Gene: PHLPP2

23035
PHLPPL|PPM3B
PH domain and leucine rich repeat protein phosphatase 2
protein-coding
16q22.2
Ensembl:ENSG00000040199 MIM:611066 Vega:OTTHUMG00000176867 UniprotKB:Q6ZVD8
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.541e-1 (AD)  1.138e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RALGAPB0.956
ATRN0.954
RAPGEF20.954
BTRC0.954
ARHGAP260.949
LMTK20.949
PPM1L0.948
MTMR40.948
DENND5B0.947
INPP4A0.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.477
HEY2-0.472
CSAG1-0.471
COPZ2-0.462
OR4F5-0.453
RAB13-0.44
SNHG18-0.424
RAI14-0.42
ROM1-0.412
TFPI2-0.409

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000079AcetaldehydeAcetaldehyde results in decreased expression of PHLPP2 mRNA23416264
D000082AcetaminophenAcetaminophen results in decreased expression of PHLPP2 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of PHLPP2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PHLPP2 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of PHLPP2 protein26767949
D000082Acetaminophenmorin inhibits the reaction [Acetaminophen results in increased expression of PHLPP2 protein]26767949
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PHLPP2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHLPP2 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of PHLPP2 mRNA22378314
D001554BenzeneBenzene results in increased expression of PHLPP2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of PHLPP2 promoter28329817
C006780bisphenol Abisphenol A results in decreased expression of PHLPP2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLPP2 mRNA28628672
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PHLPP2 mRNA28472532
D003042CocaineCocaine affects the expression of PHLPP2 mRNA20187946
D016572CyclosporineCyclosporine results in decreased expression of PHLPP2 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLPP2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PHLPP2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of PHLPP2 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PHLPP2 mRNA29097150
C024565ethylene dichlorideethylene dichloride results in decreased expression of PHLPP2 mRNA28189721
D005557FormaldehydeFormaldehyde results in decreased expression of PHLPP2 mRNA20655997
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLPP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLPP2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PHLPP2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PHLPP2 mRNA24796395
D007854LeadLead results in decreased expression of PHLPP2 mRNA19921347
C008548morinmorin inhibits the reaction [Acetaminophen results in increased expression of PHLPP2 protein]26767949
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PHLPP2 mRNA19710929
C017947sodium arsenitesodium arsenite results in decreased expression of PHLPP2 protein21268130
D014520UrethaneUrethane results in increased expression of PHLPP2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PHLPP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PHLPP2 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PHLPP2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activity-IBA21873635  
GO:0005515protein binding-IPI18162466  19615732  21804599  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IBA21873635  
GO:0021766hippocampus development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segment-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0042622photoreceptor outer segment membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29223853Role of miR-195 in cigarette smoke-induced chronic obstructive pulmonary disease. (2018 Feb)Gu WInt Immunopharmacol