Gene info: ID 23034

Gene: SAMD4A

GENE ID: 23034

Synonyms: SAMD4|SMAUG|SMAUG1|SMG|SMGA

Description: sterile alpha motif domain containing 4A

Gene type: protein-coding

Location: 14q22.2

dbXrefs: Ensembl:ENSG00000020577 MIM:610747 Vega:OTTHUMG00000170999 UniprotKB:Q9UPU9

RefSeq: NC_000014.9

Retrived from: SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.310e-1 (AD) 1.182e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs11845379	chr14:54727746 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs911620	chr14:54658981 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HNRNPF	0.747
ENAH	0.747
BAZ1A	0.735
RAI14	0.727
YBX1	0.724
MAP4K4	0.724
KLHL5	0.722
TANC1	0.719
PPP1R18	0.717
CLIC4	0.717

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
F7	-0.448
BHLHA9	-0.446
EIF4E1B	-0.434
MYADML2	-0.431
RHOV	-0.427
FGF9	-0.423
TPBGL	-0.413
CRHR1	-0.413
PVALB	-0.412
NOS2	-0.411

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SAMD4A mRNA"	28973690
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of SAMD4A mRNA	22230336\|2906747
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SAMD4A mRNA	21641981
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SAMD4A mRNA	23630614
C015001	arsenite	arsenite results in decreased methylation of SAMD4A promoter	23974009
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SAMD4A mRNA"	18687144
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SAMD4A mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SAMD4A mRNA	21632981\|2187194
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of SAMD4A gene	25435355
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SAMD4A mRNA"	19150397
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SAMD4A mRNA"	26238291
C006780	bisphenol A	bisphenol A results in increased expression of SAMD4A mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SAMD4A gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SAMD4A mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in increased expression of SAMD4A mRNA	26079696
D002220	Carbamazepine	Carbamazepine affects the expression of SAMD4A mRNA	25979313
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of SAMD4A mRNA	26272509
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SAMD4A mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SAMD4A mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SAMD4A mRNA	19549813
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of SAMD4A mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of SAMD4A mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of SAMD4A mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of SAMD4A mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased methylation of SAMD4A promoter	27989131
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of SAMD4A mRNA	24921660
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SAMD4A mRNA]	27941970
D003976	Diazinon	Diazinon results in increased methylation of SAMD4A gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SAMD4A mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SAMD4A mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SAMD4A mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of SAMD4A mRNA	28302478
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of SAMD4A mRNA"	23811387
D005473	Fluoxetine	Fluoxetine results in decreased expression of SAMD4A mRNA	17033635
C039281	furan	furan results in increased expression of SAMD4A mRNA	25539665
C039281	furan	furan results in increased methylation of SAMD4A gene	22079235
D005978	Glutathione	Glutathione deficiency results in increased expression of SAMD4A mRNA	20621112
D017313	Fenretinide	Fenretinide results in increased expression of SAMD4A mRNA	28973697
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of SAMD4A mRNA	17183730
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of SAMD4A mRNA	21396975
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SAMD4A mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SAMD4A mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of SAMD4A mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of SAMD4A mRNA	24796395
C045463	leflunomide	leflunomide results in increased expression of SAMD4A mRNA	28988120
C042720	mercuric bromide	mercuric bromide results in increased expression of SAMD4A mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
D008727	Methotrexate	Methotrexate results in increased expression of SAMD4A mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SAMD4A mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
D009285	Naphthoquinones	Naphthoquinones results in increased expression of SAMD4A mRNA	23811387
C022838	nickel chloride	nickel chloride affects the expression of SAMD4A mRNA	22110744
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of SAMD4A mRNA	18593933
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SAMD4A mRNA	26272509
C005556	propionaldehyde	propionaldehyde results in increased expression of SAMD4A mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SAMD4A mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of SAMD4A mRNA	21632981
C031389	resorcinol	resorcinol results in decreased expression of SAMD4A mRNA	22623647
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of SAMD4A mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of SAMD4A protein	25505154
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SAMD4A mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SAMD4A mRNA	25351596
D012834	Silver	Silver results in increased expression of SAMD4A mRNA	26014281
C016104	sodium bichromate	sodium bichromate affects the expression of SAMD4A mRNA	22110744
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SAMD4A mRNA	20106945\|2163298
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SAMD4A mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of SAMD4A mRNA	23411599
D014212	Tretinoin	Tretinoin results in increased expression of SAMD4A mRNA	23724009
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of SAMD4A gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of SAMD4A mRNA	24935251\|2627250
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SAMD4A mRNA"	26179874
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of SAMD4A mRNA	17183730
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD4A mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SAMD4A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SAMD4A mRNA	23179753\|2438349
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of SAMD4A mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0003729	mRNA binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	15324660 17353931 25416956
GO:0030371	translation repressor activity	-	IBA	21873635
GO:0030371	translation repressor activity	-	IDA	16221671

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	-	IBA	21873635
GO:0017148	negative regulation of translation	-	IBA	21873635
GO:0017148	negative regulation of translation	-	IEA	-
GO:0043488	regulation of mRNA stability	-	IBA	21873635
GO:0045727	positive regulation of translation	-	IDA	16221671

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000932	P-body	-	IBA	21873635
GO:0001650	fibrillar center	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0030054	cell junction	-	IDA	-
GO:0030425	dendrite	-	IEA	-
GO:0045202	synapse	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal