Gene: PPP6R1

22870
KIAA1115|PP6R1|SAP190|SAPS1
protein phosphatase 6 regulatory subunit 1
protein-coding
19q13.42
Ensembl:ENSG00000105063 MIM:610875 Vega:OTTHUMG00000180704 UniprotKB:Q9UPN7
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.983e-1 (AD)  6.848e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4473307chr19:55255438 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIK3R20.951
DLGAP40.951
RAB11FIP30.95
SEMA6B0.945
CBX60.939
DENND4B0.937
SYNPO0.937
BAP10.936
NACC10.935
C6orf1060.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.673
OR4F29-0.621
S100A12-0.361
HBD-0.349
IL18RAP-0.348
SNHG18-0.333
CTNNA3-0.333
KCNJ15-0.327
VNN2-0.326
CST7-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D004958EstradiolEstradiol affects the expression of PPP6R1 mRNA22574217
C006780bisphenol Abisphenol A affects the expression of PPP6R1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PPP6R1 gene28505145
C584509C646 compoundC646 compound results in decreased expression of PPP6R1 mRNA26191083
C018021cobaltous chloridecobaltous chloride results in increased expression of PPP6R1 mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of PPP6R1 mRNA25562108
C000944dicrotophosdicrotophos results in increased expression of PPP6R1 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PPP6R1 mRNA17557909
D018120FinasterideFinasteride results in increased expression of PPP6R1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of PPP6R1 mRNA24136188
C492448ICG 001ICG 001 results in decreased expression of PPP6R1 mRNA26191083
D007657Ketone BodiesKetone Bodies results in increased expression of PPP6R1 mRNA16807920
D007854LeadLead results in decreased expression of PPP6R1 mRNA19921347
D008694MethamphetamineMethamphetamine results in increased expression of PPP6R1 mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PPP6R1 mRNA"20188158
D009532NickelNickel results in increased expression of PPP6R1 mRNA25583101
D010938Plant OilsPlant Oils results in increased expression of PPP6R1 mRNA23370395
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PPP6R1 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PPP6R1 mRNA25895662
D013467SulindacSulindac results in decreased expression of PPP6R1 mRNA24136188
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PPP6R1 mRNA28065790
D014520UrethaneUrethane results in increased expression of PPP6R1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of PPP6R1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of PPP6R1 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14743216  16769727  18186651  21187329  24255178  28330616  
GO:0017048Rho GTPase binding-IPI25743393  
GO:0019903protein phosphatase binding-IPI16716191  
GO ID GO Term Qualifier Evidence PubMed
GO:0043666regulation of phosphoprotein phosphatase activity-IDA16716191  
GO:0048208COPII vesicle coating-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal