Gene: SMG1

23049
61E3.4|ATX|LIP
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
protein-coding
16p12.3
Ensembl:ENSG00000157106 MIM:607032 Vega:OTTHUMG00000166900 UniprotKB:Q96Q15
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.433e-2 (AD)  1.306e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTUD40.937
KMT2A0.926
ZC3H140.921
FAM208B0.918
ANKRD170.917
ZFC3H10.915
HELZ0.915
CSPP10.911
UBR20.911
EPG50.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.507
OR4F29-0.473
KLRC2-0.295
NANOGNB-0.293
S100A1-0.291
KLRB1-0.287
RBP1-0.277
OR4F16-0.275
KLRC3-0.26
S100A14-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of SMG1 mRNA28522335
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SMG1 mRNA19038236
D000082AcetaminophenAcetaminophen results in increased expression of SMG1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SMG1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SMG1 mRNA19770486
C030935benz(a)anthracenebenz(a)anthracene affects the expression of SMG1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMG1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMG1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMG1 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of SMG1 mRNA16705744
D004958EstradiolEstradiol results in increased expression of SMG1 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SMG1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMG1 mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of SMG1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of SMG1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SMG1 mRNA28628672
C018021cobaltous chloridecobaltous chloride results in increased expression of SMG1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of SMG1 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of SMG1 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of SMG1 mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of SMG1 mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of SMG1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SMG1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMG1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SMG1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SMG1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SMG1 mRNA27594783
D002945CisplatinSMG1 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]21418860
D002945CisplatinSMG1 protein inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]21418860
D002945CisplatinSMG1 protein results in decreased susceptibility to Cisplatin21418860
D002945CisplatinCisplatin results in increased phosphorylation of SMG1 protein22006019
D004317DoxorubicinDoxorubicin results in increased expression of SMG1 mRNA25896364
C056507gemcitabineSMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]21418860
C056507gemcitabineSMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]21418860
C056507gemcitabineSMG1 protein results in decreased susceptibility to gemcitabine21418860
D019833GenisteinGenistein results in decreased expression of SMG1 mRNA16705744
D019833GenisteinGenistein results in increased expression of SMG1 mRNA23019147
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SMG1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMG1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SMG1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMG1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SMG1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMG1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SMG1 mRNA28628672
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMG1 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SMG1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SMG1 mRNA26272509
D010416PentachlorophenolPentachlorophenol results in increased expression of SMG1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SMG1 mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of SMG1 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SMG1 mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of SMG1 mRNA23370395
D011441PropylthiouracilPropylthiouracil results in decreased expression of SMG1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of SMG1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SMG1 mRNA25895662
D012906SmokeSmoke results in decreased expression of SMG1 mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of SMG1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of SMG1 mRNA28595984
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMG1 mRNA26378955
C004648testosterone enanthatetestosterone enanthate affects the expression of SMG1 mRNA17440010
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMG1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SMG1 mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of SMG1 mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of SMG1 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SMG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0004672protein kinase activity-TAS14636577  
GO:0004674protein serine/threonine kinase activity-EXP11544179  
GO:0004674protein serine/threonine kinase activity-IDA11544179  15175154  19417104  
GO:0004674protein serine/threonine kinase activity-NAS11331269  
GO:0005515protein binding-IPI11544179  16452507  18256688  19417104  20371770  20864032  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IBA21873635  
GO:0042162telomeric DNA binding-IDA17916692  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-IDA11544179  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-NAS11331269  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS16488880  
GO:0006281DNA repair-IBA21873635  
GO:0006406mRNA export from nucleus-TAS16488880  
GO:0018105peptidyl-serine phosphorylation-IDA11544179  15175154  
GO:0018105peptidyl-serine phosphorylation-TAS14636577  
GO:0032204regulation of telomere maintenance-IMP17916692  
GO:0046777protein autophosphorylation-IDA11331269  11544179  
GO:0046854phosphatidylinositol phosphorylation-IDA11331269  
GO:2001020regulation of response to DNA damage stimulus-IDA15175154  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA14636577  15175154  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA14636577  15175154  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa03015mRNA surveillance pathway
Reactome ID Reactome Term Evidence
R-HSA-8953854Metabolism of RNATAS
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19038236Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2009 Feb 12)Prokopczyk BChem Biol Interact