Gene info: ID 22949

Gene: PTGR1

GENE ID: 22949

Synonyms: LTB4DH|PGR1|ZADH3

Description: prostaglandin reductase 1

Gene type: protein-coding

Location: 9q31.3

dbXrefs: Ensembl:ENSG00000106853 MIM:601274 Vega:OTTHUMG00000020493 UniprotKB:Q14914

RefSeq: NC_000009.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) 8.667e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.478e-1 (AD) 3.065e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RPUSD4	0.862
PGK1	0.854
NMT2	0.847
SND1	0.847
UBE2Z	0.846
MRPL45	0.845
PSMC1	0.844
ALAS1	0.843
ZNF174	0.843
MPP1	0.843

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.488
OR4F29	-0.447
CTNNA3	-0.38
VNN3	-0.364
C5orf64	-0.359
MBNL3	-0.35
MTRNR2L6	-0.341
HEY2	-0.338
RAI14	-0.33
P2RY14	-0.325

ID	Drug Name	Drug Type	Status	Role
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule	Experimental	Target
DB04066	para-Coumaric Acid	Small Molecule	Experimental	Target
DB07177	(5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID	Small Molecule	Experimental	Target

ID	Drug Name	Action	PubMed
C521487	10-nitro-oleic acid	PTGR1 protein inhibits the reaction [10-nitro-oleic acid analog results in increased expression of HOX1 protein]	23878198
C521487	10-nitro-oleic acid	PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog	23878198
C521487	10-nitro-oleic acid	15-ketoprostaglandin E2 inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]	23878198
C521487	10-nitro-oleic acid	Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]	23878198
C521487	10-nitro-oleic acid	Indomethacin inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]	23878198
C521487	10-nitro-oleic acid	PTGR1 protein inhibits the reaction [10-nitro-oleic acid analog results in increased expression of HOX1 protein]	23878198
C521487	10-nitro-oleic acid	PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog	23878198
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of PTGR1 mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of PTGR1 mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of PTGR1 mRNA"	18711122
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of PTGR1 mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of PTGR1 mRNA]"	27071940
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of and results in increased activity of PTGR1 protein"	25179160
C036808	13,14-dihydro-15-ketoprostaglandin E1	"PTGR1 protein results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1"	25619643
C036808	13,14-dihydro-15-ketoprostaglandin E1	"[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E] which results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1"	25619643
C025087	15-keto-13,14-dihydroprostaglandin E2	"PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2"	25619643
C025087	15-keto-13,14-dihydroprostaglandin E2	"[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2"	25619643
C008228	15-keto-13,14-dihydroprostaglandin F2alpha	"PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha"	25619643
C008228	15-keto-13,14-dihydroprostaglandin F2alpha	"[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha"	25619643
C011008	15-ketoprostaglandin E	PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E	25619643
C011008	15-ketoprostaglandin E	"[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E] which results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1"	25619643
C026346	15-ketoprostaglandin E2	PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2	25619643
C026346	15-ketoprostaglandin E2	"[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2"	25619643
C026346	15-ketoprostaglandin E2	15-ketoprostaglandin E2 inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]	23878198
C026346	15-ketoprostaglandin E2	Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]	23878198
C026346	15-ketoprostaglandin E2	Indomethacin inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]	23878198
C026346	15-ketoprostaglandin E2	PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2	23878198
C026528	15-ketoprostaglandin F2alpha	PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha	25619643
C026528	15-ketoprostaglandin F2alpha	"[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha"	25619643
C033146	1-hydroxypyrene	1-hydroxypyrene results in increased expression of PTGR1 mRNA	21854004
C057461	1-pentene-3-one	[PTGR1 protein co-treated with NADP] affects the reduction of 1-pentene-3-one	11524419
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of PTGR1 mRNA"	23829299
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of PTGR1 mRNA"	19095052
C412886	2,4-nonadienal	"[PTGR1 protein co-treated with NADP] affects the reduction of 2,4-nonadienal"	11524419
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of PTGR1 mRNA"	23829299
C012796	2-butenal	[PTGR1 protein co-treated with NADP] affects the reduction of 2-butenal	11524419
C476489	(2E)-decenal	[PTGR1 protein co-treated with NADP] affects the reduction of (2E)-decenal	11524419
C051750	2-hexenal	[PTGR1 protein co-treated with NADP] affects the reduction of 2-hexenal	11524419
