Gene info: ID 2289

Gene: FKBP5

GENE ID: 2289

Description: FK506 binding protein 5

Gene type: protein-coding

Location: 6p21.31

dbXrefs: Ensembl:ENSG00000096060 MIM:602623 Vega:OTTHUMG00000014576 UniprotKB:Q13451

RefSeq: NG_012645.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.136e-2 (AD) 9.287e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07633853	chr6:35569471	FKBP5	Gene body	7.293e-5	Alcohol use disorders	26763658
cg19014730	chr6:35635985	FKBP5		6.200e-12	Smoking	27651444
cg20813374	chr6:35657180	FKBP5		6.300e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDK4	0.778
CALCOCO2	0.777
PRKX	0.774
SLC52A3	0.774
RPGR	0.77
GMNN	0.742
OSBPL11	0.74
IFNGR1	0.734
CHST3	0.732
IL4R	0.73

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRH	-0.505
CPLX3	-0.488
HAPLN1	-0.48
IGF1	-0.471
ABCC12	-0.459
HCRTR1	-0.457
NOTUM	-0.455
PTHLH	-0.45
WNT7A	-0.449
VIP	-0.449

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of FKBP5 mRNA"	15375163
C020365	17-alpha-hydroxy-progesterone caproate	17-alpha-hydroxy-progesterone caproate inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
C020365	17-alpha-hydroxy-progesterone caproate	17-alpha-hydroxy-progesterone caproate inhibits the reaction [NR3C1 protein results in increased expression of FKBP5 mRNA]	19255438
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FKBP5 mRNA"	25614096
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of FKBP5 mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FKBP5 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of FKBP5 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of FKBP5 mRNA"	20406850
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of FKBP5 mRNA"	21346803
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FKBP5 mRNA]"	19467301
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of FKBP5 mRNA	12958071
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of FKBP5 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FKBP5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FKBP5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FKBP5 mRNA"	27188386
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to FKBP5 protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to FKBP5 protein]	26598702
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FKBP5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FKBP5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FKBP5 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of FKBP5 mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in decreased expression of FKBP5 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of FKBP5 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of FKBP5 mRNA]	18829485
C109238	acyline	acyline results in decreased expression of FKBP5 mRNA	17510436
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of FKBP5 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of FKBP5 gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of FKBP5 mRNA	21757418
D000452	Aldrin	Aldrin results in decreased expression of FKBP5 mRNA	18579281
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of FKBP5 mRNA	18007998\|2655845
D000638	Amiodarone	Amiodarone affects the expression of FKBP5 mRNA	25064622
C006632	arsenic trioxide	arsenic trioxide affects the expression of FKBP5 mRNA	25873331
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to FKBP5 protein]	26598702
D001262	Atenolol	Atenolol results in decreased expression of FKBP5 mRNA	19915711
C017037	aurin	aurin inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
C017037	aurin	aurin inhibits the reaction [NR3C1 protein results in increased expression of FKBP5 mRNA]	19255438
C547126	AZM551248	AZM551248 results in increased expression of FKBP5 mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in increased expression of FKBP5 mRNA	23656298
C065857	beclomethasone 17-monopropionate	beclomethasone 17-monopropionate results in increased expression of FKBP5 mRNA	23704983
D001554	Benzene	Benzene results in increased expression of FKBP5 protein	15036117
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FKBP5 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FKBP5 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FKBP5 mRNA	21569818
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FKBP5 mRNA"	20382639
D004958	Estradiol	Estradiol results in decreased expression of FKBP5 mRNA	24223173
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of FKBP5 mRNA	20660070
D004958	Estradiol	Estradiol inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	23183181
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of FKBP5 mRNA	17404688
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of FKBP5 mRNA	19693291
D004958	Estradiol	Estradiol inhibits the reaction [[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 mRNA]	26427651
D004958	Estradiol	Estradiol results in increased expression of FKBP5 mRNA	19484750
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FKBP5 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of FKBP5 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of FKBP5 mRNA	26364221
C006780	bisphenol A	bisphenol A results in decreased expression of FKBP5 mRNA	18007998\|2927551
C006780	bisphenol A	[bisphenol A co-treated with Bucladesine] results in increased methylation of FKBP5 intron	26427651
C006780	bisphenol A	bisphenol A promotes the reaction [[fulvestrant co-treated with Bucladesine] results in increased methylation of FKBP5 intron]	26427651
C006780	bisphenol A	bisphenol A results in increased expression of FKBP5 mRNA	25594700
C006780	bisphenol A	[Bucladesine co-treated with bisphenol A] results in decreased expression of FKBP5 mRNA	26427651
C006780	bisphenol A	[Bucladesine co-treated with bisphenol A] results in decreased expression of FKBP5 protein	26427651
C006780	bisphenol A	Dexamethasone inhibits the reaction [[Bucladesine co-treated with bisphenol A] results in decreased expression of FKBP5 mRNA]	26427651
C006780	bisphenol A	bisphenol A results in decreased expression of FKBP5 protein	26427651
C006780	bisphenol A	bisphenol A results in increased expression of FKBP5 mRNA	24988533
