Gene: FH

2271
FMRD|HLRCC|LRCC|MCL|MCUL1
fumarate hydratase
protein-coding
1q43
Ensembl:ENSG00000091483 MIM:136850 Vega:OTTHUMG00000039597 UniprotKB:P07954
NG_012338.1
PubMed|SNP Mapped
CD|ND|AD
112   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.075e-1 (AD)  4.992e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6678986chr1:241521531 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UQCRC20.947
OCIAD10.943
APEX10.943
CDC1230.939
PDHB0.939
VPS450.936
ATXN100.936
PPT10.935
ISCU0.935
MRPL150.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.744
OR4F29-0.69
MTRNR2L6-0.386
MTRNR2L9-0.367
MTRNR2L10-0.328
KLRB1-0.322
PABPC4L-0.315
TFPI2-0.309
SIX1-0.307
FOLR3-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased expression of FH mRNA"11227219
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FH mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FH mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FH gene27153756
D000535AluminumAluminum results in decreased expression of and results in decreased activity of FH protein16906525
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FH mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of FH mRNA22521957
D001280AtrazineAtrazine results in decreased expression of FH mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of FH mRNA29275510
C006780bisphenol Abisphenol A affects the expression of FH mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FH mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FH mRNA28628672
C013418bromfenacoumbromfenacoum results in increased expression of FH protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FH mRNA15336504
C018021cobaltous chloridecobaltous chloride results in decreased expression of FH mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of FH mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of FH mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of FH protein21641295
D016572CyclosporineCyclosporine results in decreased expression of FH mRNA20106945|2556210
D003703DemecolcineDemecolcine results in decreased expression of FH mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FH mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of FH mRNA28302478
D004837EpinephrineEpinephrine results in increased expression of FH protein19464573
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FH mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of FH mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of FH mRNA19167457
D006046Gold[Polyethyleneimine binds to Gold] which results in increased expression of FH mRNA28433809
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FH mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of FH mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FH mRNA28628672
C051890irinotecanirinotecan affects the expression of FH mRNA20097248
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FH mRNA28628672
D007854LeadLead results in decreased expression of FH mRNA19921347
C052901lemongrass oillemongrass oil affects the expression of FH mRNA25976427
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FH mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in decreased expression of FH mRNA29191790
D009020MorphineMorphine results in increased expression of FH protein23056601
C028007nickel monoxidenickel monoxide results in decreased expression of FH mRNA19167457
D010126OzoneOzone results in increased expression of FH mRNA25838073
D010634PhenobarbitalPhenobarbital affects the expression of FH mRNA19159669
D010695PhlorhizinPhlorhizin results in decreased expression of FH mRNA22538082
C049032pinosylvinpinosylvin results in decreased expression of FH mRNA23333577
D010936Plant ExtractsPlant Extracts results in increased expression of FH mRNA23557933
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in increased expression of FH mRNA28433809
D011374ProgesteroneProgesterone results in increased expression of FH mRNA20631399
D011374ProgesteroneProgesterone results in decreased expression of FH mRNA18037150
D011794QuercetinQuercetin results in increased expression of FH protein17292933
D015474IsotretinoinIsotretinoin results in decreased expression of FH mRNA20436886
D012715Sesame OilSesame Oil results in increased expression of FH mRNA29191790
C017947sodium arsenitesodium arsenite results in increased expression of FH mRNA17879257
D010042OuabainOuabain affects the expression of FH protein17268060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FH mRNA21215274
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FH protein"25852303
D019284ThapsigarginThapsigargin results in decreased expression of FH mRNA22378314
D014212TretinoinTretinoin results in decreased expression of FH mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FH mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of FH mRNA26272509
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FH mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FH mRNA23179753|2493525
C111237vorinostatvorinostat results in increased expression of FH mRNA27188386
D019820Xanthine[Xanthine co-treated with XDH protein] results in increased expression of FH protein19464573

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004333fumarate hydratase activity-EXP8200987  
GO:0004333fumarate hydratase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  26237645  27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0006099tricarboxylic acid cycle-IBA21873635  
GO:0006099tricarboxylic acid cycle-IEA-  
GO:0006099tricarboxylic acid cycle-TAS-  
GO:0006106fumarate metabolic process-IBA21873635  
GO:0006108malate metabolic process-IBA21873635  
GO:0048873homeostasis of number of cells within a tissue-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS8200987  
GO:0005739mitochondrion-HDA20833797  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0045239tricarboxylic acid cycle enzyme complex-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22574676Novel medication targets for the treatment of alcoholism: preclinical studies. (2012 Aug)Rezvani AHRecent Pat CNS Drug Discov
3620099P300 from normals and adult children of alcoholics. (1987 Jul-Aug)Polich JAlcohol
24404629Familial Hypercholesterolemia (1993)Youngblom E-
3214464Familial hypercholesterolemia and apolipoprotein E4. (1988 Aug)Eto MAtherosclerosis
9622436Differential sensitivity to alcohol reinforcement in groups of men at risk for distinct alcoholism subtypes. (1998 May)Conrod PJAlcohol Clin Exp Res
25682442Prevalence of DNA-confirmed familial hypercholesterolaemia in young patients with myocardial infarction. (2015 Mar)Wald DSEur J Intern Med
27478447Prevalence of familial hypercholesterolemia: a meta-analysis of six large, observational, population-based studies in Poland. (2016 Aug 1)Pajak AArch Med Sci
16189249Association of testosterone, insulin-like growth factor-I, and C-reactive protein with metabolic syndrome in Chinese middle-aged men with a family history of type 2 diabetes. (2005 Dec)Tong PCJ Clin Endocrinol Metab
11230837Evaluation of coronary risk factors in patients with heterozygous familial hypercholesterolemia. (2001 Mar 1)Hopkins PNAm J Cardiol
17090611Influence of LDL-receptor mutation type on age at first cardiovascular event in patients with familial hypercholesterolaemia. (2007 Feb)Souverein OWEur Heart J
15216550Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: a randomized controlled trial. (2004 Jul 30)Marteau TAm J Med Genet A
14643564The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. (2003 Nov)Ponce GEur Psychiatry
26340131Elevated lipoprotein(a), hypertension and renal insufficiency as predictors of coronary artery disease in patients with genetically confirmed heterozygous familial hypercholesterolemia. (2015 Dec 15)Chan DCInt J Cardiol
7748355Reduced P300 amplitude in relation to family history of alcoholism and antisocial personality disorder among young men at risk for alcoholism. (1993)Hesselbrock VAlcohol Alcohol Suppl
22111029Premature coronary artery disease and familial hypercholesterolemia: need for early diagnosis and cascade screening in the Indian population. (2012)Setia NCardiol Res Pract
16426891P300 development during adolescence: effects of DRD2 genotype. (2006 Mar)Berman SMClin Neurophysiol
27919350Identification and characterization of severe familial hypercholesterolemia in patients presenting for cardiac catheterization. (2016 Nov - Dec)Zafrir BJ Clin Lipidol
20595220A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients. (2011 Feb)Versmissen JEur Heart J
2677611Different localization of early arterial lesions in insulin-dependent diabetes mellitus and in familial hypercholesterolemia. (1989 Oct)Rubba PMetabolism
26350818Frequency of familial hypercholesterolemia in patients with early-onset coronary artery disease admitted to a coronary care unit. (2015 Sep-Oct)Pang JJ Clin Lipidol
28499609Achilles tendon xanthomas are associated with the presence and burden of subclinical coronary atherosclerosis in heterozygous familial hypercholesterolemia: A pilot study. (2017 Aug)Mangili LCAtherosclerosis
29292049Assessment of arterial stiffness in patients with familial hypercholesterolemia. (2018 Mar - Apr)Tada HJ Clin Lipidol
15864114Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia. (2005 Apr)Miltiadous GPharmacogenet Genomics
29279246Complement system biomarkers in first episode psychosis. (2017 Dec 23)Kopczynska MSchizophr Res
28391914The Montreal-FH-SCORE: A new score to predict cardiovascular events in familial hypercholesterolemia. (2017 Jan - Feb)Paquette MJ Clin Lipidol
9603531Angiotensin-converting enzyme DD genotype and cardiovascular disease in heterozygous familial hypercholesterolemia. (1998 May 12)O'Malley JPCirculation
28434814Novel protein biomarkers associated with coronary artery disease in statin-treated patients with familial hypercholesterolemia. (2017 May - Jun)Bos SJ Clin Lipidol
26666465Assessment of Subclinical Atherosclerosis Using Computed Tomography Calcium Scores in Patients with Familial and Nonfamilial Hypercholesterolemia. (2016 May 2)Galaska RJ Atheroscler Thromb
26632531Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations. (2016)Tada HCirc J
7634440Coronary artery disease in heterozygous familial hypercholesterolemia patients with the same LDL receptor gene mutation. (1995 Aug 1)Ferrieres JCirculation
27581271Progress in the care of familial hypercholesterolaemia: 2016. (2016 Sep 5)Bell DAMed J Aust
14522571Patients with familial hypercholesterolaemia show enhanced spontaneous chemokine release from peripheral blood mononuclear cells ex vivo. Dependency of xanthomas/xanthelasms, smoking and gender. (2003 Oct)Holven KBEur Heart J
1674216Clinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function. (1991 May-Jun)Myant NBArterioscler Thromb
19673742Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. (2009 Nov)Arolfo MPAlcohol Clin Exp Res
17550346The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men. (2007 Dec)Scartezini MClin Sci (Lond)
25110223rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia. (2014 Jul-Aug)Sanchez Munoz-Torrero JFJ Clin Lipidol
9848890Carotid and femoral artery wall thickness and stiffness in patients at risk for cardiovascular disease, with special emphasis on hyperhomocysteinemia. (1998 Dec)Smilde TJArterioscler Thromb Vasc Biol
25413729Determinants of premature familial arterial thrombosis in patients with juvenile ischaemic stroke. The Italian Project on Stroke in Young Adults (IPSYS). (2015 Mar)Pezzini AThromb Haemost
18775537Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. (2009 Apr)van der Net JBAtherosclerosis
23251355Can multiple lifestyle behaviours be improved in people with familial hypercholesterolemia? Results of a parallel randomised controlled trial. (2012)Broekhuizen KPLoS One
22893714Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication. (2012 Nov)Benn MJ Clin Endocrinol Metab
18096825Femoral atherosclerosis in heterozygous familial hypercholesterolemia: influence of the genetic defect. (2008 Mar)Junyent MArterioscler Thromb Vasc Biol
9034533Association of the D2 dopamine receptor A1 allele with alcoholism: medical severity of alcoholism and type of controls. (1997 Feb 15)Lawford BRBiol Psychiatry
12513947Hypothalamic-pituitary-adrenal system adaptation to detoxification in alcohol-dependent patients is affected by family history of alcoholism. (2003 Jan 1)Zimmermann UBiol Psychiatry
15172136Effects of borderline personality disorder features and a family history of alcohol or drug dependence on P300 in adolescents. (2004 Jun)Houston RJInt J Psychophysiol
1319736Binding of 111In-labeled HDL to platelets from normolipemic volunteers and patients with heterozygous familial hypercholesterolemia. (1992 Jul)Virgolini IArterioscler Thromb
29523491Cascade screening program for familial hypercholesterolemia. (2018 May)Rubio-Marin PEndocrinol Diabetes Nutr
16014750The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. (2005 Nov)Cowen MSJ Pharmacol Exp Ther
10349036Serotonergic function in cocaine addicts: prolactin responses to sequential D,L-fenfluramine challenges. (1999 May 15)Buydens-Branchey LBiol Psychiatry
20156339A tailored lifestyle intervention to reduce the cardiovascular disease risk of individuals with Familial Hypercholesterolemia (FH): design of the PRO-FIT randomised controlled trial. (2010 Feb 15)Broekhuizen KBMC Public Health
28719663The prevalence of familial hypercholesterolemia in the West Siberian region of the Russian Federation: A substudy of the ESSE-RF. (2017)Ershova AIPLoS One
11082147Renin-angiotensin system polymorphisms and coronary events in familial hypercholesterolemia. (2000 Nov)Wierzbicki ASHypertension
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-
25859052Increased Mean Platelet Volume in Familial Hypercholesterolemia. (2016 Feb)Icli AAngiology
10978268Clinical expression of familial hypercholesterolemia in clusters of mutations of the LDL receptor gene that cause a receptor-defective or receptor-negative phenotype. (2000 Sep)Bertolini SArterioscler Thromb Vasc Biol
12147152A family history of Type 2 diabetes is associated with increased plasma levels of C-reactive protein in non-smoking healthy adult women. (2002 Aug)Pannacciulli NDiabet Med
11901354The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism. (2002 Mar)Rezvani AHPsychiatr Genet
12696393[Cardiovascular reactivity and cardiovascular risk factors in normotensive individuals of less than 40 years of age]. (2003 Jan-Feb)Benet Rodriguez MRev Esp Salud Publica
7625586Autonomic reactivity and alcohol-induced dampening in men at risk for alcoholism and men at risk for hypertension. (1995 Apr)Conrod PJAlcohol Clin Exp Res
15554949The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients. (2004 Dec)Jansen ACJ Intern Med
15256765Clinical features of familial hypercholesterolemia in Japan in a database from 1996-1998 by the research committee of the ministry of health, labour and welfare of Japan. (2004)Bujo HJ Atheroscler Thromb
8399083Phenotypic variation among familial hypercholesterolemics heterozygous for either one of two Afrikaner founder LDL receptor mutations. (1993 Oct)Kotze MJArterioscler Thromb
15585985Exercise testing in asymptomatic patients with heterozygous familial hypercholesterolaemia. (2004 Dec)Michaelides APCoron Artery Dis
20172523Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia. (2010 Jun)Garcia-Rios AAtherosclerosis
9683821What causes p53 mutations in patients with lung cancer? (1998 Sep-Oct)Sekine IOncol Rep
10605666[Clinical manifestations of familial hypercholesterolemia in Mediterranean population]. (1999 Oct 30)Alonso-Villaverde CMed Clin (Barc)
9409302Familial hypercholesterolemia in the Finnish north Karelia. A molecular, clinical, and genealogical study. (1997 Nov)Vuorio AFArterioscler Thromb Vasc Biol
27526533[Essence of the Japan Atherosclerosis Society (JAS) Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases in Japan-2012 Version and Treatment Guide for Dyslipidemia 2013--Current Strategy for the Lipid Assessment]. (2014 Sep)Arai HRinsho Byori
16601526Disease knowledge and adherence to treatment in patients with familial hypercholesterolemia. (2006 Mar-Apr)Hollman GJ Cardiovasc Nurs
16271954The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. (2005 Nov)Jin MJCancer Genet Cytogenet
9046387Biphasic effects of alcohol on heart rate are influenced by alcoholic family history and rate of alcohol ingestion. (1997 Feb)Conrod PJAlcohol Clin Exp Res
10745972Diagnosis, management and prevention of the common dyslipidaemias in South Africa--clinical guideline, 2000. South African Medical Association and Lipid and Atherosclerosis Society of Southern Africa Working Group. (2000 Feb)-S Afr Med J
18540914Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. (2008 Jul)Spadoni ADAlcohol Clin Exp Res
18250133Carotid atherosclerotic alterations in systemic lupus erythematosus patients treated at a Brazilian university setting. (2008 Feb)Telles RWLupus
3361911Assessment of young men at risk for alcoholism with P300 from a visual discrimination task. (1988 Mar)Polich JJ Stud Alcohol
7583549Differences in the phenotypic characteristics of subjects with familial defective apolipoprotein B-100 and familial hypercholesterolemia. (1995 Oct)Miserez ARArterioscler Thromb Vasc Biol
28275165Predicting Cardiovascular Events in Familial Hypercholesterolemia: The SAFEHEART Registry (Spanish Familial Hypercholesterolemia Cohort Study). (2017 May 30)Perez de Isla LCirculation
26425622When Coke Is Not Hydrating: Cocaine-Induced Acute Interstitial Nephritis. (2014 Jul-Sep)Bahaa Aldeen MJ Investig Med High Impact Case Rep
27046326A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence. (2017 Sep)Hendershot CSAddict Biol
20534948Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia. (2010 Jul 30)Harada-Shiba MJ Atheroscler Thromb
27196462Familial Clustering of Gastric Cancer: A Retrospective Study Based on the Number of First-Degree Relatives. (2016 May)Choi YJMedicine (Baltimore)
19699477Cardiovascular risk factors and non-invasive assessment of subclinical atherosclerosis in youth. (2010 Feb)Morrison KMAtherosclerosis
24796636Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project. (2014 Jun)Lovallo WRAlcohol Clin Exp Res
23095242Guidelines for the management of familial hypercholesterolemia. (2012)Harada-Shiba MJ Atheroscler Thromb
3435251Relationship between LDL receptor activity and development of coronary heart disease in Japanese cases with heterozygous familial hypercholesterolemia. (1987)Yamashita SArtery
2563220Genetic aspects of familial hypercholesterolemia and its diagnosis. (1989 Jan-Feb)Motulsky AGArteriosclerosis
8561276Family history of alcoholism and the mediation of alcohol intake by catalase: further evidence for catalase as a marker of the propensity to ingest alcohol. (1995 Oct)Koechling UMAlcohol Clin Exp Res
20692138Polymorphism at the TRIB1 gene modulates plasma lipid levels: insight from the Spanish familial hypercholesterolemia cohort study. (2011 Dec)Garcia-Rios ANutr Metab Cardiovasc Dis
29626436Remnant-like particles and coronary artery disease in familial hypercholesterolemia. (2018 Jul)Tada HClin Chim Acta
12121347LDL receptor mutation genotype and vascular disease phenotype in heterozygous familial hypercholesterolaemia. (2002 Jun)Brorholt-Petersen JUClin Genet
16562403An evaluation of the level of response to alcohol, externalizing symptoms, and depressive symptoms as predictors of alcoholism. (2006 Mar)Schuckit MAJ Stud Alcohol
12796755Apolipoprotein E genotype is not associated with cardiovascular disease in heterozygous subjects with familial hypercholesterolemia. (2003 Jun)Mozas PAm Heart J
8216504Relation of lipoprotein(a) to coronary heart disease and duplexsonographic findings of the carotid arteries in heterozygous familial hypercholesterolemia. (1993 Jun)Tato FAtherosclerosis
12755140Importance of LDL/HDL cholesterol ratio as a predictor for coronary heart disease events in patients with heterozygous familial hypercholesterolaemia: a 15-year follow-up (1987-2002). (2003)Panagiotakos DBCurr Med Res Opin
16030523Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia. (2005 Oct)van Aalst-Cohen ESEur J Hum Genet
17135283Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11. (2007 Jan)Amisten SEur Heart J
18243212Cardiovascular disease in familial hypercholesterolaemia: influence of low-density lipoprotein receptor mutation type and classic risk factors. (2008 Oct)Alonso RAtherosclerosis
1998646Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia. (1991 Mar-Apr)Hill JSArterioscler Thromb
24712315Risk stratification of patients with familial hypercholesterolemia in a multi-ethnic cohort. (2014 Apr 8)Allard MDLipids Health Dis
8579620Does the presence of the 3500 mutant apolipoprotein B-100 in low density lipoprotein particles affect their atherogenicity? (1995 Nov)Maher VMAtherosclerosis
27678431Familial hypercholesterolemia among unselected contemporary patients presenting with first myocardial infarction: Prevalence, risk factor burden, and impact on age at presentation. (2016 Sep-Oct)Mortensen MBJ Clin Lipidol
24424782Effects of Delta9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism. (2014 Jun)Ranganathan MPsychopharmacology (Berl)
21792933Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues. (2011 Sep)Maxwell PHJ Pathol
15389757Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (2005 Jan 5)Johann MAm J Med Genet B Neuropsychiatr Genet
11253736Fibrinolytic parameters and insulin resistance in young survivors of myocardial infarction with heterozygous familial hypercholesterolemia. (2001 Feb 15)Sebestjen MWien Klin Wochenschr
25126774[Two forms of familial hypercholesterolemia: differences in cardiovascular risk factors, cardiac and extracardiac atherosclerosis]. (2014 Dec)Vogt ADtsch Med Wochenschr
7885284Monocytes from patients with combined hypercholesterolemia-hypertriglyceridemia and isolated hypercholesterolemia show an increased adhesion to endothelial cells in vitro: II. Influence of intrinsic and extrinsic factors on monocyte binding. (1995 Mar)Jongkind JFMetabolism
11472751C-reactive protein in patients with familial hypercholesterolemia: no effect of simvastatin therapy. (2001 Aug)Mohrschladt MFAtherosclerosis
20065615Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia. (2009)Real JTJ Atheroscler Thromb
16201856Effects of a controlled family-based health education/counseling intervention. (2005 Sep-Oct)Salminen MAm J Health Behav
28801029Cardiovascular disease in familial hypercholesterolemia: Validation and refinement of the Montreal-FH-SCORE. (2017 Sep - Oct)Paquette MJ Clin Lipidol
9509496Determinants of P3 amplitude and response to alcohol in Native American Mission Indians. (1998 Apr)Ehlers CLNeuropsychopharmacology