Gene: NID2

22795
NID-2
nidogen 2
protein-coding
14q22.1
Ensembl:ENSG00000087303 MIM:605399 Vega:OTTHUMG00000140298 UniprotKB:Q14112
NC_000014.9
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.560e-1 (AD)  3.517e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COBLL10.762
TNFRSF190.761
PTPRB0.707
RCSD10.701
VWA20.7
KLHL200.693
HMCN10.689
SH3D190.689
PROM10.685
ABCG20.683

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.401
WNT7B-0.38
TLCD1-0.379
PPP1R3G-0.379
C9orf24-0.378
ASPDH-0.365
PRR5-0.35
CABLES1-0.346
ARSF-0.332
SLC7A10-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NID2 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NID2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of NID2 mRNA26690555
D000393Air PollutantsAir Pollutants analog results in increased expression of NID2 mRNA21757418
D000447AldehydesAldehydes results in increased expression of NID2 mRNA25014914
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of NID2 mRNA18585445
C015001arsenitearsenite results in increased methylation of NID2 promoter23974009
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of NID2 mRNA18585445
D001379AzathioprineAzathioprine results in increased expression of NID2 mRNA19192274
C547126AZM551248AZM551248 results in increased expression of NID2 mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NID2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NID2 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of NID2 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of NID2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of NID2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NID2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of NID2 mRNA20147733
C018475butyraldehydebutyraldehyde results in increased expression of NID2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NID2 mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NID2 mRNA17484886
D002330CarmustineCarmustine results in decreased expression of NID2 mRNA16005536
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NID2 gene20938992
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of NID2 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of NID2 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of NID2 mRNA]20032058
D004041Dietary FatsDietary Fats results in increased expression of NID2 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NID2 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NID2 mRNA15171707
D002117CalcitriolCalcitriol results in decreased expression of NID2 mRNA16002434
D004237DiuronDiuron results in decreased expression of NID2 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NID2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NID2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of NID2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NID2 mRNA17557909
C024565ethylene dichlorideethylene dichloride results in decreased expression of NID2 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NID2 gene20938992
C039281furanfuran results in increased expression of NID2 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of NID2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NID2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of NID2 mRNA16054899
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of NID2 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NID2 gene20938992
D008727MethotrexateMethotrexate results in increased expression of NID2 mRNA19192274
D008727MethotrexateMethotrexate affects the expression of NID2 mRNA18502557
D008727MethotrexateMethotrexate results in decreased expression of NID2 mRNA16005536
D008775MethylprednisoloneMethylprednisolone results in increased expression of NID2 mRNA19192274
D008777MethyltestosteroneMethyltestosterone results in increased expression of NID2 mRNA29191790
D008942MitoxantroneNID2 protein affects the susceptibility to Mitoxantrone16217747
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NID2 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of NID2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of NID2 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NID2 mRNA"25554681
C558013NSC 689534NSC 689534 results in increased expression of NID2 mRNA20971185
D000073878Palm OilPalm Oil results in increased expression of NID2 mRNA18042831
C046012pentanalpentanal results in increased expression of NID2 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NID2 protein26178269
D010656PhenylephrinePhenylephrine results in increased expression of NID2 mRNA18158353
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NID2 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NID2 mRNA19710929
D010894PiroxicamPiroxicam results in increased expression of NID2 mRNA19192274
D011239PrednisolonePrednisolone results in increased expression of NID2 mRNA19192274
D011374ProgesteroneProgesterone results in decreased expression of NID2 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of NID2 mRNA23018184
C005556propionaldehydepropionaldehyde results in increased expression of NID2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of NID2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NID2 mRNA27029645
C059514resveratrolresveratrol affects the secretion of NID2 protein24802182
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of NID2 mRNA16054899
C089730rosiglitazonerosiglitazone results in increased expression of NID2 mRNA21515302
C010327salinomycinsalinomycin results in decreased expression of NID2 mRNA19682730
D012643SeleniumSelenium results in decreased expression of NID2 mRNA19244175
D012715Sesame OilSesame Oil results in decreased expression of NID2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NID2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NID2 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NID2 mRNA22431001
D013629TamoxifenTamoxifen affects the expression of NID2 mRNA17555576
C501413tesaglitazartesaglitazar results in increased expression of NID2 mRNA21515302
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of NID2 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NID2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of NID2 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NID2 mRNA25613284
D013866ThioguanineThioguanine results in decreased expression of NID2 mRNA16005536
C009495titanium dioxidetitanium dioxide results in decreased expression of NID2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NID2 mRNA27865774
D014118Toxins, Biological"Toxins, Biological affects the expression of NID2 mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of NID2 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of NID2 mRNA24935251
C057693troglitazonetroglitazone results in increased expression of NID2 mRNA19140230
C057693troglitazonetroglitazone results in increased expression of NID2 mRNA21515302
D014635Valproic AcidValproic Acid results in increased expression of NID2 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of NID2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NID2 mRNA19101580|2493525
D014635Valproic AcidValproic Acid results in increased expression of NID2 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NID2 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of NID2 mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of NID2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI11956183  
GO:0005518collagen binding-TAS9733643  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-TAS9733643  
GO:0007160cell-matrix adhesion-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0071711basement membrane organization-TAS22952693  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IDA22952693  
GO:0005886plasma membrane-IDA-  
GO:0031012extracellular matrix-HDA23658023  
GO:0062023collagen-containing extracellular matrix-HDA27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-3000157Laminin interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26027762Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer. (2015 Sep)Fantony JJUrol Oncol
28106542Urinary NID2 and TWIST1 methylation to augment conventional urine cytology for the detection of bladder cancer. (2017)Fantony JJCancer Biomark