Gene: PHLDA1

22822
DT1P1B11|PHRIP|TDAG51
pleckstrin homology like domain family A member 1
protein-coding
12q21.2
Ensembl:ENSG00000139289 MIM:605335 Vega:OTTHUMG00000169783 UniprotKB:Q8WV24
NC_000012.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.080e-2 (AD)  8.090e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MPZL10.767
SYNCRIP0.732
KDELR20.726
PDE4B0.726
DPYSL30.725
ARFGAP30.725
IL1RAP0.721
UBE2J10.719
DCAF130.715
OSTC0.714

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.582
OR4F29-0.519
EDN3-0.184
HES5-0.153
TDGF1-0.144
SPRR2A-0.14
CRYBA2-0.133
FAM25A-0.13
FAM180B-0.127
KRT13-0.126

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PHLDA1 mRNA"22698814
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PHLDA1 mRNA28329830
C0512461-methylanthraceneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PHLDA1 mRNA]28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of PHLDA1 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PHLDA1 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PHLDA1 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PHLDA1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PHLDA1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of PHLDA1 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of PHLDA1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of PHLDA1 mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of PHLDA1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of PHLDA1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PHLDA1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of PHLDA1 mRNA17585979
D000082AcetaminophenAcetaminophen results in increased expression of PHLDA1 mRNA15976192
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PHLDA1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHLDA1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHLDA1 mRNA19770486
C430898AGN 194204AGN 194204 results in increased expression of PHLDA1 mRNA16339527
D000393Air PollutantsAir Pollutants analog results in increased expression of PHLDA1 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of PHLDA1 mRNA"23195993
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of PHLDA1 mRNA17023530
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PHLDA1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PHLDA1 mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in increased expression of PHLDA1 mRNA16704987
C006632arsenic trioxidearsenic trioxide results in decreased expression of PHLDA1 mRNA20458559
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of PHLDA1 mRNA"20831825
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PHLDA1 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PHLDA1 mRNA"18687144|2083182
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of PHLDA1 mRNA17639512
C487081belinostatbelinostat results in increased expression of PHLDA1 mRNA26272509
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PHLDA1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHLDA1 mRNA20064835|2010694
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of PHLDA1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHLDA1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHLDA1 mRNA15034205|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PHLDA1 mRNA"19150397
D004958EstradiolEstradiol affects the expression of PHLDA1 mRNA25321415
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PHLDA1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of PHLDA1 mRNA18556351|2010694
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PHLDA1 mRNA18556351
D004958EstradiolEstradiol results in increased expression of PHLDA1 mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of PHLDA1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of PHLDA1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PHLDA1 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of PHLDA1 mRNA20977926
C032036bromobenzenebromobenzene results in increased expression of PHLDA1 mRNA15976192
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PHLDA1 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PHLDA1 mRNA15501611
D002220CarbamazepineCarbamazepine affects the expression of PHLDA1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PHLDA1 mRNA15976192
D002330CarmustinePHLDA1 mRNA affects the susceptibility to Carmustine16365179
D000068579CelecoxibCelecoxib results in decreased expression of PHLDA1 mRNA28201806
C100187chloropicrinchloropicrin results in decreased expression of PHLDA1 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PHLDA1 mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of PHLDA1 mRNA18353800
C019304ciprofibrateciprofibrate results in decreased expression of PHLDA1 mRNA12771043
D002994ClofibrateClofibrate results in increased expression of PHLDA1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of PHLDA1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of PHLDA1 mRNA22941251
D003300CopperCopper results in decreased expression of PHLDA1 mRNA17205981
D019327Copper SulfateCopper Sulfate results in increased expression of PHLDA1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PHLDA1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of PHLDA1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of PHLDA1 mRNA23958496
C089595cylindrospermopsincylindrospermopsin results in increased expression of PHLDA1 mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PHLDA1 mRNA23914054
C014347decitabinedecitabine affects the expression of PHLDA1 mRNA17194187|2330084
