Gene info: ID 2268

Gene: FGR

GENE ID: 2268

Description: FGR proto-oncogene, Src family tyrosine kinase

Gene type: protein-coding

Location: 1p35.3

dbXrefs: Ensembl:ENSG00000000938 MIM:164940 Vega:OTTHUMG00000003516 UniprotKB:P09769

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 19

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.753e-1 (AD) 7.855e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg06827976	chr1:27950589	FGR		4.700e-12	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TGM2	0.882
ACSL5	0.874
PKN3	0.849
ERG	0.847
MMRN2	0.844
EPHB4	0.841
ICAM2	0.841
PLA1A	0.836
STARD8	0.832
ACVRL1	0.829

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SMIM18	-0.525
CRH	-0.517
MARCH4	-0.505
ABCC12	-0.485
SLC7A4	-0.478
PPEF1	-0.466
NEUROD6	-0.465
HAS1	-0.464
VWC2	-0.463
SPEF1	-0.459

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01254	Dasatinib	Small Molecule	302962-49-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of FGR mRNA	25596134
C569670	1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one	"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in decreased activity of FGR protein"	21981714
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of FGR mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of FGR mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of FGR protein"	25670856
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of FGR mRNA	19191707
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of FGR mRNA	19191707
D000082	Acetaminophen	Acetaminophen results in increased expression of FGR mRNA	26690555
C412373	AG 1879	AG 1879 results in decreased activity of FGR protein	25980585
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of FGR mRNA"	23195993
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGR mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of FGR mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of FGR mRNA	15761015
D001241	Aspirin	Aspirin results in decreased expression of FGR mRNA	15928584
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGR mRNA	21569818
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of FGR mRNA	20404318
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FGR mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of FGR mRNA	25181051
C471992	bosutinib	bosutinib results in decreased activity of FGR protein	17114238
D020001	1-Butanol	1-Butanol inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with dihydrocytochalasin B] results in increased activity of FGR protein]	11078731
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of FGR mRNA	25596134
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of FGR mRNA	18636392
D002737	Chloroprene	Chloroprene results in decreased expression of FGR mRNA	23125180
D002737	Chloroprene	Chloroprene results in decreased expression of FGR mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of FGR mRNA	25596134
D003471	Cuprizone	Cuprizone results in increased expression of FGR mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGR mRNA	25596134
D000069439	Dasatinib	Dasatinib binds to FGR protein	18180381
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FGR mRNA	28628672
D002945	Cisplatin	Cisplatin results in increased expression of FGR mRNA	27594783
C014476	diethyl maleate	diethyl maleate results in decreased expression of FGR mRNA	21161181
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of FGR mRNA	15766595
C024794	dihydrocytochalasin B	1-Butanol inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with dihydrocytochalasin B] results in increased activity of FGR protein]	11078731
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of FGR mRNA	25380136
D004391	Dust	Dust results in increased expression of FGR mRNA	17805423
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGR mRNA	17942748
D011345	Fenofibrate	Fenofibrate affects the expression of FGR mRNA	25596134
D009240	N-Formylmethionine Leucyl-Phenylalanine	1-Butanol inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with dihydrocytochalasin B] results in increased activity of FGR protein]	11078731
D009240	N-Formylmethionine Leucyl-Phenylalanine	N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of FGR protein	25980585
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of FGR mRNA	20846436
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of FGR mRNA	19376150
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FGR mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FGR mRNA	28628672
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of FGR mRNA	23086925
C045463	leflunomide	leflunomide results in decreased expression of FGR mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of FGR mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of FGR mRNA	12057914
D008687	Metformin	Metformin results in decreased expression of FGR mRNA	25596134
C500085	muraglitazar	muraglitazar results in increased expression of FGR mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of FGR mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of FGR mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FGR mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of FGR mRNA	25380136
D009532	Nickel	Nickel results in decreased expression of FGR mRNA	23195993
D009532	Nickel	Nickel results in increased expression of FGR mRNA	25583101
C022838	nickel chloride	nickel chloride affects the expression of FGR mRNA	22546817
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of FGR mRNA	18636392
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of FGR mRNA	28511854
D010712	Phosphatidic Acids	Phosphatidic Acids results in increased activity of FGR protein	11078731
D059808	Polyphenols	Polyphenols results in decreased expression of FGR mRNA	16293270
C545373	ponatinib	ponatinib results in decreased activity of FGR protein	19878872
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FGR mRNA	24780913
C059514	resveratrol	resveratrol results in increased expression of FGR mRNA	25905778
C089730	rosiglitazone	rosiglitazone results in increased expression of FGR mRNA	25596134
C089730	rosiglitazone	rosiglitazone results in increased expression of FGR mRNA	21515302
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of FGR mRNA	23806026\|2589566
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of FGR mRNA	27862939
C061133	tamibarotene	tamibarotene results in increased expression of FGR mRNA	15498508
C501413	tesaglitazar	tesaglitazar results in increased expression of FGR mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FGR mRNA	28922406
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGR mRNA	17942748
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of FGR mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGR mRNA	21215274
C009495	titanium dioxide	titanium dioxide results in increased expression of FGR mRNA	23557971
D014212	Tretinoin	KAT2B protein promotes the reaction [Tretinoin results in increased expression of FGR mRNA]	28053092
D014212	Tretinoin	Tretinoin results in increased expression of FGR mRNA	15498508\|1605412
C057693	troglitazone	troglitazone results in increased expression of FGR mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in increased methylation of FGR gene	29154799
D014750	Vincristine	Vincristine results in decreased expression of FGR mRNA	23649840
C029297	vinylidene chloride	vinylidene chloride results in increased expression of FGR mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001784	phosphotyrosine residue binding	-	IPI	20624904
GO:0001784	phosphotyrosine residue binding	-	ISS	-
GO:0004713	protein tyrosine kinase activity	-	EXP	10861086 16921024
GO:0004713	protein tyrosine kinase activity	-	IDA	7519620
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IBA	21873635
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IDA	8327512
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	16273093 22939624 24658140 24728074 24860872
GO:0005524	ATP binding	-	IEA	-
GO:0019901	protein kinase binding	-	ISS	-
GO:0034987	immunoglobulin receptor binding	-	ISS	-
GO:0034988	Fc-gamma receptor I complex binding	-	IDA	8327512

