Gene: SBNO2

22904
KIAA0963|SNO|STNO
strawberry notch homolog 2
protein-coding
19p13.3
Ensembl:ENSG00000064932 MIM:615729 Vega:OTTHUMG00000181875 UniprotKB:Q9Y2G9
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.567e-1 (AD)  6.552e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07573872chr19:1126342SBNO29.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIM10.881
BCL30.876
PXN0.874
PPP1R180.873
TNFRSF10B0.873
NFKB20.872
PLAUR0.867
STAT30.859
PNP0.857
IL15RA0.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EDN3-0.398
HAPLN1-0.392
KIT-0.381
SMIM18-0.379
NEUROD6-0.379
CRH-0.373
DLX1-0.355
MARCH4-0.354
PPEF1-0.352
VWC2-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SBNO2 mRNA"28903501
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SBNO2 mRNA28329830
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SBNO2 mRNA19191707
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SBNO2 mRNA24449571
D001151ArsenicArsenic affects the expression of SBNO2 mRNA25304211
D001151ArsenicArsenic affects the methylation of SBNO2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SBNO2 mRNA22228805
D004958EstradiolEstradiol results in increased expression of SBNO2 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of SBNO2 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of SBNO2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SBNO2 promoter22457795
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SBNO2 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of SBNO2 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of SBNO2 mRNA25562108
D003976DiazinonDiazinon results in increased methylation of SBNO2 gene22964155
C000944dicrotophosdicrotophos results in increased expression of SBNO2 mRNA28302478
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SBNO2 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SBNO2 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of SBNO2 mRNA19167457
D017313FenretinideFenretinide results in decreased expression of SBNO2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SBNO2 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of SBNO2 mRNA26191083
D007545IsoproterenolIsoproterenol results in increased expression of SBNO2 mRNA20003209
C008261lead acetatelead acetate results in increased expression of SBNO2 mRNA20542052
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SBNO2 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of SBNO2 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SBNO2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SBNO2 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of SBNO2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of SBNO2 mRNA19167457
C016030pantogabpantogab results in increased expression of SBNO2 mRNA17379144
C006253pirinixic acidpirinixic acid results in increased expression of SBNO2 mRNA18301758
C045950propiconazolepropiconazole results in decreased expression of SBNO2 mRNA21278054
D012999SomanSoman results in increased expression of SBNO2 mRNA19281266
D053260SootSoot results in increased expression of SBNO2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SBNO2 mRNA21570461
C009495titanium dioxidetitanium dioxide affects the expression of SBNO2 mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SBNO2 mRNA18087596
C406224valdecoxibvaldecoxib results in increased expression of SBNO2 mRNA24136188
D014635Valproic AcidValproic Acid results in increased methylation of SBNO2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SBNO2 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of SBNO2 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0031490chromatin DNA binding-IBA21873635  
GO:0042393histone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002281macrophage activation involved in immune response-IBA21873635  
GO:0002281macrophage activation involved in immune response-IMP18025162  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0030282bone mineralization-IEA-  
GO:0030316osteoclast differentiation-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IMP18025162  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0050727regulation of inflammatory response-IBA21873635  
GO:0050727regulation of inflammatory response-IMP18025162  
GO:0061430bone trabecula morphogenesis-IEA-  
GO:0071222cellular response to lipopolysaccharide-ISS-  
GO:0071348cellular response to interleukin-11-ISS-  
GO:0071354cellular response to interleukin-6-IBA21873635  
GO:0071354cellular response to interleukin-6-IDA25903009  
GO:0072675osteoclast fusion-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29326313DNA Methylation and Age-Independent Cardiovascular Risk, an Epigenome-Wide Approach: The REGICOR Study (REgistre GIroni del COR). (2018 Mar)Fernandez-Sanles AArterioscler Thromb Vasc Biol