Gene: ITGA11

22801
HsT18964
integrin subunit alpha 11
protein-coding
15q23
Ensembl:ENSG00000137809 MIM:604789 Vega:OTTHUMG00000172657 UniprotKB:Q9UKX5
NG_046911.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.609e-1 (AD)  7.305e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OLFML2B0.672
LRMP0.607
ATP8B10.603
SMYD10.597
PIK3CD0.593
EPS8L20.59
PCBP30.584
ABCC30.582
PTK70.578
STAT60.576

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RXRG-0.383
DIO2-0.368
LRAT-0.351
ENDOU-0.339
WIF1-0.33
ACBD7-0.326
CALB2-0.32
PPP1R3C-0.316
COL17A1-0.313
RELN-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ITGA11 mRNA12958071
D000082AcetaminophenAcetaminophen results in decreased expression of ITGA11 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of ITGA11 mRNA29067470
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ITGA11 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGA11 mRNA22316170
C006780bisphenol Abisphenol A results in increased expression of ITGA11 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ITGA11 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ITGA11 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ITGA11 protein24552547
C099555CD 437CD 437 results in decreased expression of ITGA11 mRNA12958071
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of ITGA11 mRNA19524605
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ITGA11 mRNA24690739
D016572CyclosporineCyclosporine results in increased expression of ITGA11 mRNA20106945
D000069439DasatinibDasatinib results in increased expression of ITGA11 mRNA20579391
D003907DexamethasoneDexamethasone results in decreased expression of ITGA11 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ITGA11 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of ITGA11 mRNA22733784
D003976DiazinonDiazinon results in increased methylation of ITGA11 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ITGA11 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ITGA11 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ITGA11 mRNA25016146
C058705diethyl malatediethyl malate affects the expression of ITGA11 mRNA24814887
D002117CalcitriolCalcitriol results in decreased expression of ITGA11 mRNA26485663
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ITGA11 mRNA24690739
D004237DiuronDiuron results in increased expression of ITGA11 mRNA21551480
C118739entinostatentinostat results in increased expression of ITGA11 mRNA27188386
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ITGA11 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGA11 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ITGA11 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ITGA11 mRNA27392435
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of ITGA11 mRNA20843944
D010100OxygenOxygen deficiency results in increased expression of ITGA11 mRNA26516004
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ITGA11 mRNA26705709
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ITGA11 mRNA22714537
C005556propionaldehydepropionaldehyde results in decreased expression of ITGA11 mRNA26079696
C502851quinocetonequinocetone results in decreased expression of ITGA11 mRNA27046791
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ITGA11 mRNA25895662
D012834SilverSilver results in decreased expression of ITGA11 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ITGA11 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ITGA11 mRNA25613284
D014635Valproic AcidValproic Acid results in increased expression of ITGA11 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ITGA11 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005518collagen binding-IMP11518510  
GO:0038064collagen receptor activity-IMP11518510  
GO:0046872metal ion binding-IEA-  
GO:0098639collagen binding involved in cell-matrix adhesion-IMP24823363  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-HDA16210410  
GO:0006929substrate-dependent cell migration-IMP11518510  
GO:0007155cell adhesion-TAS10486209  
GO:0007160cell-matrix adhesion-IMP11518510  24823363  
GO:0007229integrin-mediated signaling pathway-IMP24823363  
GO:0007517muscle organ development-TAS10464311  
GO:0030198extracellular matrix organization-TAS-  
GO:0033627cell adhesion mediated by integrin-IMP11518510  
GO:0038065collagen-activated signaling pathway-IMP11518510  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA11518510  
GO:0008305integrin complex-TAS10486209  
GO:0016020membrane-HDA16210410  
GO:0034681integrin alpha11-beta1 complex-IDA24823363  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-216083Integrin cell surface interactionsIEA
R-HSA-216083Integrin cell surface interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27143927Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)Zheng WOnco Targets Ther