Gene: DKK1

22943
DKK-1|SK
dickkopf WNT signaling pathway inhibitor 1
protein-coding
10q21.1
Ensembl:ENSG00000107984 MIM:605189 Vega:OTTHUMG00000018247 UniprotKB:O94907
NC_000010.11
PubMed
0   ANCO-SNPs
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.558e-1 (AD)  5.957e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR830.623
STEAP10.586
TYW1B0.584
DMRT30.57
ZNF1840.567
CDC60.561
CLDN200.555
WNT20.555
HOPX0.548
ARL90.546

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UACA-0.316
KDR-0.304
CTNNA3-0.294
COX4I2-0.287
SLCO1A2-0.28
ZFP57-0.273
ASPA-0.27
AIF1L-0.268
PTCRA-0.265
VRK2-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of DKK1 mRNA19041380
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of DKK1 mRNA"19095052
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of DKK1 mRNA"17547211
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DKK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DKK1 mRNA"27188386
C0138134-anisidine4-anisidine results in decreased expression of DKK1 mRNA22623647
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA28321046
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneAcetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneBenzamides analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonediphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonewortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DKK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DKK1 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of DKK1 mRNA"26238291
D000079AcetaldehydeAcetaldehyde results in decreased expression of DKK1 mRNA23416264
D000079AcetaldehydeAcetaldehyde affects the expression of DKK1 mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of DKK1 mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DKK1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DKK1 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
D000242Cyclic AMPDKK1 protein affects the susceptibility to Cyclic AMP21546446
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DKK1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DKK1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DKK1 mRNA22100608|2715375
D013196Dihydrotestosteroneascorbate-2-phosphate inhibits the reaction [Dihydrotestosterone results in increased expression of DKK1 mRNA]20701628
D013196Dihydrotestosteroneascorbate-2-phosphate inhibits the reaction [Dihydrotestosterone results in increased expression of DKK1 protein]20701628
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of DKK1 mRNA20701628
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of DKK1 protein20701628
D000667AmpicillinAmpicillin results in increased expression of DKK1 mRNA21632981
C006632arsenic trioxidearsenic trioxide results in increased expression of DKK1 mRNA17547211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of DKK1 mRNA"25757056
C011669ascorbate-2-phosphateascorbate-2-phosphate inhibits the reaction [Dihydrotestosterone results in increased expression of DKK1 mRNA]20701628
C011669ascorbate-2-phosphateascorbate-2-phosphate inhibits the reaction [Dihydrotestosterone results in increased expression of DKK1 protein]20701628
D001205Ascorbic AcidAscorbic Acid results in decreased expression of DKK1 mRNA19197388
D001280AtrazineAtrazine results in decreased expression of DKK1 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of DKK1 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of DKK1 mRNA22323515
C487081belinostatbelinostat results in increased expression of DKK1 mRNA26272509
D001549BenzamidesBenzamides analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
D001554BenzeneBenzene results in increased expression of DKK1 mRNA22960397
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of DKK1 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DKK1 mRNA20106945|2163298
D001599BerberineDKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]26478571
D001599BerberineDKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]26478571
D001599BerberineDKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]26478571
D001599BerberineDKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]26478571
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of DKK1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of DKK1 mRNA20106945|2163298
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of DKK1 mRNA17404688
C095105bexarotenebexarotene results in increased expression of DKK1 mRNA17178900
C006780bisphenol Abisphenol A results in decreased expression of DKK1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of DKK1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of DKK1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of DKK1 mRNA25381574|2596372
C006780bisphenol Abisphenol A results in increased expression of DKK1 protein25381574|2596372
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]25963729
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]25963729
C006780bisphenol A[DKK1 protein co-treated with bisphenol A] results in decreased expression of CCND1 mRNA25381574
C006780bisphenol A[DKK1 protein co-treated with bisphenol A] results in decreased expression of LEF1 mRNA25381574
C025703bleomycetinbleomycetin results in decreased expression of DKK1 mRNA21040473
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of DKK1 mRNA22079614
D002064Buserelin[Buserelin co-treated with CGB3 protein] results in increased expression of DKK1 mRNA19955106
D002064Buserelin[Buserelin co-treated with CGB3 protein] results in increased expression of DKK1 protein19955106
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of DKK1 mRNA12414654|1533650
C584509C646 compoundC646 compound results in decreased expression of DKK1 mRNA26191083
D002104CadmiumCadmium results in increased expression of DKK1 mRNA21172416|2437683
D002220CarbamazepineCarbamazepine affects the expression of DKK1 mRNA24752500|2597931
D002220CarbamazepineCarbamazepine affects the expression of DKK1 mRNA22634333
D002330CarmustineDKK1 protein results in increased susceptibility to Carmustine20920327
D004390ChlorpyrifosChlorpyrifos results in increased expression of DKK1 mRNA18502319
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of DKK1 mRNA16197558
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DKK1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DKK1 mRNA]17585979
D002996ClomipheneClomiphene results in decreased expression of DKK1 protein21851939
C018021cobaltous chloridecobaltous chloride results in decreased expression of DKK1 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in increased expression of DKK1 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of DKK1 protein21304589
D003345CorticosteroneMifepristone inhibits the reaction [Corticosterone results in increased expression of DKK1 protein]21304589
D003345CorticosteroneNR3C1 protein promotes the reaction [Corticosterone results in increased expression of DKK1 protein]21304589
C029892cupric chloridecupric chloride results in increased expression of DKK1 mRNA17211630
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]25963729
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]25963729
D003474CurcuminCurcumin results in decreased expression of DKK1 mRNA25963729
D003474CurcuminCurcumin results in decreased expression of DKK1 protein25963729
D016572CyclosporineCyclosporine results in decreased expression of DKK1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of DKK1 mRNA25562108
D000069439DasatinibDasatinib results in decreased expression of DKK1 mRNA20579391
C014347decitabine[decitabine affects the methylation of DKK1 promoter] which affects the expression of DKK1 mRNA18283316|1828331
C014347decitabinedecitabine results in decreased methylation of DKK1 promoter19387464
C014347decitabinedecitabine results in increased expression of DKK1 mRNA17785578|1938746
D003907DexamethasoneDexamethasone promotes the reaction [NR3C1 protein binds to DKK1 promoter]22048647
D003907DexamethasoneDexamethasone results in increased expression of DKK1 mRNA22048647|2504701
D003907DexamethasoneDKK1 protein affects the susceptibility to Dexamethasone22048647
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of DKK1 mRNA]22048647
D003907DexamethasoneNR3C1 protein inhibits the reaction [Dexamethasone results in increased expression of DKK1 mRNA]22048647
D003976DiazinonDiazinon results in increased expression of DKK1 mRNA18502319
D002945CisplatinDKK1 protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac affects the expression of DKK1 mRNA24752500
D004147DioxinsDioxins affects the expression of DKK1 mRNA20463971
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
D004178DiquatDiquat results in increased expression of DKK1 mRNA21172416
D004317DoxorubicinDKK1 protein affects the susceptibility to Doxorubicin16217747
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DKK1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DKK1 mRNA17555576
D005013EthosuximideDKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]26420483
D005013EthosuximideDKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]26420483
D005013EthosuximideEthosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]26420483
D005013EthosuximideEthosuximide results in decreased expression of DKK1 mRNA26420483
D015025ZearalenoneZearalenone results in decreased expression of DKK1 mRNA25455459
D005419FlavonoidsDKK1 protein inhibits the reaction [Flavonoids results in increased expression of CTNNB1 mRNA]23238999
D005419FlavonoidsDKK1 protein inhibits the reaction [Flavonoids results in increased expression of LRP5 mRNA]23238999
D005472FluorouracilDKK1 protein affects the susceptibility to Fluorouracil15352031|1621774
D005472FluorouracilFluorouracil results in decreased expression of DKK1 protein15352031
C061365flusilazoleflusilazole affects the expression of DKK1 mRNA22634333
D005492Folic AcidFolic Acid affects the expression of DKK1 mRNA17320366
