Gene: FGG

2266
-
fibrinogen gamma chain
protein-coding
4q32.1
Ensembl:ENSG00000171557 MIM:134850 Vega:OTTHUMG00000150329 UniprotKB:P02679
NG_008834.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.845e-1 (AD)  4.443e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGA0.926
FGB0.905
ORM10.866
HP0.774
AMBP0.754
CRP0.739
ORM20.722
AGXT0.682
APCS0.65
APOH0.634

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTRH1-0.265
ZRANB3-0.244
RGPD4-0.243
A4GNT-0.241
PCDHGA5-0.24
CDHR1-0.228
IL1RL2-0.226
SP7-0.224
PATE2-0.22
DCDC1-0.22

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00364SucralfateSmall Molecule54182-58-0ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of FGG mRNA"17690111
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of FGG mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FGG mRNA"28903501
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGG mRNA"20566314
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of FGG mRNA20566314
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased expression of FGG mRNA2440878
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FGG mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of FGG mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FGG mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGG mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of FGG mRNA"26238291
D000082AcetaminophenAcetaminophen results in decreased expression of FGG mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of FGG mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FGG mRNA25265579
D000082Acetaminophensaikosaponin inhibits the reaction [Acetaminophen results in increased expression of FGG mRNA]25265579
D000082AcetaminophenAcetaminophen results in increased expression of FGG mRNA15800402
D000082AcetaminophenAcetaminophen results in increased expression of FGG protein15800402
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGG mRNA"20566314
D000244Adenosine DiphosphateAdenosine Diphosphate results in increased secretion of FGG protein17303692
D000244Adenosine DiphosphateAspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein]17303692
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of FGG mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGG gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of FGG mRNA21757418
D000447AldehydesAldehydes results in decreased expression of FGG mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGG mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of FGG mRNA"22863853
D034341Aristolochic AcidsAristolochic Acids results in increased expression of FGG mRNA21834575
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of FGG mRNA"18687144
D001241AspirinAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGG protein]17303692
D001241AspirinAspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein]17303692
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGG mRNA16532367
C406592azaspiracidazaspiracid results in decreased expression of FGG mRNA28939011
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FGG mRNA26377693
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of FGG mRNA17690111
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of FGG mRNA22120849
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of FGG mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of FGG mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGG mRNA18061397|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGG mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FGG mRNA"26238291
D004958EstradiolEstradiol results in increased expression of FGG mRNA23557687
D004958EstradiolEstradiol results in decreased expression of FGG mRNA19484750
D004958EstradiolEstradiol results in decreased expression of FGG mRNA21984479
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of FGG mRNA26496021
C095105bexarotenebexarotene results in decreased expression of FGG mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of FGG mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of FGG mRNA27104808
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of FGG mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of FGG mRNA24988533
C006780bisphenol Abisphenol A results in decreased expression of FGG protein20219716
C006780bisphenol Abisphenol A results in increased expression of FGG mRNA25181051
C032036bromobenzenebromobenzene results in decreased expression of FGG mRNA12628495
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FGG mRNA12414654
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FGG mRNA18804290
C018475butyraldehydebutyraldehyde results in decreased expression of FGG mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FGG mRNA17023062
D019256Cadmium ChlorideCadmium Chloride affects the expression of FGG mRNA18804290
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of FGG mRNA20360939
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FGG mRNA26921287
D002251Carbon TetrachlorideFGG protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]26921287
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FGG mRNA16239168
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FGG mRNA12921627
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) affects the expression of FGG mRNA18804290
C041167chromium nitratechromium nitrate results in increased expression of FGG protein23618972
C418118CI 1044CI 1044 results in increased expression of FGG mRNA17569694
D002994ClofibrateClofibrate results in decreased expression of FGG mRNA25270620
D002994ClofibrateClofibrate results in decreased expression of FGG mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of FGG mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of FGG mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of FGG mRNA19549813
C030123coumarincoumarin affects the expression of FGG mRNA16963487
C029892cupric chloridecupric chloride results in increased expression of FGG mRNA16835292
D003471CuprizoneCuprizone results in increased expression of FGG mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of FGG mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of FGG mRNA21163907
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGG mRNA"20566314
D000069604DabigatranDabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]25138021
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FGG mRNA]27941970
D004008Diclofenac"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein"25772430
D004008Diclofenac"Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]"25772430
D004008DiclofenacDiclofenac results in decreased expression of FGG protein25772430
D004008Diclofenac"lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein]"25772430
C000944dicrotophosdicrotophos results in decreased expression of FGG mRNA28302478
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004041Dietary FatsDabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]25138021
D004041Dietary FatsDietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]25138021
C014476diethyl maleatediethyl maleate results in decreased expression of FGG mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of FGG mRNA20360939
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of FGG mRNA14757319
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of FGG protein14757319
D004147DioxinsDioxins affects the expression of FGG mRNA20463971
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGG mRNA16532367
D004237DiuronDiuron results in decreased expression of FGG mRNA25152437
C070609EMD 53998EMD 53998 analog results in decreased expression of FGG mRNA24977338
C454300estradiol valerate-dienogest[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FGG mRNA16954407
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12616980|1261698
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251|1528821
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]14561536
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12616980|1261698
D011345FenofibrateFenofibrate results in decreased expression of FGG mRNA10216095
D005472FluorouracilFGG protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilFluorouracil results in decreased expression of FGG mRNA17039268
C039281furanfuran binds to FGG protein22240984
C039281furanfuran results in decreased expression of FGG mRNA25539665
C056507gemcitabinegemcitabine affects the expression of FGG mRNA17039268
D019833GenisteinGenistein affects the expression of FGG mRNA18214933
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12616980|1261698
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGG mRNA"20566314
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of FGG mRNA20566314
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in increased expression of FGG protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in increased expression of FGG protein23178681
D006854HydrocortisoneHydrocortisone results in increased expression of FGG mRNA16835292
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FGG mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FGG mRNA12414654
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in increased expression of FGG protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FGG protein23178681
C020758indium trichlorideindium trichloride results in increased expression of FGG protein19539025
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in decreased expression of FGG mRNA"18061397
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGG mRNA16532367
C544151jinfukangjinfukang results in decreased expression of FGG mRNA27392435
C410337K 7174K 7174 results in decreased expression of FGG mRNA24086573
C008261lead acetatelead acetate results in decreased expression of FGG mRNA25270620
C000589733leukadherin-1FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]]26921287
C000589733leukadherin-1FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]]26921287
C000589733leukadherin-1FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB1 mRNA]]26921287
C000589733leukadherin-1FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]]26921287
C000589733leukadherin-1FGG protein affects the susceptibility to leukadherin-126921287
C482199lipopolysaccharide, E coli O55-B5"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein"25772430
C482199lipopolysaccharide, E coli O55-B5"Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]"25772430
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein]"25772430
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein"25772430
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGG mRNA"20566314
D008627Mercuric ChlorideMercuric Chloride affects the expression of FGG mRNA20353558
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of FGG mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FGG mRNA17961207|2345815
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FGG mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FGG mRNA23179753
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of FGG mRNA27544571
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of FGG mRNA24128854
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FGG mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FGG mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of FGG mRNA"19836432
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate affects the expression of FGG mRNA26921287
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FGG mRNA20974703
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of NOS2 mRNA]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB1 mRNA]]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]]26921287
D0150581-NaphthylisothiocyanateFGG protein affects the susceptibility to 1-Naphthylisothiocyanate26921287
D010866NatamycinNatamycin results in increased expression of FGG mRNA22863853
C051752nefazodonenefazodone results in decreased expression of FGG mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of FGG mRNA19167457
D009640Norethindrone[Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]14561536
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251|1528821
D009761NystatinNystatin results in increased expression of FGG mRNA22863853
C025589ochratoxin Aochratoxin A results in decreased expression of FGG mRNA29274910
D052638Particulate MatterParticulate Matter results in decreased expression of FGG mRNA22178795
C046012pentanalpentanal results in decreased expression of FGG mRNA26079696
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of FGG mRNA21984479
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of FGG mRNA23602845
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of FGG mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of FGG mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FGG mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of FGG mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FGG mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of FGG mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FGG mRNA21984479
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGG mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FGG mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in decreased expression of FGG mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGG mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of FGG mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of FGG mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of FGG mRNA16940010
D010936Plant ExtractsPlant Extracts results in decreased expression of FGG mRNA18061397
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FGG protein23618972
D011192Potassium DichromatePotassium Dichromate affects the expression of FGG mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FGG mRNA28903501
C005556propionaldehydepropionaldehyde results in decreased expression of FGG mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of FGG mRNA24780913
D011791QuartzQuartz results in increased expression of FGG mRNA19836432
D011794QuercetinQuercetin results in decreased expression of FGG mRNA21632981
C089730rosiglitazonerosiglitazone affects the expression of FGG protein19556978
C025759saikosaponinsaikosaponin inhibits the reaction [Acetaminophen results in increased expression of FGG mRNA]25265579
D012643Selenium[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of FGG mRNA11444866
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FGG mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of FGG mRNA22431001
D012834SilverSilver results in decreased expression of FGG mRNA26014281
C017947sodium arsenitesodium arsenite results in decreased expression of FGG mRNA25270620
D053260SootSoot results in increased expression of FGG mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGG mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGG mRNA11489354|1806139
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FGG mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of FGG mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGG mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGG mRNA16267337
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of FGG mRNA2440878
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of FGG mRNA2440878
C096900thrombin receptor-activating peptide SFLLRNPNDKYAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGG protein]17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGG protein17303692
C009495titanium dioxidetitanium dioxide results in decreased expression of FGG mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of FGG mRNA27760801
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of FGG protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FGG mRNA20133372
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of FGG mRNA"17951470
D014204Trenbolone AcetateTrenbolone Acetate affects the expression of FGG protein24072461
D014212TretinoinTretinoin results in increased expression of FGG mRNA18230668
D014212TretinoinTretinoin results in increased expression of FGG mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FGG mRNA"26179874
D014425TurpentineTurpentine results in increased expression of FGG mRNA14757319
D014425TurpentineTurpentine results in increased expression of FGG protein14757319
D014520UrethaneUrethane results in decreased expression of FGG mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of FGG mRNA18422935
D014635Valproic AcidValproic Acid affects the expression of FGG mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FGG mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of FGG gene29154799
C025643vinclozolinvinclozolin affects the expression of FGG mRNA19015723
D014810Vitamin E[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of FGG mRNA11444866
D014812Vitamin KVitamin K affects the expression of FGG mRNA16636460
D024483Vitamin K 3Vitamin K 3 affects the expression of FGG mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in increased expression of FGG mRNA12414654

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI7822297  
GO:0005198structural molecule activity-IDA8910396  
GO:0005515protein binding-IPI10788510  21546586  26627825  
GO:0042803protein homodimerization activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0050839cell adhesion molecule binding-IPI7822297  
GO ID GO Term Qualifier Evidence PubMed
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002576platelet degranulation-TAS-  
GO:0007160cell-matrix adhesion-IDA10903502  
GO:0007596blood coagulation-TAS-  
GO:0009306protein secretion-IMP18676163  
GO:0030198extracellular matrix organization-TAS-  
GO:0031639plasminogen activation-IDA16846481  
GO:0034116positive regulation of heterotypic cell-cell adhesion-IDA8100742  
GO:0034622cellular protein-containing complex assembly-IDA8910396  
GO:0036345platelet maturation-IEA-  
GO:0042730fibrinolysis-IDA16846481  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045907positive regulation of vasoconstriction-IDA15739255  
GO:0045921positive regulation of exocytosis-IDA19193866  
GO:0050714positive regulation of protein secretion-IDA19193866  
GO:0051258protein polymerization-IMP12706644  
GO:0051592response to calcium ion-IDA6777381  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA10903502  19193866  
GO:0070527platelet aggregation-IDA6281794  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0071354cellular response to interleukin-6-IEA-  
GO:0072378blood coagulation, fibrin clot formation-IDA16846481  
GO:0072378blood coagulation, fibrin clot formation-IMP11001902  
GO:0090277positive regulation of peptide hormone secretion-IDA19193866  
GO:0090331negative regulation of platelet aggregation-IEA-  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-NAS24041635  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IDA10903502  
GO:2000352negative regulation of endothelial cell apoptotic process-IDA10903502  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005577fibrinogen complex-IDA6451630  8470043  8910396  16846481  18676163  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA6777381  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA6777381  
GO:0009986cell surface-IDA6777381  
GO:0031091platelet alpha granule-IDA6777381  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-354192Integrin alphaIIb beta3 signalingTAS
R-HSA-354194GRB2:SOS provides linkage to MAPK signaling for Integrins TAS
R-HSA-372708p130Cas linkage to MAPK signaling for integrinsTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5686938Regulation of TLR by endogenous ligandTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-9006921Integrin signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25592583Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations. (2015)Jeff JMPac Symp Biocomput
20709368The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease. (2010 Oct)Bahadori BThromb Res
22707612Genetic risk factors for thrombosis in systemic lupus erythematosus. (2012 Aug)Kaiser RJ Rheumatol