Gene: FOXE1

2304
FKHL15|FOXE2|HFKH4|HFKL5|NMTC4|TITF2|TTF-2|TTF2
forkhead box E1
protein-coding
9q22.33
Ensembl:ENSG00000178919 MIM:602617 Vega:OTTHUMG00000020333 UniprotKB:O00358
NG_011979.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.941e-1 (AD)  8.743e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IYD0.943
TPO0.93
KRT70.848
TG0.841
WDR720.832
TFF30.829
DIO10.816
KRTAP4-90.78
SLC26A70.765
MTRNR2L30.762

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C3orf18-0.361
SPAG8-0.343
SORCS2-0.341
HDDC3-0.337
TMEM53-0.336
BOLA1-0.33
PAQR4-0.328
CYS1-0.327
FBXO15-0.324
HHATL-0.324

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FOXE1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FOXE1 mRNA"18648102
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FOXE1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of FOXE1 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOXE1 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of FOXE1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of FOXE1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of FOXE1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of FOXE1 mRNA23238275|2682790
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FOXE1 mRNA21297351
D002509CephaloridineCephaloridine results in decreased expression of FOXE1 mRNA18500788
C014347decitabinedecitabine results in increased expression of FOXE1 mRNA27915011
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of FOXE1 mRNA21658437
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of FOXE1 mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FOXE1 mRNA17557909
D005557FormaldehydeFormaldehyde results in decreased expression of FOXE1 mRNA20655997
C039281furanfuran results in decreased expression of FOXE1 mRNA25539665|2738771
C039281furanfuran results in increased methylation of FOXE1 gene27387713
D008694MethamphetamineMethamphetamine results in increased expression of FOXE1 mRNA28341135
D008694MethamphetamineMethamphetamine results in increased expression of FOXE1 protein28341135
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of FOXE1 mRNA19095052
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of FOXE1 mRNA16079270
C059514resveratrolresveratrol results in increased expression of FOXE1 mRNA23594881
C059514resveratrolresveratrol results in decreased expression of FOXE1 mRNA28668442
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXE1 mRNA24058054
D014810Vitamin EVitamin E results in decreased expression of FOXE1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA24219130  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IMP12165566  16882747  20094846  20484477  21177256  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-IDA9697705  
GO:0043565sequence-specific DNA binding-IDA9697705  24219130  
GO:0043565sequence-specific DNA binding-IMP12165566  16882747  20094846  20484477  21177256  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0000122negative regulation of transcription by RNA polymerase II-NAS9169137  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IDA24219130  
GO:0006357regulation of transcription by RNA polymerase II-IMP12165566  16882747  20094846  20484477  21177256  
GO:0006590thyroid hormone generation-ISS-  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0009653anatomical structure morphogenesis-NAS9169137  
GO:0016477cell migration-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030878thyroid gland development-IEP15494458  
GO:0030878thyroid gland development-IMP9697705  
GO:0031069hair follicle morphogenesis-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA9697705  
GO:0048538thymus development-IEP15494458  
GO:0048562embryonic organ morphogenesis-ISS-  
GO:0060022hard palate development-IMP12165566  
GO:0060023soft palate development-IMP12165566  
GO:0060465pharynx development-IEP15494458  
GO:1904888cranial skeletal system development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9697705  21177256  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet
27610545FOXE1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population. (2016 Dec)Ren YThyroid