Gene: IGSF9B

22997
-
immunoglobulin superfamily member 9B
protein-coding
11q25
Ensembl:ENSG00000080854 MIM:613773 Vega:OTTHUMG00000167124 UniprotKB:Q9UPX0
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.050e-1 (AD)  8.870e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11825659chr11:133925624 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06610125chr11:133823700IGSF9B4.500e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1C0.732
TET30.728
DNMT3A0.708
IGSF220.707
GPR680.688
SNAI30.679
HIVEP30.674
KMT2D0.671
DOT1L0.667
ANKRD520.657

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DYNLRB2-0.388
CDNF-0.384
APOM-0.37
HMGN5-0.36
FAM227B-0.357
IL20RA-0.355
ASB4-0.353
DIAPH3-0.34
LRRCC1-0.339
GINS2-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGSF9B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGSF9B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGSF9B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGSF9B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGSF9B mRNA"25510870
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of IGSF9B mRNA24449571
D001151ArsenicArsenic affects the methylation of IGSF9B gene25304211
C006780bisphenol Abisphenol A results in increased expression of IGSF9B mRNA29097150
D003471CuprizoneCuprizone results in decreased expression of IGSF9B mRNA27523638
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of IGSF9B mRNA27392435
D002945CisplatinCisplatin results in increased expression of IGSF9B mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IGSF9B mRNA29097150
C004312glycidolglycidol results in increased expression of IGSF9B mRNA24915197
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IGSF9B mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of IGSF9B mRNA27392435
D007854LeadLead affects the expression of IGSF9B mRNA28903495
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IGSF9B mRNA26011545
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGSF9B mRNA"25510870
C017947sodium arsenitesodium arsenite affects the methylation of IGSF9B gene28589171
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IGSF9B mRNA25613284
D014635Valproic AcidValproic Acid results in increased methylation of IGSF9B gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019900kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007399nervous system development-IEA-  
GO:0097151positive regulation of inhibitory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0014069postsynaptic density-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IEA-  
GO:0045211postsynaptic membrane-IEA-  
GO:0060077inhibitory synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal