Gene: IKZF3

22806
AIO|AIOLOS|ZNFN1A3
IKAROS family zinc finger 3
protein-coding
17q12-q21.1
Ensembl:ENSG00000161405 MIM:606221 Vega:OTTHUMG00000133250 UniprotKB:Q9UKT9
NG_029104.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.250e-1 (AD)  8.635e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NHSL20.543
ALG110.525
SHPRH0.518
ITGA40.514
ZNF5730.512
ZNF8520.503
ACTA2-AS10.502
RAPH10.502
ZNF2210.5
HTR1F0.493

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.316
IZUMO4-0.294
PLA2G5-0.293
ENDOU-0.28
C16orf74-0.272
TST-0.264
C1orf53-0.26
S100A1-0.259
ZNF296-0.259
TMEM253-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of IKZF3 mRNA"27567155
C496492abrineabrine results in decreased expression of IKZF3 mRNA22595364
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IKZF3 mRNA24449571
D001280AtrazineAtrazine results in increased expression of IKZF3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IKZF3 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of IKZF3 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of IKZF3 mRNA23125180
D019327Copper SulfateCopper Sulfate results in increased expression of IKZF3 mRNA19549813
C014347decitabinedecitabine affects the methylation of IKZF3 promoter18206652
C014347decitabinetrichostatin A promotes the reaction [decitabine results in increased expression of IKZF3 mRNA]18206652
D016264Dextran SulfateDextran Sulfate results in increased expression of IKZF3 mRNA23894361
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IKZF3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IKZF3 mRNA24796395|2675264
D009532NickelNickel results in increased expression of IKZF3 mRNA24768652
C028007nickel monoxidenickel monoxide results in decreased expression of IKZF3 mRNA19167457
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IKZF3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of IKZF3 mRNA23557971
C012589trichostatin Atrichostatin A affects the expression of IKZF3 mRNA18206652
C012589trichostatin Atrichostatin A affects the expression of IKZF3 protein18206652
C012589trichostatin Atrichostatin A promotes the reaction [decitabine results in increased expression of IKZF3 mRNA]18206652
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IKZF3 mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of IKZF3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IKZF3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS10552935  
GO:0005515protein binding-IPI10369681  11714801  20676092  21516116  25416956  25910212  
26871637  27107012  27107014  
GO:0042802identical protein binding-IPI25416956  
GO:0042803protein homodimerization activity-IDA17646674  
GO:0043565sequence-specific DNA binding-ISS-  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IDA17646674  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-TAS10552935  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007498mesoderm development-TAS10552935  
GO:0030888regulation of B cell proliferation-ISS-  
GO:0042113B cell activation-IEA-  
GO:0042981regulation of apoptotic process-IMP10369681  
GO:0045577regulation of B cell differentiation-ISS-  
GO:0045619regulation of lymphocyte differentiation-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10369681  17646674  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA10369681  17646674  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2262659217q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. (2012 Jun)Marinho SAnn Allergy Asthma Immunol
2362200517q12-21 and asthma: interactions with early-life environmental exposures. (2013 May)Blekic MAnn Allergy Asthma Immunol