Gene: SNW1

22938
Bx42|FUN20|NCOA-62|PRPF45|Prp45|SKIIP|SKIP|SKIP1
SNW domain containing 1
protein-coding
14q24.3
Ensembl:ENSG00000100603 MIM:603055 Vega:OTTHUMG00000171527 UniprotKB:Q13573
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.942e-1 (AD)  3.863e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IK0.949
ILF20.945
GDI20.939
UBE2R20.937
PA2G40.936
PSMC20.929
PSMA60.929
PAIP10.928
CHTOP0.928
XRCC60.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.787
OR4F5-0.781
MTRNR2L6-0.225
MTRNR2L9-0.221
MTRNR2L10-0.198
C8orf74-0.19
MTRNR2L3-0.181
KLRB1-0.167
RNF223-0.164
OR4F16-0.16

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of SNW1 protein"27026707
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SNW1 gene27153756
D001280AtrazineAtrazine results in increased expression of SNW1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNW1 mRNA22228805
D004958EstradiolEstradiol results in decreased phosphorylation of SNW1 protein27026707
C006780bisphenol Abisphenol A affects the expression of SNW1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SNW1 mRNA25181051
C054133casticincasticin results in decreased expression of SNW1 mRNA28444820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SNW1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SNW1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SNW1 protein24386269
D003471CuprizoneCuprizone results in decreased expression of SNW1 mRNA26577399
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SNW1 mRNA19684285
D016572CyclosporineCyclosporine results in increased expression of SNW1 mRNA25562108
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of SNW1 protein23352502
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SNW1 mRNA17361019|2126653
C000944dicrotophosdicrotophos results in decreased expression of SNW1 mRNA28302478
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of SNW1 mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SNW1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SNW1 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SNW1 gene20938992
C492448ICG 001ICG 001 results in decreased expression of SNW1 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of SNW1 mRNA21396975
C410337K 7174K 7174 results in increased expression of SNW1 mRNA24086573
D007854LeadLead affects the splicing of SNW1 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SNW1 gene20938992
D008731MethoxychlorMethoxychlor affects the expression of SNW1 mRNA20829426
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SNW1 mRNA26011545
D010634PhenobarbitalPhenobarbital affects the expression of SNW1 mRNA19159669
D010936Plant ExtractsPlant Extracts results in increased expression of SNW1 mRNA23557933
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of SNW1 mRNA"16251409
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SNW1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNW1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SNW1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of SNW1 mRNA19465110
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of SNW1 protein20109541
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SNW1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SNW1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IDA11514567  14985122  23566155  
GO:0003714transcription corepressor activity-IDA14985122  
GO:0003723RNA binding-HDA22681889  
GO:0005112Notch binding-IPI10713164  
GO:0005515protein binding-IPI9569025  9632709  10713164  11278756  11371506  12529369  
12840015  14985122  15316101  16102918  16595688  18729074  
18794151  19934264  20368803  20467437  21460037  22365833  
25277244  25416956  
GO:0019899enzyme binding-IPI20007319  
GO:0035257nuclear hormone receptor binding-IDA19934264  
GO:0042809vitamin D receptor binding-IDA12529369  
GO:0042974retinoic acid receptor binding-IDA11514567  
GO:0046332SMAD binding-IDA11278756  
GO:0050681androgen receptor binding-IPI23566155  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA14985122  
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-IDA15194481  28076346  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006357regulation of transcription by RNA polymerase II-TAS9632709  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0016032viral process-IEA-  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IDA11278756  
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-IMP21460037  
GO:0043923positive regulation by host of viral transcription-IDA15905409  
GO:0043923positive regulation by host of viral transcription-IMP19818711  
GO:0045747positive regulation of Notch signaling pathway-TAS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA10713164  15878163  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14985122  19934264  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048026positive regulation of mRNA splicing, via spliceosome-IMP12840015  
GO:0048384retinoic acid receptor signaling pathway-IDA19934264  
GO:0048385regulation of retinoic acid receptor signaling pathway-IDA14985122  
GO:0050769positive regulation of neurogenesis-ISS-  
GO:0051571positive regulation of histone H3-K4 methylation-IMP19818711  
GO:0070562regulation of vitamin D receptor signaling pathway-IDA14985122  
GO:0070564positive regulation of vitamin D receptor signaling pathway-IDA9632709  11514567  
GO:0071300cellular response to retinoic acid-IDA19934264  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA9569025  15878163  28076346  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-IDA15194481  
GO:0008024cyclin/CDK positive transcription elongation factor complexcolocalizes_withIDA15905409  
GO:0016363nuclear matrix-IDA12840015  
GO:0016604nuclear body-IDA-  
GO:0016607nuclear speck-IDA23566155  
GO:0071007U2-type catalytic step 2 spliceosome-IDA28076346  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
hsa03040Spliceosome
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-350054Notch-HLH transcription pathwayTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3IEA
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8941856RUNX3 regulates NOTCH signalingIEA
R-HSA-8941856RUNX3 regulates NOTCH signalingTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23908141Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk. (2013 Nov)Jang JHMol Carcinog