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002768	immune response-regulating cell surface receptor signaling pathway	-	TAS	8327512
GO:0006468	protein phosphorylation	-	TAS	2995972
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	-	IBA	21873635
GO:0007229	integrin-mediated signaling pathway	-	IBA	21873635
GO:0007229	integrin-mediated signaling pathway	-	IMP	7519620 10739672
GO:0007229	integrin-mediated signaling pathway	-	ISS	-
GO:0008360	regulation of cell shape	-	ISS	-
GO:0009615	response to virus	-	TAS	3003578
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	IMP	10739672
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	7519620 8327512
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030335	positive regulation of cell migration	-	ISS	-
GO:0038083	peptidyl-tyrosine autophosphorylation	-	IBA	21873635
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0042127	regulation of cell proliferation	-	IBA	21873635
GO:0043306	positive regulation of mast cell degranulation	-	ISS	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	-	IMP	10739672
GO:0045087	innate immune response	-	IBA	21873635
GO:0045088	regulation of innate immune response	-	ISS	-
GO:0045859	regulation of protein kinase activity	-	ISS	-
GO:0046777	protein autophosphorylation	-	IDA	2181286 8327512
GO:0050715	positive regulation of cytokine secretion	-	ISS	-
GO:0050764	regulation of phagocytosis	-	ISS	-
GO:0050830	defense response to Gram-positive bacterium	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005743	mitochondrial inner membrane	-	IEA	-
GO:0005758	mitochondrial intermembrane space	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	colocalizes_with	IDA	8603737
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	ISS	-
GO:0015629	actin cytoskeleton	colocalizes_with	ISS	-
GO:0016235	aggresome	-	IDA	-
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IBA	21873635
GO:0032587	ruffle membrane	colocalizes_with	ISS	-
GO:0034774	secretory granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029481	FCGR activation	TAS
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-432142	Platelet sensitization by LDL	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28585144	Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer. (2017 Jun)	Zhang C	J Huazhong Univ Sci Technolog Med Sci
17900829	Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit. (2007 Nov)	Jauniaux E	Early Hum Dev
20815277	[Effect of Bushen Yiqi Huoxue Recipe on placental trophoblast apoptosis in fetal growth restricted pregnant rat]. (2010 Jun)	Chen ZY	Zhongguo Zhong Xi Yi Jie He Za Zhi
17392355	Polymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeans. (2007 Jun)	Dissanayake VH	Mol Hum Reprod
24067588	[Effect of high altitude on birth weight and adverse perinatal outcomes in two Argentine populations]. (2013)	Grandi C	Rev Fac Cien Med Univ Nac Cordoba
20423831	[Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]. (2010 Apr)	Huang P	Nan Fang Yi Ke Da Xue Xue Bao
29573501	First-trimester and combined first- and second-trimester prediction of small-for-gestational age and fetuses with late growth restriction. (2018 Mar 24)	Sotiriadis A	Ultrasound Obstet Gynecol
27452439	Dichotomous effects of aryl hydrocarbon receptor (AHR) activation on human fetoplacental endothelial cell function. (2016 Aug)	Palatnik A	Placenta
23592147	Effect of Bushen Yiqi Huoxue recipe on placental vasculature in pregnant rats with fetal growth restriction induced by passive smoking. (2013 Apr)	Chen ZY	J Huazhong Univ Sci Technolog Med Sci
26413870	Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth. (2015 Nov 2)	Wang A	J Clin Invest
26846589	First-trimester screening with specific algorithms for early- and late-onset fetal growth restriction. (2016 Sep)	Crovetto F	Ultrasound Obstet Gynecol
23017269	Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: the EDEN mother-child cohort study. (2012 Dec)	Menai M	Reprod Toxicol
20200807	Predictors of fetal growth in maternal HIV disease. (2010 Aug)	Iqbal SN	Am J Perinatol
18509788	Protease inhibitor therapy and fetal growth potential in HIV-positive women. (2008 Jun)	Iqbal S	Am J Perinatol
16144812	Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. (2006 Jan)	Yang K	Am J Physiol Endocrinol Metab
16696336	The effects of magnesium sulfate on fetal rats of FGR and the expression of caspase-3 in the placenta of maternal rat. (2005)	Gao H	J Huazhong Univ Sci Technolog Med Sci
18752569	Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis. (2008 Nov)	Dudding T	J Thromb Haemost
17083835	[Effect of magnesium sulfate on fetal rats of fetal growth retardation and its relation with expression of caspase-3 on the placenta of maternal rat]. (2006 Aug)	Gao H	Zhonghua Fu Chan Ke Za Zhi
12487923	[Effect of traditional Chinese medicine on expression of extracellular signal-regulating kinase-1 and mitogen activated protein kinase phosphatase-1 in brain and liver of fetal rats with fetal growth restriction]. (2002 Nov)	Wu Y	Zhonghua Fu Chan Ke Za Zhi