Gene: LIMCH1

22998
LIMCH1A|LMO7B
LIM and calponin homology domains 1
protein-coding
4p13
Ensembl:ENSG00000064042 MIM:617750 Vega:OTTHUMG00000160575 UniprotKB:Q9UPQ0
NC_000004.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.815e-1 (AD)  8.212e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POGK0.914
SECISBP2L0.897
MAP70.893
SPAG90.889
SEPT70.883
SEPT80.88
DENND5A0.876
COBL0.874
TEX20.868
DLG10.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.637
OR4F5-0.583
DPPA4-0.262
C8orf74-0.256
TRIM10-0.255
SIX1-0.249
PDE6G-0.246
OR51A7-0.245
ABCA13-0.243
FMO1-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LIMCH1 mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of LIMCH1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIMCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIMCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIMCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIMCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LIMCH1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LIMCH1 gene27153756
D000452AldrinAldrin results in decreased expression of LIMCH1 mRNA18579281
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LIMCH1 mRNA24449571
D001151ArsenicArsenic affects the methylation of LIMCH1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of LIMCH1 mRNA"25351596
C487081belinostatbelinostat results in decreased expression of LIMCH1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIMCH1 mRNA"27188386
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LIMCH1 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LIMCH1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of LIMCH1 mRNA19167446
D004958EstradiolEstradiol results in increased expression of LIMCH1 mRNA19619570|2118537
D004958EstradiolRaloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of LIMCH1 mRNA]21185374
C006780bisphenol Abisphenol A results in decreased expression of LIMCH1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of LIMCH1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LIMCH1 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of LIMCH1 protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LIMCH1 mRNA16997883
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LIMCH1 mRNA15336504
C054133casticincasticin results in increased expression of LIMCH1 mRNA28444820
D002737ChloropreneChloroprene results in increased expression of LIMCH1 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in increased expression of LIMCH1 mRNA22202117
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of LIMCH1 mRNA]22202117
D003300Copper[Disulfiram binds to Copper] which results in increased expression of LIMCH1 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LIMCH1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of LIMCH1 mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of LIMCH1 mRNA22147139|2798913
D003561CytarabineCytarabine results in increased expression of LIMCH1 mRNA21198554
D000069439DasatinibDasatinib results in increased expression of LIMCH1 mRNA20579391
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LIMCH1 mRNA16997883
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LIMCH1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of LIMCH1 mRNA27392435
D002945CisplatinLIMCH1 protein affects the susceptibility to Cisplatin16217747
D002117CalcitriolCalcitriol results in decreased expression of LIMCH1 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of LIMCH1 mRNA"22485181
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of LIMCH1 mRNA24690739
D000431EthanolEthanol results in decreased expression of LIMCH1 mRNA28986285
D005047EtoposideLIMCH1 protein affects the susceptibility to Etoposide16217747
D017313FenretinideFenretinide results in increased expression of LIMCH1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LIMCH1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LIMCH1 mRNA16997883
D007854LeadLead affects the splicing of LIMCH1 mRNA28903495
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LIMCH1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LIMCH1 mRNA"20188158
D016685MitomycinLIMCH1 protein affects the susceptibility to Mitomycin16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of LIMCH1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LIMCH1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LIMCH1 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LIMCH1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of LIMCH1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of LIMCH1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of LIMCH1 mRNA26516004
D010100OxygenOxygen deficiency affects the methylation of LIMCH1 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of LIMCH1 mRNA24205000
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIMCH1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of LIMCH1 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LIMCH1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of LIMCH1 mRNA20813756
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of LIMCH1 mRNA]21185374
D015474IsotretinoinIsotretinoin results in increased expression of LIMCH1 mRNA20436886
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of LIMCH1 mRNA19244175
D012643SeleniumSelenium results in decreased expression of LIMCH1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LIMCH1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of LIMCH1 mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of LIMCH1 gene28589171
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LIMCH1 mRNA"18579281
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of LIMCH1 mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LIMCH1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIMCH1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIMCH1 mRNA19465110
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of LIMCH1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LIMCH1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LIMCH1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of LIMCH1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of LIMCH1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of LIMCH1 mRNA21934132|2372400
C012589trichostatin Atrichostatin A results in decreased expression of LIMCH1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of LIMCH1 mRNA24935251
C012589trichostatin Atrichostatin A results in decreased expression of LIMCH1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LIMCH1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIMCH1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LIMCH1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LIMCH1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of LIMCH1 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in decreased expression of LIMCH1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LIMCH1 gene25487561
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LIMCH1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of LIMCH1 mRNA26682919
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of LIMCH1 mRNA19244175
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of LIMCH1 mRNA]22202117
C088658zoledronic acidzoledronic acid results in increased expression of LIMCH1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0032034myosin II head/neck binding-IDA28228547  
GO:0032034myosin II head/neck binding-IPI28228547  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IMP28228547  
GO:0030336negative regulation of cell migration-IMP28228547  
GO:0031032actomyosin structure organization-IEA-  
GO:0051496positive regulation of stress fiber assembly-IMP28228547  
GO:0051893regulation of focal adhesion assembly-IMP28228547  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IDA28228547  
GO:0016460myosin II complexcolocalizes_withIDA28228547  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24479813ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. (2014 Jan 31)Eckel-Passow JEBMC Urol