Gene: ATG14

22863
ATG14L|BARKOR|KIAA0831
autophagy related 14
protein-coding
14q22.3
Ensembl:ENSG00000126775 MIM:613515 Vega:OTTHUMG00000172129 UniprotKB:Q6ZNE5
NC_000014.9
SNP Mapped
1   ANCO-SNPs
ND
0   
6.293e-1 (AD)  1.095e-2 (ND)   (Frontal_Cortex)
4.936e-1 (AD)  4.430e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17128434chr14:55386810 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MED140.908
RBM50.902
TNRC6A0.901
RCOR30.9
PPWD10.9
ELP20.899
U2SURP0.896
RBM260.892
SRSF110.892
TIA10.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.592
OR4F29-0.559
KLRC2-0.27
NKX6-1-0.264
MTRNR2L9-0.255
MTRNR2L6-0.244
WDR38-0.235
MTRNR2L10-0.235
CCDC102A-0.232
PGF-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ATG14 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ATG14 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of ATG14 mRNA"23146750
D000082AcetaminophenAcetaminophen affects the expression of ATG14 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ATG14 gene27153756
D001280AtrazineAtrazine results in increased expression of ATG14 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of ATG14 mRNA23146750
C006780bisphenol Abisphenol A results in increased expression of ATG14 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ATG14 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of ATG14 mRNA26079696
C034939cadmium sulfidecadmium sulfide results in increased expression of ATG14 mRNA27866839
C018021cobaltous chloridecobaltous chloride results in increased expression of ATG14 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in increased expression of ATG14 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of ATG14 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of ATG14 mRNA19167446
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ATG14 mRNA]27941970
D000431EthanolEthanol results in increased expression of ATG14 mRNA24095927
D000431EthanolFOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of ATG14 mRNA]24095927
D005485FlutamideFlutamide results in increased expression of ATG14 mRNA24793618
C410337K 7174K 7174 results in increased expression of ATG14 mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ATG14 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ATG14 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ATG14 mRNA"25554681
C046012pentanalpentanal results in decreased expression of ATG14 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ATG14 mRNA23146750
D010634PhenobarbitalPhenobarbital results in increased expression of ATG14 mRNA19270015
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ATG14 mRNA28903501
D012643SeleniumSelenium results in decreased expression of ATG14 mRNA19244175
D012999SomanSoman results in decreased expression of ATG14 mRNA19281266
D013605T-2 ToxinT-2 Toxin results in increased expression of ATG14 mRNA26138683
D014520UrethaneUrethane results in increased expression of ATG14 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ATG14 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19050071  19270696  20562859  21062745  22081109  22493499  
23112296  23332761  23954414  24034250  24785657  25127057  
25490155  25594178  25686604  26496610  
GO:0051020GTPase binding-IPI25891078  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000045autophagosome assembly-IMP19270696  
GO:0000423mitophagy-IBA21873635  
GO:0000423mitophagy-IMP23878393  
GO:0001932regulation of protein phosphorylation-IMP23878393  
GO:0001933negative regulation of protein phosphorylation-ISS-  
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0008333endosome to lysosome transport-IGI22797916  
GO:0009267cellular response to starvation-IBA21873635  
GO:0009267cellular response to starvation-IMP23878393  
GO:0010608posttranscriptional regulation of gene expression-IMP23878393  
GO:0016236macroautophagy-IMP23878393  
GO:0016236macroautophagy-TAS-  
GO:0016240autophagosome membrane docking-IDA25686604  
GO:0042149cellular response to glucose starvation-ISS-  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IBA21873635  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IDA21062745  
GO:0061635regulation of protein complex stability-IC23878393  
GO:0098780response to mitochondrial depolarisation-IMP23878393  
GO ID GO Term Qualifier Evidence PubMed
GO:0000421autophagosome membrane-IEA-  
GO:0005776autophagosome-IBA21873635  
GO:0005776autophagosome-IDA19270696  25686604  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0005930axoneme-ISS-  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0034045phagophore assembly site membrane-IBA21873635  
GO:0034045phagophore assembly site membrane-IDA19270696  
GO:0034045phagophore assembly site membrane-TAS-  
GO:0035032phosphatidylinositol 3-kinase complex, class III-IBA21873635  
GO:0035032phosphatidylinositol 3-kinase complex, class III-ISS-  
GO:0044233ER-mitochondrion membrane contact site-IBA21873635  
GO:0097629extrinsic component of omegasome membrane-IBA21873635  
GO:0097629extrinsic component of omegasome membrane-IDA21518905  
GO:0097632extrinsic component of phagophore assembly site membrane-IBA21873635  
GO:0097632extrinsic component of phagophore assembly site membrane-IDA21518905  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal