Gene: FOXM1

2305
FKHL16|FOXM1A|FOXM1B|FOXM1C|HFH-11|HFH11|HNF-3|INS-1|MPHOSPH2|MPP-2|MPP2|PIG29|TRIDENT
forkhead box M1
protein-coding
12p13.33
Ensembl:ENSG00000111206 MIM:602341 Vega:OTTHUMG00000168118 UniprotKB:Q08050
NG_029590.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.216e-1 (AD)  8.275e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNPEPL10.528
PLCG10.523
RGL20.515
MED220.513
MTMR30.513
WDR60.512
ZHX30.508
KREMEN10.503
TCF30.503
RBM60.502

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.315
OR4F29-0.282
C9orf153-0.258
HMX3-0.25
PAGE4-0.25
AVP-0.237
CD8B-0.237
IAPP-0.233
KRTAP1-1-0.23
PNLIPRP3-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to FOXM1 promoter]"26171734
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOXM1 mRNA"21705713|2269881
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOXM1 protein"15382178
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to FOXM1 promoter]]"26171734
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"CTNNB1 gene mutant form promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOXM1 mRNA]"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"CTNNB1 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOXM1 mRNA]"21705713|2357839
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOXM1 mRNA]"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXM1 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FOXM1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXM1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXM1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXM1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FOXM1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXM1 mRNA"25510870
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FOXM1 mRNA19191707
C5497535,7,3'-trihydroxy-3,4'-dimethoxyflavone"5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of FOXM1 protein"21229608
D000082AcetaminophenAcetaminophen results in increased expression of FOXM1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FOXM1 protein20106945
D000732Androstanols"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to FOXM1 promoter]]"26171734
C006632arsenic trioxidearsenic trioxide results in decreased expression of FOXM1 mRNA26705709
C006632arsenic trioxidearsenic trioxide results in increased expression of FOXM1 mRNA23255470
C006632arsenic trioxidearsenic trioxide results in increased expression of FOXM1 protein23255470
D001379AzathioprineAzathioprine results in decreased expression of FOXM1 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of FOXM1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOXM1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOXM1 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOXM1 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of FOXM1 protein]22094256
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA24657404
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA]20208560
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 protein]20208560
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to FOXM1 promoter]20208560
D004958EstradiolEstradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]20208560|2020856
D004958EstradiolEstradiol results in increased activity of FOXM1 protein27592001
D004958EstradiolEstradiol results in increased expression of FOXM1 mRNA18310284|1916744
D004958EstradiolEstradiol results in increased expression of FOXM1 protein20208560
D004958EstradiolFOXM1 protein results in increased susceptibility to Estradiol20208560
D004958EstradiolTamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]20208560|2020856
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of FOXM1 mRNA25210133
C006780bisphenol Abisphenol A affects the expression of FOXM1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of FOXM1 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of FOXM1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of FOXM1 mRNA25181051
C515564bromovaninbromovanin results in decreased expression of FOXM1 protein21419150
D002084Butylated HydroxytolueneButylated Hydroxytoluene affects the localization of FOXM1 mRNA12867420
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of FOXM1 mRNA11238010|1286742
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA12867420
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA12867420
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA12867420
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA12867420
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of FOXM1 protein11238010
D002084Butylated HydroxytolueneFOXM1 protein affects the susceptibility to Butylated Hydroxytoluene18345025|1967231
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FOXM1 mRNA12414654|1533650
C584509C646 compoundC646 compound results in decreased expression of FOXM1 mRNA26191083
D002110CaffeineCaffeine results in decreased expression of FOXM1 protein17182611
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FOXM1 mRNA17256749
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of FOXM1 mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of FOXM1 mRNA28954213
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of FOXM1 mRNA22135065
D002635Chenodeoxycholic AcidNR1H4 affects the reaction [Chenodeoxycholic Acid results in increased expression of FOXM1 mRNA]22135065
D002706ChlordanChlordan results in increased expression of FOXM1 mRNA20403969
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FOXM1 mRNA20938992
C073341citraconic acidcitraconic acid results in increased expression of FOXM1 protein28289076
