Gene: CARD8

22900
CARDINAL|DACAR|DAKAR|NDPP|NDPP1|TUCAN
caspase recruitment domain family member 8
protein-coding
19q13.33
Ensembl:ENSG00000105483 MIM:609051 Vega:OTTHUMG00000165047 UniprotKB:Q9Y2G2
NG_029574.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.051e-1 (AD)  6.874e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10500299chr19:48218923 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKD30.869
PARP40.866
REST0.856
NEDD40.851
EPS80.849
FAM111A0.841
FYCO10.839
KDELC20.836
ITGB10.834
WWTR10.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB2-0.644
SLC7A4-0.635
ABCC12-0.635
MARCH4-0.621
HAS1-0.616
PPEF1-0.611
CALHM1-0.607
ADRA1D-0.602
LRTM2-0.601
SVOP-0.598

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CARD8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CARD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CARD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CARD8 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CARD8 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CARD8 gene27153756
D001194AsbestosCARD8 gene SNP affects the susceptibility to Asbestos24142982
D001280AtrazineAtrazine results in increased expression of CARD8 mRNA22982499
C018475butyraldehydebutyraldehyde results in decreased expression of CARD8 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CARD8 mRNA16934159
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CARD8 mRNA20971185
D003375CoumestrolCoumestrol results in increased expression of CARD8 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of CARD8 mRNA20106945
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of CARD8 mRNA17490981
D004397FonofosFonofos results in decreased methylation of CARD8 promoter22847954
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CARD8 mRNA23649840
C025256nonylphenolnonylphenol results in increased expression of CARD8 mRNA22982499
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CARD8 mRNA20971185
D010269ParaquatParaquat results in decreased expression of CARD8 mRNA18836921
D010278ParathionParathion results in decreased methylation of CARD8 promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CARD8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CARD8 mRNA26272509
C017947sodium arsenitesodium arsenite results in decreased expression of CARD8 mRNA28595984
C012568terbufosterbufos results in decreased methylation of CARD8 promoter22847954
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CARD8 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CARD8 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CARD8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CARD8 mRNA23179753|2438349
C088658zoledronic acidzoledronic acid results in increased expression of CARD8 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11551959  12067710  15030775  
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process-IDA15030775  
GO:0032089NACHT domain binding-IPI15030775  
GO:0042802identical protein binding-IPI12067710  
GO:0042803protein homodimerization activity-IDA15030775  
GO:0050700CARD domain binding-IPI11821383  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway-IMP11821383  
GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway-IDA11821383  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IMP11821383  
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IDA11551959  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA11821383  15030775  
GO:0050713negative regulation of interleukin-1 beta secretion-IDA11821383  
GO:0050718positive regulation of interleukin-1 beta secretion-IDA15030775  
GO:0097340inhibition of cysteine-type endopeptidase activity-IDA11821383  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11551959  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA15030775  
GO:0005829cytosol-IDA-  
GO:0032991protein-containing complex-IDA11821383  
GO:0072559NLRP3 inflammasome complex-IDA15030775  
KEGG ID KEGG Term
hsa04621NOD-like receptor signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21621776Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. (2011 Sep)Roberts RLAtherosclerosis
17030188TUCAN (CARD8) genetic variants and inflammatory bowel disease. (2006 Oct)McGovern DPGastroenterology
28135700The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population. (2017)Zhang KCell Physiol Biochem