D005492Folic AcidFolic Acid results in increased expression of DKK1 mRNA17868486
D004397FonofosFonofos results in increased methylation of DKK1 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of DKK1 mRNA20655997
D019833GenisteinGenistein results in decreased expression of DKK1 mRNA20884965
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in decreased expression of CDH1 mRNA]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in decreased expression of CDH1 protein]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of ACTA2 mRNA]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of ACTA2 protein]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of CTNNB1 mRNA]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of CTNNB1 protein]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]29163160
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of LEF1 mRNA]29163160
C010974glyphosateglyphosate results in increased expression of DKK1 mRNA28780397
C554645GSK525762ADKK1 protein inhibits the reaction [KMT2A protein results in decreased susceptibility to GSK525762A]26367796
D006861Hydrogen PeroxideDKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]26482937
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DKK1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of DKK1 mRNA12414654
C031927hydroquinonehydroquinone affects the expression of DKK1 mRNA22960397
C492448ICG 001ICG 001 results in decreased expression of DKK1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DKK1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DKK1 mRNA23430699|2479639
D007854LeadLead results in increased expression of DKK123086611
C045463leflunomideleflunomide results in decreased expression of DKK1 mRNA28988120
C067431letrozoleletrozole results in increased expression of DKK1 mRNA21851939
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DKK1 mRNA22235868
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DKK1 mRNA12057914
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of DKK1 mRNA20843944
D008694MethamphetamineMethamphetamine results in increased expression of DKK1 mRNA25290377
D008727MethotrexateDKK1 mRNA results in decreased susceptibility to Methotrexate19732436
D008727MethotrexateMethotrexate results in decreased expression of DKK1 mRNA17320366
D008727MethotrexateMethotrexate results in decreased expression of DKK1 mRNA17320366
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DKK1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DKK1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK1 mRNA"27188386
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of DKK1 mRNA17475336
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of DKK1 mRNA]22048647
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of DKK1 mRNA]16449346
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of DKK1 protein]16449346
D015735MifepristoneMifepristone inhibits the reaction [Corticosterone results in increased expression of DKK1 protein]21304589
C005274naringinDKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]26482937
D009532NickelNickel results in decreased expression of DKK1 mRNA19130878
C022838nickel chloridenickel chloride results in increased expression of DKK1 mRNA17547211
D010278ParathionParathion results in increased methylation of DKK1 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of DKK1 mRNA22178795|2841250
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of DKK1 mRNA19095052
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the methylation of DKK1 5' UTR28011154
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the methylation of DKK1 exon28011154
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the methylation of DKK1 promoter28011154
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DKK1 mRNA28011154
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of DKK1 mRNA27018151
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DKK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DKK1 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DKK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DKK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DKK1 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of DKK1 mRNA23018184
D011374ProgesteroneDKK1 protein affects the susceptibility to Progesterone21546446
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of DKK1 mRNA20660070
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of DKK1 mRNA]16449346
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of DKK1 protein]16449346
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of DKK1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of DKK1 mRNA16449346|1740468
D011374ProgesteroneProgesterone results in increased expression of DKK1 protein16449346
D011374ProgesteroneProgesterone results in increased expression of DKK1 mRNA19690047
D011374ProgesteroneProgesterone results in decreased expression of DKK117510236
D011441PropylthiouracilPropylthiouracil results in increased expression of DKK1 mRNA24780913
C024631pyrviniumpyrvinium results in decreased expression of DKK1 mRNA21170416
D011794QuercetinQuercetin affects the expression of DKK1 mRNA21632981
C004532quinonequinone results in increased expression of DKK1 mRNA22960397
C059514resveratrolresveratrol inhibits the reaction [DKK1 protein inhibits the reaction [WNT3A protein results in increased expression of CTNNB1]]19665018
C059514resveratrolresveratrol inhibits the reaction [DKK1 protein results in decreased activity of WNT3A protein]19665018
C093642SB 203580SB 203580 inhibits the reaction [BMP5 protein results in increased expression of DKK1 mRNA]15242789
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DKK1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of DKK1 mRNA25351596|2709509
D012834SilverSilver results in decreased expression of DKK1 mRNA26014281
D012834SilverSilver results in decreased expression of DKK1 mRNA27131904
D019821SimvastatinDKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]22058016
D019821SimvastatinDKK1 inhibits the reaction [Simvastatin results in increased expression of RUNX2 mRNA]22058016
D019821SimvastatinDKK1 inhibits the reaction [Simvastatin results in increased expression of SP7 mRNA]22058016
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased expression of ALPL mRNA]24300170
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased expression of COL1A1 mRNA]24300170
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased expression of RUNX2 mRNA]24300170
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased expression of RUNX2 protein]24300170
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased expression of SPARC mRNA]24300170
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased phosphorylation of AKT1 protein]24300170
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased phosphorylation of GSK3B protein]24300170
C012568terbufosterbufos results in increased methylation of DKK1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DKK1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DKK1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DKK1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of DKK1 mRNA22378314
D013893ThiramThiram results in increased expression of DKK1 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DKK1 mRNA28065790
D014118Toxins, Biological"Toxins, Biological affects the expression of DKK1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of DKK1 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of DKK1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of DKK1 mRNA21934132
D014212TretinoinDKK1 protein promotes the reaction [Tretinoin results in increased expression of DLX2 protein]17064353
D014212TretinoinDKK1 protein promotes the reaction [Tretinoin results in increased expression of TUBB3 protein]17064353
D014212TretinoinTretinoin results in increased expression of DKK1 mRNA17064353
D014212TretinoinTretinoin results in increased expression of DKK1 protein17064353
C011559tributyltintributyltin results in decreased expression of DKK1 mRNA28011154
C012589trichostatin Atrichostatin A results in decreased expression of DKK1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DKK1 mRNA"26179874
C113580U 0126U 0126 results in decreased expression of DKK1 mRNA17320366
C113580U 0126U 0126 results in decreased expression of DKK1 mRNA17320366
D014520UrethaneUrethane results in decreased expression of DKK1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DKK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DKK1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DKK1 mRNA23179753|2438349
D014747VinblastineDKK1 protein affects the susceptibility to Vinblastine16217747
D024483Vitamin K 3Vitamin K 3 affects the expression of DKK1 mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in increased expression of DKK1 mRNA12414654
C085514wogoninDKK1 protein promotes the reaction [wogonin results in decreased expression of CTNNB1 protein]23872260
C085514wogoninDKK1 protein promotes the reaction [wogonin results in increased expression of GFAP protein]23872260
C085514wogoninDKK1 protein results in increased susceptibility to wogonin23872260
C009687wortmanninwortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]28321046
C088658zoledronic acidzoledronic acid results in decreased expression of DKK1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11448771  16189514  17804805  19060904  21944579  21984209  
GO:0008083growth factor activity-TAS10383463  
GO:0039706co-receptor binding-IBA21873635  
GO:0039706co-receptor binding-IPI11433302  20093360  
GO:0039706co-receptor binding-TAS22988876  
GO:0048019receptor antagonist activity-IBA21873635  
GO:0048019receptor antagonist activity-IDA20723538  
GO:0050750low-density lipoprotein particle receptor binding-IDA16263759  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA20723538  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0000904cell morphogenesis involved in differentiation-IEA-  
GO:0001706endoderm formation-IEA-  
GO:0001707mesoderm formation-IEA-  
GO:0001942hair follicle development-IEA-  
GO:0002090regulation of receptor internalization-IDA17804805  
GO:0007611learning or memory-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010628positive regulation of gene expression-IGI23164821  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010942positive regulation of cell death-TAS23164821  
GO:0030178negative regulation of Wnt signaling pathway-IDA15020244  22615920  
GO:0030279negative regulation of ossification-ISS-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0030514negative regulation of BMP signaling pathway-IEA-  
GO:0030900forebrain development-IEA-  
GO:0032091negative regulation of protein binding-IDA20093360  
GO:0032526response to retinoic acid-IEA-  
GO:0033137negative regulation of peptidyl-serine phosphorylation-IDA20723538  
GO:0042662negative regulation of mesodermal cell fate specification-IDA20559569  
GO:0042663regulation of endodermal cell fate specification-IDA20559569  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043507positive regulation of JUN kinase activity-IDA23164821  
GO:0045813positive regulation of Wnt signaling pathway, calcium modulating pathway-TAS23164821  
GO:0048642negative regulation of skeletal muscle tissue development-IEA-  
GO:0050807regulation of synapse organization-IEA-  
GO:0051966regulation of synaptic transmission, glutamatergic-IEA-  
GO:0060173limb development-ISS-  
GO:0060325face morphogenesis-IEA-  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-IDA20559569  
GO:0061743motor learning-IEA-  
GO:0090082positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA11433302  11448771  11742004  12857724  17804805  18044981  20039315  20093360  22902902  
GO:0090090negative regulation of canonical Wnt signaling pathway-IGI18166153  
GO:0090090negative regulation of canonical Wnt signaling pathway-NAS24431302  
GO:0090090negative regulation of canonical Wnt signaling pathway-TAS23164821  24449494  
GO:0090244Wnt signaling pathway involved in somitogenesis-IEA-  
GO:0090647modulation of age-related behavioral decline-ISS-  
GO:0098883synapse disassembly-TAS24449494  
GO:1900116extracellular negative regulation of signal transduction-IEA-  
GO:1901216positive regulation of neuron death-ISS-  
GO:1901296negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment-IDA20559569  
GO:1902949positive regulation of tau-protein kinase activity-ISS-  
GO:1904338regulation of dopaminergic neuron differentiation-TAS24431302  
GO:1904723negative regulation of Wnt-Frizzled-LRP5/6 complex assembly-IDA11448771  20093360  
GO:1904723negative regulation of Wnt-Frizzled-LRP5/6 complex assembly-IPI11433302  
GO:1904723negative regulation of Wnt-Frizzled-LRP5/6 complex assembly-TAS23164821  
GO:1904958positive regulation of midbrain dopaminergic neuron differentiation-IEA-  
GO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway-TAS23164821  
GO:2000726negative regulation of cardiac muscle cell differentiation-IDA20559569  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11448771  11742004  
GO:0005886plasma membrane-IDA16263759  
GO:0031901early endosome membrane-TAS-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5339717Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24641868Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens. (2014 May)Evans RLCancer Prev Res (Phila)
23125289Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. (2013 Jan)Register TCJ Clin Endocrinol Metab
29282619Dickkopf 1 protein circulating levels as a possible biomarker of functional disability and chronic damage in patients with rheumatoid arthritis. (2018 Mar)Santos AMClin Rheumatol
29243300Antagonists of Wnt/beta-catenin signalling in the periodontitis associated with type 2 diabetes and smoking. (2018 Mar)Miranda TSJ Clin Periodontol
24276456Severe abdominal aortic calcification in older men is negatively associated with DKK1 serum levels: the STRAMBO study. (2014 Feb)Szulc PJ Clin Endocrinol Metab
27457487Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility. (2016 Jul 26)Wu JBMC Gastroenterol
25886059Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren's syndrome: prevalence, clinical and laboratory associations. (2015 Apr 11)Gravani FArthritis Res Ther
28321046Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells. (2017)Hirata NJ Toxicol Sci
22966878Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients. (2012)Rawson JBNutr Cancer
25854266Osteoprotegerin and sclerostin in chronic kidney disease prior to dialysis: potential partners in vascular calcifications. (2015 Aug)Morena MNephrol Dial Transplant
28927744Impact of resveratrol on bone repair in rats exposed to cigarette smoke inhalation: histomorphometric and bone-related gene expression analysis. (2018 Apr)Franck FCInt J Oral Maxillofac Surg