C013166	2-nonenal	[PTGR1 protein co-treated with NADP] affects the reduction of 2-nonenal	11524419
C057348	2-octenal	[PTGR1 protein co-treated with NADP] affects the reduction of 2-octenal	11524419
C064599	2-pentenal	[PTGR1 protein co-treated with NADP] affects the reduction of 2-pentenal	11524419
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of PTGR1 mRNA	16014739
C057920	3-buten-2-one	[PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one	11524419
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGR1 mRNA"	27188386
C045934	4-hydroxy-2-hexenal	[PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-hexenal	11524419
C027576	4-hydroxy-2-nonenal	[PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenal	11524419
C027576	4-hydroxy-2-nonenal	PTGR1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal	11524419
C029370	4-toluidine	4-toluidine results in increased expression of PTGR1 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGR1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of PTGR1 mRNA	21420995\|2906747
D000171	Acrolein	[PTGR1 protein co-treated with NADP] affects the reduction of Acrolein	11524419
C079422	acylfulvene	ERCC6 protein affects the reaction [PTGR1 protein results in increased susceptibility to acylfulvene]	28076683
C079422	acylfulvene	PTGR1 protein results in increased activity of acylfulvene	21939268
C079422	acylfulvene	PTGR1 protein results in increased susceptibility to acylfulvene	21939268\|2807668
C079422	acylfulvene	[PTGR1 protein co-treated with NADP] results in increased reduction of and results in increased activity of acylfulvene	21939268
C079422	acylfulvene	PTGR1 protein results in increased metabolism of acylfulvene	28076683
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PTGR1 mRNA	23630614
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of PTGR1 mRNA"	21854004
C000188	alachlor	alachlor results in increased expression of PTGR1 mRNA	12419858
D000447	Aldehydes	PTGR1 protein results in increased metabolism of Aldehydes	25619643
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PTGR1 mRNA	16483693
D000667	Ampicillin	Ampicillin results in decreased expression of PTGR1 mRNA	21632981
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PTGR1 mRNA	22521957
D001379	Azathioprine	Azathioprine results in increased expression of PTGR1 mRNA	22623647
C051597	Bandrowski's base	Bandrowski's base results in increased expression of PTGR1 mRNA	20566472
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of PTGR1 mRNA	26377693
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of PTGR1 mRNA	18711122
D019817	Benzoic Acid	Benzoic Acid results in increased expression of PTGR1 mRNA	20566472
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTGR1 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of PTGR1 mRNA	21714911
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTGR1 mRNA	20064835\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTGR1 mRNA	21715664
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of PTGR1 mRNA"	18711122
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of PTGR1 mRNA	18711122
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of PTGR1 mRNA"	18711122
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of PTGR1 mRNA	18711122
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTGR1 mRNA"	20018196
C025383	benzylideneacetone	[PTGR1 protein co-treated with NADP] affects the reduction of benzylideneacetone	11524419
C038328	BEP protocol	BEP protocol results in increased expression of PTGR1 mRNA	18987330
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of PTGR1 mRNA	20660070
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in decreased expression of PTGR1 mRNA	15912405
C006780	bisphenol A	bisphenol A results in decreased expression of PTGR1 mRNA	28079927
C006780	bisphenol A	bisphenol A affects the expression of PTGR1 mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of PTGR1 mRNA	26496021
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PTGR1 mRNA	23410634
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PTGR1 mRNA	14729362
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PTGR1 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PTGR1 mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PTGR1 mRNA	25993096
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PTGR1 mRNA	18654764
D002110	Caffeine	Caffeine results in decreased expression of PTGR1 mRNA	25868845
D002211	Capsaicin	naringin inhibits the reaction [[Tobacco Smoke Pollution co-treated with Capsaicin] results in increased expression of PTGR1 protein]	22575871
D002211	Capsaicin	[Tobacco Smoke Pollution co-treated with Capsaicin] results in increased expression of PTGR1 protein	22575871
D002220	Carbamazepine	Carbamazepine affects the expression of PTGR1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PTGR1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PTGR1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PTGR1 protein	27623180
D002509	Cephaloridine	Cephaloridine results in increased expression of PTGR1 mRNA	18500788
D002599	Chalcone	[PTGR1 protein co-treated with NADP] affects the reduction of Chalcone	11524419
C100187	chloropicrin	chloropicrin results in increased expression of PTGR1 mRNA	26352163
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of PTGR1 mRNA	28472532
C012843	cinnamic aldehyde	[PTGR1 protein co-treated with NADP] affects the reduction of cinnamic aldehyde	11524419
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of PTGR1 mRNA	20566472
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PTGR1 mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PTGR1 mRNA	24386269
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 1-pentene-3-one	11524419
D009249	NADP	"[PTGR1 protein co-treated with NADP] affects the reduction of 2,4-nonadienal"	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 2-butenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of (2E)-decenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 2-hexenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 2-nonenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 2-octenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 2-pentenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-hexenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenal	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of Acrolein	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of benzylideneacetone	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of Chalcone	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] affects the reduction of cinnamic aldehyde	11524419
D009249	NADP	[PTGR1 protein co-treated with NADP] results in increased reduction of and results in increased activity of acylfulvene	21939268
D003300	Copper	Copper deficiency results in decreased expression of PTGR1 protein	25150618
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of PTGR1 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PTGR1 mRNA	19549813
C030123	coumarin	coumarin results in increased expression of PTGR1 mRNA	18480146
C089698	CP 105696	CP 105696 results in decreased activity of PTGR1 protein	23611293
C089698	CP 105696	CP 105696 inhibits the reaction [PTGR1 protein binds to LTB4R protein]	7714764
C089698	CP 105696	CP 105696 inhibits the reaction [PTGR1 protein results in increased expression of ITGAM]	7714764
D016572	Cyclosporine	Cyclosporine results in increased expression of PTGR1 mRNA	25562108
C014347	decitabine	decitabine affects the expression of PTGR1 mRNA	23300844
D003907	Dexamethasone	Dexamethasone inhibits the reaction [sephadex results in increased expression of PTGR1 protein]	25878373
D003907	Dexamethasone	Dexamethasone results in decreased expression of PTGR1 mRNA	14618091
C041517	dibenzo(a,l)pyrene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of PTGR1 mRNA"	18711122
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of PTGR1 mRNA"	18711122
C061481	dibenzoylmethane	[sulforafan co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA	17942926
D002945	Cisplatin	Cisplatin affects the expression of PTGR1 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of PTGR1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PTGR1 mRNA	21151649
D004008	Diclofenac	Diclofenac results in decreased activity of PTGR1 protein	25619643
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of PTGR1 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of PTGR1 mRNA	18042831
C014476	diethyl maleate	diethyl maleate results in increased expression of PTGR1 mRNA	25270620
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PTGR1 mRNA	24535843
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA	16158176
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of PTGR1 mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PTGR1 mRNA"	22485181
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of PTGR1 mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of PTGR1 mRNA	20566472
D004221	Disulfiram	Disulfiram results in increased expression of PTGR1 mRNA	20566472
D004228	Dithionitrobenzoic Acid	Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]	23878198
D004228	Dithionitrobenzoic Acid	Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]	23878198
D004237	Diuron	Diuron results in decreased expression of PTGR1 mRNA	21551480
C012301	domoic acid	domoic acid results in decreased expression of PTGR1 mRNA	18936300
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of PTGR1 mRNA	28189721
D005054	Eugenol	Eugenol results in increased expression of PTGR1 mRNA	20566472
D005279	Fenoprofen	Fenoprofen affects the activity of PTGR1 protein	25619643
C007738	fluoranthene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of PTGR1 mRNA"	18711122
C007738	fluoranthene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of PTGR1 mRNA	18711122
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA	16158176
D005472	Fluorouracil	Fluorouracil results in increased expression of PTGR1 protein	15585135
D005485	Flutamide	Flutamide results in decreased expression of PTGR1 mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of PTGR1 mRNA	24136188
C069837	fullerene C60	fullerene C60 results in decreased expression of PTGR1 mRNA	19167457
C039281	furan	furan results in increased expression of PTGR1 mRNA	25539665\|2619464
D017965	gamma-Linolenic Acid	gamma-Linolenic Acid results in increased expression of PTGR1 mRNA	20664735
D005897	Glafenine	Glafenine results in decreased expression of PTGR1 mRNA	24136188
C071834	glycidamide	glycidamide results in increased expression of PTGR1 mRNA	17822822
D007975	Leukotriene B4	Indomethacin binds to and affects the folding of and results in decreased activity of [Leukotriene B4 binds to [PTGR1 protein binds to PTGR2 protein]]	16916844
D007975	Leukotriene B4	Leukotriene B4 binds to [PTGR1 protein binds to PTGR2 protein]	16916844
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of PTGR1 mRNA	20566472
D017313	Fenretinide	Fenretinide results in decreased expression of PTGR1 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of PTGR1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PTGR1 mRNA	23410634
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PTGR1 mRNA	14729362
D007052	Ibuprofen	Ibuprofen results in increased expression of PTGR1 mRNA	16827938
D007052	Ibuprofen	Ibuprofen affects the activity of PTGR1 protein	25619643
D007213	Indomethacin	Indomethacin binds to and affects the folding of and results in decreased activity of [Leukotriene B4 binds to [PTGR1 protein binds to PTGR2 protein]]	16916844
D007213	Indomethacin	Indomethacin results in decreased activity of PTGR1 protein	25619643
D007213	Indomethacin	Indomethacin inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]	23878198
D007213	Indomethacin	Indomethacin inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]	23878198
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTGR1 mRNA	25613284
C036643	isoeugenol	isoeugenol results in increased expression of PTGR1 mRNA	20566472
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of PTGR1 mRNA	27392435
C410337	K 7174	K 7174 results in increased expression of PTGR1 mRNA	24086573
D048628	Ketolides	Ketolides analog results in increased expression of PTGR1 mRNA	24967691
D007659	Ketones	PTGR1 protein results in increased metabolism of Ketones	25619643
D019344	Lactic Acid	Lactic Acid results in increased expression of PTGR1 mRNA	20566472
C008261	lead acetate	lead acetate results in increased expression of PTGR1 mRNA	22839698
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PTGR1 mRNA	18654764
C045463	leflunomide	leflunomide results in decreased expression of PTGR1 mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of PTGR1 mRNA"	24972896
C025340	manganese chloride	manganese chloride results in increased expression of PTGR1 mRNA	22281203
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PTGR1 mRNA	26011545
C033069	methyl salicylate	methyl salicylate results in increased expression of PTGR1 mRNA	20566472
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of PTGR1 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PTGR1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PTGR1 mRNA"	25554681\|2562005
C005274	naringin	naringin inhibits the reaction [[Tobacco Smoke Pollution co-treated with Capsaicin] results in increased expression of PTGR1 protein]	22575871
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of PTGR1 mRNA	19812364
C026385	n-hexane	n-hexane results in increased expression of PTGR1 mRNA	20566472
C022838	nickel chloride	nickel chloride affects the expression of PTGR1 mRNA	22110744
C028007	nickel monoxide	nickel monoxide results in decreased expression of PTGR1 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of PTGR1 mRNA	20566472
D009544	Niflumic Acid	Niflumic Acid results in decreased activity of PTGR1 protein	25619643
C012655	nimesulide	nimesulide affects the activity of PTGR1 protein	25619643
C012655	nimesulide	nimesulide results in increased expression of PTGR1 mRNA	24136188
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of PTGR1 mRNA	20971185
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PTGR1 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of PTGR1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of PTGR1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PTGR1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PTGR1 mRNA]	17655762
D000073878	Palm Oil	Palm Oil results in decreased expression of PTGR1 mRNA	18042831
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of PTGR1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of PTGR1 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PTGR1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter results in increased expression of PTGR1 mRNA	28341207
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in decreased expression of PTGR1 mRNA	19095052
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of PTGR1 mRNA	18692542
D010634	Phenobarbital	Phenobarbital affects the expression of PTGR1 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGR1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PTGR1 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTGR1 mRNA	19710929
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of PTGR1 mRNA	20660070
D011374	Progesterone	Progesterone results in decreased activity of PTGR1 protein	11524419
D011374	Progesterone	Progesterone results in increased expression of PTGR1 mRNA	20726854
D019840	2-Propanol	2-Propanol results in increased expression of PTGR1 mRNA	20566472
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of PTGR1 mRNA	24780913
C100006	prostaglandin F1	PTGR1 protein results in increased metabolism of prostaglandin F1 analog	25619643
D011794	Quercetin	Quercetin results in increased expression of PTGR1 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]	20093625
D011794	Quercetin	Quercetin affects the expression of PTGR1 mRNA	18178720
D011794	Quercetin	Quercetin results in decreased activity of PTGR1 protein	11524419
C031389	resorcinol	resorcinol results in increased expression of PTGR1 mRNA	22623647
D012643	Selenium	Selenium affects the expression of PTGR1 protein	19351701
C025614	sephadex	Dexamethasone inhibits the reaction [sephadex results in increased expression of PTGR1 protein]	25878373
C025614	sephadex	sephadex results in increased expression of PTGR1 protein	25878373
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of PTGR1 mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in increased expression of PTGR1 mRNA	25270620
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of PTGR1 mRNA	20566472
C016766	sulforafan	[sulforafan co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA	17942926
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of PTGR1 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTGR1 mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PTGR1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PTGR1 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTGR1 mRNA	25613284
C056068	theaflavin	theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]	20093625
C009495	titanium dioxide	titanium dioxide affects the expression of PTGR1 mRNA	23557971
D014028	Tobacco Smoke Pollution	naringin inhibits the reaction [[Tobacco Smoke Pollution co-treated with Capsaicin] results in increased expression of PTGR1 protein]	22575871
D014028	Tobacco Smoke Pollution	[Tobacco Smoke Pollution co-treated with Capsaicin] results in increased expression of PTGR1 protein	22575871
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PTGR1 mRNA	25447457
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PTGR1 protein	27818348
C012589	trichostatin A	trichostatin A results in increased expression of PTGR1 mRNA	15901671
C012589	trichostatin A	trichostatin A results in increased expression of PTGR1 mRNA	27188386
D014520	Urethane	Urethane results in decreased expression of PTGR1 mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of PTGR1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of PTGR1 mRNA	15901671
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGR1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of PTGR1 mRNA	19101580\|2317975
D014638	Vanadates	Vanadates results in decreased expression of PTGR1 mRNA	22714537
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of PTGR1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of PTGR1 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PTGR1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of PTGR1 mRNA	23940539
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of PTGR1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of PTGR1 mRNA	15541757
C029297	vinylidene chloride	vinylidene chloride results in increased expression of PTGR1 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of PTGR1 mRNA	23410634
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of PTGR1 mRNA	25270620
C111237	vorinostat	vorinostat results in increased expression of PTGR1 mRNA	27188386
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of PTGR1 mRNA"	23246600

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0032440	2-alkenal reductase [NAD(P)] activity	-	IEA	-
GO:0036132	13-prostaglandin reductase activity	-	IEA	-
GO:0047522	15-oxoprostaglandin 13-oxidase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006691	leukotriene metabolic process	-	NAS	8576264
GO:0006693	prostaglandin metabolic process	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0097327	response to antineoplastic agent	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	IEA
R-HSA-2142700	Synthesis of Lipoxins (LX)	IEA
R-HSA-2142753	Arachidonic acid metabolism	IEA
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-8978868	Fatty acid metabolism	IEA
R-HSA-9018678	Biosynthesis of specialized proresolving mediators (SPMs)	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25447457	Tobacco smoking-response genes in blood and buccal cells. (2015 Jan 22)	Na HK	Toxicol Lett