C006780	bisphenol A	bisphenol A results in increased methylation of FKBP5 intron	26427651
D000069286	Bortezomib	Bortezomib results in decreased expression of FKBP5 mRNA	20977926
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of FKBP5 protein	23736079
D002101	Cacodylic Acid	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of FKBP5 mRNA	23192986
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of FKBP5 mRNA	18560533
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of FKBP5 mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of FKBP5 promoter	22457795
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of FKBP5 mRNA	25993096
D002330	Carmustine	Carmustine results in increased expression of FKBP5 mRNA	16005536
C099555	CD 437	CD 437 results in decreased expression of FKBP5 mRNA	12958071
D002737	Chloroprene	Chloroprene results in increased expression of FKBP5 mRNA	23125180
D002737	Chloroprene	Chloroprene results in increased expression of FKBP5 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of FKBP5 mRNA	25064622
D002746	Chlorpromazine	Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein]	21034739
C011585	ciclopirox	ciclopirox inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
D002922	Ciguatoxins	Ciguatoxins affects the expression of FKBP5 mRNA	18353800
D002994	Clofibrate	Clofibrate results in decreased expression of FKBP5 mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FKBP5 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of FKBP5 mRNA	24386269
D005576	Colforsin	Colforsin promotes the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of FKBP5 mRNA	20971185
D003300	Copper	Copper results in increased expression of FKBP5 mRNA	25646894
D019327	Copper Sulfate	Copper Sulfate results in increased expression of FKBP5 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of FKBP5 mRNA	18579281
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of FKBP5 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of FKBP5 mRNA	19167446
D003471	Cuprizone	Cuprizone results in decreased expression of FKBP5 mRNA	26577399
D016572	Cyclosporine	Cyclosporine affects the expression of FKBP5 mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in decreased expression of FKBP5 mRNA	20106945
D003622	Dapsone	Dapsone analog inhibits the reaction [Metribolone results in increased expression of FKBP5 mRNA]	21440447
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of FKBP5 mRNA	24317228
C017180	decamethrin	decamethrin results in increased expression of FKBP5 mRNA	19017407
D003907	Dexamethasone	17-alpha-hydroxy-progesterone caproate inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
D003907	Dexamethasone	aurin inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
D003907	Dexamethasone	ciclopirox inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
D003907	Dexamethasone	Colforsin promotes the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	19255438
D003907	Dexamethasone	Dexamethasone results in increased expression of FKBP5 mRNA	12732289\|1567904
D003907	Dexamethasone	Dexamethasone results in increased expression of FKBP5 protein	15679045
D003907	Dexamethasone	Estradiol inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	23183181
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FKBP5 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FKBP5 mRNA	28628672
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	17690134
D003907	Dexamethasone	[Bucladesine co-treated with Dexamethasone] results in increased expression of FKBP5 mRNA	26427651
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FKBP5 mRNA	16054899
D003907	Dexamethasone	Dexamethasone inhibits the reaction [[Bucladesine co-treated with bisphenol A] results in decreased expression of FKBP5 mRNA]	26427651
D003907	Dexamethasone	Dexamethasone results in increased expression of FKBP5 mRNA	22733784\|2349337
D003907	Dexamethasone	NR3C1 gene mutant form inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	23493372
D003907	Dexamethasone	Dexamethasone results in increased expression of FKBP5 mRNA	20032058\|2911145
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	20032058
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FKBP5 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of FKBP5 mRNA	21266533
D003994	Bucladesine	[bisphenol A co-treated with Bucladesine] results in increased methylation of FKBP5 intron	26427651
D003994	Bucladesine	bisphenol A promotes the reaction [[fulvestrant co-treated with Bucladesine] results in increased methylation of FKBP5 intron]	26427651
D003994	Bucladesine	[Bucladesine co-treated with bisphenol A] results in decreased expression of FKBP5 mRNA	26427651
D003994	Bucladesine	[Bucladesine co-treated with bisphenol A] results in decreased expression of FKBP5 protein	26427651
D003994	Bucladesine	[Bucladesine co-treated with Dexamethasone] results in increased expression of FKBP5 mRNA	26427651
D003994	Bucladesine	[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 mRNA	26427651
D003994	Bucladesine	[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 protein	26427651
D003994	Bucladesine	Dexamethasone inhibits the reaction [[Bucladesine co-treated with bisphenol A] results in decreased expression of FKBP5 mRNA]	26427651
D003994	Bucladesine	Estradiol inhibits the reaction [[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 mRNA]	26427651
D003994	Bucladesine	[fulvestrant co-treated with Bucladesine] results in increased methylation of FKBP5 intron	26427651
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of FKBP5 mRNA	28962523
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FKBP5 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats affects the expression of FKBP5 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of FKBP5 mRNA	18042831\|2501614
D004041	Dietary Fats	Dietary Fats results in increased expression of FKBP5 mRNA	19467301
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of FKBP5 mRNA	21318169
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FKBP5 mRNA	18164116
D002117	Calcitriol	Calcitriol results in increased expression of FKBP5 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of FKBP5 mRNA	21592394
C062856	dimethylarsine	[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of FKBP5 mRNA	25873331
D004147	Dioxins	Dioxins affects the expression of FKBP5 mRNA	20463971
D004317	Doxorubicin	FKBP5 protein affects the reaction [Doxorubicin results in increased degradation of and results in decreased expression of NFKBIA protein]	15571967
D004317	Doxorubicin	Doxorubicin results in increased expression of FKBP5 mRNA	25896364
C118739	entinostat	entinostat results in increased expression of FKBP5 mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FKBP5 mRNA"	27188386
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FKBP5 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of FKBP5 mRNA	25064622
D015025	Zearalenone	Zearalenone results in decreased expression of FKBP5 mRNA	24412631
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of FKBP5 mRNA]	15016801
C069837	fullerene C60	fullerene C60 affects the expression of FKBP5 mRNA	19167457
C408042	fullerol C60(OH)24	fullerol C60(OH)24 results in decreased expression of FKBP5 mRNA	21513982
C070081	fulvestrant	bisphenol A promotes the reaction [[fulvestrant co-treated with Bucladesine] results in increased methylation of FKBP5 intron]	26427651
C070081	fulvestrant	[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 mRNA	26427651
C070081	fulvestrant	[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 protein	26427651
C070081	fulvestrant	Estradiol inhibits the reaction [[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 mRNA]	26427651
C070081	fulvestrant	[fulvestrant co-treated with Bucladesine] results in increased methylation of FKBP5 intron	26427651
C039281	furan	furan results in increased expression of FKBP5 mRNA	26194646
D019833	Genistein	Genistein results in decreased expression of FKBP5 mRNA	23160963
D005897	Glafenine	Glafenine results in increased expression of FKBP5 mRNA	24136188
C004312	glycidol	glycidol results in increased expression of FKBP5 mRNA	24915197
C010974	glyphosate	[Surface-Active Agents co-treated with glyphosate] results in increased expression of FKBP5 mRNA	22467014
D006854	Hydrocortisone	Hydrocortisone results in increased expression of FKBP5 mRNA	21267416
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of FKBP5 mRNA	26846883
C492448	ICG 001	ICG 001 results in decreased expression of FKBP5 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FKBP5 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FKBP5 mRNA	28628672
C051890	irinotecan	irinotecan results in increased expression of FKBP5 mRNA	20097248
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FKBP5 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FKBP5 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FKBP5 mRNA	16054899
D007545	Isoproterenol	Isoproterenol results in increased expression of FKBP5 mRNA	20003209
C008261	lead acetate	lead acetate results in increased expression of FKBP5 mRNA	22641619
D064704	Levofloxacin	Levofloxacin results in increased expression of FKBP5 mRNA	24136188
D008070	Lipopolysaccharides	Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein]	21034739
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of FKBP5 protein	21034739
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA	18386188
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of FKBP5 mRNA	19146866\|2084394
C042720	mercuric bromide	mercuric bromide results in decreased expression of FKBP5 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FKBP5 mRNA"	27188386
D008727	Methotrexate	Methotrexate results in increased expression of FKBP5 mRNA	16005536
C543395	methylarsine	[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of FKBP5 mRNA	25873331
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of FKBP5 mRNA	26011545
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of FKBP5 protein	26558463
C008493	methylselenic acid	methylselenic acid affects the expression of FKBP5 mRNA	14617803
D015741	Metribolone	Dapsone analog inhibits the reaction [Metribolone results in increased expression of FKBP5 mRNA]	21440447
D015741	Metribolone	Metribolone results in increased expression of FKBP5 mRNA	16751804\|1701067
D015741	Metribolone	Metribolone results in increased expression of FKBP5 protein	17152098
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	17690134
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of FKBP5 mRNA	22401849
C020300	monomethylarsonic acid	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of FKBP5 mRNA	23192986
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of FKBP5 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of FKBP5 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of FKBP5 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FKBP5 mRNA"	25554681\|2562005
C031721	naphthalene	naphthalene results in increased expression of FKBP5 mRNA	18978301
D019829	Nevirapine	Nevirapine metabolite results in increased expression of FKBP5 mRNA	23947594
D019829	Nevirapine	Nevirapine results in increased expression of FKBP5 mRNA	23947594
C022838	nickel chloride	nickel chloride results in decreased expression of FKBP5 mRNA	24612858
C028007	nickel monoxide	nickel monoxide results in increased expression of FKBP5 mRNA	19167457
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of FKBP5 mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of FKBP5 mRNA	25729387
D010098	Oxycodone	Oxycodone results in increased expression of FKBP5 mRNA	23439660
D010126	Ozone	Ozone results in increased expression of FKBP5 mRNA	17460151\|1955522
D010126	Ozone	Ozone results in increased expression of FKBP5 mRNA	28623178
D000073878	Palm Oil	Palm Oil affects the expression of FKBP5 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of FKBP5 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of FKBP5 mRNA	17379144
D010269	Paraquat	Paraquat affects the expression of FKBP5 mRNA	25064622
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA	18386188
D010269	Paraquat	Paraquat results in increased expression of FKBP5 mRNA	12595580
D010269	Paraquat	Paraquat affects the expression of FKBP5 mRNA	16854511
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of FKBP5 mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of FKBP5 mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of FKBP5 mRNA	17560707
D010634	Phenobarbital	Phenobarbital affects the expression of FKBP5 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of FKBP5 mRNA	19270015
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FKBP5 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of FKBP5 mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in decreased expression of FKBP5 mRNA	22538082
C006253	pirinixic acid	pirinixic acid results in increased expression of FKBP5 mRNA	18301758\|1844570
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of FKBP5 mRNA]	21318169
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of FKBP5 mRNA	28903501
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of FKBP5 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of FKBP5 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of FKBP5 mRNA	17404688\|1803715
D011374	Progesterone	Progesterone affects the expression of FKBP5 mRNA	21291521
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of FKBP5 mRNA	19693291
D011441	Propylthiouracil	Propylthiouracil affects the expression of FKBP5 mRNA	24780913
C005266	quinomethionate	quinomethionate affects the expression of FKBP5 mRNA	15387888
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of FKBP5 mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of FKBP5 protein	25505154
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FKBP5 mRNA	16054899
D012402	Rotenone	Rotenone results in decreased expression of FKBP5 mRNA	23186747
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of FKBP5 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of FKBP5 mRNA	23221170
D020123	Sirolimus	Sirolimus binds to and results in decreased activity of FKBP5 protein	15571967\|1587898
C009277	sodium arsenate	sodium arsenate results in decreased expression of FKBP5 mRNA	23922661
C017947	sodium arsenite	[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of FKBP5 mRNA	25873331
C017947	sodium arsenite	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of FKBP5 mRNA	23192986
C017947	sodium arsenite	sodium arsenite results in increased expression of FKBP5 mRNA	28595984
C017947	sodium arsenite	sodium arsenite results in increased expression of FKBP5 mRNA	17682005
C016104	sodium bichromate	sodium bichromate results in decreased expression of FKBP5 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of FKBP5 mRNA	22561333\|2599309
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of FKBP5 protein	28918527
D053260	Soot	Soot affects the expression of FKBP5 mRNA	26551751
D013501	Surface-Active Agents	[Surface-Active Agents co-treated with glyphosate] results in increased expression of FKBP5 mRNA	22467014
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FKBP5 mRNA"	18579281
D016559	Tacrolimus	Tacrolimus inhibits the reaction [NR3C1 protein binds to FKBP5 protein]	15697228
C013698	tallow	tallow affects the expression of FKBP5 mRNA	19680557
C061133	tamibarotene	tamibarotene results in decreased expression of FKBP5 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of FKBP5 mRNA	20937368
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of FKBP5 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of FKBP5 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of FKBP5 mRNA	19693291\|2040306
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]	20032058
C004648	testosterone enanthate	testosterone enanthate affects the expression of FKBP5 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FKBP5 mRNA	16443690\|1849575
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FKBP5 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FKBP5 mRNA	24680724
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of FKBP5 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FKBP5 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FKBP5 mRNA	17035482
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FKBP5 mRNA	21215274
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of FKBP5 mRNA	28973375
D013752	Tetracycline	Tetracycline affects the expression of FKBP5 mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	BAG1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FKBP5 mRNA]	20858459
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of FKBP5 mRNA	20858459
D013853	Thioacetamide	Thioacetamide affects the expression of FKBP5 mRNA	25064622
D013866	Thioguanine	Thioguanine results in increased expression of FKBP5 mRNA	16005536
C009495	titanium dioxide	titanium dioxide results in decreased expression of FKBP5 mRNA	21513982
C009495	titanium dioxide	titanium dioxide results in decreased expression of FKBP5 mRNA	19464567
C009495	titanium dioxide	titanium dioxide results in increased expression of FKBP5 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of FKBP5 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of FKBP5 gene	26756918
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of FKBP5 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of FKBP5 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of FKBP5 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of FKBP5 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of FKBP5 mRNA	15498508\|2193413
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of FKBP5 gene	27618143
D014520	Urethane	Urethane results in increased expression of FKBP5 mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of FKBP5 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of FKBP5 mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of FKBP5 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of FKBP5 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in decreased expression of FKBP5 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of FKBP5 gene	25560391
D014752	Vinyl Chloride	Vinyl Chloride results in decreased expression of FKBP5 mRNA	18579281
D015032	Zinc	Zinc results in decreased expression of FKBP5 mRNA	20932299

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	-	IBA	21873635
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	-	IDA	11350175
GO:0005515	protein binding	-	IPI	14676191 14743216 19615732 20562859 21170051 23455922 23602568 24169621 25036637 25852190 27086506
GO:0005528	FK506 binding	-	IBA	21873635
GO:0031072	heat shock protein binding	-	IPI	9660753

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000413	protein peptidyl-prolyl isomerization	-	IBA	21873635
GO:0000413	protein peptidyl-prolyl isomerization	-	IEA	-
GO:0006457	protein folding	-	TAS	9001212
GO:0061077	chaperone-mediated protein folding	-	IBA	21873635
GO:0061077	chaperone-mediated protein folding	-	IDA	11350175

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22671426	Role of adrenal glucocorticoid signaling in prefrontal cortex gene expression and acute behavioral responses to ethanol. (2013 Jan)	Costin BN	Alcohol Clin Exp Res
20393453	Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. (2010 Jul)	Xie P	Neuropsychopharmacology
28018293	Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants. (2016)	Piyasena C	Front Endocrinol (Lausanne)
24845178	Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. (2014 Jul)	Levran O	Psychoneuroendocrinology
29325449	Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. (2018 Jan 12)	Marzi SJ	Am J Psychiatry
23981442	Stress-response pathways are altered in the hippocampus of chronic alcoholics. (2013 Nov)	McClintick JN	Alcohol
25532758	FKBP5 variation is associated with the acute and chronic effects of nicotine. (2015 Aug)	Jensen KP	Pharmacogenomics J
28393267	Charting the perfect storm: emerging biological interfaces between stress and stroke. (2017 Sep)	Kronenberg G	Eur Arch Psychiatry Clin Neurosci
27397864	Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction. (2016 Sep)	Rovaris DL	Eur Neuropsychopharmacol
24766650	Drug addiction and stress-response genetic variability: association study in African Americans. (2014 Jul)	Levran O	Ann Hum Genet
28300138	Reduced DNA methylation and psychopathology following endogenous hypercortisolism - a genome-wide study. (2017 Mar 16)	Glad CA	Sci Rep