Gene: RPH3A

22895
-
rabphilin 3A
protein-coding
12q24.13
Ensembl:ENSG00000089169 MIM:612159 Vega:OTTHUMG00000169713 UniprotKB:Q9Y2J0
NG_052871.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.140e-1 (AD)  9.254e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRN10.934
NCALD0.928
DIRAS10.926
STX1A0.923
STX1B0.919
RGS40.919
RNF1570.916
MPPED10.915
RAB3A0.914
NREP0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf87-0.527
CLEC2B-0.527
OR4F5-0.521
RHOD-0.521
WWTR1-0.518
RNF135-0.508
PHEX-0.507
RBPMS-0.499
EGFLAM-0.492
OR4F29-0.491

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RPH3A mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RPH3A mRNA"27291303
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of RPH3A mRNA"20206263
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RPH3A gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPH3A mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in increased expression of RPH3A mRNA15305145
D001280AtrazineAtrazine results in increased expression of RPH3A mRNA25929836
C006780bisphenol Abisphenol A results in decreased methylation of RPH3A promoter27312807
C006780bisphenol Abisphenol A results in increased expression of RPH3A mRNA17010207
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPH3A mRNA20360939
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of RPH3A mRNA26033743
D003300CopperCopper deficiency results in increased expression of RPH3A mRNA26033743
D013759DronabinolDronabinol results in decreased expression of RPH3A mRNA21955143
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of RPH3A mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of RPH3A mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPH3A mRNA20360939
D000431EthanolEthanol results in decreased expression of RPH3A mRNA21955143
C540355fenamidonefenamidone results in decreased expression of RPH3A mRNA27029645
D019833GenisteinGenistein results in increased expression of RPH3A mRNA17010207
D007854LeadLead affects the expression of RPH3A mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RPH3A mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of RPH3A mRNA22401849
D009020MorphineMorphine results in decreased expression of RPH3A mRNA21955143
D009538NicotineNicotine results in increased expression of RPH3A mRNA21955143
C025256nonylphenolnonylphenol results in increased expression of RPH3A mRNA17010207
D011441PropylthiouracilPropylthiouracil results in decreased expression of RPH3A mRNA24780913
D012715Sesame OilSesame Oil results in increased expression of RPH3A mRNA29191790
D014212TretinoinTretinoin results in decreased expression of RPH3A mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of RPH3A gene27618143
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RPH3A gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of RPH3A mRNA25423262

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI11377421  
GO:0005544calcium-dependent phospholipid binding-ISS-  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-ISS-  
GO:0008270zinc ion binding-ISS-  
GO:0008430selenium binding-ISS-  
GO:0017137Rab GTPase binding-IEA-  
GO:0042301phosphate ion binding-ISS-  
GO:0044877protein-containing complex binding-ISS-  
GO:0070679inositol 1,4,5 trisphosphate binding-ISS-  
GO:1901981phosphatidylinositol phosphate binding-TAS10099709  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatuscolocalizes_withISS-  
GO:0005829cytosol-ISS-  
GO:0008021synaptic vesicle-TAS10099709  
GO:0019898extrinsic component of membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0030141secretory granule-ISS-  
GO:0030672synaptic vesicle membrane-ISS-  
GO:0032991protein-containing complex-ISS-  
GO:0043005neuron projection-ISS-  
GO:0045202synapse-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21270382Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (2011 Apr)Baik IAm J Clin Nutr