Gene: PDZRN3

23024
LNX3|SEMACAP3|SEMCAP3
PDZ domain containing ring finger 3
protein-coding
3p13
Ensembl:ENSG00000121440 MIM:609729 Vega:OTTHUMG00000158865 UniprotKB:Q9UPQ7
NG_047128.1
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.319e-2 (AD)  4.210e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12632758chr3:73499249 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12632755chr3:73499184 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3816831chr3:73401047 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAST40.826
TRAK10.823
TCF40.811
EFNB20.809
NR1D20.806
ARHGAP320.8
RORB0.799
FOXG10.798
SLC35E10.798
ARHGEF120.797

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.523
OR4F29-0.478
SH2D1A-0.478
CTNNA3-0.45
C5orf64-0.44
ANXA13-0.428
TNFRSF13B-0.422
TRPV5-0.408
FXYD4-0.406
ACAP1-0.397

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of PDZRN3 mRNA"20702594
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of PDZRN3 mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of PDZRN3 mRNA"20702594
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PDZRN3 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDZRN3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDZRN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDZRN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDZRN3 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of PDZRN3 mRNA28959563
D000638AmiodaroneAmiodarone results in increased expression of PDZRN3 mRNA24535564
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PDZRN3 mRNA19737545
C015001arsenitearsenite results in increased methylation of PDZRN3 promoter23974009
D001280AtrazineAtrazine results in decreased expression of PDZRN3 mRNA22378314
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PDZRN3 mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDZRN3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDZRN3 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of PDZRN3 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDZRN3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of PDZRN3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PDZRN3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PDZRN3 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PDZRN3 mRNA22079614
D002737ChloropreneChloroprene results in decreased expression of PDZRN3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PDZRN3 gene20938992
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDZRN3 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of PDZRN3 mRNA22733784
D002945CisplatinCisplatin results in decreased expression of PDZRN3 mRNA22023808
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PDZRN3 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of PDZRN3 mRNA26485663
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of PDZRN3 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of PDZRN3 mRNA25380136
D005485FlutamideFlutamide results in decreased expression of PDZRN3 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PDZRN3 gene20938992
C039281furanfuran results in decreased expression of PDZRN3 mRNA25539665
D005897GlafenineGlafenine results in decreased expression of PDZRN3 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PDZRN3 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDZRN3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDZRN3 mRNA28628672
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PDZRN3 mRNA27339419
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PDZRN3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PDZRN3 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDZRN3 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDZRN3 mRNA"26251327
C523799MRK 003PDZRN3 results in increased susceptibility to MRK 00319903844
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of PDZRN3 mRNA25380136
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDZRN3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PDZRN3 mRNA18301758|1844570
D011192Potassium DichromatePotassium Dichromate results in increased expression of PDZRN3 mRNA23608068
C024273profenofosprofenofos results in increased expression of PDZRN3 mRNA17569032
D011441PropylthiouracilPropylthiouracil results in increased expression of PDZRN3 mRNA24780913
D012834SilverSilver results in decreased expression of PDZRN3 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of PDZRN3 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of PDZRN3 gene28589171
D012999SomanSoman results in increased expression of PDZRN3 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDZRN3 mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PDZRN3 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDZRN3 mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDZRN3 mRNA18796159|2323856
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDZRN3 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDZRN3 mRNA23238561
D013853ThioacetamideThioacetamide results in decreased expression of PDZRN3 mRNA23411599
D014212TretinoinTretinoin results in increased expression of PDZRN3 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDZRN3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PDZRN3 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of PDZRN3 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of PDZRN3 mRNA28818685
D014520UrethaneUrethane results in increased expression of PDZRN3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PDZRN3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PDZRN3 mRNA24535564

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0008270zinc ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007528neuromuscular junction development-IBA21873635  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IEA-  
GO:0016567protein ubiquitination-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0030054cell junction-IEA-  
GO:0031594neuromuscular junction-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21546767Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (2011)Murea MAm J Nephrol