C018021cobaltous chloridecobaltous chloride results in decreased expression of FOXM1 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FOXM1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of FOXM1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FOXM1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of FOXM1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of FOXM1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of FOXM1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of FOXM1 mRNA20106945|2556210
D000069439DasatinibDasatinib results in decreased expression of FOXM1 mRNA20579391
D013759DronabinolDronabinol results in decreased expression of FOXM1 mRNA18454173
D003976DiazinonDiazinon results in increased methylation of FOXM1 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of FOXM1 mRNA28962523
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of FOXM1 mRNA21858171
D002945CisplatinCisplatin results in increased expression of FOXM1 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of FOXM1 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FOXM1 mRNA13679865
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FOXM1 mRNA17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased phosphorylation of FOXM1 protein18393292
D004052DiethylnitrosamineFOXM1 protein affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25B protein]15082532
D004052DiethylnitrosamineFOXM1 protein affects the susceptibility to [Diethylnitrosamine co-treated with Phenobarbital]15082532
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FOXM1 mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of FOXM1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FOXM1 mRNA21592394
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of FOXM1 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FOXM1 mRNA20938992
C070081fulvestrant[fulvestrant co-treated with Sirolimus] results in decreased expression of FOXM1 mRNA19016759
C070081fulvestrantfulvestrant results in decreased expression of FOXM1 mRNA19016759|2020856
C070081fulvestrantfulvestrant results in decreased expression of FOXM1 protein20208560
C568713GSK1210151AGSK1210151A results in decreased expression of FOXM1 mRNA26877780
C568713GSK1210151AGSK1210151A results in decreased expression of FOXM1 protein26877780
D006247HarmineHarmine results in increased expression of FOXM1 mRNA25751815
D006247HarmineHarmine results in increased expression of FOXM1 protein25751815
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FOXM1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of FOXM1 mRNA12414654
C544151jinfukangjinfukang results in increased expression of FOXM1 mRNA27392435
C561695(+)-JQ1 compoundFOXM1 protein results in decreased susceptibility to (+)-JQ1 compound26877780
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOXM127256375
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOXM1 mRNA24796395|2687778
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOXM1 protein26877780|2700647
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of FOXM1 mRNA28954213
D007840LatexLatex analog results in increased expression of FOXM1 mRNA24768652
D007854LeadLead affects the expression of FOXM1 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FOXM1 mRNA22135065
D008154LucanthoneLucanthone results in decreased expression of FOXM1 mRNA21148553
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FOXM1 mRNA20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of FOXM1 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of FOXM1 mRNA24657277
D008748MethylcholanthreneFOXM1 protein affects the susceptibility to Methylcholanthrene18345025|1967231
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FOXM1 mRNA26011545
D009151Mustard GasMustard Gas results in decreased expression of FOXM1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FOXM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FOXM1 mRNA"25554681
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of FOXM1 mRNA27206323
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FOXM1 mRNA20971185
C464660obeticholic acidNR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]22135065
C464660obeticholic acidobeticholic acid results in increased expression of FOXM1 mRNA22135065
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FOXM1 mRNA25729387
C500026palbociclibbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of FOXM1 protein]22094256
C500026palbociclibCDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]22094256
C500026palbociclibpalbociclib results in decreased expression of and results in decreased activity of FOXM1 protein22094256
C500026palbociclibpalbociclib results in decreased expression of FOXM1 mRNA22869556
D010269ParaquatParaquat results in decreased expression of FOXM1 mRNA23315990
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXM1 mRNA"25510870
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of FOXM1 mRNA26678675
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FOXM1 mRNA13679865
D010634PhenobarbitalFOXM1 protein affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25B protein]15082532
D010634PhenobarbitalFOXM1 protein affects the susceptibility to [Diethylnitrosamine co-treated with Phenobarbital]15082532
D010634PhenobarbitalPhenobarbital affects the expression of FOXM1 mRNA23091169
D048789PhytoestrogensPhytoestrogens results in increased expression of FOXM1 mRNA18310284
C006253pirinixic acidpirinixic acid results in decreased expression of FOXM1 mRNA20059764
C006253pirinixic acidpirinixic acid results in increased expression of FOXM1 mRNA23811191
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of FOXM1 mRNA]20059764
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of FOXM1 mRNA21858171
D011285Pregnenolone CarbonitrileNR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of FOXM1 mRNA]22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FOXM1 mRNA22698814
C045950propiconazolepropiconazole results in increased expression of FOXM1 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of FOXM1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of FOXM1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of FOXM1 mRNA21632981
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of FOXM1 mRNA25800948
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of FOXM1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of FOXM1 mRNA19167446
C078903seocalcitolseocalcitol results in decreased expression of FOXM1 mRNA12040012
C024711siomycin Asiomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of FOXM1 protein]27517622
D020123Sirolimus[fulvestrant co-treated with Sirolimus] results in decreased expression of FOXM1 mRNA19016759
C009277sodium arsenatesodium arsenate results in decreased expression of FOXM1 mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of FOXM1 gene28589171
D012999SomanSoman results in increased expression of FOXM1 mRNA19281266
D053260SootSoot results in increased expression of FOXM1 mRNA26551751
C025462sulindac sulfidesulindac sulfide results in decreased expression of FOXM1 mRNA16184548
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of FOXM1 mRNA"26680231
D013629TamoxifenESR1 protein inhibits the reaction [Tamoxifen results in decreased expression of FOXM1 mRNA]20208560
D013629TamoxifenESR1 protein promotes the reaction [Tamoxifen results in decreased expression of FOXM1 protein]20208560
D013629TamoxifenFOXM1 protein affects the reaction [ESR1 protein results in increased susceptibility to Tamoxifen]20208560
D013629TamoxifenFOXM1 protein results in decreased susceptibility to Tamoxifen20208560
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]20208560|2020856
D013629TamoxifenTamoxifen promotes the reaction [HDAC1 protein binds to FOXM1 promoter]20208560
D013629TamoxifenTamoxifen promotes the reaction [HDAC2 protein binds to FOXM1 promoter]20208560
D013629TamoxifenTamoxifen results in decreased expression of FOXM1 mRNA20208560
D013629TamoxifenTamoxifen results in decreased expression of FOXM1 protein20208560
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FOXM1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FOXM1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXM1 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXM1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXM1 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOXM1 mRNA15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXM1 mRNA22298810
D013893ThiramThiram results in increased expression of FOXM1 mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FOXM1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of FOXM1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of FOXM1 mRNA18230668
D014241TrichloroethyleneTrichloroethylene results in decreased expression of FOXM1 mRNA26745549
D014241TrichloroethyleneTrichloroethylene results in increased expression of FOXM1 mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of FOXM1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FOXM1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FOXM1 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of FOXM1 mRNA22378314
D014520UrethaneFOXM1 protein affects the susceptibility to Urethane19672312
D014520UrethaneUrethane results in increased expression of FOXM1 protein16489016
D014635Valproic AcidValproic Acid results in decreased expression of FOXM1 mRNA28001369
C029297vinylidene chloridevinylidene chloride results in increased expression of FOXM1 mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of FOXM1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 results in decreased expression of FOXM1 mRNA12414654

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA21860419  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0005515protein binding-IPI16504183  16809346  22014570  25609649  26871637  
GO:0019901protein kinase binding-IPI19160488  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IDA19160488  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP20531406  
GO:0006281DNA repair-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator-IMP17101782  
GO:0008284positive regulation of cell proliferation-IMP19696738  
GO:0032873negative regulation of stress-activated MAPK cascade-IMP19696738  
GO:0045892negative regulation of transcription, DNA-templated-IMP20531406  
GO:0045893positive regulation of transcription, DNA-templated-IMP17101782  20531406  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA19160488  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP20531406  
GO:0046578regulation of Ras protein signal transduction-IMP19696738  
GO:0051726regulation of cell cycle-TAS-  
GO:0071156regulation of cell cycle arrest-IMP19696738  
GO:0090344negative regulation of cell aging-IMP19696738  
GO:2000377regulation of reactive oxygen species metabolic process-IMP19696738  
GO:2000781positive regulation of double-strand break repair-IMP17101782  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-156711Polo-like kinase mediated eventsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24715097Overexpression of FOXM1 is associated with EMT and is a predictor of poor prognosis in non-small cell lung cancer. (2014 Jun)Kong FFOncol Rep
19287496FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. (2009)Gemenetzidis EPLoS One
23536876FoxM1 is associated with poor prognosis of non-small cell lung cancer patients through promoting tumor metastasis. (2013)Xu NPLoS One
22109759Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma. (2011 Dec)Janus JRLaryngoscope