Gene: XPO7

23039
EXP7|RANBP16
exportin 7
protein-coding
8p21.3
Ensembl:ENSG00000130227 MIM:606140 Vega:OTTHUMG00000163789 UniprotKB:Q9UIA9
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.689e-1 (AD)  9.740e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6996493chr8:21936097 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDR820.97
AP2B10.965
CKAP50.961
SENP20.961
COPA0.959
KAT70.959
ATP2A20.958
RALGAPB0.957
NPEPPS0.953
MAPRE20.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.68
OR4F29-0.635
MTRNR2L6-0.33
CSAG1-0.317
MTRNR2L10-0.317
TFPI2-0.313
KLRB1-0.312
MYL3-0.306
HEY2-0.302
MTRNR2L9-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of XPO7 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of XPO7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of XPO7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of XPO7 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of XPO7 mRNA"25510870
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of XPO7 protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of XPO7 mRNA21420995
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of XPO7 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XPO7 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of XPO7 gene27153756
D000638AmiodaroneAmiodarone results in decreased expression of XPO7 mRNA17991464
D001280AtrazineAtrazine results in increased expression of XPO7 mRNA26518232
C006780bisphenol Abisphenol A results in decreased expression of XPO7 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of XPO7 gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of XPO7 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XPO7 mRNA]17585979
D003375CoumestrolCoumestrol results in increased expression of XPO7 mRNA19167446
D002117CalcitriolCalcitriol results in decreased expression of XPO7 mRNA16847355|1861484
C118739entinostatentinostat results in decreased expression of XPO7 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of XPO7 mRNA17942748
D018120FinasterideFinasteride results in increased expression of XPO7 mRNA24136188
D005485FlutamideFlutamide results in increased expression of XPO7 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of XPO7 gene20938992
D005839GentamicinsGentamicins results in decreased expression of XPO7 mRNA22061828
D007213IndomethacinIndomethacin results in decreased expression of XPO7 mRNA28201806
C051890irinotecanirinotecan analog results in decreased expression of XPO7 mRNA18927307
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of XPO7 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of XPO7 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in decreased expression of XPO7 mRNA29191790
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of XPO7 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of XPO7 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of XPO7 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of XPO7 mRNA19162173
D012715Sesame OilSesame Oil results in increased expression of XPO7 mRNA29191790
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XPO7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XPO7 mRNA21215274
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of XPO7 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of XPO7 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of XPO7 mRNA18614847
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of XPO7 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of XPO7 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of XPO7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of XPO7 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of XPO7 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005049nuclear export signal receptor activity-IBA21873635  
GO:0005049nuclear export signal receptor activity-IDA11024021  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006611protein export from nucleus-IBA21873635  
GO:0006611protein export from nucleus-IDA11024021  
GO:0051028mRNA transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11071879  
GO:0005643nuclear pore-IBA21873635  
GO:0005643nuclear pore-IDA11024021  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA11071879  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal