Gene info: ID 2261

Gene: FGFR3

GENE ID: 2261

Synonyms: ACH|CD333|CEK2|HSFGFR3EX|JTK4

Description: fibroblast growth factor receptor 3

Gene type: protein-coding

Location: 4p16.3

dbXrefs: Ensembl:ENSG00000068078 MIM:134934 Vega:OTTHUMG00000121148 UniprotKB:P22607

RefSeq: NG_012632.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 13

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.397e-2 (AD) 3.430e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg21339581	chr4:1800987	FGFR3	Gene body	1.290e-4	Alcohol use disorders	26763658
cg21782511	chr4:1808376	FGFR3	Gene body	1.726e-4	Alcohol use disorders	26763658
cg19625524	chr4:1803148	FGFR3	Gene body	1.771e-4	Alcohol use disorders	26763658
cg03262295	chr4:1807954	FGFR3	Gene body	2.601e-4	Alcohol use disorders	26763658
cg13131329	chr4:1801148	FGFR3	Gene body	2.966e-4	Alcohol use disorders	26763658
cg05203875	chr4:1801294	FGFR3	Gene body	3.575e-4	Alcohol use disorders	26763658
cg00907756	chr4:1803077	FGFR3	Gene body	5.329e-4	Alcohol use disorders	26763658
cg00525145	chr4:1803443	FGFR3	Gene body	5.458e-4	Alcohol use disorders	26763658
cg12997579	chr4:1801063	FGFR3	Gene body	6.276e-4	Alcohol use disorders	26763658
cg01903185	chr4:1808586	FGFR3	Gene body	6.764e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MLC1	0.94
GPR37L1	0.939
SLC1A2	0.932
ACSS1	0.931
BMP7	0.913
ACSBG1	0.905
PRODH	0.903
GRIN2C	0.902
NTRK2	0.899
TTYH1	0.895

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FER1L6	-0.42
TDRD1	-0.413
OR4F5	-0.409
GADL1	-0.402
KLK8	-0.375
OR4F29	-0.372
OR52E4	-0.359
PLA2G4A	-0.359
CCDC68	-0.357
SCARA5	-0.357

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00039	Palifermin	BiotechDrug	162394-19-6	Approved	Target
DB05014	XL999	Small Molecule	921206-68-0	Investigational	Target
DB06589	Pazopanib	Small Molecule	444731-52-6	Approved	Target
DB08901	Ponatinib	Small Molecule	943319-70-8	Approved\|Investigational	Target
DB09078	Lenvatinib	Small Molecule	417716-92-8	Approved\|Investigational	Target
DB09079	Nintedanib	Small Molecule	656247-17-5	Approved	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of FGFR3 mRNA"	26377693
C482402	20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol	20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol results in decreased expression of FGFR3 mRNA	12963989
C482402	20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol	20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol results in decreased expression of FGFR3 protein	12963989
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of FGFR3 mRNA"	20453058
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of FGFR3 mRNA"	23829299
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FGFR3 mRNA"	19114083
C013186	2,3-pentanedione	"2,3-pentanedione results in decreased expression of FGFR3 mRNA"	25710175
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of FGFR3 mRNA"	20406850
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in increased expression of FGFR3 mRNA	25088246
C568950	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	"FGFR3 protein results in increased susceptibility to 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea"	21936542
C568950	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	"3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea results in decreased activity of FGFR3 protein"	21936542
C568950	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	"3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea results in decreased activity of FGFR3 protein mutant form"	21936542
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of FGFR3 mRNA	18544908
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C561052	5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one	"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of FGFR3 protein"	21608528
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of FGFR3 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in decreased expression of FGFR3 mRNA	18544908
D020106	Acrylamide	Acrylamide results in increased expression of FGFR3 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FGFR3 mRNA	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGFR3 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of FGFR3 mRNA	16704987
D001104	Arbutin	Arbutin results in decreased expression of FGFR3 mRNA	17103032
D001151	Arsenic	Arsenic affects the methylation of FGFR3 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of FGFR3 mRNA	25929836
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of FGFR3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGFR3 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGFR3 mRNA	22316170\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to FGFR3 promoter]	19654925
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of FGFR3 mRNA	20404318
D004958	Estradiol	Estradiol results in increased expression of FGFR3 mRNA alternative form	14602803
D004958	Estradiol	ESR1 protein promotes the reaction [Estradiol results in increased expression of FGFR3 mRNA]	25210133
D004958	Estradiol	Estradiol results in increased expression of FGFR3 mRNA	25210133
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of FGFR3 mRNA	25912373
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FGFR3 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of FGFR3 mRNA	20170705
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FGFR3 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of FGFR3 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of FGFR3 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of FGFR3 mRNA	26191083
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FGFR3 mRNA	16644059
D002752	Chlorthalidone	Chlorthalidone results in decreased expression of FGFR3 mRNA	20625077
C031180	chrysene	chrysene results in increased expression of FGFR3 mRNA	26377693
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FGFR3 mRNA	24612858
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of FGFR3 mRNA	19549813
C009160	cyclonite	cyclonite results in increased expression of FGFR3 mRNA	25559034
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGFR3 mRNA	20106945\|2556210
D003907	Dexamethasone	Dexamethasone results in decreased expression of FGFR3 mRNA	28453788
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FGFR3 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FGFR3 mRNA	28628672
D003907	Dexamethasone	FGFR3 protein results in decreased susceptibility to Dexamethasone	12393593
D003976	Diazinon	Diazinon results in increased methylation of FGFR3 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FGFR3 mRNA	21266533
D003998	Dicarboxylic Acids	FGFR3 protein affects the metabolism of and affects the abundance of Dicarboxylic Acids	11879084
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of FGFR3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of FGFR3 mRNA	12066199\|2739243
D002117	Calcitriol	Calcitriol results in decreased expression of FGFR3 protein	15728789
D004112	Dimercaprol	Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of FGFR3 mRNA]	16377760
D004221	Disulfiram	Disulfiram results in decreased expression of FGFR3 mRNA	20530235
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in decreased expression of FGFR3 mRNA	16623957
D004317	Doxorubicin	Doxorubicin results in increased expression of FGFR3 mRNA	25896364
C118739	entinostat	entinostat results in increased expression of FGFR3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of FGFR3 mRNA	20170705
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of FGFR3 mRNA	18936297
C540355	fenamidone	fenamidone results in increased expression of FGFR3 mRNA	27029645
C082360	fipronil	fipronil results in increased methylation of FGFR3 gene	28536466
D019833	Genistein	Genistein results in increased expression of FGFR3 mRNA	22228119
D005839	Gentamicins	Gentamicins results in decreased expression of FGFR3 mRNA	11784008
D005839	Gentamicins	Gentamicins results in decreased expression of FGFR3 protein	11784008
D006072	Gossypol	Gossypol results in decreased expression of FGFR3 mRNA	19825521
D006072	Gossypol	zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGFR3 mRNA]	19825521
C010176	halofuginone	halofuginone results in increased expression of FGFR3 mRNA	17180598
D006493	Heparin	Heparin affects the activity of FGFR3 protein	1379594
D006493	Heparin	Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]	1379594
D006497	Heparitin Sulfate	Heparitin Sulfate analog results in increased activity of FGFR3 protein alternative form	12460940
D017313	Fenretinide	Fenretinide results in increased expression of FGFR3 mRNA	28973697
D006851	Hydrochloric Acid	Hydrochloric Acid results in increased expression of FGFR3 mRNA	15046208
C492448	ICG 001	ICG 001 results in decreased expression of FGFR3 mRNA	26191083
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of FGFR3 mRNA	14562121
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of FGFR3 protein	14562121
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FGFR3 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FGFR3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FGFR3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FGFR3 mRNA	28628672
D007545	Isoproterenol	Isoproterenol results in increased expression of FGFR3 mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of FGFR3 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of FGFR3 mRNA	25961927
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of FGFR3 mRNA	25307878\|2675264
D007649	Ketamine	Ketamine results in increased expression of FGFR3 mRNA	20080153
C011890	kojic acid	kojic acid results in decreased expression of FGFR3 mRNA	16595896
D007854	Lead	Lead affects the expression of FGFR3 mRNA	28903495
C533894	LG 100815	LG 100815 results in decreased expression of FGFR3 mRNA	16951191
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA	23963992
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA]	23963992
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of FGFR3 mRNA	20353558
D008694	Methamphetamine	Methamphetamine results in increased expression of FGFR3 mRNA	26307267
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of FGFR3 mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C059539	midostaurin	midostaurin results in decreased activity of FGFR3 protein	16091734
D009151	Mustard Gas	Mustard Gas results in decreased expression of FGFR3 mRNA	16173061
D009151	Mustard Gas	Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of FGFR3 mRNA]	16377760
D009151	Mustard Gas	Mustard Gas results in decreased expression of FGFR3 mRNA	16377760
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of FGFR3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of FGFR3 mRNA"	25554681\|2562005
C007350	nitrofen	nitrofen results in increased expression of FGFR3 mRNA	9859898
C007350	nitrofen	nitrofen results in decreased expression of FGFR3 mRNA	20638522
C007350	nitrofen	nitrofen results in increased expression of FGFR3 mRNA	21994076
C007350	nitrofen	nitrofen results in increased expression of FGFR3 protein	21994076
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in decreased expression of FGFR3 mRNA"	16951191
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of FGFR3 mRNA	26272509
C016030	pantogab	pantogab results in decreased expression of FGFR3 mRNA	17379144
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA	23963992
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA]	23963992
C410127	PCB 180	PCB 180 results in decreased expression of FGFR3 mRNA	23829299
C115711	PD 173074	PD 173074 results in decreased activity of FGFR3 protein	15029211
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of FGFR3 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of FGFR3 mRNA	19429403
C551178	PF-04254644	PF-04254644 affects the activity of FGFR3 protein	20231546
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGFR3 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of FGFR3 mRNA	20813756\|2381119
C545373	ponatinib	ponatinib analog results in decreased activity of FGFR3 protein	21561767
C545373	ponatinib	ponatinib results in decreased activity of FGFR3 protein	19878872
C545373	ponatinib	ponatinib results in decreased activity of FGFR3 protein	22238366
C045950	propiconazole	propiconazole results in decreased expression of FGFR3 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FGFR3 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of FGFR3 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of FGFR3 mRNA	21632981
C059514	resveratrol	resveratrol results in decreased expression of FGFR3 mRNA	23525482
D015474	Isotretinoin	Isotretinoin results in increased expression of FGFR3 mRNA	20436886
C009166	retinol acetate	retinol acetate results in increased expression of FGFR3 mRNA	16772331
C089730	rosiglitazone	rosiglitazone results in decreased expression of FGFR3 mRNA	25572481
C093642	SB 203580	SB 203580 inhibits the reaction [BMP5 protein results in increased expression of FGFR3 mRNA]	15242789
D000068677	Sildenafil Citrate	Sildenafil Citrate results in increased expression of FGFR3 mRNA	20583517
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of FGFR3 mRNA	25895662
D012834	Silver	Silver results in decreased expression of FGFR3 mRNA	26014281
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA]	23963992
C105686	SU 5402	SU 5402 affects the expression of FGFR3 protein	14871245
C105686	SU 5402	SU 5402 inhibits the reaction [FGF1 protein results in increased activity of FGFR3 protein]	14871245
C105686	SU 5402	SU 5402 results in decreased activity of FGFR3 protein	15029211\|1609173
C105686	SU 5402	SU 5402 results in decreased phosphorylation of FGFR3 protein	14871245
C105686	SU 5402	SU 5402 results in decreased phosphorylation of FGFR3 protein	14871245
C105686	SU 5402	SU 5402 results in decreased activity of FGFR3 protein	15514005
D014284	Triiodothyronine	Triiodothyronine results in increased expression of FGFR3 mRNA	16150908
D013629	Tamoxifen	Tamoxifen results in decreased expression of FGFR3 mRNA	25123088
C112765	tanespimycin	tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein	16061882
D013739	Testosterone	Testosterone results in increased expression of FGFR3 mRNA	7536664
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of FGFR3 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGFR3 mRNA	18495758
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to FGFR3 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FGFR3 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGFR3 mRNA	16960034\|2121527
D013893	Thiram	Thiram results in decreased expression of FGFR3 mRNA	20530235
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of FGFR3 mRNA	28065790
D014212	Tretinoin	Tretinoin results in decreased expression of FGFR3 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of FGFR3 mRNA	23830798\|7680553
C034613	triacsin C	triacsin C results in decreased expression of FGFR3 mRNA	16704987
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGFR3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of FGFR3 mRNA	26272509
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of FGFR3 mRNA	23537331
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FGFR3 mRNA"	26179874
D014520	Urethane	Urethane results in increased expression of FGFR3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of FGFR3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FGFR3 mRNA	23179753\|2519280
D014635	Valproic Acid	Valproic Acid results in increased expression of FGFR3 mRNA	19101580\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of FGFR3 gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of FGFR3 mRNA	18930951
C111237	vorinostat	vorinostat results in decreased expression of FGFR3 mRNA	27188386
C088658	zoledronic acid	zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGFR3 mRNA]	19825521
C088658	zoledronic acid	zoledronic acid results in decreased expression of FGFR3 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IDA	11294897
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005007	fibroblast growth factor-activated receptor activity	-	IMP	8663044
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005515	protein binding	-	IPI	14732692 22939624
GO:0005524	ATP binding	-	IEA	-
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0017134	fibroblast growth factor binding	-	IDA	8663044
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0042802	identical protein binding	-	IPI	14732692 23972473 24120763
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0001501	skeletal system development	-	TAS	8601314
GO:0001958	endochondral ossification	-	TAS	15748888
GO:0002062	chondrocyte differentiation	-	TAS	15748888
GO:0003416	endochondral bone growth	-	TAS	15748888
GO:0007267	cell-cell signaling	-	IEA	-
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	IGI	8663044
GO:0008284	positive regulation of cell proliferation	-	IMP	8663044 11294897
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IDA	8663044
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IGI	8663044
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	-
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0010518	positive regulation of phospholipase activity	-	IMP	17561467
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	11294897
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030282	bone mineralization	-	ISS	20582225
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0035988	chondrocyte proliferation	-	TAS	15748888
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IMP	11294897 17561467
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0043410	positive regulation of MAPK cascade	-	IMP	11294897
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	-	IMP	11294897
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	-	TAS	15748888
GO:0046777	protein autophosphorylation	-	IDA	11294897
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0048640	negative regulation of developmental growth	-	ISS	20582225
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0060349	bone morphogenesis	-	ISS	20582225
GO:0060349	bone morphogenesis	-	TAS	15748888
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	11294897
GO:0070977	bone maturation	-	ISS	20582225
GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway	-	IMP	17561467

