Gene: FHIT

2272
AP3Aase|FRA3B
fragile histidine triad
protein-coding
3p14.2
Ensembl:ENSG00000189283 MIM:601153 Vega:OTTHUMG00000158591 UniprotKB:P49789
NG_007551.2
PubMed|SNP Mapped
ND|AD
63   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.099e-1 (AD)  1.042e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6445194chr3:61125522 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9825823chr3:61096480 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17064083chr3:60866766 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1735460chr3:60705872 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1735457chr3:60698004 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17062350chr3:60143118 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs931317chr3:59943125 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPOX0.811
DPH70.808
C1orf1230.786
COMMD40.786
PCBP40.784
CDK5RAP30.784
FAHD2A0.783
FAHD2B0.783
SDCCAG80.779
ZFPL10.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.541
OR4F29-0.498
MTRNR2L6-0.335
MTRNR2L9-0.308
MTRNR2L10-0.287
TTLL10-0.259
MTRNR2L2-0.252
RAX2-0.247
MTRNR2L8-0.246
EPPIN-0.239

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02373Adenosine MonotungstateSmall MoleculeExperimentalTarget
DB04173FructoseSmall Molecule-Approved|ExperimentalTarget
DB04389Ado-P-Ch2-P-Ps-AdoSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of FHIT mRNA"17070881
C0353141-nitropropane1-nitropropane results in increased expression of FHIT mRNA17070881
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FHIT mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FHIT mRNA"19114083
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of FHIT mRNA"17070881
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of FHIT mRNA"17070881
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of FHIT mRNA"22100608
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FHIT mRNA"22100608
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in increased expression of FHIT mRNA17070881
C0166172-nitropropane2-nitropropane results in decreased expression of FHIT mRNA17070881
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of FHIT mRNA15618236
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of FHIT protein15618236
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FHIT mRNA"18648102
C0286764-acetylaminofluorene4-acetylaminofluorene results in decreased expression of FHIT mRNA17070881
C0238294-nitroso-N-phenylanilineFHIT gene SNP affects the susceptibility to 4-nitroso-N-phenylaniline25622337
D000082AcetaminophenAcetaminophen affects the expression of FHIT mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein]16585223
D020106AcrylamideAcrylamide affects the expression of FHIT mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FHIT protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FHIT mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FHIT mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FHIT mRNA22545673
D001151ArsenicArsenic affects the methylation of FHIT gene25304211
D001280AtrazineAtrazine results in decreased expression of FHIT mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of FHIT mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FHIT mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FHIT mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FHIT mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of FHIT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FHIT gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of FHIT mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FHIT mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of FHIT promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FHIT mRNA27339419
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNA19684285
C014347decitabinedecitabine affects the methylation of FHIT promoter17019711
C014347decitabine[decitabine affects the methylation of FHIT promoter] which affects the expression of FHIT mRNA17019711|1701971
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of FHIT protein17019711
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein]23618899
C014347decitabinedecitabine results in decreased methylation of FHIT promoter15937960
C014347decitabinedecitabine results in increased expression of FHIT mRNA15937960
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FHIT mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FHIT mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FHIT mRNA25270620
D002945CisplatinCisplatin results in decreased expression of FHIT mRNA22023808
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein20970405
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter20970405
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FHIT protein12112319
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of FHIT mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FHIT mRNA"15937960
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FHIT protein"15937960
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased methylation of FHIT intron"15937960
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased methylation of FHIT promoter"15937960
C024565ethylene dichlorideethylene dichloride results in decreased expression of FHIT mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FHIT mRNA23649840
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of FHIT mRNA17070881
D017313FenretinideFenretinide results in decreased expression of FHIT mRNA28973697
D006830HydralazineHydralazine results in decreased methylation of FHIT promoter15862127
D006830HydralazineHydralazine results in increased expression of FHIT mRNA15862127
C016517indole-3-carbinolindole-3-carbinol affects the expression of FHIT mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FHIT mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FHIT mRNA27392435
D048628KetolidesKetolides analog results in increased expression of FHIT mRNA24967691
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FHIT mRNA26378955
D008694MethamphetamineFHIT gene SNP affects the susceptibility to Methamphetamine18316681
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of FHIT mRNA22100608
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein20970405
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter20970405
C005223methyleugenolmethyleugenol results in decreased expression of FHIT mRNA15618236
C005223methyleugenolmethyleugenol results in decreased expression of FHIT protein15618236
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FHIT mRNA22100608
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of FHIT mRNA15937960|1741250
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of FHIT protein15937960
D008770MethylnitrosoureaMethylnitrosourea results in increased methylation of FHIT intron15937960
D008770MethylnitrosoureaMethylnitrosourea results in increased methylation of FHIT promoter15937960
D016685MitomycinMitomycin results in decreased expression of FHIT mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FHIT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FHIT mRNA"25554681
C022838nickel chloridenickel chloride results in decreased expression of FHIT protein14971660
C017557nickel subsulfidenickel subsulfide results in decreased expression of FHIT protein14971660
C017558nickel sulfidenickel sulfide results in decreased expression of FHIT mRNA17044645
C017558nickel sulfidenickel sulfide results in decreased expression of FHIT protein17044645
C017558nickel sulfidenickel sulfide results in increased mutagenesis of FHIT mRNA17044645
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of FHIT protein19854247
D010634PhenobarbitalPhenobarbital affects the expression of FHIT mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of FHIT mRNA19270015
C008999ponasterone Aponasterone A affects the expression of FHIT protein17019711
D011794QuercetinQuercetin results in decreased expression of FHIT mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FHIT mRNA25351596
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein]23618899
C017947sodium arsenitesodium arsenite results in decreased expression of FHIT mRNA23618899
C017947sodium arsenitesodium arsenite results in decreased expression of FHIT protein23618899
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein]23618899
C016104sodium bichromatesodium bichromate affects the expression of FHIT mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of FHIT mRNA25993096
D053260SootSoot results in increased expression of FHIT mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FHIT mRNA26378955
C004648testosterone enanthatetestosterone enanthate affects the expression of FHIT mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FHIT mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FHIT mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FHIT mRNA26290441|2658280
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FHIT mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of FHIT mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of FHIT promoter25214829
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FHIT protein16585223
D014028Tobacco Smoke PollutionAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein]16585223
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FHIT mRNA16585223
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FHIT protein16585223
D014212TretinoinTretinoin results in decreased expression of FHIT mRNA23724009
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of FHIT protein17019711
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of FHIT mRNA29024780
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein]23618899
D014635Valproic AcidValproic Acid affects the expression of FHIT mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FHIT mRNA28001369
C017963vinyl carbamatevinyl carbamate results in decreased expression of FHIT mRNA17849452
D024483Vitamin K 3FHIT protein results in increased susceptibility to Vitamin K 319622739

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0003824catalytic activity-TAS8598045  
GO:0005515protein binding-IPI18077326  
GO:0016787hydrolase activity-IDA8794732  
GO:0031625ubiquitin protein ligase binding-IPI15313915  
GO:0042802identical protein binding-IPI9261067  9576908  16189514  18077326  25416956  27107012  
GO:0047710bis(5'-adenosyl)-triphosphatase activity-IDA8794732  9323207  
GO ID GO Term Qualifier Evidence PubMed
GO:0006163purine nucleotide metabolic process-IDA9323207  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0009117nucleotide metabolic process-TAS8794732  
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP15313915  
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator-IMP15313915  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005737cytoplasm-IDA15007172  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IDA15313915  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10745170The FHIT gene in oral squamous cell carcinoma: allelic imbalance is frequent but cDNA aberrations are uncommon. (2000 Mar)Pateromichelakis SOral Oncol
15231689Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung. (2004 Nov)Kim JSCarcinogenesis
15541815Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer. (2004 Dec)Tomizawa YLung Cancer
24935385Assessment of the prognostic value of methylation status and expression levels of FHIT, GSTP1 and p16 in non-small cell lung cancer in Egyptian patients. (2014)Haroun RAAsian Pac J Cancer Prev
16800968Decreased fragile histidine triad gene messenger RNA expression in lung cancer. (2006 May)Sasaki HClin Lung Cancer
11788890Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients. (2002 Feb)Pylkkanen LInt J Oncol
11776848[Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes]. (1999 Mar)Wang XZhonghua Zhong Liu Za Zhi
21118644[The biological significance of FHIT protein expression in lung cancer and precancerous tissues detected by tissue microarray]. (2007 Jun 20)Yuan LZhongguo Fei Ai Za Zhi
27572663FHIT promoter methylation status, low protein and high mRNA levels in patients with non-small cell lung cancer. (2016 Sep)Czarnecka KHInt J Oncol
26796853The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review. (2016 Jan 22)Yan WSci Rep
10493985Lung tumours from non-smoking subjects: A p53-related genetic instability in a subset of cases. (1999 Oct)Pellegrini SInt J Mol Med
17140695Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. (2007 Feb)Lin RKLung Cancer
16821595Expression of FHIT in esophageal epithelium and carcinoma: reference to drinking, smoking and multicentric carcinogenesis. (2006 May-Jun)Morita MAnticancer Res
10728669Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus. (2000 Mar 1)Mori MCancer Res
12610869[Idiopathic pulmonary fibrosis and lung cancer]. (2003 Feb)Yoshimura AGan To Kagaku Ryoho
15197197Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer. (2004 Jun 15)Kim HJ Clin Oncol
16115913The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer. (2005 Aug 15)Holschneider CHClin Cancer Res
23709347Detection of FHIT and p16 mRNA deletion in biopsy specimens obtained by bronchoscopy for the diagnosis of lung cancer. (2013 Sep 27)Chen PInt J Biol Markers
15150628Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers. (2004 Jun 14)Lee YCBr J Cancer
20521346CpG island methylator phenotype involving chromosome 3p confers an increased risk of non-small cell lung cancer. (2010 Jun)Liu ZJ Thorac Oncol
21315018[Reduction of FHIT gene expression in primary lung cancer]. (2002 Feb 20)Wang YZhongguo Fei Ai Za Zhi
26929601The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review. (2016)Wu XDrug Des Devel Ther
23614702Quantitative assessment of lung cancer associated with genes methylation in the peripheral blood. (2013 May-Jun)Tan SExp Lung Res
18243046Increased sensitivity to bleomycin in upper aerodigestive tract mucosa of head and neck squamous cell carcinoma patients. (2008 Mar 29)Jin CMutat Res
26368609Oncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles. (2000 Jan)Kane ABInhal Toxicol
21144304[FHIT protein expression during malignant transformation of human bronchial epithelial cells induced by NNK]. (2006 Apr 20)Kong LZhongguo Fei Ai Za Zhi
12518864Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer. (2002)Ho WLCancer Detect Prev
28693228Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia. (2017 Jul)Hosoda KOncol Lett
21176446[Expression of FHIT gene in precancerous lesions and primary lung cancer tissues]. (2006)Chang XZhongguo Fei Ai Za Zhi
23552698Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation. (2012 Jun 25)Moore LEOncogenesis
11297252Aberrant methylation during cervical carcinogenesis. (2001 Mar)Virmani AKClin Cancer Res
19751438Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients. (2009 Oct)Stec-Michalska KHelicobacter
21040629[A study on the allelic deletion and mutation of FHIT gene in human non-small cell lung cancer]. (2001 Feb 20)Zhou QZhongguo Fei Ai Za Zhi
26653646[DNA methylation and telomere damage in occupational people exposed to coal tar pitch]. (2015 Jul)Wang YZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
11479891Molecular genetics of small cell lung carcinoma. (2001 Apr)Wistuba IISemin Oncol
12948402[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]. (2003 Jun)Zhu LQAi Zheng
17711772Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma. (2007 Jun)Zhigang HJ Otolaryngol
17518271Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma. (2007)Yohena TOncol Res
26171037Effect of FHIT loss and p53 mutation on HPV-infected lung carcinoma development. (2015 Jul)Yu YOncol Lett
14719099Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer. (2004 Feb)Paradiso AInt J Oncol
23504373Significant frequency of allelic imbalance in 3p region covering RARbeta and MLH1 loci seems to be essential in molecular non-small cell lung cancer diagnosis. (2013 Jun)Antczak AMed Oncol
29197760Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb)Callahan CLEnviron Res
27110300The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016)Ma KClin Epigenetics
12007194Direct correlation between FRA3B expression and cigarette smoking. (2002 Jul)Stein CKGenes Chromosomes Cancer
25754026Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients. (2015 Mar 10)Huang TSci Rep
17255269Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. (2007 Jan 15)Li RClin Cancer Res
28927526Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. (2017 Jul)Cardoso MFSMutat Res
25813726Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. (2015 Feb)Ottini LMutat Res Genet Toxicol Environ Mutagen
9850082Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. (1998 Dec 1)Tomizawa YCancer Res
28135125Effect of Age at Exposure on the Incidence of Lung and Mammary Cancer after Thoracic X-Ray Irradiation in Wistar Rats. (2017 Feb)Yamada YRadiat Res
11402444[Reduction of FHIT gene expression in primary lung cancer: relationship with the proliferation and apoptosis of tumor cell]. (2001 Jun)Wang YZhonghua Yi Xue Yi Chuan Xue Za Zhi
23573237Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population. (2013)Sinha RPLoS One
16570269Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells. (2006 Sep 1)Soma TInt J Cancer
10896994Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient's prognosis and smoking history. (2000 Jul 1)Shimada YCancer
24962429Exhaled HPV infection in lung cancer: role of MA at 3p. (2014 Jul)Carpagnano GEArch Med Res
11821780Risk factors for esophageal cancer and the multiple occurrence of carcinoma in the upper aerodigestive tract. (2002 Jan)Morita MSurgery
11161381Loss of heterozygosity is related to p53 mutations and smoking in lung cancer. (2001 Jan)Zienolddiny SBr J Cancer
24278325Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)Urashima MPLoS One
19138934Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs. (2008 Jun)Bhutani MCancer Prev Res (Phila)
23443232Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma. (2012 Dec 15)Vaiphei KWorld J Gastrointest Oncol
15935551Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan. (2006 Apr 8)Wang JCancer Lett
9157994Abnormal FHIT transcripts in human breast carcinomas: a clinicopathological and epidemiological analysis of 61 Japanese cases. (1997 May 15)Hayashi SCancer Res
10519387Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers. (1999 Oct 1)Tseng JECancer Res