Gene info: ID 23037

SNP ID	Position	Alleles	Trait	Variation Type
rs4867084	chr5:31818841 (GRCh38.p7)	G>A / G>C / G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs7731219	chr5:31804466 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs253922	chr5:31723153 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg13039251	chr5:32018601	PDZD2		1.400e-15	Smoking	27651444
cg13039251	chr5:32018601	PDZD2		5.230e-11	Tobacco smoking	28225026

Gene Symbol	Pearson Correlation Coefficient
PDE4DIP	0.76
ARNT2	0.756
SIPA1L1	0.75
ATP9B	0.749
CRTC1	0.746
C14orf132	0.744
NCOA1	0.743
KDM3B	0.739
MAGI2	0.738
PRKDC	0.737

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.519
OR4F29	-0.482
C9orf135	-0.32
UTS2	-0.31
XPNPEP2	-0.308
C17orf64	-0.288
C11orf88	-0.284
GNG8	-0.276
PDZK1IP1	-0.275
FUOM	-0.274

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PDZD2 mRNA"	28903501
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PDZD2 mRNA	19933214
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PDZD2 mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PDZD2 mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDZD2 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDZD2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDZD2 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in decreased expression of PDZD2 mRNA	28959563
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PDZD2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PDZD2 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of PDZD2 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PDZD2 mRNA	15761015
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PDZD2 mRNA	27195522
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDZD2 mRNA"	19150397
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of PDZD2 mRNA	20660070
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of PDZD2 mRNA	17404688
C006780	bisphenol A	bisphenol A affects the expression of PDZD2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PDZD2 gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PDZD2 mRNA	15336504
D002211	Capsaicin	Capsaicin results in increased expression of PDZD2 mRNA	16278290
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDZD2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of PDZD2 mRNA	26272509
C015763	cumene	cumene results in decreased expression of PDZD2 mRNA	18648096
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PDZD2 mRNA	21266533
D004041	Dietary Fats	Dietary Fats results in decreased expression of PDZD2 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of PDZD2 mRNA	21852083
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased expression of PDZD2 mRNA]	21852083
D002117	Calcitriol	Calcitriol results in increased expression of PDZD2 mRNA	16002434
D005419	Flavonoids	Flavonoids results in increased expression of PDZD2 mRNA	18035473
C069837	fullerene C60	fullerene C60 results in increased expression of PDZD2 mRNA	19167457
C412815	GW 4064	GW 4064 results in increased expression of PDZD2 mRNA	26655953
D017313	Fenretinide	Fenretinide results in decreased expression of PDZD2 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of PDZD2 mRNA	28973697
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of PDZD2 mRNA"	26377693
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of PDZD2 mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased methylation of PDZD2 gene	21212295
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of PDZD2 gene	21212295
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of PDZD2 mRNA	16507785
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PDZD2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PDZD2 mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDZD2 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PDZD2 mRNA"	20188158
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PDZD2 promoter"	26251327
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PDZD2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PDZD2 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of PDZD2 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride results in increased expression of PDZD2 mRNA	17312168
C029938	nickel sulfate	nickel sulfate results in decreased expression of PDZD2 mRNA	22714537
D010100	Oxygen	Oxygen deficiency results in increased expression of PDZD2 mRNA	26516004
D011189	Potassium Chloride	Potassium Chloride deficiency results in increased expression of PDZD2 mRNA	24478344
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PDZD2 mRNA	22714537
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of PDZD2 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of PDZD2 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of PDZD2 mRNA	17404688
C502851	quinocetone	quinocetone results in increased expression of PDZD2 mRNA	27046791
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased expression of PDZD2 mRNA]	21852083
D012906	Smoke	Smoke results in decreased expression of PDZD2 mRNA	21095227
D053260	Soot	Soot results in decreased expression of PDZD2 mRNA	26551751
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of PDZD2 gene	21212295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PDZD2 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased methylation of PDZD2 gene	21212295
C009495	titanium dioxide	titanium dioxide affects the expression of PDZD2 mRNA	17656681
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of PDZD2 gene	26756918
D014212	Tretinoin	Tretinoin results in increased expression of PDZD2 mRNA	21934132
D014635	Valproic Acid	Valproic Acid results in increased expression of PDZD2 mRNA	23179753\|2438349
D014640	Vancomycin	Vancomycin results in increased expression of PDZD2 mRNA	18930951

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	ISS	12671685
GO:0005634	nucleus	-	ISS	12671685
GO:0005737	cytoplasm	-	IDA	11289102
GO:0005783	endoplasmic reticulum	-	ISS	12671685
GO:0005911	cell-cell junction	-	ISS	12671685

Gene: PDZD2

ANCO-SNPs

DNA Methylation

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)