Gene: FOXF1

2294
ACDMPV|FKHL5|FREAC1
forkhead box F1
protein-coding
16q24.1
Ensembl:ENSG00000103241 MIM:601089 Vega:OTTHUMG00000137651 UniprotKB:Q12946
NG_016273.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.376e-1 (AD)  4.667e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09338251chr16:86546979FOXF13'UTR8.754e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GIMAP50.81
DLL40.785
SIK10.782
LRRC320.778
TBX30.768
APOLD10.758
ICAM20.755
BTG20.753
DUSP10.75
CLDN50.747

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAR-0.435
KNCN-0.434
SVOP-0.431
SMIM18-0.431
FSTL5-0.428
PTPRR-0.424
DACH2-0.419
CSRNP3-0.418
SERF1B-0.418
SLC7A4-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of FOXF1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of FOXF1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FOXF1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FOXF1 mRNA22100608
D001151ArsenicArsenic results in increased methylation of FOXF1 promoter21291286
C547126AZM551248AZM551248 results in increased expression of FOXF1 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of FOXF1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of FOXF1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FOXF1 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of FOXF1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOXF1 mRNA22610609
C006780bisphenol Abisphenol A results in increased expression of FOXF1 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of FOXF1 gene28582417
C006780bisphenol Abisphenol A affects the methylation of FOXF1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of FOXF1 mRNA25181051
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in decreased expression of FOXF1 mRNA11238010
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FOXF1 mRNA25270620
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FOXF1 protein12500195
D002251Carbon TetrachlorideFOXF1 protein affects the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]12500195
D002251Carbon TetrachlorideFOXF1 protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]12500195
D002251Carbon TetrachlorideFOXF1 protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCL10 mRNA]12500195
D002251Carbon TetrachlorideFOXF1 protein affects the reaction [Carbon Tetrachloride results in increased expression of NOTCH2 protein]12500195
D002251Carbon TetrachlorideFOXF1 protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]12500195
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FOXF1 mRNA16644059
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FOXF1 mRNA24763279
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of FOXF1 mRNA27858113
C031180chrysenechrysene results in increased expression of FOXF1 mRNA26377693
C000541cyclopaminecyclopamine results in decreased expression of FOXF1 mRNA22265815
D016572CyclosporineCyclosporine results in increased expression of FOXF1 mRNA20106945
C016366dibenzothiophenedibenzothiophene results in decreased expression of FOXF1 mRNA23656968
D004041Dietary FatsDietary Fats results in increased expression of FOXF1 mRNA25016146
C024629dimethyl phthalatedimethyl phthalate affects the expression of FOXF1 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FOXF1 mRNA26379055
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of FOXF1 mRNA]18424623
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FOXF1 mRNA24763279
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOXF1 mRNA27432991
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FOXF1 mRNA23179753
C020771methylmercury hydroxidemethylmercury hydroxide results in increased expression of FOXF1 mRNA20493249
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FOXF1 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FOXF1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FOXF1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXF1 mRNA"25554681
D009532NickelNickel results in increased expression of FOXF1 mRNA25583101
C007350nitrofennitrofen results in decreased expression of FOXF1 mRNA27663689
C007350nitrofennitrofen results in decreased expression of FOXF1 protein27663689
C011272perfosfamideperfosfamide affects the expression of FOXF1 mRNA19429390
D010936Plant ExtractsPlant Extracts results in decreased expression of FOXF1 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FOXF1 mRNA23806026
D012834SilverSilver results in decreased expression of FOXF1 mRNA27131904
D012834SilverSilver results in increased expression of FOXF1 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of FOXF1 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOXF1 mRNA24058054
C009495titanium dioxidetitanium dioxide affects the expression of FOXF1 mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FOXF1 mRNA20133372
C057693troglitazonetroglitazone results in increased expression of FOXF1 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of FOXF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FOXF1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of FOXF1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FOXF1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IMP8626802  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP8626802  
GO:0003677DNA binding-IDA9769171  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IBA21873635  
GO:0043565sequence-specific DNA binding-ISS7957066  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001568blood vessel development-IMP19500772  
GO:0001570vasculogenesis-IEA-  
GO:0001701in utero embryonic development-IMP19500772  
GO:0001756somitogenesis-IEA-  
GO:0001763morphogenesis of a branching structure-IMP19500772  
GO:0002053positive regulation of mesenchymal cell proliferation-IEA-  
GO:0003197endocardial cushion development-IMP19500772  
GO:0003214cardiac left ventricle morphogenesis-IMP19500772  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007224smoothened signaling pathway-IEA-  
GO:0007368determination of left/right symmetry-IEA-  
GO:0007494midgut development-IMP19500772  
GO:0007507heart development-IMP19500772  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0014822detection of wounding-IEA-  
GO:0030198extracellular matrix organization-IEA-  
GO:0030323respiratory tube development-IMP19500772  
GO:0030324lung development-IMP19500772  
GO:0030335positive regulation of cell migration-IEA-  
GO:0031016pancreas development-IMP19500772  
GO:0043305negative regulation of mast cell degranulation-IEA-  
GO:0045198establishment of epithelial cell apical/basal polarity-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA8626802  9769171  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP8626802  
GO:0048286lung alveolus development-IEA-  
GO:0048371lateral mesodermal cell differentiation-IEA-  
GO:0048557embryonic digestive tract morphogenesis-IMP19500772  
GO:0048565digestive tract development-IMP19500772  
GO:0048613embryonic ectodermal digestive tract morphogenesis-IMP19500772  
GO:0048617embryonic foregut morphogenesis-IEA-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0051145smooth muscle cell differentiation-IEA-  
GO:0051150regulation of smooth muscle cell differentiation-IEA-  
GO:0060426lung vasculature development-IMP19500772  
GO:0060438trachea development-IMP19500772  
GO:0060441epithelial tube branching involved in lung morphogenesis-IEA-  
GO:0060461right lung morphogenesis-IEA-  
GO:0060463lung lobe morphogenesis-IEA-  
GO:0060841venous blood vessel development-IMP19500772  
GO:0061030epithelial cell differentiation involved in mammary gland alveolus development-IEA-  
GO:0071345cellular response to cytokine stimulus-IEA-  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:0072001renal system development-IMP19500772  
GO:0072189ureter development-IMP19500772  
GO:0090131mesenchyme migration-IEA-  
GO:0097070ductus arteriosus closure-IMP19500772  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC9769171  
GO:0005667transcription factor complex-TAS9722567  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23504527Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk. (2013 Oct 1)Dura PInt J Cancer