Gene: GPC5

2262
-
glypican 5
protein-coding
13q31.3
Ensembl:ENSG00000179399 MIM:602446 Vega:OTTHUMG00000017200 UniprotKB:P78333
NG_009370.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.822e-2 (AD)  6.445e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs716623chr13:92329669 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A40.924
ELOVL20.913
SDC20.894
SLC1A30.894
EDNRB0.89
SOX90.89
BMPR1B0.89
PREX20.889
SPON10.886
ARHGEF260.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.4
NRG1-0.368
TRABD2A-0.363
DUSP27-0.361
ADTRP-0.36
AGMAT-0.36
GALNT14-0.356
QRFPR-0.356
SYNPO2-0.354
THEM5-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPC5 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of GPC5 mRNA"23829299
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPC5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPC5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPC5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPC5 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GPC5 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPC5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GPC5 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPC5 mRNA]22129741
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GPC5 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GPC5 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GPC5 mRNA24449571
D001280AtrazineAtrazine results in increased expression of GPC5 mRNA22378314
C406592azaspiracidazaspiracid results in decreased expression of GPC5 mRNA28939011
D001507BeclomethasoneBeclomethasone results in decreased expression of GPC5 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPC5 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of GPC5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GPC5 gene28505145
D003042CocaineCocaine results in increased expression of GPC5 mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in increased expression of GPC5 mRNA]18355967
D003630DaunorubicinGPC5 affects the susceptibility to Daunorubicin17545624
D004041Dietary FatsDietary Fats results in increased expression of GPC5 mRNA25016146
D004052DiethylnitrosamineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPC5 mRNA]22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPC5 mRNA22129741
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of GPC5 mRNA28939011
C016517indole-3-carbinolAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPC5 mRNA]22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPC5 mRNA22129741
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPC5 mRNA"25510870
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of GPC5 mRNA27029645
D014520UrethaneUrethane results in increased expression of GPC5 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPC5 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of GPC5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GPC5 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GPC5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0006024glycosaminoglycan biosynthetic process-TAS-  
GO:0006027glycosaminoglycan catabolic process-TAS-  
GO:0009966regulation of signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-TAS7657705  
GO:0043202lysosomal lumen-TAS-  
GO:0046658anchored component of plasma membrane-IEA-  
GO:0062023collagen-containing extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismIEA
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismIEA
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-1971475A tetrasaccharide linker sequence is required for GAG synthesisTAS
R-HSA-2022928HS-GAG biosynthesisTAS
R-HSA-2022928HS-GAG biosynthesisIEA
R-HSA-2024096HS-GAG degradationTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3560783Defective B4GALT7 causes EDS, progeroid typeTAS
R-HSA-3560801Defective B3GAT3 causes JDSSDHDTAS
R-HSA-3656237Defective EXT2 causes exostoses 2TAS
R-HSA-3656253Defective EXT1 causes exostoses 1, TRPS2 and CHDSTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-4420332Defective B3GALT6 causes EDSP2 and SEMDJL1TAS
R-HSA-5358346Hedgehog ligand biogenesisTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5362798Release of Hh-Np from the secreting cellTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-71387Metabolism of carbohydratesIEA
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24456789Variants in the 5'-upstream region of GPC5 confer risk of lung cancer in never smokers. (2014 Feb)Liu LCancer Epidemiol
22384374Glypican Gene GPC5 Participates in the Behavioral Response to Ethanol: Evidence from Humans, Mice, and Fruit Flies. (2011 Dec)Joslyn GG3 (Bethesda)