Gene: LMTK2

22853
AATYK2|BREK|KPI-2|KPI2|LMR2|PPP1R100|cprk|hBREK
lemur tyrosine kinase 2
protein-coding
7q21.3
Ensembl:ENSG00000164715 MIM:610989 Vega:OTTHUMG00000154256 UniprotKB:Q8IWU2
NG_013375.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.212e-1 (AD)  8.368e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00747187chr7:97800068LMTK2Gene body1.826e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INPP4A0.972
MYH100.971
KIAA1549L0.969
LNX10.968
KALRN0.968
AAK10.967
DOCK30.967
MYCBP20.966
THRB0.965
TLN20.965

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.568
HEY2-0.567
MYL3-0.564
YES1-0.541
RAB13-0.539
RNF135-0.521
ASB4-0.517
SNHG18-0.513
CSAG1-0.51
REST-0.509

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of LMTK2 mRNA]22228805
C006780bisphenol Abisphenol A results in increased methylation of LMTK2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of LMTK2 mRNA25181051
D002330CarmustineLMTK2 mRNA affects the susceptibility to Carmustine16365179
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LMTK2 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of LMTK2 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of LMTK2 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of LMTK2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of LMTK2 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LMTK2 mRNA23640034
C000944dicrotophosdicrotophos results in increased expression of LMTK2 mRNA28302478
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of LMTK2 mRNA24690739
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LMTK2 gene20938992
C045463leflunomideleflunomide results in increased expression of LMTK2 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LMTK2 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LMTK2 gene20938992
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of LMTK2 mRNA"25926378
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LMTK2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LMTK2 mRNA"20188158
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of LMTK2 mRNA"25926378
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of LMTK2 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of LMTK2 mRNA]"21673326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LMTK2 mRNA25729387
C014153pirimiphos methylpirimiphos methyl results in increased expression of LMTK2 mRNA27845199
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of LMTK2 mRNA"26680231
C047246temozolomideLMTK2 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LMTK2 mRNA21570461|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LMTK2 mRNA21354282
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LMTK2 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LMTK2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LMTK2 mRNA19042947
D014520UrethaneUrethane results in increased expression of LMTK2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of LMTK2 mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in increased methylation of LMTK2 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of LMTK2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IDA12393858  16887929  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004864protein phosphatase inhibitor activity-IDA12393858  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI12393858  12832520  
GO:0005524ATP binding-NAS12393858  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0070853myosin VI binding-IPI18029400  18429820  
GO ID GO Term Qualifier Evidence PubMed
GO:0001881receptor recycling-IMP18029400  18429820  
GO:0001934positive regulation of protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA12393858  
GO:0007275multicellular organism development-IBA21873635  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA16887929  
GO:0018107peptidyl-threonine phosphorylation-IDA16887929  
GO:0030154cell differentiation-IBA21873635  
GO:0032456endocytic recycling-IMP18029400  
GO:0032515negative regulation of phosphoprotein phosphatase activity-IEA-  
GO:0033572transferrin transport-IMP18029400  18429820  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0045022early endosome to late endosome transport-IMP18429820  
GO:0046777protein autophosphorylation-IDA12393858  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005769early endosome-IDA18029400  18429820  
GO:0005794Golgi apparatus-IDA12832520  
GO:0005829cytosol-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IDA12393858  
GO:0030426growth cone-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IDA12832520  18429820  
GO:0055037recycling endosome-IDA18029400  18429820  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22975805The transcriptional landscape and mutational profile of lung adenocarcinoma. (2012 Nov)Seo JSGenome Res
23985253[Association of TET2, LMTK2 and FAM84B gene expression with prostate cancer risk in Chinese patients]. (2013 Apr)Wang NNZhonghua Zhong Liu Za Zhi