Gene info: ID 22874

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg00067196	chr1:204189242	PLEKHA6	3'UTR	4.066e-4	Alcohol use disorders	26763658
cg16029875	chr1:204320179	PLEKHA6		1.600e-10	Smoking	27651444
cg23094674	chr1:204329186	PLEKHA6		7.800e-10	Smoking	27651444
cg26895569	chr1:204329222	PLEKHA6		9.800e-9	Smoking	27651444

Gene Symbol	Pearson Correlation Coefficient
CLASP1	0.925
GRAMD1B	0.917
RUSC2	0.913
WIPF2	0.913
MAPT	0.911
FAIM2	0.911
CORO2B	0.91
CTIF	0.91
TMEM25	0.907
FAM171A1	0.904

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.593
OR4F29	-0.564
TFPI2	-0.557
C9orf135	-0.514
FCRLA	-0.475
CD48	-0.456
KLRF1	-0.45
PROK2	-0.45
SLAMF6	-0.448
PRRX2	-0.447

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLEKHA6 mRNA"	25510870
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLEKHA6 mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLEKHA6 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLEKHA6 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLEKHA6 mRNA"	25510870
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PLEKHA6 mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLEKHA6 mRNA"	25510870
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PLEKHA6 mRNA	16788091
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of PLEKHA6 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in decreased expression of PLEKHA6 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of PLEKHA6 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of PLEKHA6 mRNA	17562736
D001151	Arsenic	Arsenic affects the methylation of PLEKHA6 gene	25304211
C006632	arsenic trioxide	PLEKHA6 protein results in decreased susceptibility to arsenic trioxide	20707922
D001280	Atrazine	Atrazine results in decreased expression of PLEKHA6 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PLEKHA6 mRNA	21569818\|2222880
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLEKHA6 mRNA	25566086
D004958	Estradiol	Estradiol results in increased expression of PLEKHA6 mRNA	19484750
D004958	Estradiol	Estradiol results in increased expression of PLEKHA6 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of PLEKHA6 mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of PLEKHA6 gene	22576693
C006780	bisphenol A	bisphenol A results in decreased methylation of PLEKHA6 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of PLEKHA6 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of PLEKHA6 mRNA	26079696
D002220	Carbamazepine	Carbamazepine affects the expression of PLEKHA6 mRNA	25979313
D002737	Chloroprene	Chloroprene results in decreased expression of PLEKHA6 mRNA	23125180
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PLEKHA6 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of PLEKHA6 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of PLEKHA6 mRNA	25562108
C007262	deoxynivalenol	deoxynivalenol affects the phosphorylation of PLEKHA6 protein	23811945
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PLEKHA6 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of PLEKHA6 mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of PLEKHA6 mRNA	28302478
D002117	Calcitriol	Calcitriol results in increased expression of PLEKHA6 mRNA	21592394\|2648566
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of PLEKHA6 mRNA	21592394
D004237	Diuron	Diuron results in decreased expression of PLEKHA6 mRNA	25152437
D005485	Flutamide	Flutamide results in decreased expression of PLEKHA6 mRNA	24136188
D017313	Fenretinide	Fenretinide results in increased expression of PLEKHA6 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PLEKHA6 mRNA	20044591\|2117940
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of PLEKHA6 mRNA	23527032
D008694	Methamphetamine	Methamphetamine results in increased expression of PLEKHA6 mRNA	26307267
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [AHR protein binds to PLEKHA6 promoter]	20348232
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PLEKHA6 mRNA	23103053
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PLEKHA6 mRNA	26011545
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of PLEKHA6 mRNA	29191790
C523799	MRK 003	PLEKHA6 results in decreased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PLEKHA6 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of PLEKHA6 mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in decreased expression of PLEKHA6 mRNA	19167457
C016030	pantogab	pantogab results in decreased expression of PLEKHA6 mRNA	17379144
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLEKHA6 mRNA"	25510870
D010634	Phenobarbital	Phenobarbital affects the expression of PLEKHA6 mRNA	23091169
C005556	propionaldehyde	propionaldehyde results in decreased expression of PLEKHA6 mRNA	26079696
D011794	Quercetin	Quercetin results in increased expression of PLEKHA6 mRNA	21632981
D012715	Sesame Oil	Sesame Oil results in increased expression of PLEKHA6 mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of PLEKHA6 mRNA	25895662
D053260	Soot	Soot results in decreased expression of PLEKHA6 mRNA	22461453
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of PLEKHA6 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of PLEKHA6 mRNA	21592394
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of PLEKHA6 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PLEKHA6 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PLEKHA6 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PLEKHA6 mRNA	21215274
D013849	Thimerosal	Thimerosal results in decreased expression of PLEKHA6 mRNA	24675092
C009495	titanium dioxide	titanium dioxide results in decreased expression of PLEKHA6 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of PLEKHA6 mRNA	20133372
D014212	Tretinoin	Tretinoin results in increased expression of PLEKHA6 mRNA	21934132\|2372400
D014212	Tretinoin	Tretinoin results in increased expression of PLEKHA6 mRNA	16788091
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of PLEKHA6 mRNA	19042947
D014635	Valproic Acid	Valproic Acid results in increased expression of PLEKHA6 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of PLEKHA6 gene	29154799
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PLEKHA6 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of PLEKHA6 mRNA	27188386

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1483255	PI Metabolism	TAS
R-HSA-1483257	Phospholipid metabolism	TAS
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	TAS
R-HSA-556833	Metabolism of lipids	TAS

Gene: PLEKHA6

DNA Methylation

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)