaoxonParaoxon results in decreased expression of FGFR1 mRNA24413757
D052638Particulate MatterParticulate Matter results in increased expression of FGFR1 mRNA28412507
C107527PD 161570PD 161570 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]12805413
C113399PD 166866PD 166866 results in decreased activity of FGFR1 protein15522930
C113399PD 166866PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]15773903
C113399PD 166866PD 166866 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]12805413
C113399PD 166866PD 166866 results in decreased activity of FGFR1 protein15121739|1577390
C115711PD 173074arsenic trioxide promotes the reaction [PD 173074 results in decreased expression of FGFR1 protein]27794399
C115711PD 173074PD 173074 promotes the reaction [arsenic trioxide results in decreased expression of FGFR1 protein]27794399
C115711PD 173074PD 173074 results in decreased activity of FGFR1 protein22683780|2779439
C115711PD 173074[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]22683780
C115711PD 173074PD 173074 results in decreased expression of FGFR1 protein27794399
D030421Peroxynitrous AcidFGFR1 protein alternative form affects the susceptibility to Peroxynitrous Acid12573278
D010578PetroleumPetroleum affects the expression of FGFR1 mRNA25208076
D010710PhosphatesFGFR1 protein alternative form promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
C008922piperinepiperine binds to FGFR1 protein28341137
C006253pirinixic acidpirinixic acid results in increased expression of FGFR1 mRNA12832660
C545373ponatinibponatinib analog results in decreased activity of FGFR1 protein21561767
C545373ponatinibponatinib results in decreased activity of FGFR1 protein19878872|2156176
C545373ponatinibponatinib results in decreased activity of FGFR1 protein mutant form19878872
C545373ponatinibponatinib results in decreased phosphorylation of FGFR1 protein mutant form21482694|2287561
C545373ponatinibponatinib affects the activity of FGFR1 protein mutant form22301675
C545373ponatinibponatinib inhibits the reaction [FGFR1 protein mutant form results in increased phosphorylation of SRC protein]22781593
C545373ponatinibponatinib results in decreased activity of FGFR1 protein22238366
C545373ponatinibponatinib results in decreased phosphorylation of and results in decreased activity of FGFR1 protein mutant form22781593
D011374Progesteroneestrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form]15120423
D011374ProgesteroneProgesterone results in decreased expression of FGFR1 mRNA alternative form15120423
D011441PropylthiouracilPropylthiouracil results in decreased expression of FGFR1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FGFR1 mRNA27029645
C059514resveratrolresveratrol results in increased expression of FGFR1 mRNA12002526
D015474IsotretinoinIsotretinoin results in increased expression of FGFR1 mRNA20436886
C089730rosiglitazonerosiglitazone inhibits the reaction [Streptozocin results in decreased expression of FGFR1]24136780
C010327salinomycinsalinomycin results in decreased expression of FGFR1 mRNA19682730
C009277sodium arsenatesodium arsenate results in increased expression of FGFR1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of FGFR1 mRNA21281968
C017947sodium arsenitesodium arsenite results in decreased expression of FGFR1 mRNA16876216
C016104sodium bichromatesodium bichromate results in decreased expression of FGFR1 mRNA12760830
D013311Streptozocinrosiglitazone inhibits the reaction [Streptozocin results in decreased expression of FGFR1]24136780
D013311StreptozocinStreptozocin results in decreased expression of FGFR124136780
C105686SU 5402SU 5402 results in decreased activity of FGFR1 protein16091734|1615419
C105686SU 5402SU 5402 results in decreased activity of FGFR1 protein mutant form16103074
C105686SU 5402SU 5402 results in decreased activity of FGFR1 protein12421715
C105686SU 5402SU 5402 results in increased expression of FGFR1 mRNA alternative form12421715
C105686SU 5402SU 5402 results in decreased activity of FGFR1 protein12704805|1525595
D014284TriiodothyronineTriiodothyronine results in increased expression of FGFR1 mRNA16150908
D014284TriiodothyronineCycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]12805413
D014284TriiodothyronineDactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]12805413
D014284TriiodothyronineTriiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]12805413
D014284TriiodothyronineTriiodothyronine results in increased expression of FGFR1 mRNA12805413
D014284TriiodothyronineTriiodothyronine results in increased expression of FGFR1 protein12805413
C061133tamibarotenetamibarotene results in decreased expression of FGFR1 mRNA15498508
D013629TamoxifenFGFR1 protein results in decreased susceptibility to Tamoxifen20179196
D013654TaurineTaurine results in decreased expression of FGFR1 mRNA16579726
D013739TestosteroneTestosterone results in increased expression of FGFR1 mRNA7536664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGFR1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of FGFR1 mRNA]15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGFR1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGFR1 mRNA17586704
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FGFR1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FGFR1 mRNA15289447
D024505TocopherolsTocopherols results in decreased expression of FGFR1 mRNA15144885
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FGFR1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of FGFR1 mRNA25729387
D014204Trenbolone AcetateTrenbolone Acetate results in increased expression of FGFR1 mRNA23314276
D014212TretinoinTretinoin affects the expression of FGFR1 mRNA15498508
D014212TretinoinTretinoin results in decreased expression of FGFR1 mRNA15498508
D014212TretinoinTretinoin results in increased expression of FGFR1 mRNA16604517
D014212TretinoinTretinoin results in increased expression of FGFR1 protein15389522
D014508UreaUrea analog results in decreased activity of FGFR1 protein16000000
D014520UrethaneUrethane results in increased expression of FGFR1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FGFR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FGFR1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of FGFR1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of FGFR1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of FGFR1 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FGFR1 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of FGFR1 mRNA19165385
C025643vinclozolinvinclozolin results in increased expression of FGFR1 mRNA22615374
C029297vinylidene chloridevinylidene chloride results in decreased expression of FGFR1 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of FGFR1 mRNA26272509
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of FGFR1 mRNA"25208076
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IDA8622701  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005007fibroblast growth factor-activated receptor activity-IBA21873635  
GO:0005007fibroblast growth factor-activated receptor activity-IDA18480409  20133753  
GO:0005007fibroblast growth factor-activated receptor activity-TAS2167437  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI1656221  8321198  8753773  9660748  10464310  10490103  
10830168  11030354  11401320  18412956  18441324  19665973  
19696444  19966287  20932831  21765395  22035699  22751148  
23063561  23597563  24157794  25241761  26267536  
GO:0005524ATP binding-IEA-  
GO:0008201heparin binding-IDA18480409  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0017134fibroblast growth factor binding-IBA21873635  
GO:0017134fibroblast growth factor binding-IDA8663044  18480409  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0042802identical protein binding-IPI19696444  20133753  
GO:0042803protein homodimerization activity-IPI20133753  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:0090722receptor-receptor interaction-IDA24157794  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000165MAPK cascade-TAS-  
GO:0001501skeletal system development-TAS7874169  
GO:0001525angiogenesis-IBA21873635  
GO:0001525angiogenesis-IEA-  
GO:0001657ureteric bud development-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001759organ induction-IEA-  
GO:0001764neuron migration-TAS15863030  
GO:0002053positive regulation of mesenchymal cell proliferation-IEA-  
GO:0002062chondrocyte differentiation-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-NAS1846977  2159626  
GO:0007275multicellular organism development-IBA21873635  
GO:0007417central nervous system development-IBA21873635  
GO:0007605sensory perception of sound-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA8663044  
GO:0008284positive regulation of cell proliferation-IGI8663044  
GO:0008284positive regulation of cell proliferation-IMP8622701  
GO:0008543fibroblast growth factor receptor signaling pathway-IDA8663044  
GO:0008543fibroblast growth factor receptor signaling pathway-IGI8663044  
GO:0008543fibroblast growth factor receptor signaling pathway-IPI10830168  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS22235191  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010518positive regulation of phospholipase activity-TAS12141425  
GO:0010863positive regulation of phospholipase C activity-IDA18480409  
GO:0010966regulation of phosphate transport-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-TAS15863030  
GO:0016477cell migration-TAS15863030  
GO:0018108peptidyl-tyrosine phosphorylation-IDA8622701  18480409  
GO:0021847ventricular zone neuroblast division-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0030901midbrain development-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0035607fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0042472inner ear morphogenesis-IEA-  
GO:0042473outer ear morphogenesis-IEA-  
GO:0042474middle ear morphogenesis-IEA-  
GO:0043009chordate embryonic development-TAS15863030  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043406positive regulation of MAP kinase activity-IDA8622701  18480409  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IMP8622701  
GO:0043536positive regulation of blood vessel endothelial cell migration-IGI23263626  
GO:0045595regulation of cell differentiation-TAS12141425  
GO:0045666positive regulation of neuron differentiation-IMP8622701  
GO:0046777protein autophosphorylation-IDA8622701  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048015phosphatidylinositol-mediated signaling-TAS12141425  
GO:0048339paraxial mesoderm development-IEA-  
GO:0048378regulation of lateral mesodermal cell fate specification-IEA-  
GO:0048469cell maturation-IEA-  
GO:0048705skeletal system morphogenesis-TAS15863030  
GO:0048762mesenchymal cell differentiation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0060117auditory receptor cell development-IEA-  
GO:0060445branching involved in salivary gland morphogenesis-IEA-  
GO:0060484lung-associated mesenchyme development-IEA-  
GO:0060665regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070640vitamin D3 metabolic process-IEA-  
GO:0090080positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway-IEA-  
GO:0090272negative regulation of fibroblast growth factor production-IEA-  
GO:1903465positive regulation of mitotic cell cycle DNA replication-IEA-  
GO:1905564positive regulation of vascular endothelial cell proliferation-IGI23263626  
GO:2000546positive regulation of endothelial cell chemotaxis to fibroblast growth factor-IDA21885851  
GO:2000830positive regulation of parathyroid hormone secretion-IEA-  
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS1652059  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IDA18480409  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10918587  
GO:0016021integral component of membrane-NAS1652059  1846977  2159626  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839120Signaling by FGFR1 amplification mutantsTAS
R-HSA-1839122Signaling by activated point mutants of FGFR1TAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190242FGFR1 ligand binding and activationTAS
R-HSA-190370FGFR1b ligand binding and activationTAS
R-HSA-190373FGFR1c ligand binding and activationTAS
R-HSA-190374FGFR1c and Klotho ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-445144Signal transduction by L1TAS
R-HSA-5654219Phospholipase C-mediated cascade: FGFR1TAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654688SHC-mediated cascade:FGFR1TAS
R-HSA-5654689PI-3K cascade:FGFR1TAS
R-HSA-5654693FRS-mediated FGFR1 signalingTAS
R-HSA-5654726Negative regulation of FGFR1 signalingTAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-8853336Signaling by plasma membrane FGFR1 fusionsTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27785367FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer. (2016 Oct)Theelen WSJ Pathol Clin Res
25537505Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma. (2015 Feb 10)Kim HSOncotarget
25433983FGFR1 amplification in lung squamous cell carcinoma: a systematic review with meta-analysis. (2015 Jan)Jiang TLung Cancer
24736592Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease. (2014)Toschi LPLoS One
29764586[Relationship between FGFR1 Gene Regulation of Circulating Tumor Cells and Clinical Features of Non-small Cell Lung Cancer]. (2018 May 20)Liu LZhongguo Fei Ai Za Zhi
23182986Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. (2013 Feb 20)Kim HRJ Clin Oncol
22179561Increased FGFR1 copy number in lung squamous cell carcinomas. (2012 Mar)Sasaki HMol Med Rep
19856868Pfeiffer-like syndrome with holoprosencephaly: a newborn with maternal smoking and alcohol exposure. (2009 Oct)Su PHPediatr Neonatol
25870798Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. (2015 Apr)Kohno TTransl Lung Cancer Res
26164066Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma. (2015 Sep)Preusser MEur J Cancer
28483948High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer. (2017 Aug)Sokolowska-Wedzina AMol Cancer Res
26793001The clinical pathological characteristics and prognosis of FGFR1 gene amplification in non-small-cell lung cancer: a meta-analysis. (2016)Xie FJOnco Targets Ther
27901003Fibroblast Growth Factor Receptor 1 Gene Amplification in Nonsmall Cell Lung Cancer. (2016 Dec 5)Miao JLChin Med J (Engl)
23154548FGFR1 amplification in squamous cell carcinoma of the lung. (2012 Dec)Heist RSJ Thorac Oncol
23887299Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer. (2014 Feb)Schultheis AMMod Pathol
23434054Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. (2013 Jun)Young RJOral Oncol
24077455Prognostic value of fibroblast growth factor receptor 1 gene locus amplification in resected lung squamous cell carcinoma. (2013 Nov)Craddock KJJ Thorac Oncol
29281903Assessment of FGFR1 Over-Expression and Over-Activity in Lung Cancer Cells: A Toolkit for Anti-FGFR1 Drug Screening. (2018 Feb)Hu PHum Gene Ther Methods
26601054Experience with targeted next generation sequencing for the care of lung cancer: insights into promises and limitations of genomic oncology in day-to-day practice. (2015)Rangachari DCancer Treat Commun
28240520Roles of Signal Transducer Pathways in Investigation of Biopsies from Patients with Bladder Tumors (2017 Jan 1)Bayrak AAsian Pac J Cancer Prev
26617686Expression of fibroblast growth factor receptor 1, fibroblast growth factor 2, phosphatidyl inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma of the lung. (2015)Usul Afsar CInt J Clin Exp Pathol
25662388Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. (2015 Apr)Kim MYLung Cancer
21160076A therapeutic target for smoking-associated lung cancer. (2010 Dec 15)Turner NCSci Transl Med
25086725FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer. (2014 Nov)Seo ANVirchows Arch
23806793Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer. (2013 Sep)Tran TNLung Cancer
24850843FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. (2014 Aug 1)Wang RClin Cancer Res
25488863Alterations of a spectrum of driver genes in female Chinese patients with advanced or metastatic squamous cell carcinoma of the lung. (2015 Feb)Qiong ZLung Cancer
24163741Molecular biology of lung cancer. (2013 Oct)Cooper WAJ Thorac Dis
22074045The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate. (2013 Jan)Wang HCleft Palate Craniofac J