D003703DemecolcineDemecolcine results in increased expression of PHLDA1 mRNA23649840
D003976DiazinonDiazinon results in increased methylation of PHLDA1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PHLDA1 mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PHLDA1 mRNA28962523
D002945CisplatinCisplatin affects the expression of PHLDA1 mRNA23300844
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of PHLDA1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of PHLDA1 mRNA19561079|2739243
D002945CisplatinCisplatin results in increased expression of PHLDA1 mRNA21603599
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of PHLDA1 mRNA]27392435
D002945CisplatinPHLDA1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in increased expression of PHLDA1 mRNA21151649
D004008DiclofenacDiclofenac results in decreased expression of PHLDA1 mRNA26934552
D004026DieldrinDieldrin affects the expression of PHLDA1 mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PHLDA1 mRNA12771043
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of PHLDA1 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PHLDA1 mRNA15976192
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of PHLDA1 mRNA17374397
D004726EndosulfanEndosulfan results in decreased expression of PHLDA1 mRNA26615145
C118739entinostatentinostat results in increased expression of PHLDA1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PHLDA1 mRNA26865667
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PHLDA1 mRNA23649840
D011345FenofibrateFenofibrate results in decreased expression of PHLDA1 mRNA11798191
C000499ferric oxideferric oxide analog results in increased expression of PHLDA1 mRNA25086211
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PHLDA1 mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of PHLDA1 mRNA28329830
C007738fluorantheneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PHLDA1 mRNA]28329830
C061365flusilazoleflusilazole results in decreased expression of PHLDA1 mRNA22382673
C061365flusilazoleflusilazole results in increased expression of PHLDA1 mRNA22382673
D005485FlutamideFlutamide results in increased expression of PHLDA1 mRNA24793618
D004397FonofosFonofos results in decreased methylation of PHLDA1 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of PHLDA1 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of PHLDA1 mRNA23416264|2766457
C056933fumonisin B1fumonisin B1 results in decreased expression of PHLDA1 mRNA16221962
D019833GenisteinGenistein results in decreased expression of PHLDA1 mRNA22228119|2686566
D005947GlucoseGlucose results in increased expression of PHLDA1 mRNA17178593
D006418HemeHeme metabolite results in decreased expression of PHLDA1 mRNA19191707
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PHLDA1 mRNA20044591
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of PHLDA1 mRNA17572062
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHLDA1 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of PHLDA1 mRNA18927307
D007529IsoflavonesIsoflavones affects the expression of PHLDA1 mRNA16365062
D007545IsoproterenolIsoproterenol results in decreased expression of PHLDA1 mRNA20003209
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of PHLDA1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of PHLDA1 mRNA]27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PHLDA1 mRNA24435446
C045463leflunomideleflunomide results in increased expression of PHLDA1 mRNA28988120
C533894LG 100815LG 100815 results in increased expression of PHLDA1 mRNA16951191
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PHLDA1 mRNA"18930950
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PHLDA1 mRNA27339419
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PHLDA1 mRNA21641980
D008558MelphalanMelphalan results in increased expression of PHLDA1 mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of PHLDA1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PHLDA1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C500085muraglitazarmuraglitazar results in decreased expression of PHLDA1 mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of PHLDA1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of PHLDA1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PHLDA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PHLDA1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PHLDA1 mRNA"25554681
D009532NickelNickel results in increased expression of PHLDA1 mRNA23195993
C029938nickel sulfatenickel sulfate results in increased expression of PHLDA1 mRNA16780908|1737439
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PHLDA1 mRNA17616710
C025256nonylphenolnonylphenol results in decreased expression of PHLDA1 mRNA22982499
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of PHLDA1 mRNA"16951191
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of PHLDA1 mRNA24888373
D010081OxazoloneOxazolone results in increased expression of PHLDA1 mRNA17374397
D010100OxygenOxygen deficiency results in increased expression of PHLDA1 mRNA24236059
D010126OzoneOzone results in increased expression of PHLDA1 mRNA17095637
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PHLDA1 mRNA26272509
D010278ParathionParathion results in decreased methylation of PHLDA1 promoter22847954
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PHLDA1 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PHLDA1 mRNA25868421
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PHLDA1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of PHLDA1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of PHLDA1 mRNA19482888
D010656PhenylephrinePhenylephrine results in increased expression of PHLDA1 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PHLDA1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of PHLDA1 mRNA11798191|1844570
D010936Plant ExtractsPlant Extracts results in increased expression of PHLDA1 mRNA21920417
D010938Plant OilsPlant Oils results in increased expression of PHLDA1 mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of PHLDA1 mRNA24888373
D011374ProgesteroneProgesterone results in decreased expression of PHLDA1 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PHLDA1 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of PHLDA1 mRNA21795739
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PHLDA1 mRNA18556351
D011372ProgestinsProgestins results in increased expression of PHLDA1 mRNA19609016
C005556propionaldehydepropionaldehyde results in increased expression of PHLDA1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PHLDA1 mRNA24780913
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of PHLDA1 mRNA17639512
D011794QuercetinQuercetin results in increased expression of PHLDA1 mRNA21632981
D015474Isotretinoin[vorinostat co-treated with Isotretinoin] results in increased expression of PHLDA1 mRNA18769122
C089730rosiglitazonerosiglitazone results in decreased expression of PHLDA1 mRNA21515302
C093642SB 203580SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PHLDA1 mRNA]28329830
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of PHLDA1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of PHLDA1 mRNA19073995
D012834SilverSilver results in decreased expression of PHLDA1 mRNA26014281
D012906SmokeSmoke results in increased expression of PHLDA1 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of PHLDA1 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of PHLDA1 mRNA21281968
C016104sodium bichromatesodium bichromate results in increased expression of PHLDA1 mRNA27859739
C016104sodium bichromatesodium bichromate affects the expression of PHLDA1 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of PHLDA1 mRNA22561333
D018038Sodium SeleniteSodium Selenite results in increased expression of PHLDA1 mRNA24383545
D053260SootSoot results in increased expression of PHLDA1 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PHLDA1 mRNA21641980
D016559TacrolimusTacrolimus results in increased expression of PHLDA1 mRNA23958496
C047246temozolomidePHLDA1 mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in decreased methylation of PHLDA1 promoter22847954
C501413tesaglitazartesaglitazar results in decreased expression of PHLDA1 mRNA21515302
D013739TestosteroneTestosterone results in increased expression of PHLDA1 mRNA21669218
C004648testosterone enanthatetestosterone enanthate affects the expression of PHLDA1 mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of PHLDA1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHLDA1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PHLDA1 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PHLDA1 mRNA16704738|1969266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHLDA1 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PHLDA1 mRNA15034205|1869160
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHLDA1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHLDA1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of PHLDA1 mRNA15976192|1633717
C009495titanium dioxidetitanium dioxide results in increased expression of PHLDA1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PHLDA1 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of PHLDA1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of PHLDA1 mRNA21934132|2383079
D014212TretinoinTretinoin results in increased expression of PHLDA1 mRNA16604517
C034613triacsin Ctriacsin C results in increased expression of PHLDA1 mRNA16704987
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PHLDA1 mRNA25549359
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PHLDA1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PHLDA1 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PHLDA1 mRNA"18930950
D014520UrethaneUrethane results in decreased expression of PHLDA1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PHLDA1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PHLDA1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of PHLDA1 mRNA20546886
D014638VanadatesVanadates results in increased expression of PHLDA1 mRNA22714537
C025643vinclozolinvinclozolin affects the expression of PHLDA1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of PHLDA1 mRNA26682919
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of PHLDA1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of PHLDA1 mRNA20044591
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA1 mRNA"27188386
C111237vorinostat[vorinostat co-treated with Isotretinoin] results in increased expression of PHLDA1 mRNA18769122
C111237vorinostatvorinostat results in increased expression of PHLDA1 mRNA26272509
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PHLDA1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11369516  16189514  19060904  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0006915apoptotic process-IEA-  
GO:0045210FasL biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-TAS-  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854521Interaction between PHLDA1 and AURKATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27829007Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. (2016)Xu JPLoS One