Gene: CLSTN1

22883
ALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2
calsyntenin 1
protein-coding
1p36.22
Ensembl:ENSG00000171603 MIM:611321 Vega:OTTHUMG00000001451 UniprotKB:O94985
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.504e-1 (AD)  7.387e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04570362chr1:9871402CLSTN1Gene body3.439e-4Alcohol use disorders26763658
cg03986322chr1:9789699CLSTN14.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V0A10.987
FAIM20.977
MAPT0.977
RUSC20.977
GSK3A0.976
SCAMP50.974
TOLLIP0.974
HK10.973
SYNGR10.972
ATG9A0.972

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.669
OR4F29-0.621
TFPI2-0.485
RAI14-0.444
REST-0.432
WWTR1-0.422
IL18RAP-0.418
CD48-0.417
C9orf135-0.416
KCNJ15-0.412

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CLSTN1 mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CLSTN1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of CLSTN1 mRNA22230336
C016601afimoxifeneafimoxifene results in decreased expression of CLSTN1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLSTN1 mRNA19770486
C006632arsenic trioxidearsenic trioxide results in decreased expression of CLSTN1 mRNA22521957
C547126AZM551248AZM551248 results in decreased expression of CLSTN1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLSTN1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLSTN1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of CLSTN1 mRNA16514628
C044887beta-methylcholinebeta-methylcholine affects the expression of CLSTN1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CLSTN1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CLSTN1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of CLSTN1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CLSTN1 mRNA15336504
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA]"20230807
C100187chloropicrinchloropicrin results in decreased expression of CLSTN1 mRNA28476498
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLSTN1 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of CLSTN1 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of CLSTN1 mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of CLSTN1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CLSTN1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CLSTN1 mRNA21266533
D004147DioxinsDioxins affects the expression of CLSTN1 mRNA20463971
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLSTN1 mRNA20938992
C070081fulvestrantfulvestrant results in decreased expression of CLSTN1 mRNA16514628
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of CLSTN1 gene28505145
C010974glyphosateglyphosate results in increased expression of CLSTN1 mRNA25636363
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA28628672
D007854LeadLead affects the expression of CLSTN1 mRNA28903495
D007854LeadLead affects the splicing of CLSTN1 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CLSTN1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLSTN1 mRNA20938992
D008727MethotrexateCLSTN1 protein affects the susceptibility to Methotrexate16217747
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CLSTN1 mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA]"20230807
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CLSTN1 mRNA"25554681
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA]"20230807
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CLSTN1 mRNA25729387
C006253pirinixic acidpirinixic acid results in decreased expression of CLSTN1 mRNA17426115
D011374ProgesteroneProgesterone results in increased expression of CLSTN1 mRNA23018184
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of CLSTN1 mRNA16514628
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of CLSTN1 protein25895662
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CLSTN1 mRNA25729387
D014415TunicamycinTunicamycin results in decreased expression of CLSTN1 mRNA17127020
D014520UrethaneUrethane results in increased expression of CLSTN1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of CLSTN1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of CLSTN1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CLSTN1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of CLSTN1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IDA17332754  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI17332754  
GO:0019894kinesin binding-IPI17332754  
GO:0042988X11-like protein binding-IPI12972431  17332754  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IEA-  
GO:0007155cell adhesion-TAS17332754  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0050806positive regulation of synaptic transmission-IBA21873635  
GO:0050806positive regulation of synaptic transmission-IEA-  
GO:0051965positive regulation of synapse assembly-IBA21873635  
GO:0051965positive regulation of synapse assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IEA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0042995cell projection-IEA-  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis