Gene: SCMH1

22955
Scml3
Scm polycomb group protein homolog 1
protein-coding
1p34.2
Ensembl:ENSG00000010803 MIM:616396 Vega:OTTHUMG00000005720 UniprotKB:Q96GD3
NC_000001.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.845e-1 (AD)  5.275e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6672508chr1:41200899 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRRC2A0.925
TNPO20.906
WDTC10.905
ABR0.903
PRRC2B0.902
DAB2IP0.898
LASP10.897
MGAT4B0.894
NACC10.894
PPP6R10.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.726
OR4F29-0.669
CTNNA3-0.349
SGMS2-0.324
MUSK-0.305
OR6C74-0.302
MYOT-0.297
ANXA13-0.294
DTHD1-0.284
C5orf64-0.279

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03345Beta-MercaptoethanolSmall Molecule60-24-2ExperimentalTarget
ID Drug Name Action PubMed
D000393Air PollutantsAir Pollutants analog results in decreased expression of SCMH1 mRNA21757418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SCMH1 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCMH1 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in increased expression of SCMH1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of SCMH1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of SCMH1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SCMH1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of SCMH1 mRNA26079696
D002706ChlordanChlordan analog affects the expression of SCMH1 mRNA24050789
C018021cobaltous chloridecobaltous chloride results in increased expression of SCMH1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of SCMH1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SCMH1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of SCMH1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA28628672
D004237DiuronDiuron results in decreased expression of SCMH1 mRNA21551480
D005557FormaldehydeFormaldehyde results in decreased expression of SCMH1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of SCMH1 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of SCMH1 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA28628672
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SCMH1 mRNA"20188158
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SCMH1 mRNA17097637
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SCMH1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SCMH1 mRNA19482888
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SCMH1 mRNA23608068
D011794QuercetinQuercetin results in decreased expression of SCMH1 mRNA21632981
D012834SilverSilver results in increased expression of SCMH1 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of SCMH1 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCMH1 mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCMH1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCMH1 mRNA21570461
D014212TretinoinTretinoin results in increased expression of SCMH1 mRNA21934132
D014520UrethaneUrethane results in decreased expression of SCMH1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of SCMH1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of SCMH1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of SCMH1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006338chromatin remodeling-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0016458gene silencing-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-NAS10524249  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0010369chromocenter-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4570464SUMOylation of RNA binding proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal