Gene: MON1B

22879
HSRG1|SAND2|SRG1
MON1 homolog B, secretory trafficking associated
protein-coding
16q23.1
Ensembl:ENSG00000103111 MIM:608954 Vega:OTTHUMG00000137618 UniprotKB:Q7L1V2
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  1.792e-1 (ND)   (Frontal_Cortex)
9.256e-1 (AD)  3.420e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11640619chr16:77199271 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCAF70.914
SNX190.903
EIF3A0.896
NBR10.891
BAZ1B0.881
RNF200.867
NUCKS10.867
WDFY30.865
TPR0.863
TEX20.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.706
OR4F5-0.682
PSMB11-0.179
C17orf112-0.178
NANOGNB-0.17
OR4F16-0.169
PAEP-0.144
GRHL2-0.136
SPRR2D-0.133
FGA-0.13

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide affects the expression of MON1B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MON1B gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MON1B mRNA24449571
D001280AtrazineAtrazine results in increased expression of MON1B mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MON1B mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of MON1B mRNA25181051
D003471CuprizoneCuprizone affects the expression of MON1B mRNA27523638
D003471CuprizoneCuprizone results in increased expression of MON1B mRNA26577399
D003976DiazinonDiazinon results in increased methylation of MON1B gene22964155
D004026DieldrinDieldrin results in increased expression of MON1B mRNA20438755
C039281furanfuran results in decreased expression of MON1B mRNA25539665
C004312glycidolglycidol results in increased expression of MON1B mRNA24915197
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MON1B mRNA"24972896
C028007nickel monoxidenickel monoxide results in decreased expression of MON1B mRNA19167457
C006253pirinixic acidpirinixic acid results in decreased expression of MON1B mRNA20813756
D011441PropylthiouracilPropylthiouracil results in decreased expression of MON1B mRNA24780913
D012643SeleniumSelenium results in increased expression of MON1B mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of MON1B mRNA20371982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MON1B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MON1B mRNA22298810
D013806TheophyllineTheophylline results in decreased expression of MON1B mRNA18951874
D014520UrethaneUrethane results in increased expression of MON1B mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MON1B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MON1B mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of MON1B gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MON1B gene25560391
C025643vinclozolinvinclozolin results in increased expression of MON1B mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20434987  21509660  
GO ID GO Term Qualifier Evidence PubMed
GO:0019085early viral transcription-IDA21509660  
GO:0019086late viral transcription-IDA21509660  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA21509660  
GO:0035658Mon1-Ccz1 complex-IDA29038162  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal