Gene: MSRB2

22921
CBS-1|CBS1|CGI-131|MSRB|PILB
methionine sulfoxide reductase B2
protein-coding
10p12.2
Ensembl:ENSG00000148450 MIM:613782 Vega:OTTHUMG00000017812 UniprotKB:Q9Y3D2
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.044e-1 (AD)  4.361e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11013291chr10:23111262 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMA70.915
RPL360.906
RPL350.897
RPL35A0.897
RPL240.897
RPL310.895
TMEM2190.893
RPL270.891
RPS140.89
RPL340.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.745
OR4F5-0.745
PCDHA5-0.254
PCDHAC1-0.253
KCNH1-0.253
GCNT4-0.248
PPM1E-0.247
PCDHA12-0.243
HTR3B-0.238
GDF7-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of MSRB2 mRNA"20206263
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of MSRB2 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSRB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSRB2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MSRB2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MSRB2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of MSRB2 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MSRB2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of MSRB2 mRNA15725085
D001280AtrazineAtrazine results in decreased expression of MSRB2 mRNA25929836
D001374AzacitidineAzacitidine results in increased expression of MSRB2 mRNA19194470
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSRB2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSRB2 mRNA21715664|2222880
D004958EstradiolEstradiol affects the expression of MSRB2 mRNA22574217
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MSRB2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MSRB2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MSRB2 mRNA25912373
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MSRB2 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of MSRB2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of MSRB2 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of MSRB2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MSRB2 mRNA28628672
D020122tert-ButylhydroperoxideMSRB2 protein results in decreased susceptibility to tert-Butylhydroperoxide15914630
C018475butyraldehydebutyraldehyde results in decreased expression of MSRB2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of MSRB2 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MSRB2 mRNA17484886
D003042CocaineCocaine affects the expression of MSRB2 mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of MSRB2 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of MSRB2 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of MSRB2 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MSRB2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MSRB2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MSRB2 mRNA28628672
C016366dibenzothiophenedibenzothiophene results in increased expression of MSRB2 mRNA23656968
D004229DithiothreitolDithiothreitol results in increased reduction of MSRB2 protein16735467
D004317DoxorubicinDoxorubicin results in decreased expression of MSRB2 mRNA26873546
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MSRB2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSRB2 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MSRB2 mRNA23649840
D018120FinasterideFinasteride results in increased expression of MSRB2 mRNA24136188
D005485FlutamideFlutamide results in increased expression of MSRB2 mRNA24136188
C492448ICG 001ICG 001 results in increased expression of MSRB2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MSRB2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MSRB2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MSRB2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MSRB2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MSRB2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MSRB2 mRNA28628672
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MSRB2 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MSRB2 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MSRB2 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of MSRB2 mRNA24136188
D009532NickelNickel results in decreased expression of MSRB2 mRNA25583101
D010100OxygenOxygen deficiency results in increased expression of MSRB2 mRNA22230185
C006253pirinixic acidpirinixic acid results in increased expression of MSRB2 mRNA18301758|2381119
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of MSRB2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MSRB2 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of MSRB2 mRNA24612858
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSRB2 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MSRB2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSRB2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSRB2 mRNA19770486
D019284ThapsigarginThapsigargin results in increased expression of MSRB2 mRNA22378314
D013853ThioacetamideThioacetamide results in decreased expression of MSRB2 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MSRB2 gene27618143
D014415TunicamycinTunicamycin results in decreased expression of MSRB2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of MSRB2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSRB2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MSRB2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MSRB2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased expression of MSRB2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MSRB2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of MSRB2 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of MSRB2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003700DNA-binding transcription factor activity-TAS10375640  
GO:0003779actin binding-ISS-  
GO:0008270zinc ion binding-ISS14699060  
GO:0033743peptide-methionine (R)-S-oxide reductase activity-IBA21873635  
GO:0033743peptide-methionine (R)-S-oxide reductase activity-ISS14699060  
GO:0033743peptide-methionine (R)-S-oxide reductase activity-TAS-  
GO:0033745L-methionine-(R)-S-oxide reductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006979response to oxidative stress-IEA-  
GO:0030041actin filament polymerization-ISS-  
GO:0030091protein repair-ISS14699060  
GO:0030091protein repair-TAS-  
GO:0034599cellular response to oxidative stress-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-ISS14699060  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5676934Protein repairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal