Gene: PALLD

23022
CGI-151|CGI151|MYN|PNCA1|SIH002
palladin, cytoskeletal associated protein
protein-coding
4q32.3
Ensembl:ENSG00000129116 MIM:608092 Vega:OTTHUMG00000161097 UniprotKB:Q8WX93
NG_013376.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.348e-1 (AD)  9.846e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6831359chr4:168751479 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YAP10.911
LRP100.899
CNN30.895
FERMT20.895
ABHD40.89
PLSCR40.889
GNG120.887
PARD30.881
FGF20.879
GNA120.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.637
PPEF1-0.624
SLC7A4-0.617
CALHM1-0.592
ADRA1D-0.583
MYOZ3-0.576
GPR61-0.575
AGMAT-0.568
ADTRP-0.56
FBLN7-0.545

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PALLD mRNA16788091
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of PALLD mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PALLD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PALLD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PALLD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PALLD mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of PALLD mRNA"26238291
D000082AcetaminophenAcetaminophen affects the expression of PALLD mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of PALLD mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PALLD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PALLD gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PALLD mRNA21632981|2164198
D000638AmiodaroneAmiodarone affects the expression of PALLD mRNA25064622
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PALLD mRNA24449571
D001379AzathioprineAzathioprine results in increased expression of PALLD mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of PALLD mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of PALLD mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of PALLD mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PALLD mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PALLD mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PALLD mRNA"19150397
D004958EstradiolEstradiol affects the expression of PALLD mRNA14699072|2257421
D004958EstradiolEstradiol results in decreased expression of PALLD mRNA19167446
D004958EstradiolEstradiol results in increased expression of PALLD mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of PALLD mRNA25181051
D000069286BortezomibBortezomib results in increased expression of PALLD mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of PALLD mRNA23410634
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of PALLD mRNA26272509
C100187chloropicrinchloropicrin affects the expression of PALLD mRNA26352163
D002746ChlorpromazineChlorpromazine affects the expression of PALLD mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PALLD mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PALLD mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PALLD mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of PALLD mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of PALLD mRNA17211630
D016572CyclosporineCyclosporine affects the expression of PALLD mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of PALLD mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of PALLD mRNA19770486
C014347decitabinedecitabine affects the expression of PALLD mRNA23300844
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of PALLD protein23811945
D003907DexamethasoneDexamethasone results in increased expression of PALLD mRNA25047013
D002945CisplatinCisplatin affects the expression of PALLD mRNA23300844
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of PALLD mRNA25242112
D002117CalcitriolCalcitriol results in decreased expression of PALLD mRNA16002434
D004317DoxorubicinDoxorubicin results in decreased expression of PALLD mRNA19277126
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of PALLD mRNA"23811387
C118739entinostatentinostat results in decreased expression of PALLD mRNA26272509
C118739entinostatentinostat results in increased expression of PALLD mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PALLD mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PALLD mRNA25064622
C540355fenamidonefenamidone results in increased expression of PALLD mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PALLD mRNA20938992
D017313FenretinideFenretinide results in decreased expression of PALLD mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PALLD mRNA23410634
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PALLD mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of PALLD mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PALLD mRNA26644586
C045463leflunomideleflunomide results in increased expression of PALLD mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PALLD mRNA25613284
C042720mercuric bromidemercuric bromide results in increased expression of PALLD mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of PALLD mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PALLD mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of PALLD mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PALLD mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PALLD mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PALLD mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of PALLD mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PALLD protein24625837
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PALLD mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PALLD mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of PALLD mRNA23811387
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of PALLD mRNA19812364
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PALLD mRNA19812364
C029938nickel sulfatenickel sulfate results in decreased expression of PALLD mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PALLD mRNA20971185
D010269ParaquatParaquat affects the expression of PALLD mRNA25064622
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PALLD mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PALLD mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of PALLD mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of PALLD mRNA18301758
D010894PiroxicamPiroxicam results in decreased expression of PALLD mRNA21858171
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PALLD mRNA22714537
C045950propiconazolepropiconazole results in increased expression of PALLD mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of PALLD mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PALLD mRNA27029645
D011794QuercetinQuercetin results in increased expression of PALLD mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of PALLD mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PALLD mRNA14699072
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of PALLD mRNA21427059
D012643SeleniumSelenium results in decreased expression of PALLD mRNA19244175
D012715Sesame OilSesame Oil results in decreased expression of PALLD mRNA29191790
D012834SilverSilver results in increased expression of PALLD mRNA26014281
D013629TamoxifenTamoxifen affects the expression of PALLD mRNA14699072
D013629TamoxifenTamoxifen results in increased expression of PALLD mRNA17555576
C004648testosterone enanthatetestosterone enanthate affects the expression of PALLD mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PALLD mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PALLD mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PALLD mRNA23238561
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PALLD mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PALLD mRNA23238561
D013752TetracyclineTetracycline affects the expression of PALLD mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PALLD mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of PALLD protein20109541
D013792ThalidomideThalidomide results in increased expression of PALLD mRNA19751816
D013853ThioacetamideThioacetamide affects the expression of PALLD mRNA25064622
C483909torcetrapibtorcetrapib results in increased expression of PALLD mRNA23228038
D014212TretinoinTretinoin results in decreased expression of PALLD mRNA21934132
D014212TretinoinTretinoin results in increased expression of PALLD mRNA16054129|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PALLD mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of PALLD mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of PALLD mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PALLD mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of PALLD mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of PALLD mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PALLD mRNA19101580|2317975
D014800VitalliumVitallium analog results in increased expression of PALLD mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of PALLD mRNA23410634
C111237vorinostatvorinostat results in decreased expression of PALLD mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI11598191  16125169  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0051371muscle alpha-actinin binding-TAS16125169  
GO ID GO Term Qualifier Evidence PubMed
GO:0003334keratinocyte development-IEA-  
GO:0003382epithelial cell morphogenesis-IEA-  
GO:0007010cytoskeleton organization-NAS11598191  
GO:0016477cell migration-IEA-  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0030036actin cytoskeleton organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0002102podosome-IEA-  
GO:0005634nucleus-IDA11598191  
GO:0005829cytosol-IDA-  
GO:0005884actin filament-IBA21873635  
GO:0005884actin filament-IDA11598191  
GO:0005886plasma membrane-IDA-  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeleton-IBA21873635  
GO:0015629actin cytoskeleton-IDA-  
GO:0030018Z disc-IEA-  
GO:0030027lamellipodium-IEA-  
GO:0030426growth cone-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26614807Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)Martin FHum Exp Toxicol
19150414Genetic predisposition and environmental risk factors to pancreatic cancer: A review of the literature. (2009 Mar-Jun)Landi SMutat Res