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0005794	Golgi apparatus	-	IDA	18061161
GO:0005886	plasma membrane	-	IDA	18061161
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	8663044
GO:0005925	focal adhesion	colocalizes_with	TAS	15748888
GO:0009986	cell surface	-	IEA	-
GO:0030133	transport vesicle	-	IDA	18061161
GO:0043235	receptor complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04144	Endocytosis
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05219	Bladder cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1839130	Signaling by activated point mutants of FGFR3	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-190239	FGFR3 ligand binding and activation	TAS
R-HSA-190371	FGFR3b ligand binding and activation	TAS
R-HSA-190372	FGFR3c ligand binding and activation	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2033514	FGFR3 mutant receptor activation	TAS
R-HSA-2033515	t(4;14) translocations of FGFR3	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	TAS
R-HSA-5654704	SHC-mediated cascade:FGFR3	TAS
R-HSA-5654706	FRS-mediated FGFR3 signaling	TAS
R-HSA-5654708	Downstream signaling of activated FGFR3	TAS
R-HSA-5654710	PI-3K cascade:FGFR3	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5655332	Signaling by FGFR3 in disease	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-8853334	Signaling by FGFR3 fusions in cancer	TAS
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27785367	FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer. (2016 Oct)	Theelen WS	J Pathol Clin Res
25537505	Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma. (2015 Feb 10)	Kim HS	Oncotarget
19909015	Combined analysis of smoking, TP53, and FGFR3 mutations in Tunisian patients with invasive and superficial high-grade bladder tumors. (2009 Dec)	Ouerhani S	Cancer Invest
23108201	Plasma 25-hydroxyvitamin D(3) and bladder cancer risk according to tumor stage and FGFR3 status: a mechanism-based epidemiological study. (2012 Dec 19)	Amaral AF	J Natl Cancer Inst
19722178	Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma. (2010 Jan)	Bakkar AA	Mol Carcinog
18815929	Detection of tumours of the urinary tract in voided urine. (2008 Sep)	Zwarthoff EC	Scand J Urol Nephrol Suppl
24850843	FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. (2014 Aug 1)	Wang R	Clin Cancer Res
28169993	The evolving genomic landscape of urothelial carcinoma. (2017 Feb 7)	Glaser AP	Nat Rev Urol
27352265	Bladder Cancer and Genetic Mutations. (2015 Sep)	Zhang X	Cell Biochem Biophys
15347601	Mutations in TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced by smoking: contribution of exogenous versus endogenous carcinogens. (2005 Jan)	Wallerand H	Carcinogenesis
18501499	Microsatellite analysis of voided-urine samples for surveillance of low-grade non-muscle-invasive urothelial carcinoma: feasibility and clinical utility in a prospective multicenter study (Cost-Effectiveness of Follow-Up of Urinary Bladder Cancer trial [CEFUB]). (2009 Mar)	van der Aa MN	Eur Urol
19856868	Pfeiffer-like syndrome with holoprosencephaly: a newborn with maternal smoking and alcohol exposure. (2009 Oct)	Su PH	Pediatr Neonatol
21459758	Chromosome 4p16.3 variant modify bladder cancer risk in a Chinese population. (2011 Jun)	Wang M	Carcinogenesis