| SNP ID | Position | Alleles | Trait | Variation Type |
|---|---|---|---|---|
| rs6445194 | chr3:61125522 (GRCh38.p7) | G>T | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs9825823 | chr3:61096480 (GRCh38.p7) | T>C | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs17064083 | chr3:60866766 (GRCh38.p7) | C>G | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs1735460 | chr3:60705872 (GRCh38.p7) | T>C | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs1735457 | chr3:60698004 (GRCh38.p7) | G>A | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs17062350 | chr3:60143118 (GRCh38.p7) | C>T | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs931317 | chr3:59943125 (GRCh38.p7) | A>G | nicotine dependence | SNV(Single Nucleotide Variation) |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| PPOX | 0.811 |
| DPH7 | 0.808 |
| C1orf123 | 0.786 |
| COMMD4 | 0.786 |
| PCBP4 | 0.784 |
| CDK5RAP3 | 0.784 |
| FAHD2A | 0.783 |
| FAHD2B | 0.783 |
| SDCCAG8 | 0.779 |
| ZFPL1 | 0.778 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F5 | -0.541 |
| OR4F29 | -0.498 |
| MTRNR2L6 | -0.335 |
| MTRNR2L9 | -0.308 |
| MTRNR2L10 | -0.287 |
| TTLL10 | -0.259 |
| MTRNR2L2 | -0.252 |
| RAX2 | -0.247 |
| MTRNR2L8 | -0.246 |
| EPPIN | -0.239 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB02373 | Adenosine Monotungstate | Small Molecule | Experimental | Target | |
| DB04173 | Fructose | Small Molecule | - | Approved|Experimental | Target |
| DB04389 | Ado-P-Ch2-P-Ps-Ado | Small Molecule | Experimental | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C012277 | 1,2-diamino-4-nitrobenzene | "1,2-diamino-4-nitrobenzene results in increased expression of FHIT mRNA" | 17070881 |
| C035314 | 1-nitropropane | 1-nitropropane results in increased expression of FHIT mRNA | 17070881 |
| C511295 | 2,2',4,4'-tetrabromodiphenyl ether | "2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FHIT mRNA" | 25614096 |
| C111118 | 2',3,3',4',5-pentachloro-4-hydroxybiphenyl | "2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FHIT mRNA" | 19114083 |
| C010914 | 2,4-diaminotoluene | "2,4-diaminotoluene results in decreased expression of FHIT mRNA" | 17070881 |
| C025235 | 2,6-diaminotoluene | "2,6-diaminotoluene results in decreased expression of FHIT mRNA" | 17070881 |
| C049584 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | "2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of FHIT mRNA" | 22100608 |
| C036990 | 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline | "2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FHIT mRNA" | 22100608 |
| C014706 | 2-nitro-4-phenylenediamine | 2-nitro-4-phenylenediamine results in increased expression of FHIT mRNA | 17070881 |
| C016617 | 2-nitropropane | 2-nitropropane results in decreased expression of FHIT mRNA | 17070881 |
| C029955 | 2-nitrotoluene | 2-nitrotoluene results in decreased expression of FHIT mRNA | 15618236 |
| C029955 | 2-nitrotoluene | 2-nitrotoluene results in decreased expression of FHIT protein | 15618236 |
| C009505 | 4,4'-diaminodiphenylmethane | "4,4'-diaminodiphenylmethane results in increased expression of FHIT mRNA" | 18648102 |
| C028676 | 4-acetylaminofluorene | 4-acetylaminofluorene results in decreased expression of FHIT mRNA | 17070881 |
| C023829 | 4-nitroso-N-phenylaniline | FHIT gene SNP affects the susceptibility to 4-nitroso-N-phenylaniline | 25622337 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of FHIT mRNA | 17562736 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein] | 16585223 |
| D020106 | Acrylamide | Acrylamide affects the expression of FHIT mRNA | 28959563 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of FHIT protein | 20106945 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of FHIT mRNA | 21632981|2164198 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of FHIT mRNA | 19770486 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of FHIT mRNA | 22545673 |
| D001151 | Arsenic | Arsenic affects the methylation of FHIT gene | 25304211 |
| D001280 | Atrazine | Atrazine results in decreased expression of FHIT mRNA | 25929836 |
| C022921 | benzo(k)fluoranthene | benzo(k)fluoranthene results in increased expression of FHIT mRNA | 26377693 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of FHIT mRNA | 20106945|2163298 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of FHIT mRNA | 19770486|2171566 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FHIT mRNA" | 26238291 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of FHIT mRNA | 25181051 |
| C006780 | bisphenol A | bisphenol A results in increased methylation of FHIT gene | 28505145 |
| C018475 | butyraldehyde | butyraldehyde results in decreased expression of FHIT mRNA | 26079696 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in increased expression of FHIT mRNA | 18804290 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased methylation of FHIT promoter | 22457795 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of FHIT mRNA | 27339419 |
| D003513 | Cycloheximide | [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNA | 19684285 |
| C014347 | decitabine | decitabine affects the methylation of FHIT promoter | 17019711 |
| C014347 | decitabine | [decitabine affects the methylation of FHIT promoter] which affects the expression of FHIT mRNA | 17019711|1701971 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] affects the expression of FHIT protein | 17019711 |
| C014347 | decitabine | decitabine inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein] | 23618899 |
| C014347 | decitabine | decitabine results in decreased methylation of FHIT promoter | 15937960 |
| C014347 | decitabine | decitabine results in increased expression of FHIT mRNA | 15937960 |
| D002945 | Cisplatin | [Cisplatin co-treated with jinfukang] results in decreased expression of FHIT mRNA | 27392435 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of FHIT mRNA | 27392435 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of FHIT mRNA | 25270620 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of FHIT mRNA | 22023808 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein | 20970405 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter | 20970405 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in decreased expression of FHIT protein | 12112319 |
| C015835 | dimethyl-4-toluidine | dimethyl-4-toluidine results in decreased expression of FHIT mRNA | 27638505 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FHIT mRNA" | 15937960 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FHIT protein" | 15937960 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "9,10-Dimethyl-1,2-benzanthracene results in increased methylation of FHIT intron" | 15937960 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "9,10-Dimethyl-1,2-benzanthracene results in increased methylation of FHIT promoter" | 15937960 |
| C024565 | ethylene dichloride | ethylene dichloride results in decreased expression of FHIT mRNA | 28189721 |
| D005020 | Ethyl Methanesulfonate | Ethyl Methanesulfonate results in decreased expression of FHIT mRNA | 23649840 |
| D015073 | 2-Acetylaminofluorene | 2-Acetylaminofluorene results in decreased expression of FHIT mRNA | 17070881 |
| D017313 | Fenretinide | Fenretinide results in decreased expression of FHIT mRNA | 28973697 |
| D006830 | Hydralazine | Hydralazine results in decreased methylation of FHIT promoter | 15862127 |
| D006830 | Hydralazine | Hydralazine results in increased expression of FHIT mRNA | 15862127 |
| C016517 | indole-3-carbinol | indole-3-carbinol affects the expression of FHIT mRNA | 21396975 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FHIT mRNA | 25613284 |
| C544151 | jinfukang | [Cisplatin co-treated with jinfukang] results in decreased expression of FHIT mRNA | 27392435 |
| D048628 | Ketolides | Ketolides analog results in increased expression of FHIT mRNA | 24967691 |
| D058185 | Magnetite Nanoparticles | [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FHIT mRNA | 26378955 |
| D008694 | Methamphetamine | FHIT gene SNP affects the susceptibility to Methamphetamine | 18316681 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in decreased expression of FHIT mRNA | 22100608 |
| D008748 | Methylcholanthrene | [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein | 20970405 |
| D008748 | Methylcholanthrene | [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter | 20970405 |
| C005223 | methyleugenol | methyleugenol results in decreased expression of FHIT mRNA | 15618236 |
| C005223 | methyleugenol | methyleugenol results in decreased expression of FHIT protein | 15618236 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in decreased expression of FHIT mRNA | 22100608 |
| D008770 | Methylnitrosourea | Methylnitrosourea results in decreased expression of FHIT mRNA | 15937960|1741250 |
| D008770 | Methylnitrosourea | Methylnitrosourea results in decreased expression of FHIT protein | 15937960 |
| D008770 | Methylnitrosourea | Methylnitrosourea results in increased methylation of FHIT intron | 15937960 |
| D008770 | Methylnitrosourea | Methylnitrosourea results in increased methylation of FHIT promoter | 15937960 |
| D016685 | Mitomycin | Mitomycin results in decreased expression of FHIT mRNA | 25270620 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in decreased expression of FHIT mRNA" | 25554681 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon results in decreased expression of FHIT mRNA" | 25554681 |
| C022838 | nickel chloride | nickel chloride results in decreased expression of FHIT protein | 14971660 |
| C017557 | nickel subsulfide | nickel subsulfide results in decreased expression of FHIT protein | 14971660 |
| C017558 | nickel sulfide | nickel sulfide results in decreased expression of FHIT mRNA | 17044645 |
| C017558 | nickel sulfide | nickel sulfide results in decreased expression of FHIT protein | 17044645 |
| C017558 | nickel sulfide | nickel sulfide results in increased mutagenesis of FHIT mRNA | 17044645 |
| C522391 | perfluorododecanoic acid | perfluorododecanoic acid results in increased expression of FHIT protein | 19854247 |
| D010634 | Phenobarbital | Phenobarbital affects the expression of FHIT mRNA | 23091169 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of FHIT mRNA | 19270015 |
| C008999 | ponasterone A | ponasterone A affects the expression of FHIT protein | 17019711 |
| D011794 | Quercetin | Quercetin results in decreased expression of FHIT mRNA | 21632981 |
| D012822 | Silicon Dioxide | Silicon Dioxide results in decreased expression of FHIT mRNA | 25351596 |
| C017947 | sodium arsenite | decitabine inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein] | 23618899 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of FHIT mRNA | 23618899 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of FHIT protein | 23618899 |
| C017947 | sodium arsenite | U 0126 inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein] | 23618899 |
| C016104 | sodium bichromate | sodium bichromate affects the expression of FHIT mRNA | 22110744 |
| C016104 | sodium bichromate | sodium bichromate results in decreased expression of FHIT mRNA | 25993096 |
| D053260 | Soot | Soot results in increased expression of FHIT mRNA | 26551751 |
| D004113 | Succimer | [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FHIT mRNA | 26378955 |
| C004648 | testosterone enanthate | testosterone enanthate affects the expression of FHIT mRNA | 17440010 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNA | 19684285 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of FHIT mRNA | 19684285 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of FHIT mRNA | 26377647 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of FHIT mRNA | 26290441|2658280 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FHIT mRNA | 25613284 |
| C009495 | titanium dioxide | titanium dioxide results in decreased expression of FHIT mRNA | 23557971 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in increased methylation of FHIT promoter | 25214829 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of FHIT protein | 16585223 |
| D014028 | Tobacco Smoke Pollution | Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein] | 16585223 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of FHIT mRNA | 16585223 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of FHIT protein | 16585223 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of FHIT mRNA | 23724009 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] affects the expression of FHIT protein | 17019711 |
| C013320 | tris(2-butoxyethyl) phosphate | tris(2-butoxyethyl) phosphate affects the expression of FHIT mRNA | 29024780 |
| C113580 | U 0126 | U 0126 inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein] | 23618899 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of FHIT mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of FHIT mRNA | 28001369 |
| C017963 | vinyl carbamate | vinyl carbamate results in decreased expression of FHIT mRNA | 17849452 |
| D024483 | Vitamin K 3 | FHIT protein results in increased susceptibility to Vitamin K 3 | 19622739 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | - | IEA | - |
| GO:0003824 | catalytic activity | - | TAS | 8598045 |
| GO:0005515 | protein binding | - | IPI | 18077326 |
| GO:0016787 | hydrolase activity | - | IDA | 8794732 |
| GO:0031625 | ubiquitin protein ligase binding | - | IPI | 15313915 |
| GO:0042802 | identical protein binding | - | IPI | 9261067 9576908 16189514 18077326 25416956 27107012 |
| GO:0047710 | bis(5'-adenosyl)-triphosphatase activity | - | IDA | 8794732 9323207 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0006163 | purine nucleotide metabolic process | - | IDA | 9323207 |
| GO:0006351 | transcription, DNA-templated | - | IEA | - |
| GO:0006355 | regulation of transcription, DNA-templated | - | IEA | - |
| GO:0009117 | nucleotide metabolic process | - | TAS | 8794732 |
| GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | - | IMP | 15313915 |
| GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | - | IMP | 15313915 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001650 | fibrillar center | - | IDA | - |
| GO:0005737 | cytoplasm | - | IDA | 15007172 |
| GO:0005739 | mitochondrion | - | IEA | - |
| GO:0005829 | cytosol | - | IDA | 15313915 |
| GO:0005886 | plasma membrane | - | IDA | - |
| KEGG ID | KEGG Term |
|---|---|
| hsa00230 | Purine metabolism |
| hsa05222 | Small cell lung cancer |
| hsa05223 | Non-small cell lung cancer |
| Reactome ID | Reactome Term | Evidence |
|---|
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 10745170 | The FHIT gene in oral squamous cell carcinoma: allelic imbalance is frequent but cDNA aberrations are uncommon. (2000 Mar) | Pateromichelakis S | Oral Oncol |
| 15231689 | Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung. (2004 Nov) | Kim JS | Carcinogenesis |
| 15541815 | Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer. (2004 Dec) | Tomizawa Y | Lung Cancer |
| 24935385 | Assessment of the prognostic value of methylation status and expression levels of FHIT, GSTP1 and p16 in non-small cell lung cancer in Egyptian patients. (2014) | Haroun RA | Asian Pac J Cancer Prev |
| 16800968 | Decreased fragile histidine triad gene messenger RNA expression in lung cancer. (2006 May) | Sasaki H | Clin Lung Cancer |
| 11788890 | Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients. (2002 Feb) | Pylkkanen L | Int J Oncol |
| 11776848 | [Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes]. (1999 Mar) | Wang X | Zhonghua Zhong Liu Za Zhi |
| 21118644 | [The biological significance of FHIT protein expression in lung cancer and precancerous tissues detected by tissue microarray]. (2007 Jun 20) | Yuan L | Zhongguo Fei Ai Za Zhi |
| 27572663 | FHIT promoter methylation status, low protein and high mRNA levels in patients with non-small cell lung cancer. (2016 Sep) | Czarnecka KH | Int J Oncol |
| 26796853 | The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review. (2016 Jan 22) | Yan W | Sci Rep |
| 10493985 | Lung tumours from non-smoking subjects: A p53-related genetic instability in a subset of cases. (1999 Oct) | Pellegrini S | Int J Mol Med |
| 17140695 | Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. (2007 Feb) | Lin RK | Lung Cancer |
| 16821595 | Expression of FHIT in esophageal epithelium and carcinoma: reference to drinking, smoking and multicentric carcinogenesis. (2006 May-Jun) | Morita M | Anticancer Res |
| 10728669 | Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus. (2000 Mar 1) | Mori M | Cancer Res |
| 12610869 | [Idiopathic pulmonary fibrosis and lung cancer]. (2003 Feb) | Yoshimura A | Gan To Kagaku Ryoho |
| 15197197 | Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer. (2004 Jun 15) | Kim H | J Clin Oncol |
| 16115913 | The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer. (2005 Aug 15) | Holschneider CH | Clin Cancer Res |
| 23709347 | Detection of FHIT and p16 mRNA deletion in biopsy specimens obtained by bronchoscopy for the diagnosis of lung cancer. (2013 Sep 27) | Chen P | Int J Biol Markers |
| 15150628 | Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers. (2004 Jun 14) | Lee YC | Br J Cancer |
| 20521346 | CpG island methylator phenotype involving chromosome 3p confers an increased risk of non-small cell lung cancer. (2010 Jun) | Liu Z | J Thorac Oncol |
| 21315018 | [Reduction of FHIT gene expression in primary lung cancer]. (2002 Feb 20) | Wang Y | Zhongguo Fei Ai Za Zhi |
| 26929601 | The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review. (2016) | Wu X | Drug Des Devel Ther |
| 23614702 | Quantitative assessment of lung cancer associated with genes methylation in the peripheral blood. (2013 May-Jun) | Tan S | Exp Lung Res |
