Gene: KIN

22944
BTCD|KIN17|Rts2
Kin17 DNA and RNA binding protein
protein-coding
10p14
Ensembl:ENSG00000151657 MIM:601720 Vega:OTTHUMG00000017634 UniprotKB:O60870
NC_000010.11
PubMed
0   ANCO-SNPs
ND|AD
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.562e-1 (AD)  4.006e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COG30.895
U2SURP0.891
NUP540.876
ZBED50.875
SMARCAD10.867
ZMYM60.861
DDX180.859
DNAJC100.858
TEX100.856
RCOR30.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.518
OR4F29-0.478
MTRNR2L9-0.246
MTRNR2L6-0.229
MTRNR2L10-0.226
OR4F16-0.197
PLA2G3-0.188
NXNL1-0.187
RNF223-0.177
MTRNR2L1-0.175

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIN mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIN mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIN mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIN mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIN mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of KIN mRNA17562736
D001280AtrazineAtrazine results in increased expression of KIN mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KIN mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIN mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of KIN mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of KIN mRNA25181051
D000068579CelecoxibCelecoxib results in increased expression of KIN mRNA28201806
D002994ClofibrateClofibrate results in decreased expression of KIN mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of KIN mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of KIN mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KIN mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of KIN mRNA28302478
D005485FlutamideFlutamide results in decreased expression of KIN mRNA21126777
D005557FormaldehydeFormaldehyde results in decreased expression of KIN mRNA20655997
C039281furanfuran results in increased methylation of KIN gene22079235
D006046GoldGold results in decreased expression of KIN mRNA25523186
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIN protein18951874
D007213IndomethacinIndomethacin results in increased expression of KIN mRNA28201806
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KIN mRNA26924002
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIN mRNA"25510870
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KIN mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KIN promoter]19654925
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIN protein18951874
C012589trichostatin Atrichostatin A affects the expression of KIN mRNA28542535
D055549Volatile Organic CompoundsVolatile Organic Compounds affects the expression of KIN mRNA20823639

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS1923796  
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0003690double-stranded DNA binding-ISS-  
GO:0003723RNA binding-IDA17045609  
GO:0005515protein binding-IPI12359749  23349634  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-IBA21873635  
GO:0006260DNA replication-IDA12359749  
GO:0006281DNA repair-IEA-  
GO:0006310DNA recombination-IEA-  
GO:0006397mRNA processing-TAS17045609  
GO:0006974cellular response to DNA damage stimulus-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IEP12853634  
GO:0016032viral process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016363nuclear matrix-IDA12754299  
GO:0032991protein-containing complex-IDA23349634  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8876725Protein methylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25472679Establishment of the cancer prevention study II nutrition cohort colorectal tissue repository. (2014 Dec)Campbell PTCancer Epidemiol Biomarkers Prev
27864166Perivascular Adipose Tissue Inflammation and Coronary Artery Disease: An Autopsy Study Protocol. (2016 Nov 18)Farias-Itao DSJMIR Res Protoc
6869368Information available from surrogate respondents in case-control interview studies. (1983 Jul)Pickle LWAm J Epidemiol
1180150Body composition in control, alcoholic and depressive individuals using a multiple isotope technique and whole body counting of potassium. (1975)MacSweeney DAdv Exp Med Biol
2151133[Epidemics of lung tumors in a Biella tannery]. (1990 Sep)Bonassi SEpidemiol Prev
23305538Rebuilding community resilience in a post-war context: developing insight and recommendations - a qualitative study in Northern Sri Lanka. (2013 Jan 11)Somasundaram DInt J Ment Health Syst
22161620Diabetes and risk of esophageal and gastric adenocarcinomas. (2012 Sep 15)Jiang XInt J Cancer
3592400A case-control study of lung cancer and diesel exhaust exposure in railroad workers. (1987 Jun)Garshick EAm Rev Respir Dis
1334212[Occupation and lung cancer risk in the province of Trieste: a case-control study]. (1992 Jul-Aug)Bovenzi MMed Lav
20102864Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation. (2010 Jan)Adabag ASAm Heart J
10189006Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogenous Chinese population with normal glucose tolerance. (1999 Feb 28)Chen CHInt J Cardiol
19270799Occupational exposure to polychlorinated biphenyls and risk of breast cancer. (2009 Feb)Silver SREnviron Health Perspect
8343420Incidence of renal stones among cadmium exposed battery workers. (1993 Jul)Jarup LBr J Ind Med
24461757Serum concentrations of club cell secretory protein (Clara) and cancer mortality in adults: a population-based, prospective cohort study. (2013 Dec)Guerra SLancet Respir Med
22176604Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide. (2012 Sep)Thompson PMActa Psychiatr Scand