Gene: ATF6

22926
ACHM7|ATF6A
activating transcription factor 6
protein-coding
1q23.3
Ensembl:ENSG00000118217 MIM:605537 Vega:OTTHUMG00000023961 UniprotKB:P18850
NG_029773.1
PubMed
CD|ND
4   
4.518e-2 (AD)  1.676e-2 (ND)   (Frontal_Cortex)
2.736e-1 (AD)  4.613e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC24B0.932
GNS0.915
SON0.915
COPB20.911
NUP1530.91
CSNK1A10.909
CNOT10.906
COPB10.905
TRIP120.903
COG50.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.527
HES5-0.252
PTGDR2-0.222
RERGL-0.205
PLA2G5-0.202
KLRC2-0.196
BTBD17-0.196
APOA1-0.194
NR0B1-0.194

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"[1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein"21355074
C0252051,10-phenanthroline"[1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein"21355074
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased expression of ATF6 protein23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased expression of ATF6 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased expression of ATF6 protein23576437
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6 protein]"28181380
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of ATF6 protein"28181380
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]"23892647
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of ATF6 mRNA]"22959925
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of ATF6 mRNA20682335
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of ATF6 mRNA]25827057
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ATF6 mRNA"27291303
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of ATF6 protein"25950987
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased expression of ATF6 mRNA"25160872
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased expression of ATF6 protein"25160872
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of ATF6 protein24898257
C0432473-acetyldeoxynivalenol3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA20682335
C0020104-(2-aminoethyl)benzenesulfonylfluoride4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased cleavage of ATF6 protein]17464326
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ATF6 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form24291486
C0275764-hydroxy-2-nonenalAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]24291486
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased expression of ATF6 protein23883479
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamidearsenic trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased expression of ATF6 protein]23883479
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein]28245985
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]27578021
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]26804720
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]26804720
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
D000082AcetaminophenAcetaminophen affects the expression of ATF6 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased cleavage of and results in increased activity of ATF6 protein19931551
D000111AcetylcysteineAcetylcysteine results in increased metabolism of and results in increased activity of ATF6 protein19722195
D000111AcetylcysteineAcetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]25451595
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF6 protein]21911445
D000111AcetylcysteineAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]24291486
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenite results in increased expression of ATF6 protein]18077580
D000111AcetylcysteineAcetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]21198628
D020106AcrylamideAcrylamide results in decreased expression of ATF6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ATF6 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of and affects the localization of ATF6 protein28962527
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ATF6 mRNA24449571
D047310ApigeninApigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein]20493918
D047310ApigeninApigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein]20493918
C006632arsenic trioxidearsenic trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased expression of ATF6 protein]23883479
C006632arsenic trioxidearsenic trioxide results in decreased expression of ATF6 protein23883479
C006632arsenic trioxidearsenic trioxide results in increased expression of ATF6 mRNA17963750|1917612
C006632arsenic trioxidearsenic trioxide results in increased expression of ATF6 protein25107562|2525818
C006632arsenic trioxideresveratrol inhibits the reaction [arsenic trioxide results in increased expression of ATF6 protein]25107562
C006632arsenic trioxide"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]"23892647
C006632arsenic trioxide[arsenic trioxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased cleavage of ATF6 protein23892647
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein23892647
C006632arsenic trioxidearsenic trioxide results in increased expression of ATF6 mRNA23892647
C006632arsenic trioxideThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]23892647
C006632arsenic trioxideThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA]23892647
C015001arsenitearsenite results in increased cleavage of ATF6 protein22959463
C015001arseniteAcetylcysteine inhibits the reaction [arsenite results in increased expression of ATF6 protein]18077580
C015001arsenitearsenite results in increased expression of ATF6 protein18077580
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of ATF6 mRNA"17331233
C547126AZM551248AZM551248 results in increased expression of ATF6 mRNA22323515
C550990baicalein-7-O-diglucosidebaicalein-7-O-diglucoside results in decreased expression of ATF6 mRNA26253462
C550990baicalein-7-O-diglucosidebaicalein-7-O-diglucoside results in decreased expression of ATF6 protein26253462
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATF6 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATF6 mRNA"20018196
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ATF6 mRNA26496021
D001663BilirubinBilirubin results in increased expression of ATF6 mRNA27578021
D001663Bilirubin4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]27578021
C006780bisphenol Abisphenol A results in decreased expression of ATF6 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of ATF6 gene22576693
C006780bisphenol Abisphenol A affects the methylation of ATF6 promoter27334623
C006780bisphenol Abisphenol A affects the expression of ATF6 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ATF6 mRNA26496021
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ATF6 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ATF6 mRNA22434021
C032688boric acidboric acid results in increased cleavage of and affects the localization of ATF6 protein27587023
D020126Brefeldin AApigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein]20493918
C584509C646 compoundC646 compound results in increased expression of ATF6 mRNA26191083
D002104CadmiumCadmium results in increased expression of ATF625805271
D002104CadmiumSelenium inhibits the reaction [Cadmium results in increased expression of ATF6]25805271
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF6 mRNA25409916
D019256Cadmium Chloride4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased cleavage of ATF6 protein]17464326
D019256Cadmium ChlorideCadmium Chloride results in increased cleavage of ATF6 protein17464326
C055494caffeic acid phenethyl ester[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA28223344
C055494caffeic acid phenethyl esterGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA]28223344
D002193CantharidinCantharidin results in increased cleavage of ATF6 protein27113412
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of ATF6 mRNA]25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ATF6 mRNA25827057
C054133casticincasticin results in increased expression of ATF6 protein27862857
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ATF6 mRNA24763279
C006972chloroacetic acidAcetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]25451595
C006972chloroacetic acidchloroacetic acid results in increased cleavage of ATF6 protein25451595
C018021cobaltous chloridecobaltous chloride results in increased expression of ATF6 mRNA24386269
D003042CocaineCocaine affects the expression of ATF6 mRNA23644055
D003474CurcuminCurcumin results in increased expression of ATF6 protein21793155
D016572CyclosporineCyclosporine results in increased expression of ATF6 mRNA20106945|2497309
D016572CyclosporineCyclosporine results in increased expression of ATF6 mRNA23958496
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of ATF6 mRNA29038839
C004315danthrondanthron results in increased expression of ATF6 protein21126053
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ATF6 mRNA23640034
C050229demethoxycurcumindemethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]26264395
C007262deoxynivalenoldeoxynivalenol results in increased expression of ATF6 mRNA20682335|2284639
C007262deoxynivalenolATF6 protein affects the reaction [deoxynivalenol results in increased expression of IL6 mRNA]19336499
C007262deoxynivalenoldeoxynivalenol results in increased expression of ATF6 protein19336499
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ATF6 mRNA28628672
D003993Dibutyl Phthalate4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]26804720
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ATF6 protein26804720
D003993Dibutyl Phthalate4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]26804720
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ATF6 protein26804720
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of ATF6 protein27589886
C000944dicrotophosdicrotophos results in decreased expression of ATF6 mRNA28302478
D004041Dietary Fats1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased expression of ATF6 protein]23576437
D004041Dietary Fats[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA28223344
D004041Dietary FatsDietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of ATF6 protein]23576437
D004041Dietary FatsDietary Fats results in increased expression of ATF6 protein23576437
D004041Dietary FatsGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA]28223344
D004041Dietary Fats[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA28223344
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased cleavage of ATF6 protein22509299
D004041Dietary Fatstauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]28223344
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ATF6 mRNA25280772
D002117CalcitriolCalcitriol results in increased expression of ATF6 mRNA16002434
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ATF6 mRNA"27840820
C019357dioscindioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein]24146112
C019357dioscindioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein]24146112
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ATF6 protein"23239598
C007590emulphogene BC 720emulphogene BC 720 results in increased expression of ATF6 mRNA25398874
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of ATF6 mRNA29038839
D000431Ethanoldioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein]24146112
D000431EthanolEthanol results in increased cleavage of ATF6 protein28119953
D000431EthanolEthanol results in increased expression of ATF6 protein24146112
D000431Ethanoldioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein]24146112
D000431EthanolEthanol results in increased expression of ATF6 protein24146112
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATF6 mRNA29097150
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified results in increased expression of ATF6 protein"23527285
C017875fisetin"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6 protein]"28181380
C017875fisetinfisetin results in increased expression of ATF6 protein28181380
C069837fullerene C60fullerene C60 affects the expression of ATF6 mRNA19167457
C039281furanfuran results in increased methylation of ATF6 gene22079235
C002469fusarenon-Xfusarenon-X results in increased expression of ATF6 mRNA20682335
C038958gadolinium chlorideAcetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]21198628
C038958gadolinium chloridegadolinium chloride affects the expression of ATF6 mRNA21198628
C038958gadolinium chloridegadolinium chloride results in increased expression of ATF6 protein21198628
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]20165829
D005944GlucosamineGlucosamine results in increased expression of ATF6 mRNA19383982|2016582
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
D005944GlucosamineGlucosamine results in decreased expression of ATF6 mRNA17178593
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]20165829
D005944GlucosamineGlucosamine results in increased expression of ATF6 mRNA20165829
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
D005978GlutathioneSOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form]27349771
D006046GoldGold analog results in increased cleavage of ATF6 protein26551149
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ATF6 mRNA24763279
C412815GW 4064GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA]28223344
C492448ICG 001ICG 001 results in increased expression of ATF6 mRNA26191083
D007213IndomethacinIndomethacin results in increased cleavage of and results in increased activity of and affects the localization of ATF6 protein15131590
D007213IndomethacinIndomethacin results in increased activity of ATF6 protein17341418
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ATF6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ATF6 mRNA28628672
C410337K 7174K 7174 results in increased expression of ATF6 mRNA24086573
C008261lead acetatelead acetate results in increased expression of ATF6 mRNA21829687
C008261lead acetatelead acetate results in increased expression of ATF6 mRNA11578147
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein]28245985
D008070LipopolysaccharidesLipopolysaccharides results in increased cleavage of ATF6 protein19675143
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ATF6 protein28245985
D008345ManganeseManganese results in decreased expression of ATF6 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of ATF6 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of ATF6 protein25732873
D008550MelatoninMelatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]28070110
D008550MelatoninMelatonin inhibits the reaction [sodium arsenite results in increased activity of ATF6 protein]18715270
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]27323860
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]27323860
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]27323860
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]27323860
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 mRNA]27323860
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 protein]27323860
D008694MethamphetamineMethamphetamine affects the localization of ATF6 protein27323860
D008694MethamphetamineMethamphetamine results in decreased expression of and results in increased cleavage of ATF6 protein27323860
D008694MethamphetamineMethamphetamine results in increased cleavage of ATF6 protein27323860
D008694MethamphetamineNaltrexone inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein]27323860
D008694Methamphetaminenorbinaltorphimine inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein]27323860
D008694MethamphetamineMethamphetamine results in increased cleavage of ATF6 protein27323860
D008694MethamphetamineMelatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]28070110
D008694MethamphetamineMethamphetamine results in increased expression of ATF6 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of ATF6 protein28070110
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ATF6 mRNA"20188158
C008493methylselenic acidmethylselenic acid results in increased cleavage of and results in increased activity of ATF6 protein16205645
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ATF6 mRNA29191790
D008797MetyraponeMetyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein]19819344
D008911MinocyclineMinocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein]22245251
D009271NaltrexoneNaltrexone inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein]27323860
D019888NelfinavirNelfinavir affects the localization of ATF6 protein21355074
D019888NelfinavirNelfinavir inhibits the reaction [MBTPS2 protein results in increased cleavage of and results in increased activity of ATF6 protein]21355074
D019888NelfinavirNelfinavir results in decreased cleavage of ATF6 protein21355074
D019888NelfinavirNelfinavir results in decreased expression of ATF6 protein alternative form21355074
D019888NelfinavirNelfinavir results in increased stability of ATF6 protein21355074
D019888NelfinavirNelfinavir results in decreased cleavage of ATF6 protein21355074
C028007nickel monoxidenickel monoxide results in increased expression of ATF6 mRNA19167457
D009538NicotineNicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein]18477628
C038405nivalenolnivalenol results in increased expression of ATF6 mRNA20682335
C010615Nonidet P-40Nonidet P-40 results in increased expression of ATF6 mRNA26552463
C051844norbinaltorphiminenorbinaltorphimine inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein]27323860