| 18243046 | Increased sensitivity to bleomycin in upper aerodigestive tract mucosa of head and neck squamous cell carcinoma patients. (2008 Mar 29) | Jin C | Mutat Res |
| 26368609 | Oncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles. (2000 Jan) | Kane AB | Inhal Toxicol |
| 21144304 | [FHIT protein expression during malignant transformation of human bronchial epithelial cells induced by NNK]. (2006 Apr 20) | Kong L | Zhongguo Fei Ai Za Zhi |
| 12518864 | Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer. (2002) | Ho WL | Cancer Detect Prev |
| 28693228 | Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia. (2017 Jul) | Hosoda K | Oncol Lett |
| 21176446 | [Expression of FHIT gene in precancerous lesions and primary lung cancer tissues]. (2006) | Chang X | Zhongguo Fei Ai Za Zhi |
| 23552698 | Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation. (2012 Jun 25) | Moore LE | Oncogenesis |
| 11297252 | Aberrant methylation during cervical carcinogenesis. (2001 Mar) | Virmani AK | Clin Cancer Res |
| 19751438 | Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients. (2009 Oct) | Stec-Michalska K | Helicobacter |
| 21040629 | [A study on the allelic deletion and mutation of FHIT gene in human non-small cell lung cancer]. (2001 Feb 20) | Zhou Q | Zhongguo Fei Ai Za Zhi |
| 26653646 | [DNA methylation and telomere damage in occupational people exposed to coal tar pitch]. (2015 Jul) | Wang Y | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi |
| 11479891 | Molecular genetics of small cell lung carcinoma. (2001 Apr) | Wistuba II | Semin Oncol |
| 12948402 | [Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]. (2003 Jun) | Zhu LQ | Ai Zheng |
| 17711772 | Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma. (2007 Jun) | Zhigang H | J Otolaryngol |
| 17518271 | Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma. (2007) | Yohena T | Oncol Res |
| 26171037 | Effect of FHIT loss and p53 mutation on HPV-infected lung carcinoma development. (2015 Jul) | Yu Y | Oncol Lett |
| 14719099 | Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer. (2004 Feb) | Paradiso A | Int J Oncol |
| 23504373 | Significant frequency of allelic imbalance in 3p region covering RARbeta and MLH1 loci seems to be essential in molecular non-small cell lung cancer diagnosis. (2013 Jun) | Antczak A | Med Oncol |
| 29197760 | Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb) | Callahan CL | Environ Res |
| 27110300 | The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016) | Ma K | Clin Epigenetics |
| 12007194 | Direct correlation between FRA3B expression and cigarette smoking. (2002 Jul) | Stein CK | Genes Chromosomes Cancer |
| 25754026 | Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients. (2015 Mar 10) | Huang T | Sci Rep |
| 17255269 | Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. (2007 Jan 15) | Li R | Clin Cancer Res |
| 28927526 | Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. (2017 Jul) | Cardoso MFS | Mutat Res |
| 25813726 | Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. (2015 Feb) | Ottini L | Mutat Res Genet Toxicol Environ Mutagen |
| 9850082 | Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. (1998 Dec 1) | Tomizawa Y | Cancer Res |
| 28135125 | Effect of Age at Exposure on the Incidence of Lung and Mammary Cancer after Thoracic X-Ray Irradiation in Wistar Rats. (2017 Feb) | Yamada Y | Radiat Res |
| 11402444 | [Reduction of FHIT gene expression in primary lung cancer: relationship with the proliferation and apoptosis of tumor cell]. (2001 Jun) | Wang Y | Zhonghua Yi Xue Yi Chuan Xue Za Zhi |
| 23573237 | Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population. (2013) | Sinha R | PLoS One |
| 16570269 | Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells. (2006 Sep 1) | Soma T | Int J Cancer |
| 10896994 | Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient's prognosis and smoking history. (2000 Jul 1) | Shimada Y | Cancer |
| 24962429 | Exhaled HPV infection in lung cancer: role of MA at 3p. (2014 Jul) | Carpagnano GE | Arch Med Res |
| 11821780 | Risk factors for esophageal cancer and the multiple occurrence of carcinoma in the upper aerodigestive tract. (2002 Jan) | Morita M | Surgery |
| 11161381 | Loss of heterozygosity is related to p53 mutations and smoking in lung cancer. (2001 Jan) | Zienolddiny S | Br J Cancer |
| 24278325 | Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013) | Urashima M | PLoS One |
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