Gene: NTNG1

22854
Lmnt1
netrin G1
protein-coding
1p13.3
Ensembl:ENSG00000162631 MIM:608818 Vega:OTTHUMG00000010965 UniprotKB:Q9Y2I2
NG_042821.1
PubMed
0   ANCO-SNPs
CD|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.980e-1 (AD)  2.874e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRM70.921
SLIT20.913
PARM10.904
HTR2A0.904
RGS60.904
IGSF30.903
OLFM30.902
CA100.9
TPBG0.9
STS0.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.578
YES1-0.557
REST-0.555
ROM1-0.533
RAI14-0.531
MYOM1-0.524
TGFB3-0.522
DOCK1-0.52
STON2-0.52
ZHX2-0.519

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NTNG1 gene27153756
D000639AmitriptylineAmitriptyline results in decreased expression of NTNG1 mRNA22341215
C547126AZM551248AZM551248 results in decreased expression of NTNG1 mRNA22323515
D004958EstradiolEstradiol results in decreased expression of NTNG1 mRNA23019147
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NTNG1 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of NTNG1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NTNG1 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NTNG1 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of NTNG1 mRNA19549813
C030123coumarincoumarin results in decreased expression of NTNG1 mRNA18480146
D003561CytarabineCytarabine results in increased expression of NTNG1 mRNA21198554
D013759DronabinolDronabinol results in decreased expression of NTNG1 mRNA21955143
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NTNG1 promoter23359474
D004041Dietary FatsDietary Fats results in increased expression of NTNG1 mRNA25016146
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NTNG1 promoter23359474
D000431EthanolEthanol results in increased expression of NTNG1 mRNA21955143
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NTNG1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NTNG1 gene20938992
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of NTNG1 mRNA20886546
D009020MorphineMorphine results in decreased expression of NTNG1 mRNA21955143
D009538NicotineNicotine results in decreased expression of NTNG1 mRNA21955143
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of NTNG1 mRNA23602845
C006253pirinixic acidpirinixic acid results in increased expression of NTNG1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of NTNG1 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of NTNG1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of NTNG1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NTNG1 mRNA25351596
D019284ThapsigarginThapsigargin results in increased expression of NTNG1 mRNA22378314
C024746tobacco tartobacco tar results in decreased expression of NTNG1 mRNA19559774
D014050TolueneToluene results in increased expression of NTNG1 mRNA22967744
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of NTNG1 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of NTNG1 mRNA23179753
C111237vorinostatvorinostat results in decreased expression of NTNG1 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of NTNG1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14595443  21946559  
GO:0050839cell adhesion molecule binding-IPI23986473  
GO:0098632cell-cell adhesion mediator activity-IGI23986473  
GO ID GO Term Qualifier Evidence PubMed
GO:0007409axonogenesis-ISS-  
GO:0099560synaptic membrane adhesion-IGI23986473  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0046658anchored component of plasma membrane-ISS-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28074533Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence. (2018 Jan)Kelai SAddict Biol