Gene: FGFR4

2264
CD334|JTK2|TKF
fibroblast growth factor receptor 4
protein-coding
5q35.2
Ensembl:ENSG00000160867 MIM:134935 Vega:OTTHUMG00000151523 UniprotKB:P22455
NG_012067.1
PubMed
0   ANCO-SNPs
ND
2   
9.616e-1 (AD)  6.659e-1 (ND)   (Frontal_Cortex)
1.979e-1 (AD)  2.989e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR90.751
NPC1L10.728
SULT1A30.704
SLFNL10.7
CNTD20.7
KLK140.698
CCNA20.688
ADCY100.683
DNASE1L20.677
GSDMB0.677

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.36
SLC35G1-0.348
HPDL-0.325
FAM180B-0.321
HAPLN1-0.315
OSTN-0.313
ABCD2-0.307
ADAMTS5-0.3
HSD17B8-0.293
CCT6B-0.292

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00039PaliferminBiotechDrug162394-19-6ApprovedTarget
DB01109HeparinSmall Molecule9005-49-6Approved|InvestigationalTarget
DB08901PonatinibSmall Molecule943319-70-8Approved|InvestigationalTarget
DB09078LenvatinibSmall Molecule417716-92-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of FGFR4 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FGFR4 mRNA"28903501
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FGFR4 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FGFR4 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF2 protein binds to and results in increased activity of FGFR4 protein] which results in increased phosphorylation of MAPK1 protein]11336793
C5689503-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea"3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea results in decreased activity of FGFR4 protein"21936542
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR4 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of FGFR4 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FGFR4 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of FGFR4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FGFR4 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FGFR4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGFR4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FGFR4 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of FGFR4 mRNA21757418
D001151ArsenicArsenic results in decreased expression of FGFR4 mRNA19654921
D001542BenomylBenomyl results in increased expression of FGFR4 mRNA15885261
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGFR4 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGFR4 mRNA19770486
D001647Bile Acids and SaltsFGFR4 protein results in decreased chemical synthesis of Bile Acids and Salts15750181
D001647Bile Acids and SaltsFGFR4 protein affects the abundance of Bile Acids and Salts16213224
D001647Bile Acids and SaltsFGFR4 protein affects the metabolism of and affects the abundance of and affects the secretion of Bile Acids and Salts10809780
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FGFR4 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of FGFR4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FGFR4 gene28505145
D002251Carbon TetrachlorideFGFR4 protein results in decreased susceptibility to Carbon Tetrachloride12466116
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FGFR4 mRNA16644059|1780597
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FGFR4 mRNA17032414
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FGFR4 mRNA24763279
D002737ChloropreneChloroprene results in decreased expression of FGFR4 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of FGFR4 mRNA17589599
D002784CholesterolFGFR4 protein results in decreased metabolism of Cholesterol15750181
D002784CholesterolFGFR4 protein affects the metabolism of Cholesterol11956156
D002791Cholesterol, Dietary"FGFR4 protein affects the metabolism of and affects the abundance of Cholesterol, Dietary"10809780
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FGFR4 mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of FGFR4 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of FGFR4 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FGFR4 mRNA]17585979
D002995Clofibric Acid[Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of FGFR4 mRNA15833021
D002995Clofibric AcidClofibric Acid results in decreased expression of FGFR4 mRNA15833021
C018021cobaltous chloridecobaltous chloride results in decreased expression of FGFR4 mRNA24386269
D003300CopperCopper results in decreased expression of FGFR4 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of FGFR4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FGFR4 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of FGFR4 mRNA19770486
D016572CyclosporineCyclosporine results in increased expression of FGFR4 protein15770714
D016572Cyclosporine[Thioacetamide co-treated with Cyclosporine] results in decreased expression of FGFR4 protein15770714
D016264Dextran SulfateDextran Sulfate results in increased expression of FGFR4 mRNA27580383
D016264Dextran SulfateDextran Sulfate binds to and results in increased phosphorylation of and results in increased activity of FGFR4 protein7774576
D003976DiazinonDiazinon results in increased expression of FGFR4 mRNA17589599|1913087
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FGFR4 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of FGFR4 mRNA27392435
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of FGFR4 mRNA15885261
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FGFR4 mRNA26924002
D004026DieldrinDieldrin affects the expression of FGFR4 mRNA19130878
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of FGFR4 mRNA28433925
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of FGFR4 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FGFR4 mRNA"28433925
D004052DiethylnitrosamineFGFR4 protein results in decreased susceptibility to Diethylnitrosamine19009564
D004052Diethylnitrosamine[Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of FGFR4 mRNA15833021
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of FGFR4 mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of FGFR4 mRNA17032414
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of FGFR4 mRNA26924002
C061365flusilazoleflusilazole results in increased expression of FGFR4 mRNA28263823
D005485FlutamideFlutamide results in increased expression of FGFR4 mRNA15885261
C007789fucoidanfucoidan binds to and results in increased phosphorylation of and results in increased activity of FGFR4 protein7774576
C069837fullerene C60fullerene C60 results in increased expression of FGFR4 mRNA19167457
D005665FurosemideFurosemide affects the expression of FGFR4 mRNA16526316
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FGFR4 mRNA24763279
C412815GW 4064FGFR4 protein affects the reaction [[GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA]22467244
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR4 protein]10336501
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans affects the reaction [FGF2 protein binds to FGFR4 protein]10336501
D006493HeparinHeparin analog binds to FGFR4 protein11278860
D006493HeparinHeparin promotes the reaction [FGF19 protein binds to FGFR4 protein]10525310
D006493HeparinHeparin promotes the reaction [FGFR4 protein binds to FGFR4 protein]10736564
D006493HeparinHeparin affects the reaction [FGF1 protein binds to FGFR4 protein]10336501
D006493HeparinHeparin affects the reaction [FGF2 protein binds to FGFR4 protein]10336501
D006493HeparinHeparin binds to and results in increased phosphorylation of and results in increased activity of FGFR4 protein7774576
D006497Heparitin SulfateHeparitin Sulfate analog binds to FGFR4 protein11278860
D017313FenretinideFenretinide results in increased expression of FGFR4 mRNA28973697
C008261lead acetatelead acetate results in decreased expression of FGFR4 mRNA22609695
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of FGFR4 mRNA"24972896
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of FGFR4 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FGFR4 mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of and affects the localization of FGFR4 protein15581186
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FGFR4 mRNA26924002
C568376MT19c compoundMT19c compound results in decreased expression of FGFR4 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FGFR4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FGFR4 mRNA"25554681
D009532NickelNickel affects the expression of FGFR4 mRNA19130878
C464660obeticholic acidobeticholic acid results in decreased expression of FGFR4 mRNA27939613
D019319Okadaic AcidOkadaic Acid results in decreased phosphorylation of FGFR4 protein8576110
D009844OligosaccharidesOligosaccharides analog binds to FGFR4 protein11278860
D009844OligosaccharidesOligosaccharides promotes the reaction [FGF1 protein binds to FGFR4 protein]11714710|9174673
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of FGFR4 mRNA"23333450
C115711PD 173074PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein]15709206
C115711PD 173074PD 173074 results in decreased activity of FGFR4 protein15377668
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of FGFR4 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FGFR4 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of FGFR4 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FGFR4 mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of FGFR4 mRNA17097637
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGFR4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FGFR4 mRNA26272509
D010705PhosgenePhosgene affects the expression of FGFR4 mRNA16300373
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FGFR4 mRNA15728792
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGFR4 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of FGFR4 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of FGFR4 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in decreased expression of FGFR4 mRNA19162173
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of FGFR4 mRNA27989595
C545373ponatinibponatinib analog results in decreased activity of FGFR4 protein21561767
C545373ponatinibponatinib results in decreased activity of FGFR4 protein19878872
C545373ponatinibponatinib results in decreased activity of FGFR4 protein22238366
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of FGFR4 mRNA28903501
D011794QuercetinQuercetin results in decreased expression of FGFR4 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FGFR4 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of FGFR4 mRNA16882884
C017947sodium arsenitesodium arsenite results in increased expression of FGFR4 mRNA12377979
D053260SootSoot results in decreased expression of FGFR4 mRNA26551751
C025462sulindac sulfidesulindac sulfide results in decreased expression of FGFR4 mRNA16184548
D013656Taurocholic AcidFGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of CYP7A1 mRNA]16284190
D013656Taurocholic AcidFGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of PON1 mRNA]16284190
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FGFR4 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FGFR4 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGFR4 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FGFR4 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGFR4 mRNA21215274
D013853Thioacetamide[Thioacetamide co-treated with Cyclosporine] results in decreased expression of FGFR4 protein15770714
D013853ThioacetamideThioacetamide results in decreased expression of FGFR4 mRNA23411599
D013853ThioacetamideThioacetamide results in increased expression of FGFR4 protein15770714
C009495titanium dioxidetitanium dioxide results in decreased expression of FGFR4 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FGFR4 mRNA20133372
D014118Toxins, Biological"Toxins, Biological affects the expression of FGFR4 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of FGFR4 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of FGFR4 mRNA7680553
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FGFR4 mRNA"26552522
D014635Valproic AcidValproic Acid results in increased expression of FGFR4 mRNA28001369
D014638VanadatesVanadates results in increased phosphorylation of FGFR4 protein8576110
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FGFR4 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of FGFR4 mRNA"23246600
C009687wortmanninwortmannin inhibits the reaction [[FGF2 protein binds to and results in increased activity of FGFR4 protein] which results in increased phosphorylation of MAPK1 protein]11336793
C088658zoledronic acidzoledronic acid results in decreased expression of FGFR4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005007fibroblast growth factor-activated receptor activity-IBA21873635  
GO:0005007fibroblast growth factor-activated receptor activity-IDA8663044  18480409  21653700  
GO:0005007fibroblast growth factor-activated receptor activity-IGI10525310  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI17627937  20798051  
GO:0005524ATP binding-IEA-  
GO:0008201heparin binding-IDA18480409  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0017134fibroblast growth factor binding-IBA21873635  
GO:0017134fibroblast growth factor binding-IDA8663044  18480409  
GO:0017134fibroblast growth factor binding-IPI10525310  17627937  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001525angiogenesis-IBA21873635  
GO:0007275multicellular organism development-IBA21873635  
GO:0007417central nervous system development-IBA21873635  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA8663044  
GO:0008284positive regulation of cell proliferation-IGI8663044  
GO:0008543fibroblast growth factor receptor signaling pathway-IDA21653700  
GO:0008543fibroblast growth factor receptor signaling pathway-IGI8663044  
GO:0008543fibroblast growth factor receptor signaling pathway-IPI10525310  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010628positive regulation of gene expression-IMP19085950  
GO:0010715regulation of extracellular matrix disassembly-IMP20876804  
GO:0016477cell migration-IMP20876804  
GO:0018108peptidyl-tyrosine phosphorylation-IDA18480409  20683963  
GO:0019216regulation of lipid metabolic process-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0042593glucose homeostasis-ISS-  
GO:0042632cholesterol homeostasis-ISS-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043085positive regulation of catalytic activity-IMP20798051  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0045862positive regulation of proteolysis-IMP20798051  
GO:0046777protein autophosphorylation-IDA20798051  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0055062phosphate ion homeostasis-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP21653700  
GO:0070857regulation of bile acid biosynthetic process-IMP17623664  20683963  
GO:1903412response to bile acidNOTIMP19085950  
GO:2000573positive regulation of DNA biosynthetic process-IMP21653700  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005768endosome-IEA-  
GO:0005783endoplasmic reticulum-IDA20683963  
GO:0005794Golgi apparatus-IDA18061161  
GO:0005886plasma membrane-IDA18061161  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA20683963  
GO:0005911cell-cell junctioncolocalizes_withIDA20798051  
GO:0030133transport vesicle-IDA18061161  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04144Endocytosis
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1307965betaKlotho-mediated ligand bindingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839128FGFR4 mutant receptor activationTAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190322FGFR4 ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-5654228Phospholipase C-mediated cascade; FGFR4TAS
R-HSA-5654712FRS-mediated FGFR4 signalingTAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654719SHC-mediated cascade:FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654733Negative regulation of FGFR4 signalingTAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655291Signaling by FGFR4 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18949411Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer. (2008 Nov)Sasaki HOncol Rep
23524567FGFR4 genetic polymorphisms determine the chemotherapy response of Chinese patients with non-small cell lung cancer. (2013 Apr)Fang HMActa Pharmacol Sin