Gene: FOXF2

2295
FKHL6|FREAC-2|FREAC2
forkhead box F2
protein-coding
6p25.3
Ensembl:ENSG00000137273 MIM:603250 Vega:OTTHUMG00000016243 UniprotKB:Q12947
NG_046984.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.693e-1 (AD)  4.892e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXQ10.807
NOTCH30.749
CARD100.742
LEF10.736
GATA20.732
ESAM0.728
FOXC10.72
GPER10.708
FGD50.707
CLEC14A0.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TH-0.345
OR4F29-0.321
SLC15A5-0.312
SFRP5-0.308
HTR2C-0.306
GHRH-0.299
OR4F5-0.296
NHLH2-0.293
SEMA3E-0.285
IL13RA2-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of FOXF2 mRNA28329830
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FOXF2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FOXF2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FOXF2 gene28458013
C015001arsenitearsenite results in increased methylation of FOXF2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to FOXF2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOXF2 mRNA21569818
C006780bisphenol Abisphenol A affects the methylation of FOXF2 promoter27334623
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXF2 mRNA28628672
C584509C646 compoundC646 compound results in decreased expression of FOXF2 mRNA26191083
D002104CadmiumCadmium results in increased expression of FOXF2 mRNA24376830
D002330CarmustineFOXF2 mRNA affects the susceptibility to Carmustine16365179
D002737ChloropreneChloroprene results in decreased expression of FOXF2 mRNA23125180
D019327Copper SulfateCopper Sulfate results in increased expression of FOXF2 mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of FOXF2 mRNA22077320
D003474CurcuminCurcumin results in decreased expression of FOXF2 mRNA15713895
C017160cypermethrincypermethrin results in decreased expression of FOXF2 mRNA22528246
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXF2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FOXF2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FOXF2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FOXF2 mRNA19561079
D002117CalcitriolCalcitriol results in decreased expression of FOXF2 mRNA26485663
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of FOXF2 gene16724327
D005047EtoposideFOXF2 protein affects the susceptibility to Etoposide16217747
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of FOXF2 mRNA28329830
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FOXF2 protein18951874
C492448ICG 001ICG 001 results in decreased expression of FOXF2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXF2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXF2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FOXF2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOXF2 mRNA24796395
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FOXF2 mRNA28001369
D008942MitoxantroneFOXF2 protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FOXF2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXF2 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of FOXF2 mRNA22714537
D012643SeleniumSelenium results in decreased expression of FOXF2 mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of FOXF2 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FOXF2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of FOXF2 mRNA28595984
D053260SootSoot results in decreased expression of FOXF2 mRNA22461453|2655175
C047246temozolomideFOXF2 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOXF2 mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXF2 mRNA24058054|2637764
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FOXF2 protein18951874
C024746tobacco tartobacco tar results in decreased expression of FOXF2 mRNA19559774
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FOXF2 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of FOXF2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of FOXF2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of FOXF2 mRNA17292431
D014810Vitamin EVitamin E results in decreased expression of FOXF2 mRNA19244175
D015032ZincZinc results in decreased expression of FOXF2 mRNA19071009

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA8626802  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA8626802  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP8626802  
GO:0003677DNA binding-IDA7957066  
GO:0003700DNA-binding transcription factor activity-IDA9722567  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IBA21873635  
GO:0008134transcription factor binding-IPI9722567  
GO:0043565sequence-specific DNA binding-IDA7957066  8626802  
GO ID GO Term Qualifier Evidence PubMed
GO:0001837epithelial to mesenchymal transition-NAS19220249  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA8626802  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8626802  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP8626802  
GO:0048806genitalia development-IMP19276632  
GO:0060021roof of mouth development-IMP19276632  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC8626802  
GO:0005634nucleus-IDA9722567  
GO:0005667transcription factor complex-IDA9722567  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28222662FOXF2 promoter methylation is associated with prognosis in esophageal squamous cell carcinoma. (2017 Feb)Chen XTumour Biol