Gene: FOXJ1

2302
FKHL13|HFH-4|HFH4
forkhead box J1
protein-coding
17q25.1
Ensembl:ENSG00000129654 MIM:602291 Vega:OTTHUMG00000180120 UniprotKB:Q92949
NG_013345.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.128e-1 (AD)  4.627e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EVC20.761
EFNB10.725
EYA20.699
RFX20.689
MSX10.676
WDR380.673
P4HA10.668
CCDC102A0.668
PYCR10.667
DDIT4L0.663

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARMCX5-0.536
TASP1-0.509
NUDT18-0.497
NRG1-0.496
SLIT3-0.491
SLC4A8-0.489
PPEF1-0.485
HS6ST2-0.482
TUBGCP5-0.481
SPHKAP-0.481

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FOXJ1 mRNA"28712647
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of FOXJ1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of FOXJ1 mRNA]28655636
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of FOXJ1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXJ1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXJ1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FOXJ1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FOXJ1 mRNA21641981
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in increased expression of FOXJ1 mRNA16443354
D001205Ascorbic AcidAscorbic Acid results in increased expression of FOXJ1 mRNA15372504
D001280AtrazineAtrazine results in decreased expression of FOXJ1 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of FOXJ1 mRNA19371625
C006780bisphenol Abisphenol A affects the methylation of FOXJ1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of FOXJ1 mRNA25181051|2909715
D002330CarmustineCarmustine results in decreased expression of FOXJ1 mRNA15980968
D002737ChloropreneChloroprene results in increased expression of FOXJ1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FOXJ1 mRNA20938992
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of FOXJ1 mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of FOXJ1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of FOXJ1 mRNA26577399
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of FOXJ1 promoter] which affects the expression of FOXJ1 mRNA18836996|1883699
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FOXJ1 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FOXJ1 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of FOXJ1 mRNA19371625
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of FOXJ1 mRNA24690739
D004317DoxorubicinFOXJ1 mRNA affects the susceptibility to Doxorubicin16044152
C118739entinostatentinostat results in increased expression of FOXJ1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXJ1 mRNA"27188386
D015025ZearalenoneZearalenone results in decreased expression of FOXJ1 mRNA19371625
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FOXJ1 mRNA20938992
D004397FonofosFonofos results in increased methylation of FOXJ1 promoter22847954
D019833GenisteinGenistein results in decreased expression of FOXJ1 mRNA16705744|1937162
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in decreased expression of FOXJ1 mRNA"26833564
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FOXJ1 mRNA12057914
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FOXJ1 mRNA20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of FOXJ1 mRNA24810058
D016685MitomycinMitomycin results in increased expression of FOXJ1 mRNA25270620
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of FOXJ1 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of FOXJ1 mRNA21195148
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FOXJ1 mRNA26924002
C500085muraglitazarmuraglitazar results in decreased expression of FOXJ1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXJ1 mRNA"25554681
C031721naphthalenenaphthalene affects the expression of FOXJ1 protein16239640
C031721naphthalenenaphthalene results in increased expression of FOXJ1 mRNA18978301
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of FOXJ1 mRNA24888373
D010278ParathionParathion results in increased methylation of FOXJ1 promoter22847954
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of FOXJ1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of FOXJ1 mRNA28655636
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of FOXJ1 mRNA24888373
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FOXJ1 mRNA27029645
C089730rosiglitazonerosiglitazone results in decreased expression of FOXJ1 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FOXJ1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FOXJ1 mRNA23806026
D053260SootSoot affects the expression of FOXJ1 mRNA26551751
C012568terbufosterbufos results in increased methylation of FOXJ1 promoter22847954
C501413tesaglitazartesaglitazar results in decreased expression of FOXJ1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXJ1 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXJ1 mRNA19490992
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOXJ1 mRNA20059580
C009495titanium dioxidetitanium dioxide results in decreased expression of FOXJ1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FOXJ1 mRNA25788831
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FOXJ1 mRNA27865774
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in increased expression of FOXJ1 mRNA16443354
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of FOXJ1 promoter] which affects the expression of FOXJ1 mRNA18836996|1883699
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FOXJ1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FOXJ1 mRNA21515302
D014520UrethaneUrethane results in decreased expression of FOXJ1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FOXJ1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of FOXJ1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of FOXJ1 mRNA17292431
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of FOXJ1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of FOXJ1 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FOXJ1 gene25560391
D019287Zinc SulfateZinc Sulfate results in increased expression of FOXJ1 mRNA17506889
C088658zoledronic acidzoledronic acid results in decreased expression of FOXJ1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IDA9096351  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0003677DNA binding-NAS9073514  
GO:0003700DNA-binding transcription factor activity-NAS9073514  
GO:0005515protein binding-IPI25609649  27173435  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0002508central tolerance induction-ISS-  
GO:0002635negative regulation of germinal center formation-ISS-  
GO:0002897positive regulation of central B cell tolerance induction-ISS-  
GO:0002924negative regulation of humoral immune response mediated by circulating immunoglobulin-ISS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006959humoral immune response-ISS-  
GO:0007283spermatogenesis-NAS9073514  
GO:0007368determination of left/right symmetry-IEA-  
GO:0007389pattern specification process-ISS-  
GO:0007420brain development-ISS9073514  
GO:0007420brain development-NAS9096351  
GO:0007507heart development-IEA-  
GO:0030036actin cytoskeleton organization-ISS-  
GO:0032088negative regulation of NF-kappaB transcription factor activity-ISS-  
GO:0033085negative regulation of T cell differentiation in thymus-ISS-  
GO:0035089establishment of apical/basal cell polarity-ISS-  
GO:0035502metanephric part of ureteric bud development-IEP9530170  
GO:0042130negative regulation of T cell proliferation-IEA-  
GO:0044458motile cilium assembly-IEA-  
GO:0045409negative regulation of interleukin-6 biosynthetic process-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9096351  
GO:0050869negative regulation of B cell activation-ISS-  
GO:0050900leukocyte migration-ISS-  
GO:0060271cilium assembly-ISS-  
GO:0060428lung epithelium development-IEP9530170  
GO:0060428lung epithelium development-NAS9096351  
GO:0060429epithelium development-ISS9073514  
GO:0060972left/right pattern formation-IEA-  
GO:0072016glomerular parietal epithelial cell development-IEP9530170  
GO:0090630activation of GTPase activity-ISS-  
GO:1901248positive regulation of lung ciliated cell differentiation-IDA20539013  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17008636  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24828273FOXJ1 prevents cilia growth inhibition by cigarette smoke in human airway epithelium in vitro. (2014 Nov)Brekman AAm J Respir Cell Mol Biol
16809635Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. (2006 Dec)Lonergan KMAm J Respir Cell Mol Biol
29262847Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development. (2017 Dec 20)Chen YGenome Biol
23009827Effect of cigarette smoking on human oviductal ciliation and ciliogenesis. (2013 Jan)Pier BFertil Steril