C097760N-palmitoylsphingosine[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA28223344
C097760N-palmitoylsphingosineN-palmitoylsphingosine results in increased expression of ATF6 mRNA28223344
C097760N-palmitoylsphingosinetauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]28223344
C097760N-palmitoylsphingosinetauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]28223344
D010100OxygenOxygen deficiency results in increased expression of ATF6 protein24680926
D010269ParaquatParaquat results in increased cleavage of ATF6 protein28986289
D010269ParaquatParaquat results in increased expression of ATF6 protein modified form28986289
D010269ParaquatMinocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein]22245251
D010269ParaquatParaquat results in increased expression of ATF6 protein22245251
D052638Particulate MatterParticulate Matter results in decreased expression of ATF6 mRNA17987463
D052638Particulate MatterParticulate Matter results in increased cleavage of ATF6 protein19675143
D010396PenicillaminePenicillamine results in increased metabolism of and results in increased activity of ATF6 protein19722195
D064209PhytochemicalsPhytochemicals results in decreased expression of ATF6 protein22685690
D010936Plant ExtractsPlant Extracts results in decreased expression of ATF6 protein22685690
D010936Plant ExtractsPlant Extracts results in decreased expression of ATF6 protein23994094
D011192Potassium DichromatePotassium Dichromate results in increased expression of ATF6 mRNA25409916
C045950propiconazolepropiconazole results in increased expression of ATF6 mRNA21278054
D011710PyocyaninePyocyanine results in increased activity of ATF6 protein27613716
D011718PyrazinamidePyrazinamide results in increased expression of ATF6 mRNA28063906
C031280pyrazolepyrazole results in increased expression of ATF6 mRNA17945193
D011794QuercetinQuercetin results in increased activity of ATF6 protein25611565
D011794Quercetintauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased activity of ATF6 protein]25611565
D017382Reactive Oxygen Species[arsenic trioxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased cleavage of ATF6 protein23892647
C059514resveratrolresveratrol inhibits the reaction [arsenic trioxide results in increased expression of ATF6 protein]25107562
C059514resveratrolresveratrol results in increased expression of ATF6 protein24264887
C113180S 3483S 3483 promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein]19819344
C496827salubrinalsalubrinal results in increased expression of ATF6 mRNA23958496
D012503SaponinsSaponins results in decreased expression of ATF6 protein23994094
D019258SaquinavirSaquinavir results in increased expression of ATF6 protein19147209
D012643SeleniumSelenium inhibits the reaction [Cadmium results in increased expression of ATF6]25805271
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ATF6 protein"25324550
D012715Sesame OilSesame Oil results in increased expression of ATF6 mRNA29191790
D012834SilverSilver analog results in increased expression of ATF6 mRNA23800688
D019821SimvastatinSimvastatin results in increased expression of ATF6 mRNA18807172
D019821SimvastatinSimvastatin results in increased expression of ATF6 protein18807172
C017947sodium arsenitesodium arsenite results in decreased expression of ATF6 mRNA28595984
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF6 protein]21911445
C017947sodium arsenitesodium arsenite affects the localization of ATF6 protein21911445
C017947sodium arsenitesodium arsenite results in increased expression of ATF6 protein21911445
C017947sodium arseniteMelatonin inhibits the reaction [sodium arsenite results in increased activity of ATF6 protein]18715270
C017947sodium arsenitesodium arsenite results in increased activity of ATF6 protein18715270
C016104sodium bichromatesodium bichromate results in decreased expression of ATF6 mRNA22561333
D012969Sodium FluorideSodium Fluoride results in increased expression of ATF6 mRNA21626649
D012969Sodium FluorideSodium Fluoride affects the expression of ATF6 mRNA25132241
D016559TacrolimusTacrolimus results in increased expression of ATF6 mRNA23958496
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased activity of ATF6 protein]25611565
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]28223344
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]28223344
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]20165829
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of ATF6 mRNA19208803
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of ATF6 protein19208803
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of ATF6 protein19208803
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased cleavage of ATF6 protein24932542
D019284ThapsigarginThapsigargin results in increased cleavage of and results in increased activity of and affects the localization of ATF6 protein15131590
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]23576437
D019284ThapsigarginATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]27358234
D019284ThapsigarginATF6 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]27358234
D019284Thapsigargindemethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]26264395
D019284ThapsigarginThapsigargin results in increased activity of ATF6 protein23383089
D019284ThapsigarginThapsigargin results in increased cleavage of and affects the localization of ATF6 protein27587023
D019284ThapsigarginThapsigargin results in increased expression of ATF6 mRNA17963750|2237831
D019284ThapsigarginThapsigargin results in increased expression of ATF6 protein23576437|2626439
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]23576437
D019284ThapsigarginApigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein]20493918
D019284ThapsigarginThapsigargin results in increased cleavage of ATF6 protein20493918
D019284ThapsigarginThapsigargin results in increased expression of ATF6 mRNA28223344
D019284ThapsigarginThapsigargin results in increased expression of ATF6 protein23576437
D019284ThapsigarginThapsigargin results in increased cleavage of ATF6 protein24638036
D019284ThapsigarginThapsigargin results in increased expression of ATF6 protein18477628
D013853ThioacetamideThioacetamide results in increased expression of ATF6 protein modified form27349771
D008063Thioctic AcidThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]23892647
D008063Thioctic AcidThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA]23892647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of ATF6 protein25568320
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ATF6 mRNA27865774
D014212TretinoinTretinoin results in increased expression of ATF6 mRNA21934132
D014212TretinoinTretinoin results in increased expression of ATF6 protein19960509
D014212TretinoinTretinoin results in increased expression of ATF6 mRNA22498432
D014212TretinoinTretinoin results in increased expression of ATF6 protein22498432
C011559tributyltintributyltin results in increased cleavage of ATF6 protein23743301
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ATF6 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ATF6 mRNA19042947
C001899triptolidetriptolide results in decreased expression of ATF6 protein26990902
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF6 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ATF6 mRNA28973697
D014415TunicamycinTunicamycin results in decreased cleavage of ATF6 protein22959463
D014415TunicamycinTunicamycin results in increased cleavage of ATF6 protein26551149
D014415TunicamycinTunicamycin results in increased expression of ATF6 mRNA22378314
D014415Tunicamycin"1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of ATF6 mRNA]"22959925
D014415TunicamycinEIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein]24648495
D014415TunicamycinTunicamycin results in increased cleavage of ATF6 protein24648495
D014415TunicamycinTunicamycin results in increased expression of ATF6 mRNA22001960|2295992
D014415TunicamycinTunicamycin results in increased expression of ATF6 protein25160872
D014415TunicamycinNicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein]18477628
D014415TunicamycinTunicamycin results in increased expression of ATF6 protein18477628
D014635Valproic AcidValproic Acid affects the expression of ATF6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ATF6 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ATF6 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ATF6 mRNA17987463
D024483Vitamin K 3Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein]19819344
D024483Vitamin K 3S 3483 promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein]19819344
D024483Vitamin K 3Vitamin K 3 results in increased expression of ATF6 protein19819344
D024483Vitamin K 3SOD2 inhibits the reaction [Vitamin K 3 results in increased activity of ATF6 protein]18086661
D024483Vitamin K 3Vitamin K 3 results in increased activity of ATF6 protein18086661

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IDA16469704  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA11779464  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA24269637  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IC-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003700DNA-binding transcription factor activity-IDA11163209  
GO:0003713transcription coactivator activity-TAS10866666  
GO:0005515protein binding-IPI16469704  19543265  20102225  22682248  27238082  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO:0035497cAMP response element binding-IEA-  
GO:0042802identical protein binding-IPI12805554  20102225  25609649  
GO:0043565sequence-specific DNA binding-IDA28473536  
GO:0046982protein heterodimerization activity-IPI16469704  
GO ID GO Term Qualifier Evidence PubMed
GO:0001654eye development-IMP26029869  
GO:0006357regulation of transcription by RNA polymerase II-TAS10564271  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006457protein folding-TAS10564271  
GO:0007165signal transduction-TAS9271374  
GO:0007601visual perception-IMP26029869  
GO:0030968endoplasmic reticulum unfolded protein response-TAS19816510  
GO:0036500ATF6-mediated unfolded protein response-TAS22013210  
GO:0043065positive regulation of apoptotic process-IDA14752510  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14973138  
GO:1903893positive regulation of ATF6-mediated unfolded protein response-IDA9837962  
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-IDA11163209  11256944  16469704  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005634nucleus-IDA11163209  11256944  16236796  
GO:0005635nuclear envelope-TAS10866666  
GO:0005654nucleoplasm-TAS-  
GO:0005783endoplasmic reticulum-IDA11256944  16236796  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005794Golgi apparatus-IDA16236796  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IDA11163209  
GO:0030176integral component of endoplasmic reticulum membrane-IDA10564271  
GO:0030176integral component of endoplasmic reticulum membrane-NAS11256944  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-380994ATF4 activates genesTAS
R-HSA-381033ATF6 (ATF6-alpha) activates chaperonesTAS
R-HSA-381042PERK regulates gene expressionTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-381183ATF6 (ATF6-alpha) activates chaperone genesTAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26740650Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. (2016 Jan 6)Srinivasan RJ Neurosci
25241909Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. (2014 Sep 21)Lee JHRespir Res
23169770Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. (2013 Mar)Kenche HFASEB J
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy