Gene: FAIM2

23017
LFG|LFG2|NGP35|NMP35|TMBIM2
Fas apoptotic inhibitory molecule 2
protein-coding
12q13.12
Ensembl:ENSG00000135472 MIM:604306 Vega:OTTHUMG00000169808 UniprotKB:Q9BWQ8
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.373e-1 (AD)  7.228e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLSTN10.977
ATP6V0A10.973
RUSC20.973
GSK3A0.971
ZER10.97
CTIF0.969
GPI0.969
TMEM59L0.969
MAPRE30.968
SCAMP50.966

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.688
OR4F29-0.649
TFPI2-0.535
CD48-0.443
C9orf135-0.437
KLRB1-0.433
IL18RAP-0.432
RAI14-0.428
KLRF1-0.427
KCNJ15-0.426

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0523831,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene"1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene results in decreased expression of FAIM2 mRNA"23373633
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAIM2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAIM2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAIM2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAIM2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAIM2 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of FAIM2 mRNA"20406850
D000171AcroleinAcrolein results in decreased expression of FAIM2 mRNA18515264
C016601afimoxifeneafimoxifene results in decreased expression of FAIM2 mRNA23373633
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FAIM2 mRNA16483693
C004456beauvericinbeauvericin results in increased expression of FAIM2 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAIM2 mRNA21774909
D019207beta Carotenebeta Carotene results in increased expression of FAIM2 mRNA17034753
D004958EstradiolEstradiol results in decreased expression of FAIM2 mRNA23373633
D004958EstradiolEstradiol results in increased expression of FAIM2 mRNA19693291
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of FAIM2 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of FAIM2 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of FAIM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FAIM2 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FAIM2 mRNA20938992
D003042CocaineCocaine results in increased expression of FAIM2 mRNA16076954
D003300CopperCopper deficiency results in increased expression of FAIM2 mRNA26033743
C016366dibenzothiophenedibenzothiophene results in decreased expression of FAIM2 mRNA23656968
D004026DieldrinDieldrin affects the expression of FAIM2 mRNA22546817
D019422Dietary SucroseDietary Sucrose results in increased expression of FAIM2 mRNA26033743
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased methylation of FAIM2 promoter27415467
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FAIM2 mRNA28196854
C540355fenamidonefenamidone results in decreased expression of FAIM2 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FAIM2 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of FAIM2 mRNA19167457
C039281furanfuran results in decreased expression of FAIM2 mRNA25539665
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FAIM2 mRNA26752646
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FAIM2 mRNA20938992
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of FAIM2 mRNA17412507
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FAIM2 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of FAIM2 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAIM2 mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAIM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAIM2 mRNA"25554681
C119536nickel acetatenickel acetate affects the expression of FAIM2 mRNA12915101
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAIM2 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FAIM2 mRNA23146750
D010936Plant ExtractsPlant Extracts results in decreased expression of FAIM2 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of FAIM2 mRNA23608068
C116926rofecoxibrofecoxib results in decreased expression of FAIM2 mRNA17070997
C016104sodium bichromatesodium bichromate results in increased expression of FAIM2 mRNA22561333
D053260SootSoot results in decreased expression of FAIM2 mRNA26551751
D013739TestosteroneTestosterone results in increased expression of FAIM2 mRNA19693291
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of FAIM2 mRNA25172293
D014415TunicamycinTunicamycin results in increased expression of FAIM2 mRNA22378314
D014635Valproic AcidValproic Acid results in increased methylation of FAIM2 gene29154799
C025643vinclozolinvinclozolin affects the expression of FAIM2 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0021549cerebellum development-ISS-  
GO:0021680cerebellar Purkinje cell layer development-ISS-  
GO:0021681cerebellar granular layer development-ISS-  
GO:0021702cerebellar Purkinje cell differentiation-ISS-  
GO:0043066negative regulation of apoptotic process-NAS10535980  
GO:0043523regulation of neuron apoptotic process-IMP17635665  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IDA26582200  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045121membrane raft-IDA17635665  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes