Gene info: ID 22955

Gene: SCMH1

GENE ID: 22955

Synonyms: Scml3

Description: Scm polycomb group protein homolog 1

Gene type: protein-coding

Location: 1p34.2

dbXrefs: Ensembl:ENSG00000010803 MIM:616396 Vega:OTTHUMG00000005720 UniprotKB:Q96GD3

RefSeq: NC_000001.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.845e-1 (AD) 5.275e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6672508	chr1:41200899 (GRCh38.p7)	C>G / C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRRC2A	0.925
TNPO2	0.906
WDTC1	0.905
ABR	0.903
PRRC2B	0.902
DAB2IP	0.898
LASP1	0.897
MGAT4B	0.894
NACC1	0.894
PPP6R1	0.894

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.726
OR4F29	-0.669
CTNNA3	-0.349
SGMS2	-0.324
MUSK	-0.305
OR6C74	-0.302
MYOT	-0.297
ANXA13	-0.294
DTHD1	-0.284
C5orf64	-0.279

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03345	Beta-Mercaptoethanol	Small Molecule	60-24-2	Experimental	Target

ID	Drug Name	Action	PubMed
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of SCMH1 mRNA	21757418
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of SCMH1 mRNA	21298039
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SCMH1 mRNA	20106945\|2163298
C006780	bisphenol A	bisphenol A results in increased expression of SCMH1 mRNA	29275510
C006780	bisphenol A	bisphenol A affects the methylation of SCMH1 promoter	27334623
C006780	bisphenol A	bisphenol A affects the expression of SCMH1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SCMH1 gene	28505145
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA	28628672
C018475	butyraldehyde	butyraldehyde results in decreased expression of SCMH1 mRNA	26079696
D002706	Chlordan	Chlordan analog affects the expression of SCMH1 mRNA	24050789
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SCMH1 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SCMH1 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of SCMH1 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of SCMH1 mRNA	20106945
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA	28628672
D004237	Diuron	Diuron results in decreased expression of SCMH1 mRNA	21551480
D005557	Formaldehyde	Formaldehyde results in decreased expression of SCMH1 mRNA	23649840
C069837	fullerene C60	fullerene C60 results in decreased expression of SCMH1 mRNA	19167457
D005839	Gentamicins	Gentamicins results in decreased expression of SCMH1 mRNA	22061828
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCMH1 mRNA	28628672
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SCMH1 mRNA"	20188158
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of SCMH1 mRNA	17097637
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SCMH1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of SCMH1 mRNA	19482888
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of SCMH1 mRNA	23608068
D011794	Quercetin	Quercetin results in decreased expression of SCMH1 mRNA	21632981
D012834	Silver	Silver results in increased expression of SCMH1 mRNA	27131904
C009277	sodium arsenate	sodium arsenate results in increased expression of SCMH1 mRNA	21795629
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SCMH1 mRNA	20055451
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SCMH1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SCMH1 mRNA	21570461
D014212	Tretinoin	Tretinoin results in increased expression of SCMH1 mRNA	21934132
D014520	Urethane	Urethane results in decreased expression of SCMH1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SCMH1 gene	29154799
C025643	vinclozolin	vinclozolin results in increased expression of SCMH1 mRNA	23034163
D014810	Vitamin E	Vitamin E results in decreased expression of SCMH1 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006338	chromatin remodeling	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007283	spermatogenesis	-	IEA	-
GO:0009952	anterior/posterior pattern specification	-	IEA	-
GO:0016458	gene silencing	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	NAS	10524249

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-
GO:0010369	chromocenter	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1257604	PIP3 activates AKT signaling	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2559580	Oxidative Stress Induced Senescence	TAS
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-2990846	SUMOylation	TAS
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	TAS
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4551638	SUMOylation of chromatin organization proteins	TAS
R-HSA-4570464	SUMOylation of RNA binding proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-6807070	PTEN Regulation	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	TAS
R-HSA-8943724	Regulation of PTEN gene transcription	TAS
R-HSA-8943724	Regulation of PTEN gene transcription	IEA
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal